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Conserved domains on  [gi|350592614|ref|XP_003483500|]
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splicing factor 3A subunit 1 [Sus scrofa]

Protein Classification

SWAP and SF3a120_C domain-containing protein (domain architecture ID 12217832)

protein containing domains SWAP, Surp, PRP21_like_P, and SF3a120_C

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SF3a120_C cd01800
Ubiquitin-like domain of Mammalian splicing factor SF3a_120; SF3a120_C Mammalian splicing ...
718-793 5.41e-42

Ubiquitin-like domain of Mammalian splicing factor SF3a_120; SF3a120_C Mammalian splicing factor SF3a consists of three subunits of 60, 66, and 120 kDa and functions early during pre-mRNA splicing by converting the U2 snRNP to its active form. The 120kDa subunit (SF3a120) has a carboxy-terminal ubiquitin-like domain and two SWAP (suppressor-of-white-apricot) domains, referred to collectively as the SURP module, at its amino-terminus.


:

Pssm-ID: 176395  Cd Length: 76  Bit Score: 149.14  E-value: 5.41e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 350592614 718 TEWKLNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGGRKK 793
Cdd:cd01800    1 PEWKLNGQMLNFTLQLSDPVSVLKVKIHEETGMPAGKQKLQYEGIFIKDSNSLAYYNLANGTIIHLQLKERGGRKK 76
PRP21_like_P super family cl24249
Pre-mRNA splicing factor PRP21 like protein; This domain family is found in eukaryotes, and is ...
232-472 5.13e-37

Pre-mRNA splicing factor PRP21 like protein; This domain family is found in eukaryotes, and is typically between 212 and 238 amino acids in length. The family is found in association with pfam01805. There are two completely conserved residues (W and H) that may be functionally important. PRP21 is required for assembly of the prespliceosome and it interacts with U2 snRNP and/or pre-mRNA in the prespliceosome. This family also contains proteins similar to PRP21, such as the mammalian SF3a. SF3a also interacts with U2 snRNP from the prespliceosome, converting it to its active form.


The actual alignment was detected with superfamily member pfam12230:

Pssm-ID: 315004  Cd Length: 217  Bit Score: 139.89  E-value: 5.13e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350592614  232 EAENPREVLDQVCYRVEWAKFQERERKKEEEEKEKERVAYAQIDWHDFVVVETVDF-QPNEQGNFPPPTTPEELGARILI 310
Cdd:pfam12230   1 NLSDKQHILSRAYKRAEWRKHKEQEEQKKEEEEEEERIAFASIDWHDFVVVETIEFdDSDEVLELPKPLTLEQLIYRSLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350592614  311 QERYEKfgeseeVEMEVESDDEDEKQDKAEEPpsqldqdtqvqdmdegsddEEEGQKVPPPPETPMPPPLPPTPDQVIVR 390
Cdd:pfam12230  81 QKSKAL------ELADPVTDVEMEEDEEEEEP-------------------SKDKIAKKSKPSAVSDLASNPEGKNMKIR 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350592614  391 KDYDPKASKP-LPPAPAPDEYLVSPITGEKIPASKMQEHMRIGLLDPRWLEQRDRSIREKQSdDEVYAPGLDIESSLKQL 469
Cdd:pfam12230 136 AAGEPRLKKRkNSTPPAQKKMIKCPITGQLIPEDEFDEHMRILLLDPRYKEQKDKYVQKNFK-ESSNLTTDDVYRNLKRL 214

                  ...
gi 350592614  470 AER 472
Cdd:pfam12230 215 AKK 217
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
50-103 1.33e-24

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


:

Pssm-ID: 197818  Cd Length: 54  Bit Score: 99.58  E-value: 1.33e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 350592614    50 RNIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNPNDPYHAYYRHKVSEFKE 103
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
165-215 1.20e-20

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


:

Pssm-ID: 307771  Cd Length: 52  Bit Score: 87.95  E-value: 1.20e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 350592614  165 DVVKLTAQFVARNGRQFLTQLMQKEQRNYQFDFLRP-QHSLFNYFTKLVEQY 215
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREENNPQFAFLFDpDDPLHAYYRWKVEEY 52
 
Name Accession Description Interval E-value
SF3a120_C cd01800
Ubiquitin-like domain of Mammalian splicing factor SF3a_120; SF3a120_C Mammalian splicing ...
718-793 5.41e-42

Ubiquitin-like domain of Mammalian splicing factor SF3a_120; SF3a120_C Mammalian splicing factor SF3a consists of three subunits of 60, 66, and 120 kDa and functions early during pre-mRNA splicing by converting the U2 snRNP to its active form. The 120kDa subunit (SF3a120) has a carboxy-terminal ubiquitin-like domain and two SWAP (suppressor-of-white-apricot) domains, referred to collectively as the SURP module, at its amino-terminus.


Pssm-ID: 176395  Cd Length: 76  Bit Score: 149.14  E-value: 5.41e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 350592614 718 TEWKLNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGGRKK 793
Cdd:cd01800    1 PEWKLNGQMLNFTLQLSDPVSVLKVKIHEETGMPAGKQKLQYEGIFIKDSNSLAYYNLANGTIIHLQLKERGGRKK 76
PRP21_like_P pfam12230
Pre-mRNA splicing factor PRP21 like protein; This domain family is found in eukaryotes, and is ...
232-472 5.13e-37

Pre-mRNA splicing factor PRP21 like protein; This domain family is found in eukaryotes, and is typically between 212 and 238 amino acids in length. The family is found in association with pfam01805. There are two completely conserved residues (W and H) that may be functionally important. PRP21 is required for assembly of the prespliceosome and it interacts with U2 snRNP and/or pre-mRNA in the prespliceosome. This family also contains proteins similar to PRP21, such as the mammalian SF3a. SF3a also interacts with U2 snRNP from the prespliceosome, converting it to its active form.


Pssm-ID: 315004  Cd Length: 217  Bit Score: 139.89  E-value: 5.13e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350592614  232 EAENPREVLDQVCYRVEWAKFQERERKKEEEEKEKERVAYAQIDWHDFVVVETVDF-QPNEQGNFPPPTTPEELGARILI 310
Cdd:pfam12230   1 NLSDKQHILSRAYKRAEWRKHKEQEEQKKEEEEEEERIAFASIDWHDFVVVETIEFdDSDEVLELPKPLTLEQLIYRSLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350592614  311 QERYEKfgeseeVEMEVESDDEDEKQDKAEEPpsqldqdtqvqdmdegsddEEEGQKVPPPPETPMPPPLPPTPDQVIVR 390
Cdd:pfam12230  81 QKSKAL------ELADPVTDVEMEEDEEEEEP-------------------SKDKIAKKSKPSAVSDLASNPEGKNMKIR 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350592614  391 KDYDPKASKP-LPPAPAPDEYLVSPITGEKIPASKMQEHMRIGLLDPRWLEQRDRSIREKQSdDEVYAPGLDIESSLKQL 469
Cdd:pfam12230 136 AAGEPRLKKRkNSTPPAQKKMIKCPITGQLIPEDEFDEHMRILLLDPRYKEQKDKYVQKNFK-ESSNLTTDDVYRNLKRL 214

                  ...
gi 350592614  470 AER 472
Cdd:pfam12230 215 AKK 217
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
50-103 1.33e-24

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818  Cd Length: 54  Bit Score: 99.58  E-value: 1.33e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 350592614    50 RNIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNPNDPYHAYYRHKVSEFKE 103
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
51-101 6.68e-24

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 307771  Cd Length: 52  Bit Score: 97.19  E-value: 6.68e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 350592614   51 NIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNP-NDPYHAYYRHKVSEF 101
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREENNPQFAFLFDpDDPLHAYYRWKVEEY 52
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
165-215 1.20e-20

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 307771  Cd Length: 52  Bit Score: 87.95  E-value: 1.20e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 350592614  165 DVVKLTAQFVARNGRQFLTQLMQKEQRNYQFDFLRP-QHSLFNYFTKLVEQY 215
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREENNPQFAFLFDpDDPLHAYYRWKVEEY 52
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
164-217 4.21e-20

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818  Cd Length: 54  Bit Score: 86.49  E-value: 4.21e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 350592614   164 LDVVKLTAQFVARNGRQFLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTK 217
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
UBQ smart00213
Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of ...
718-786 7.79e-15

Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of proteins required for controlling cell cycle progression


Pssm-ID: 214563  Cd Length: 72  Bit Score: 71.91  E-value: 7.79e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350592614   718 TEWKLNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALK 786
Cdd:smart00213   4 TVKTLDGKTITLEVKPSDTVSELKEKIAELTGIPPEQQRLIYKGKVLEDDRTLADYGIQDGSTIHLVLR 72
ubiquitin pfam00240
Ubiquitin family; This family contains a number of ubiquitin-like proteins: SUMO (smt3 homolog) ...
722-788 5.56e-14

Ubiquitin family; This family contains a number of ubiquitin-like proteins: SUMO (smt3 homolog), Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.


Pssm-ID: 306702  Cd Length: 72  Bit Score: 69.52  E-value: 5.56e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 350592614  722 LNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKER 788
Cdd:pfam00240   6 LDGKKFTLEVDPSDTVLELKEKIADKEGIPVDQQRLIYKGKVLEDDQTLGEYGIKDGSTIHLVLRLR 72
UBI4 COG5272
UBI4; linked to 3D-structure
735-788 6.39e-05

UBI4; linked to 3D-structure


Pssm-ID: 319244  Cd Length: 74  Bit Score: 43.21  E-value: 6.39e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 350592614 735 DQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKER 788
Cdd:COG5272   21 DTILNFKEKIQQKEGIPPSQQRLIFSGKVLEDDKTLKDYNIQDESVLHLVLKLR 74
PTZ00044 PTZ00044
ubiquitin; Provisional
722-790 2.56e-04

ubiquitin; Provisional


Pssm-ID: 185411  Cd Length: 76  Bit Score: 41.35  E-value: 2.56e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350592614 722 LNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGG 790
Cdd:PTZ00044   8 LTGKKQSFNFEPDNTVQQVKMALQEKEGIDVKQIRLIYSGKQMSDDLKLSDYKVVPGSTIHMVLQLRGG 76
 
Name Accession Description Interval E-value
SF3a120_C cd01800
Ubiquitin-like domain of Mammalian splicing factor SF3a_120; SF3a120_C Mammalian splicing ...
718-793 5.41e-42

Ubiquitin-like domain of Mammalian splicing factor SF3a_120; SF3a120_C Mammalian splicing factor SF3a consists of three subunits of 60, 66, and 120 kDa and functions early during pre-mRNA splicing by converting the U2 snRNP to its active form. The 120kDa subunit (SF3a120) has a carboxy-terminal ubiquitin-like domain and two SWAP (suppressor-of-white-apricot) domains, referred to collectively as the SURP module, at its amino-terminus.


Pssm-ID: 176395  Cd Length: 76  Bit Score: 149.14  E-value: 5.41e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 350592614 718 TEWKLNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGGRKK 793
Cdd:cd01800    1 PEWKLNGQMLNFTLQLSDPVSVLKVKIHEETGMPAGKQKLQYEGIFIKDSNSLAYYNLANGTIIHLQLKERGGRKK 76
PRP21_like_P pfam12230
Pre-mRNA splicing factor PRP21 like protein; This domain family is found in eukaryotes, and is ...
232-472 5.13e-37

Pre-mRNA splicing factor PRP21 like protein; This domain family is found in eukaryotes, and is typically between 212 and 238 amino acids in length. The family is found in association with pfam01805. There are two completely conserved residues (W and H) that may be functionally important. PRP21 is required for assembly of the prespliceosome and it interacts with U2 snRNP and/or pre-mRNA in the prespliceosome. This family also contains proteins similar to PRP21, such as the mammalian SF3a. SF3a also interacts with U2 snRNP from the prespliceosome, converting it to its active form.


Pssm-ID: 315004  Cd Length: 217  Bit Score: 139.89  E-value: 5.13e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350592614  232 EAENPREVLDQVCYRVEWAKFQERERKKEEEEKEKERVAYAQIDWHDFVVVETVDF-QPNEQGNFPPPTTPEELGARILI 310
Cdd:pfam12230   1 NLSDKQHILSRAYKRAEWRKHKEQEEQKKEEEEEEERIAFASIDWHDFVVVETIEFdDSDEVLELPKPLTLEQLIYRSLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350592614  311 QERYEKfgeseeVEMEVESDDEDEKQDKAEEPpsqldqdtqvqdmdegsddEEEGQKVPPPPETPMPPPLPPTPDQVIVR 390
Cdd:pfam12230  81 QKSKAL------ELADPVTDVEMEEDEEEEEP-------------------SKDKIAKKSKPSAVSDLASNPEGKNMKIR 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 350592614  391 KDYDPKASKP-LPPAPAPDEYLVSPITGEKIPASKMQEHMRIGLLDPRWLEQRDRSIREKQSdDEVYAPGLDIESSLKQL 469
Cdd:pfam12230 136 AAGEPRLKKRkNSTPPAQKKMIKCPITGQLIPEDEFDEHMRILLLDPRYKEQKDKYVQKNFK-ESSNLTTDDVYRNLKRL 214

                  ...
gi 350592614  470 AER 472
Cdd:pfam12230 215 AKK 217
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
50-103 1.33e-24

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818  Cd Length: 54  Bit Score: 99.58  E-value: 1.33e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 350592614    50 RNIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNPNDPYHAYYRHKVSEFKE 103
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
51-101 6.68e-24

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 307771  Cd Length: 52  Bit Score: 97.19  E-value: 6.68e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 350592614   51 NIVDKTASFVARNGPEFEARIRQNEINNPKFNFLNP-NDPYHAYYRHKVSEF 101
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREENNPQFAFLFDpDDPLHAYYRWKVEEY 52
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
165-215 1.20e-20

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 307771  Cd Length: 52  Bit Score: 87.95  E-value: 1.20e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 350592614  165 DVVKLTAQFVARNGRQFLTQLMQKEQRNYQFDFLRP-QHSLFNYFTKLVEQY 215
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREENNPQFAFLFDpDDPLHAYYRWKVEEY 52
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
164-217 4.21e-20

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818  Cd Length: 54  Bit Score: 86.49  E-value: 4.21e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 350592614   164 LDVVKLTAQFVARNGRQFLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTK 217
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYRQ 54
UBQ smart00213
Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of ...
718-786 7.79e-15

Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of proteins required for controlling cell cycle progression


Pssm-ID: 214563  Cd Length: 72  Bit Score: 71.91  E-value: 7.79e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350592614   718 TEWKLNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALK 786
Cdd:smart00213   4 TVKTLDGKTITLEVKPSDTVSELKEKIAELTGIPPEQQRLIYKGKVLEDDRTLADYGIQDGSTIHLVLR 72
ubiquitin pfam00240
Ubiquitin family; This family contains a number of ubiquitin-like proteins: SUMO (smt3 homolog) ...
722-788 5.56e-14

Ubiquitin family; This family contains a number of ubiquitin-like proteins: SUMO (smt3 homolog), Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.


Pssm-ID: 306702  Cd Length: 72  Bit Score: 69.52  E-value: 5.56e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 350592614  722 LNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKER 788
Cdd:pfam00240   6 LDGKKFTLEVDPSDTVLELKEKIADKEGIPVDQQRLIYKGKVLEDDQTLGEYGIKDGSTIHLVLRLR 72
UBL cd01769
Ubiquitin-like domain of UBL; UBLs function by remodeling the surface of their target proteins, ...
718-786 4.72e-10

Ubiquitin-like domain of UBL; UBLs function by remodeling the surface of their target proteins, changing their target's half-life, enzymatic activity, protein-protein interactions, subcellular localization or other properties. At least 10 different ubiquitin-like modifications exist in mammals, and attachment of different ubls to a target leads to different biological consequences. Ubl-conjugation cascades are initiated by activating enzymes, which also coordinate the ubls with their downstream pathways.


Pssm-ID: 176364  Cd Length: 69  Bit Score: 58.05  E-value: 4.72e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350592614 718 TEWKLNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALK 786
Cdd:cd01769    1 TVKTLTGKTFELEVSPDDTVAELKAKIAAKEGVPPEQQRLIYAGKILKDDKTLSDYGIQDGSTLHLVLR 69
Ubiquitin cd01803
Ubiquitin; Ubiquitin (includes Ubq/RPL40e and Ubq/RPS27a fusions as well as homopolymeric ...
722-790 3.78e-07

Ubiquitin; Ubiquitin (includes Ubq/RPL40e and Ubq/RPS27a fusions as well as homopolymeric multiubiquitin protein chains)


Pssm-ID: 176398  Cd Length: 76  Bit Score: 49.87  E-value: 3.78e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350592614 722 LNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGG 790
Cdd:cd01803    8 LTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG 76
Scythe_N cd01809
Ubiquitin-like domain of Scythe protein; Scythe protein (also known as Bat3) is an apoptotic ...
705-783 6.76e-07

Ubiquitin-like domain of Scythe protein; Scythe protein (also known as Bat3) is an apoptotic regulator that is highly conserved in eukaryotes and contains a ubiquitin-like domain near its N-terminus. Scythe binds reaper, a potent apoptotic inducer, and Scythe/Reaper are thought to signal apoptosis, in part through regulating the folding and activity of apoptotic signaling molecules.


Pssm-ID: 176404  Cd Length: 72  Bit Score: 48.76  E-value: 6.76e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350592614 705 VSIKVQVPNMQDKTewklngqvlvFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHL 783
Cdd:cd01809    1 IEIKVKTLDSQTHT----------FTVEEEITVLDLKEKIAEEVGIPVEQQRLIYSGRVLKDDETLSEYKVEDGHTIHL 69
Nedd8 cd01806
Nebb8-like ubiquitin protein; Nedd8 (also known as Rub1) has a single conserved ...
722-790 8.60e-06

Nebb8-like ubiquitin protein; Nedd8 (also known as Rub1) has a single conserved ubiquitin-like domain that is part of a protein modification pathway similar to that of ubiquitin. Nedd8 modifies a family of molecular scaffold proteins called cullins that are responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis.


Pssm-ID: 176401  Cd Length: 76  Bit Score: 45.54  E-value: 8.60e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350592614 722 LNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGG 790
Cdd:cd01806    8 LTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDDKTAADYKLEGGSVLHLVLALRGG 76
UBI4 COG5272
UBI4; linked to 3D-structure
735-788 6.39e-05

UBI4; linked to 3D-structure


Pssm-ID: 319244  Cd Length: 74  Bit Score: 43.21  E-value: 6.39e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 350592614 735 DQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKER 788
Cdd:COG5272   21 DTILNFKEKIQQKEGIPPSQQRLIFSGKVLEDDKTLKDYNIQDESVLHLVLKLR 74
PTZ00044 PTZ00044
ubiquitin; Provisional
722-790 2.56e-04

ubiquitin; Provisional


Pssm-ID: 185411  Cd Length: 76  Bit Score: 41.35  E-value: 2.56e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 350592614 722 LNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGG 790
Cdd:PTZ00044   8 LTGKKQSFNFEPDNTVQQVKMALQEKEGIDVKQIRLIYSGKQMSDDLKLSDYKVVPGSTIHMVLQLRGG 76
UBQ cd00196
Ubiquitin-like proteins; Ubiquitin homologs; Includes ubiquitin and ubiquitin-like proteins. ...
720-786 3.69e-04

Ubiquitin-like proteins; Ubiquitin homologs; Includes ubiquitin and ubiquitin-like proteins. Ubiquitin-mediated proteolysis is part of the regulated turnover of proteins required for controlling cell cycle progression. Other family members are protein modifiers that perform a wide range of functions. Ubiquitination usually results in a covalent bond between the C-terminus of ubiquitin and the epsilon-amino group of a substrate lysine. The three-step mechanism requires an activating enzyme (E1) that forms a thiol ester with the C-terminal carboxy group, a conjugating enzyme (E2) that transiently carries the activated ubiquitin molecule as a thiol ester, and a ligase (E3) that transfers the activated ubiquitin from the E2 to the substrate lysine residue. In poly-ubiquitination, ubiquitin itself is the substrate.


Pssm-ID: 176352  Cd Length: 69  Bit Score: 40.59  E-value: 3.69e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 350592614 720 WKLNGQVLVFTLPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALK 786
Cdd:cd00196    3 KLNDGKTVELLVPSGTTVADLKEKLAKKLGLPPEQQRLLVNGKILPDSLTLEDYGLQDGDELVLVPR 69
Ubiquitin_2 pfam14560
Ubiquitin-like domain; This entry contains ubiquitin-like domains.
731-782 1.18e-03

Ubiquitin-like domain; This entry contains ubiquitin-like domains.


Pssm-ID: 317021  Cd Length: 86  Bit Score: 39.06  E-value: 1.18e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 350592614  731 LPLTDQVSVIKVKIHEATGMPAGKQKLQY---EGIFI----KDSNSLAYYNMANGAVIH 782
Cdd:pfam14560  20 FDKSLTIEELKKKLELITGTPPASMRLELyddDDNLVavldDDDALLGSYGVRDGMRIH 78
RAD23_N cd01805
Ubiquitin-like domain of RAD23; RAD23 belongs to a family of adaptor molecules having affinity ...
722-774 1.31e-03

Ubiquitin-like domain of RAD23; RAD23 belongs to a family of adaptor molecules having affinity for both the proteasome and ubiquitinylated proteins and thought to shuttle these ubiquitinylated proteins to the proteasome for destruction. RAD23 interacts with ubiquitin through its C-terminal ubiquitin-associated domains (UBA) and with the proteasome through its N-terminal ubiquitin-like domain (UBL).


Pssm-ID: 176400  Cd Length: 77  Bit Score: 38.85  E-value: 1.31e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 350592614 722 LNGQVLVFTLPLTDQVSVIKVKIHEATG--MPAGKQKLQYEGIFIKDSNSLAYYN 774
Cdd:cd01805    8 LKQQTFPIEVDPDDTVAELKEKIEEEKGcdYPPEQQKLIYSGKILKDDTTLEEYK 62
AN1_N cd01802
ubiquitin-like domain of AN1; AN1 (also known as ANUBL1 and RSD-7) is ubiquitin-like protein ...
735-790 2.38e-03

ubiquitin-like domain of AN1; AN1 (also known as ANUBL1 and RSD-7) is ubiquitin-like protein with a testis-specific expression in rats that has an N-terminal ubiquitin-like domain and a C-terminal zinc-binding domain. Unlike ubiquitin polyproteins and most ubiquitin fusion proteins, the N-terminal ubiquitin-like domain of An1 does not undergo proteolytic processing. The function of AN1 is unknown.


Pssm-ID: 176397  Cd Length: 103  Bit Score: 38.32  E-value: 2.38e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 350592614 735 DQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGG 790
Cdd:cd01802   48 ETVISVKAKIQRLEGIPVAQQHLIWNNMELEDEYCLNDYNISEGCTLKLVLAMRGG 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.16
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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