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Conserved domains on  [gi|402874204|ref|XP_003900933|]
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PREDICTED: glycine amidinotransferase, mitochondrial [Papio anubis]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Amidinotransf super family cl19186
Amidinotransferase; This family contains glycine (EC:2.1.4.1) and inosamine (EC:2.1.4.2) ...
86-409 6.95e-14

Amidinotransferase; This family contains glycine (EC:2.1.4.1) and inosamine (EC:2.1.4.2) amidinotransferases, enzymes involved in creatine and streptomycin biosynthesis respectively. This family also includes arginine deiminases, EC:3.5.3.6. These enzymes catalyze the reaction: arginine + H2O <=> citrulline + NH3. Also found in this family is the Streptococcus anti tumor glycoprotein.


The actual alignment was detected with superfamily member COG1834:

Pssm-ID: 327513  Cd Length: 267  Bit Score: 71.20  E-value: 6.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402874204  86 ACVPPFtIEVKANTYEkywpfYQKHGGHYFPKDhlKKAVTEIEEMCNILKMEGVIVRRPDPIDwslkyKTPDfestglyS 165
Cdd:COG1834    7 MRSPAH-SLVDYVINP-----WMKGLGEEDPQI--ERAVAQHEALVEALEKNGVEVHLLPPIE-----GLPD-------Q 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402874204 166 AMPRDILIVVGNEIIEAPMAWRSRFFEyrayRSIIKDYFHRGAkwttapkptmadelydrdYPIHSVEDRHKLAAQGKFV 245
Cdd:COG1834   67 VFTRDPGLVTGEGAVLARMGAPERRGE----EEAIKETLESLG------------------IPIYPRVEAGVFEGAGDVL 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402874204 246 TTEfepcfdaadfiraGKDIFAQRSQVTNYLGIEWMRRHLAPDYRVHIISFkDPNPMHIDATFNIIGPGTVLSNP---DR 322
Cdd:COG1834  125 MDG-------------GDTVYIGYSFRTNLEGIEQLQAWLEEGYEVSLVRL-DERYLHLDTVFNPLAEGLALAYPpafSE 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402874204 323 PCHqiDLFKKAGWTIITPPtpiipddhplWMSSKWLSMNVLMLDEKRVMVDANEvPTQKMFEKLGITTIKVNIRNANSLG 402
Cdd:COG1834  191 GAN--DVLKERGFELIEVP----------EEEAFALGCNVVSLGPNVVIALPRT-PKAEQLAAAGFEVIEVDLTEILKGG 257

                 ....*..
gi 402874204 403 GGFHCWT 409
Cdd:COG1834  258 GGLRCMT 264
 
Name Accession Description Interval E-value
DdaH COG1834
N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];
86-409 6.95e-14

N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];


Pssm-ID: 224747  Cd Length: 267  Bit Score: 71.20  E-value: 6.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402874204  86 ACVPPFtIEVKANTYEkywpfYQKHGGHYFPKDhlKKAVTEIEEMCNILKMEGVIVRRPDPIDwslkyKTPDfestglyS 165
Cdd:COG1834    7 MRSPAH-SLVDYVINP-----WMKGLGEEDPQI--ERAVAQHEALVEALEKNGVEVHLLPPIE-----GLPD-------Q 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402874204 166 AMPRDILIVVGNEIIEAPMAWRSRFFEyrayRSIIKDYFHRGAkwttapkptmadelydrdYPIHSVEDRHKLAAQGKFV 245
Cdd:COG1834   67 VFTRDPGLVTGEGAVLARMGAPERRGE----EEAIKETLESLG------------------IPIYPRVEAGVFEGAGDVL 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402874204 246 TTEfepcfdaadfiraGKDIFAQRSQVTNYLGIEWMRRHLAPDYRVHIISFkDPNPMHIDATFNIIGPGTVLSNP---DR 322
Cdd:COG1834  125 MDG-------------GDTVYIGYSFRTNLEGIEQLQAWLEEGYEVSLVRL-DERYLHLDTVFNPLAEGLALAYPpafSE 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402874204 323 PCHqiDLFKKAGWTIITPPtpiipddhplWMSSKWLSMNVLMLDEKRVMVDANEvPTQKMFEKLGITTIKVNIRNANSLG 402
Cdd:COG1834  191 GAN--DVLKERGFELIEVP----------EEEAFALGCNVVSLGPNVVIALPRT-PKAEQLAAAGFEVIEVDLTEILKGG 257

                 ....*..
gi 402874204 403 GGFHCWT 409
Cdd:COG1834  258 GGLRCMT 264
Amidinotransf pfam02274
Amidinotransferase; This family contains glycine (EC:2.1.4.1) and inosamine (EC:2.1.4.2) ...
113-414 3.25e-08

Amidinotransferase; This family contains glycine (EC:2.1.4.1) and inosamine (EC:2.1.4.2) amidinotransferases, enzymes involved in creatine and streptomycin biosynthesis respectively. This family also includes arginine deiminases, EC:3.5.3.6. These enzymes catalyze the reaction: arginine + H2O <=> citrulline + NH3. Also found in this family is the Streptococcus anti tumor glycoprotein.


Pssm-ID: 308086  Cd Length: 282  Bit Score: 54.59  E-value: 3.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402874204  113 HYF-PKDHLKKAVTEIEEMCNILKMEGVIVRRPDPIdwsLKYKTPDfestglySAMPRDILIVVGNEIIEAPMAWRSRFF 191
Cdd:pfam02274  19 LFQdDDINQERAQKEHDAFVAALRANGVEVLVLEDL---LAPPLPD-------SVFPRDWFSTIGGGVTLNPMAAPNRRR 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402874204  192 EYRAYRSIIKdyFHRGAKWTTApkptmadelydRDYPIHsvEDRHKLAAQGKFVttefepcfdaadFIRAGKDIFAqRSQ 271
Cdd:pfam02274  89 ERRLDELIYL--LHPGFKVYKV-----------LDISGK--EEDGGFLEGGDFV------------LDHDGVVAIG-VSE 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402874204  272 VTNYLGIEWMRRHLAPDYRVH----IISFKDPNPMHIDATFNIIGPGTVLS-----NPDRPCHQIDLFKKAGWTIITPPT 342
Cdd:pfam02274 141 RTDEEGIEQLARQLGYKPVAFhvvaINDPKGRAIYHLDVMFSVGDDDAVVClpsilDAEERELVAQALGEKGKRIIEISE 220
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 402874204  343 PIIPDDhplwmsskwlSMNVLMLDEKRVMVDANEVPTQKMFEKLGITTIKVNIRNANSLGGGFHCWTCDVRR 414
Cdd:pfam02274 221 EQQWNF----------GGNVLELGPGKVVAYDRNTPTQEALIEAGIEVIEIPISEIERGGGGARCMSAPIFR 282
 
Name Accession Description Interval E-value
DdaH COG1834
N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];
86-409 6.95e-14

N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];


Pssm-ID: 224747  Cd Length: 267  Bit Score: 71.20  E-value: 6.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402874204  86 ACVPPFtIEVKANTYEkywpfYQKHGGHYFPKDhlKKAVTEIEEMCNILKMEGVIVRRPDPIDwslkyKTPDfestglyS 165
Cdd:COG1834    7 MRSPAH-SLVDYVINP-----WMKGLGEEDPQI--ERAVAQHEALVEALEKNGVEVHLLPPIE-----GLPD-------Q 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402874204 166 AMPRDILIVVGNEIIEAPMAWRSRFFEyrayRSIIKDYFHRGAkwttapkptmadelydrdYPIHSVEDRHKLAAQGKFV 245
Cdd:COG1834   67 VFTRDPGLVTGEGAVLARMGAPERRGE----EEAIKETLESLG------------------IPIYPRVEAGVFEGAGDVL 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402874204 246 TTEfepcfdaadfiraGKDIFAQRSQVTNYLGIEWMRRHLAPDYRVHIISFkDPNPMHIDATFNIIGPGTVLSNP---DR 322
Cdd:COG1834  125 MDG-------------GDTVYIGYSFRTNLEGIEQLQAWLEEGYEVSLVRL-DERYLHLDTVFNPLAEGLALAYPpafSE 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402874204 323 PCHqiDLFKKAGWTIITPPtpiipddhplWMSSKWLSMNVLMLDEKRVMVDANEvPTQKMFEKLGITTIKVNIRNANSLG 402
Cdd:COG1834  191 GAN--DVLKERGFELIEVP----------EEEAFALGCNVVSLGPNVVIALPRT-PKAEQLAAAGFEVIEVDLTEILKGG 257

                 ....*..
gi 402874204 403 GGFHCWT 409
Cdd:COG1834  258 GGLRCMT 264
Amidinotransf pfam02274
Amidinotransferase; This family contains glycine (EC:2.1.4.1) and inosamine (EC:2.1.4.2) ...
113-414 3.25e-08

Amidinotransferase; This family contains glycine (EC:2.1.4.1) and inosamine (EC:2.1.4.2) amidinotransferases, enzymes involved in creatine and streptomycin biosynthesis respectively. This family also includes arginine deiminases, EC:3.5.3.6. These enzymes catalyze the reaction: arginine + H2O <=> citrulline + NH3. Also found in this family is the Streptococcus anti tumor glycoprotein.


Pssm-ID: 308086  Cd Length: 282  Bit Score: 54.59  E-value: 3.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402874204  113 HYF-PKDHLKKAVTEIEEMCNILKMEGVIVRRPDPIdwsLKYKTPDfestglySAMPRDILIVVGNEIIEAPMAWRSRFF 191
Cdd:pfam02274  19 LFQdDDINQERAQKEHDAFVAALRANGVEVLVLEDL---LAPPLPD-------SVFPRDWFSTIGGGVTLNPMAAPNRRR 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402874204  192 EYRAYRSIIKdyFHRGAKWTTApkptmadelydRDYPIHsvEDRHKLAAQGKFVttefepcfdaadFIRAGKDIFAqRSQ 271
Cdd:pfam02274  89 ERRLDELIYL--LHPGFKVYKV-----------LDISGK--EEDGGFLEGGDFV------------LDHDGVVAIG-VSE 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402874204  272 VTNYLGIEWMRRHLAPDYRVH----IISFKDPNPMHIDATFNIIGPGTVLS-----NPDRPCHQIDLFKKAGWTIITPPT 342
Cdd:pfam02274 141 RTDEEGIEQLARQLGYKPVAFhvvaINDPKGRAIYHLDVMFSVGDDDAVVClpsilDAEERELVAQALGEKGKRIIEISE 220
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 402874204  343 PIIPDDhplwmsskwlSMNVLMLDEKRVMVDANEVPTQKMFEKLGITTIKVNIRNANSLGGGFHCWTCDVRR 414
Cdd:pfam02274 221 EQQWNF----------GGNVLELGPGKVVAYDRNTPTQEALIEAGIEVIEIPISEIERGGGGARCMSAPIFR 282
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.16
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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