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Conserved domains on  [gi|38194890|gb|AAR13288|]
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Anx1 [Gossypium hirsutum]

Protein Classification

annexin( domain architecture ID 10446050)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity; similar to Mus musculus annexin A9 which may act as a low affinity receptor for acetylcholine; and Arabidopsis thaliana annexins D1 which may act in counteracting oxidative stress and in mediating regulated, targeted secretion of Golgi-derived vesicles during seedling development

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 16-78 2.18e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 88.30  E-value: 2.18e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38194890    16 DAEQLRKAFEGWGTNEQLIIDILAHRNAAQRNLIRKTYREAYGEDLLKSLDEELSSDFERAVV 78
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLL 64
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 245-310 8.17e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 86.76  E-value: 8.17e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38194890   245 YFEKVLRQAINKLGTDEWALTRVVATRAEVDMVRIKEEYQRRNSVTLEKAIAGDTSGDYEKMLLAL 310
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 87-152 7.71e-16

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 70.58  E-value: 7.71e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38194890    87 RDAFLAHEATKRFTSSHWVLMEIACTRSSHELFNVRKAYHDLYKKSLEEDVAHHTKGDYRKLLVPL 152
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin super family cl02574
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 172-234 3.88e-08

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


The actual alignment was detected with superfamily member pfam00191:

Pssm-ID: 413385  Cd Length: 66  Bit Score: 49.39  E-value: 3.88e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38194890   172 AKILREKISDKQYSDEEVIRIVTTRSKAQLNATLNHYNTAFGNAINKDLKADPEDEFLKLLRA 234
Cdd:pfam00191   3 AELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLA 65
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 16-78 2.18e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 88.30  E-value: 2.18e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38194890    16 DAEQLRKAFEGWGTNEQLIIDILAHRNAAQRNLIRKTYREAYGEDLLKSLDEELSSDFERAVV 78
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLL 64
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 245-310 8.17e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 86.76  E-value: 8.17e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38194890   245 YFEKVLRQAINKLGTDEWALTRVVATRAEVDMVRIKEEYQRRNSVTLEKAIAGDTSGDYEKMLLAL 310
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
258-310 4.56e-20

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 81.68  E-value: 4.56e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 38194890    258 GTDEWALTRVVATRAEVDMVRIKEEYQRRNSVTLEKAIAGDTSGDYEKMLLAL 310
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
28-78 1.31e-17

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 75.14  E-value: 1.31e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 38194890     28 GTNEQLIIDILAHRNAAQRNLIRKTYREAYGEDLLKSLDEELSSDFERAVV 78
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLL 51
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 87-152 7.71e-16

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 70.58  E-value: 7.71e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38194890    87 RDAFLAHEATKRFTSSHWVLMEIACTRSSHELFNVRKAYHDLYKKSLEEDVAHHTKGDYRKLLVPL 152
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
104-152 1.25e-13

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 64.35  E-value: 1.25e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 38194890    104 WVLMEIACTRSSHELFNVRKAYHDLYKKSLEEDVAHHTKGDYRKLLVPL 152
Cdd:smart00335   5 KTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 172-234 3.88e-08

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 49.39  E-value: 3.88e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38194890   172 AKILREKISDKQYSDEEVIRIVTTRSKAQLNATLNHYNTAFGNAINKDLKADPEDEFLKLLRA 234
Cdd:pfam00191   3 AELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLA 65
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 16-78 2.18e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 88.30  E-value: 2.18e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38194890    16 DAEQLRKAFEGWGTNEQLIIDILAHRNAAQRNLIRKTYREAYGEDLLKSLDEELSSDFERAVV 78
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLL 64
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 245-310 8.17e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 86.76  E-value: 8.17e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38194890   245 YFEKVLRQAINKLGTDEWALTRVVATRAEVDMVRIKEEYQRRNSVTLEKAIAGDTSGDYEKMLLAL 310
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
258-310 4.56e-20

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 81.68  E-value: 4.56e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 38194890    258 GTDEWALTRVVATRAEVDMVRIKEEYQRRNSVTLEKAIAGDTSGDYEKMLLAL 310
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
28-78 1.31e-17

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 75.14  E-value: 1.31e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 38194890     28 GTNEQLIIDILAHRNAAQRNLIRKTYREAYGEDLLKSLDEELSSDFERAVV 78
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLL 51
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 87-152 7.71e-16

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 70.58  E-value: 7.71e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38194890    87 RDAFLAHEATKRFTSSHWVLMEIACTRSSHELFNVRKAYHDLYKKSLEEDVAHHTKGDYRKLLVPL 152
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
104-152 1.25e-13

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 64.35  E-value: 1.25e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 38194890    104 WVLMEIACTRSSHELFNVRKAYHDLYKKSLEEDVAHHTKGDYRKLLVPL 152
Cdd:smart00335   5 KTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 172-234 3.88e-08

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 49.39  E-value: 3.88e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38194890   172 AKILREKISDKQYSDEEVIRIVTTRSKAQLNATLNHYNTAFGNAINKDLKADPEDEFLKLLRA 234
Cdd:pfam00191   3 AELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLA 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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