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Conserved domains on  [gi|332822868|ref|XP_518165|]
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PREDICTED: receptor of activated protein C kinase 1 isoform X1 [Pan troglodytes]

Protein Classification

WD40 repeat domain-containing protein (domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
7-311 1.31e-93

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121  Cd Length: 289  Bit Score: 283.07  E-value: 1.31e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868   7 LRGTLKGHNGWVTQIATTPQfPDMILSASRDKTIIMWKLTRDEtnygiPQRALRGHSHFVSDVVISSDGQFALSGSWDGT 86
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVAASADGTYLASGSSDKT 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868  87 LRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDesHSEWVSCVRFSPNssNPII 165
Cdd:cd00200   75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRG--HTDWVNSVAFSPD--GTFV 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868 166 VSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPN 244
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPD 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 332822868 245 RYWLCAATG-PSIKIWDLEGKIIVDELkqevistssKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311
Cdd:cd00200  231 GYLLASGSEdGTIRVWDLRTGECVQTL---------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
7-311 1.31e-93

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121  Cd Length: 289  Bit Score: 283.07  E-value: 1.31e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868   7 LRGTLKGHNGWVTQIATTPQfPDMILSASRDKTIIMWKLTRDEtnygiPQRALRGHSHFVSDVVISSDGQFALSGSWDGT 86
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVAASADGTYLASGSSDKT 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868  87 LRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDesHSEWVSCVRFSPNssNPII 165
Cdd:cd00200   75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRG--HTDWVNSVAFSPD--GTFV 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868 166 VSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPN 244
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPD 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 332822868 245 RYWLCAATG-PSIKIWDLEGKIIVDELkqevistssKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311
Cdd:cd00200  231 GYLLASGSEdGTIRVWDLRTGECVQTL---------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
2-310 1.38e-40

WD40 repeat [General function prediction only];


Pssm-ID: 225201  Cd Length: 466  Bit Score: 149.08  E-value: 1.38e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868   2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDEtnygiPQRALRGHSHFVSDVVISSDGQF-ALS 80
Cdd:COG2319  142 STPGKLIRTLEGHSESVTSLAFSPDGKLLASGSSLDGTIKLWDLRTGK-----PLSTLAGHTDPVSSLAFSPDGGLlIAS 216
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868  81 GSWDGTLRLWDLTTGTTTR-RFVGHTKDVLSvAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPN 159
Cdd:COG2319  217 GSSDGTIRLWDLSTGKLLRsTLSGHSDSVVS-SFSPDGSLLASGSSDGTIRLWDLRSSSSLLRTLSGHSSSVLSVAFSPD 295
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868 160 SSnpIIVSCGWDKLVKVWNLAN--CKLKTNHIGHTGYLNTVTVSPDGSLCASGG-KDGQAMLWDLNEGKHLYTLDGGDII 236
Cdd:COG2319  296 GK--LLASGSSDGTVRLWDLETgkLLSSLTLKGHEGPVSSLSFSPDGSLLVSGGsDDGTIRLWDLRTGKPLKTLEGHSNV 373
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 332822868 237 NALCFSPNRYWLC-AATGPSIKIWDLEGKIIVDELKQEVISTsskaeppqcTSLAWSADGQTLFAGYTDNLVRVW 310
Cdd:COG2319  374 LSVSFSPDGRVVSsGSTDGTVRLWDLSTGSLLRNLDGHTSRV---------TSLDFSPDGKSLASGSSDNTIRLW 439
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
80-222 2.67e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776  Cd Length: 793  Bit Score: 58.17  E-value: 2.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868  80 SGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS-DNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHsewVSCVRFs 157
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSiNQGVSIGTIKTKAN---ICCVQF- 625
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 332822868 158 PNSSNPIIVSCGWDKLVKVWNLANCKLK-TNHIGHTGYLNTVTVSpDGSLCASGGKDGQAMLWDLN 222
Cdd:PLN00181 626 PSESGRSLAFGSADHKVYYYDLRNPKLPlCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
94-133 4.25e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651  Cd Length: 40  Bit Score: 50.00  E-value: 4.25e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 332822868    94 TGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
95-133 7.21e-08

WD domain, G-beta repeat;


Pssm-ID: 306830  Cd Length: 39  Bit Score: 49.28  E-value: 7.21e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 332822868   95 GTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
Cdd:pfam00400   1 GKLLKTLKGHTSGVTSLAFSPDGKLLASGSDDGTVKLWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
7-311 1.31e-93

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121  Cd Length: 289  Bit Score: 283.07  E-value: 1.31e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868   7 LRGTLKGHNGWVTQIATTPQfPDMILSASRDKTIIMWKLTRDEtnygiPQRALRGHSHFVSDVVISSDGQFALSGSWDGT 86
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVAASADGTYLASGSSDKT 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868  87 LRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDesHSEWVSCVRFSPNssNPII 165
Cdd:cd00200   75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRG--HTDWVNSVAFSPD--GTFV 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868 166 VSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPN 244
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPD 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 332822868 245 RYWLCAATG-PSIKIWDLEGKIIVDELkqevistssKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311
Cdd:cd00200  231 GYLLASGSEdGTIRVWDLRTGECVQTL---------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
2-310 1.38e-40

WD40 repeat [General function prediction only];


Pssm-ID: 225201  Cd Length: 466  Bit Score: 149.08  E-value: 1.38e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868   2 TEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDEtnygiPQRALRGHSHFVSDVVISSDGQF-ALS 80
Cdd:COG2319  142 STPGKLIRTLEGHSESVTSLAFSPDGKLLASGSSLDGTIKLWDLRTGK-----PLSTLAGHTDPVSSLAFSPDGGLlIAS 216
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868  81 GSWDGTLRLWDLTTGTTTR-RFVGHTKDVLSvAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPN 159
Cdd:COG2319  217 GSSDGTIRLWDLSTGKLLRsTLSGHSDSVVS-SFSPDGSLLASGSSDGTIRLWDLRSSSSLLRTLSGHSSSVLSVAFSPD 295
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868 160 SSnpIIVSCGWDKLVKVWNLAN--CKLKTNHIGHTGYLNTVTVSPDGSLCASGG-KDGQAMLWDLNEGKHLYTLDGGDII 236
Cdd:COG2319  296 GK--LLASGSSDGTVRLWDLETgkLLSSLTLKGHEGPVSSLSFSPDGSLLVSGGsDDGTIRLWDLRTGKPLKTLEGHSNV 373
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 332822868 237 NALCFSPNRYWLC-AATGPSIKIWDLEGKIIVDELKQEVISTsskaeppqcTSLAWSADGQTLFAGYTDNLVRVW 310
Cdd:COG2319  374 LSVSFSPDGRVVSsGSTDGTVRLWDLSTGSLLRNLDGHTSRV---------TSLDFSPDGKSLASGSSDNTIRLW 439
WD40 COG2319
WD40 repeat [General function prediction only];
10-283 1.00e-37

WD40 repeat [General function prediction only];


Pssm-ID: 225201  Cd Length: 466  Bit Score: 141.38  E-value: 1.00e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868  10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWkltrDETNYGIPQRALRGHSHFVSDVViSSDGQFALSGSWDGTLRL 89
Cdd:COG2319  193 TLAGHTDPVSSLAFSPDGGLLIASGSSDGTIRLW----DLSTGKLLRSTLSGHSDSVVSSF-SPDGSLLASGSSDGTIRL 267
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868  90 WDL-TTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNT-LGVCKYTVQDESHSEWVSCVRFSPNSSNpIIVS 167
Cdd:COG2319  268 WDLrSSSSLLRTLSGHSSSVLSVAFSPDGKLLASGSSDGTVRLWDLeTGKLLSSLTLKGHEGPVSSLSFSPDGSL-LVSG 346
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868 168 CGWDKLVKVWNLANCKLKTNHIGHTGyLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPN-R 245
Cdd:COG2319  347 GSDDGTIRLWDLRTGKPLKTLEGHSN-VLSVSFSPDGRVVSSGSTDGTVRLWDLSTGSLLRNLDGhTSRVTSLDFSPDgK 425
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 332822868 246 YWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEP 283
Cdd:COG2319  426 SLASGSSDNTIRLWDLKTSLKSVSFSPDGKVLASKSSD 463
WD40 COG2319
WD40 repeat [General function prediction only];
32-315 3.79e-32

WD40 repeat [General function prediction only];


Pssm-ID: 225201  Cd Length: 466  Bit Score: 125.20  E-value: 3.79e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868  32 LSASRDKTIIMWKLTRDET--NYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV--GHTKD 107
Cdd:COG2319   32 SLGSSESGILLLALLSDSLvsLPDLSSLLLRGHEDSITSIAFSPDGELLLSGSSDGTIKLWDLDNGEKLIKSLegLHDSS 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868 108 VLSVAFSSDNRQIV---SGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNpIIVSCGWDKLVKVWNLANCKL 184
Cdd:COG2319  112 VSKLALSSPDGNSIllaSSSLDGTVKLWDLSTPGKLIRTLEGHSESVTSLAFSPDGKL-LASGSSLDGTIKLWDLRTGKP 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868 185 KTNHIGHTGYLNTVTVSPDGS-LCASGGKDGQAMLWDLNEGKHLY-TLDGGDIINALCFSPN-RYWLCAATGPSIKIWDL 261
Cdd:COG2319  191 LSTLAGHTDPVSSLAFSPDGGlLIASGSSDGTIRLWDLSTGKLLRsTLSGHSDSVVSSFSPDgSLLASGSSDGTIRLWDL 270
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 332822868 262 egkiivDELKQEVISTSSKAEPPqcTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
Cdd:COG2319  271 ------RSSSSLLRTLSGHSSSV--LSVAFSPDGKLLASGSSDGTVRLWDLETG 316
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
2-133 8.44e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121  Cd Length: 289  Bit Score: 107.81  E-value: 8.44e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868   2 TEQMTLRGTLKGHNGWVTQIATTPQfPDMILSASRDKTIIMWkltrdETNYGIPQRALRGHSHFVSDVVISSDGQFALSG 81
Cdd:cd00200  164 LRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLW-----DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASG 237
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 332822868  82 SWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
Cdd:cd00200  238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
62-310 5.00e-26

WD40 repeat [General function prediction only];


Pssm-ID: 225201  Cd Length: 466  Bit Score: 107.48  E-value: 5.00e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868  62 HSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN-TLGVCKY 140
Cdd:COG2319   22 GPSLNSLSLLSLGSSESGILLLALLSDSLVSLPDLSSLLLRGHEDSITSIAFSPDGELLLSGSSDGTIKLWDlDNGEKLI 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868 141 TVQDESHSEWVSCVRFSPNSSNPIIVSCGW-DKLVKVWNLANC-KLKTNHIGHTGYLNTVTVSPDGSLCASGG-KDGQAM 217
Cdd:COG2319  102 KSLEGLHDSSVSKLALSSPDGNSILLASSSlDGTVKLWDLSTPgKLIRTLEGHSESVTSLAFSPDGKLLASGSsLDGTIK 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868 218 LWDLNEGKHLYTLDG-GDIINALCFSPNRYWLCAATGP--SIKIWDLE-GKIIVDELKQEVISTSSkaeppqctslAWSA 293
Cdd:COG2319  182 LWDLRTGKPLSTLAGhTDPVSSLAFSPDGGLLIASGSSdgTIRLWDLStGKLLRSTLSGHSDSVVS----------SFSP 251
                        250
                 ....*....|....*..
gi 332822868 294 DGQTLFAGYTDNLVRVW 310
Cdd:COG2319  252 DGSLLASGSSDGTIRLW 268
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
80-222 2.67e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776  Cd Length: 793  Bit Score: 58.17  E-value: 2.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868  80 SGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS-DNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHsewVSCVRFs 157
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSiNQGVSIGTIKTKAN---ICCVQF- 625
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 332822868 158 PNSSNPIIVSCGWDKLVKVWNLANCKLK-TNHIGHTGYLNTVTVSpDGSLCASGGKDGQAMLWDLN 222
Cdd:PLN00181 626 PSESGRSLAFGSADHKVYYYDLRNPKLPlCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
94-133 4.25e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651  Cd Length: 40  Bit Score: 50.00  E-value: 4.25e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 332822868    94 TGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
31-261 4.30e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776  Cd Length: 793  Bit Score: 54.32  E-value: 4.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868  31 ILSASRDKTIIMWKLTRDETnygipQRALRGHSHFVSDVVISS-DGQFALSGSWDGTLRLWDLTTGTTtrrfVGHTK--- 106
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQL-----VTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVS----IGTIKtka 618
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868 107 DVLSVAFSSDN-RQIVSGSRDKTIKLWN----TLGVCKYTvqdeSHSEWVSCVRFSPNSSnpiIVSCGWDKLVKVWNLAN 181
Cdd:PLN00181 619 NICCVQFPSESgRSLAFGSADHKVYYYDlrnpKLPLCTMI----GHSKTVSYVRFVDSST---LVSSSTDNTLKLWDLSM 691
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868 182 CKLKTNH------IGHTGYLNTVTVSPDGSLCASGGKDGQAMLW--------------DLNEGKHLYTLDGGDIINALCF 241
Cdd:PLN00181 692 SISGINEtplhsfMGHTNVKNFVGLSVSDGYIATGSETNEVFVYhkafpmpvlsykfkTIDPVSGLEVDDASQFISSVCW 771
                        250       260
                 ....*....|....*....|.
gi 332822868 242 SPNRYWLCAA-TGPSIKIWDL 261
Cdd:PLN00181 772 RGQSSTLVAAnSTGNIKILEM 792
WD40 pfam00400
WD domain, G-beta repeat;
95-133 7.21e-08

WD domain, G-beta repeat;


Pssm-ID: 306830  Cd Length: 39  Bit Score: 49.28  E-value: 7.21e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 332822868   95 GTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
Cdd:pfam00400   1 GKLLKTLKGHTSGVTSLAFSPDGKLLASGSDDGTVKLWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
108-314 1.01e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776  Cd Length: 793  Bit Score: 53.17  E-value: 1.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868 108 VLSVAFSSDNRQIVSGSRDKTIKLWNtlgvCKYTVQD--ESHSEWVSCVRFSPNSS-------NPIIVSCGWDKLVKVWN 178
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFE----CESIIKDgrDIHYPVVELASRSKLSGicwnsyiKSQVASSNFEGVVQVWD 561
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868 179 LANCKLKTNHIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSpnrywlcAATGPSIK 257
Cdd:PLN00181 562 VARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFP-------SESGRSLA 634
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 332822868 258 IWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314
Cdd:PLN00181 635 FGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSM 691
WD40 pfam00400
WD domain, G-beta repeat;
53-91 3.91e-07

WD domain, G-beta repeat;


Pssm-ID: 306830  Cd Length: 39  Bit Score: 46.97  E-value: 3.91e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 332822868   53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWD 91
Cdd:pfam00400   1 GKLLKTLKGHTSGVTSLAFSPDGKLLASGSDDGTVKLWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
53-91 1.41e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651  Cd Length: 40  Bit Score: 45.38  E-value: 1.41e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 332822868    53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWD 91
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
102-213 2.33e-06

coronin; Provisional


Pssm-ID: 173611  Cd Length: 493  Bit Score: 48.74  E-value: 2.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868 102 VGHTKDVLSVAFSS-DNRQIVSGSRDKTIKLWN------TLGVCKYTVQDESHSEWVSCVRFSPnSSNPIIVSCGWDKLV 174
Cdd:PTZ00421  72 LGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGipeeglTQNISDPIVHLQGHTKKVGIVSFHP-SAMNVLASAGADMVV 150
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 332822868 175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKD 213
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKD 189
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
145-178 7.25e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651  Cd Length: 40  Bit Score: 40.76  E-value: 7.25e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 332822868   145 ESHSEWVSCVRFSPNSSnpIIVSCGWDKLVKVWN 178
Cdd:smart00320   9 KGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
190-220 1.41e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651  Cd Length: 40  Bit Score: 39.99  E-value: 1.41e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 332822868   190 GHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
11-133 3.05e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776  Cd Length: 793  Bit Score: 42.38  E-value: 3.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868  11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLtrdetNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90
Cdd:PLN00181 571 MKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI-----NQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYY 645
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 332822868  91 DLTTGTTTR-RFVGHTKDVLSVAFsSDNRQIVSGSRDKTIKLWN 133
Cdd:PLN00181 646 DLRNPKLPLcTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWD 688
PTZ00421 PTZ00421
coronin; Provisional
11-131 3.21e-04

coronin; Provisional


Pssm-ID: 173611  Cd Length: 493  Bit Score: 41.80  E-value: 3.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868  11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRD--ETNYGIPQRALRGHSHFVSDVVI--SSDGQFALSGSwDGT 86
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEglTQNISDPIVHLQGHTKKVGIVSFhpSAMNVLASAGA-DMV 149
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 332822868  87 LRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131
Cdd:PTZ00421 150 VNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 pfam00400
WD domain, G-beta repeat;
145-178 3.77e-04

WD domain, G-beta repeat;


Pssm-ID: 306830  Cd Length: 39  Bit Score: 38.49  E-value: 3.77e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 332822868  145 ESHSEWVSCVRFSPNSSnpIIVSCGWDKLVKVWN 178
Cdd:pfam00400   8 KGHTSGVTSLAFSPDGK--LLASGSDDGTVKLWD 39
WD40 pfam00400
WD domain, G-beta repeat;
183-220 4.11e-04

WD domain, G-beta repeat;


Pssm-ID: 306830  Cd Length: 39  Bit Score: 38.49  E-value: 4.11e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 332822868  183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Cdd:pfam00400   2 KLLKTLKGHTSGVTSLAFSPDGKLLASGSDDGTVKLWD 39
PTZ00420 PTZ00420
coronin; Provisional
11-92 2.97e-03

coronin; Provisional


Pssm-ID: 240412  Cd Length: 568  Bit Score: 39.16  E-value: 2.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 332822868  11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYG---IPQRALRGHSHFVSDVVISSDGQFAL-SGSWDGT 86
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKeikDPQCILKGHKKKISIIDWNPMNYYIMcSSGFDSF 149

                 ....*.
gi 332822868  87 LRLWDL 92
Cdd:PTZ00420 150 VNIWDI 155
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
4-44 4.13e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651  Cd Length: 40  Bit Score: 35.75  E-value: 4.13e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 332822868     4 QMTLRGTLKGHNGWVTQIATTPQFpDMILSASRDKTIIMWK 44
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.16
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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