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Conserved domains on  [gi|32565044|ref|NP_493723|]
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Protein Classification

Nuc_sug_transp domain-containing protein (domain architecture ID 12050620)

Nuc_sug_transp domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Nuc_sug_transp pfam04142
Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars ...
7-326 4.40e-165

Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars from the cytoplasm into Golgi vesicles. SSLC35A1 transports CMP-sialic acid, SLC35A2 transports UDP-galactose and SLC35A3 transports UDP-GlcNAc.


:

Pssm-ID: 282054  Cd Length: 315  Bit Score: 462.58  E-value: 4.40e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044     7 TSSNLKLISLVVLIVQTTALVLTLRYSQTQKsEGPRYLSSTAVVCAEIIKLITCFFVIYRNNGYRFSGMLNELNREIFAS 86
Cdd:pfam04142   1 NSSTFKYISLAVLTVQNASLVLTLRYSRTRK-DGPRYFSTTAVLMAEIIKLVVCFLLLYKETKSDARKFLRELHKEIFNS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044    87 PqtrADSLKVAVPAIMYVIQNNLLFFALKKLDAATYQVTYQLKILTTAIFSVTMLGKSLHRYNWMALILLTAGVALVQYP 166
Cdd:pfam04142  80 P---RDTLKVAVPSLIYTLQNNLLYVALSNLDAATYQVTYQLKILTTAIFSVLMLGRKLSTLQWMSLFLLMAGVALVQYQ 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044   167 SGDSTTSKSTAAEHDASDNILGLGAVLAACFSSGFAGVYFEKILKTSKVSLWIRNIQLAFFSVFGALLVCWLYDWQAISD 246
Cdd:pfam04142 157 QASSPESESAAAAAVEQNPILGLSAVLAACFSSGFAGVYFEKILKGSNVSLWIRNIQLALFGIIFALLGAWLYDGSRISE 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044   247 DGFLRGYNGVIWIVVLLQAYGGLVIALVVKYADNILKGFAVSLSIILSSFTSWLVLgDLTITTTFAIGATVVIFATFLYG 326
Cdd:pfam04142 237 KGFFFGYTDVVWIVVLLQAVGGLVIAVVVKYADNILKGFATSLSIILSTVASVLLF-DFFITLTFLLGAILVIAAIFLYG 315
 
Name Accession Description Interval E-value
Nuc_sug_transp pfam04142
Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars ...
7-326 4.40e-165

Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars from the cytoplasm into Golgi vesicles. SSLC35A1 transports CMP-sialic acid, SLC35A2 transports UDP-galactose and SLC35A3 transports UDP-GlcNAc.


Pssm-ID: 282054  Cd Length: 315  Bit Score: 462.58  E-value: 4.40e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044     7 TSSNLKLISLVVLIVQTTALVLTLRYSQTQKsEGPRYLSSTAVVCAEIIKLITCFFVIYRNNGYRFSGMLNELNREIFAS 86
Cdd:pfam04142   1 NSSTFKYISLAVLTVQNASLVLTLRYSRTRK-DGPRYFSTTAVLMAEIIKLVVCFLLLYKETKSDARKFLRELHKEIFNS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044    87 PqtrADSLKVAVPAIMYVIQNNLLFFALKKLDAATYQVTYQLKILTTAIFSVTMLGKSLHRYNWMALILLTAGVALVQYP 166
Cdd:pfam04142  80 P---RDTLKVAVPSLIYTLQNNLLYVALSNLDAATYQVTYQLKILTTAIFSVLMLGRKLSTLQWMSLFLLMAGVALVQYQ 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044   167 SGDSTTSKSTAAEHDASDNILGLGAVLAACFSSGFAGVYFEKILKTSKVSLWIRNIQLAFFSVFGALLVCWLYDWQAISD 246
Cdd:pfam04142 157 QASSPESESAAAAAVEQNPILGLSAVLAACFSSGFAGVYFEKILKGSNVSLWIRNIQLALFGIIFALLGAWLYDGSRISE 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044   247 DGFLRGYNGVIWIVVLLQAYGGLVIALVVKYADNILKGFAVSLSIILSSFTSWLVLgDLTITTTFAIGATVVIFATFLYG 326
Cdd:pfam04142 237 KGFFFGYTDVVWIVVLLQAVGGLVIAVVVKYADNILKGFATSLSIILSTVASVLLF-DFFITLTFLLGAILVIAAIFLYG 315
nst TIGR00803
UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10) ...
95-325 4.71e-55

UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10)Nucleotide-sugar transporters (NSTs) are found in the Golgi apparatus and the endoplasmic reticulum of eukaryotic cells. Members of the family have been sequenced from yeast, protozoans and animals. Animals such as C. elegans possess many of these transporters. Humans have at least two closely related isoforms of the UDP-galactose:UMP exchange transporter.NSTs generally appear to function by antiport mechanisms, exchanging a nucleotide-sugar for a nucleotide. Thus, CMP-sialic acid is exchanged for CMP; GDP-mannose is preferentially exchanged for GMP, and UDP-galactose and UDP-N-acetylglucosamine are exchanged for UMP (or possibly UDP). Other nucleotide sugars (e.g., GDP-fucose, UDP-xylose, UDP-glucose, UDP-N-acetylgalactosamine, etc.) may also be transported in exchange for various nucleotides, but their transporters have not been molecularly characterized. Each compound appears to be translocated by its own transport protein. Transport allows the compound, synthesized in the cytoplasm, to be exported to the lumen of the Golgi apparatus or the endoplasmic reticulum where it is used for the synthesis of glycoproteins and glycolipids.


Pssm-ID: 129885  Cd Length: 222  Bit Score: 179.09  E-value: 4.71e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044    95 KVAVPAIMYVIQNNLLFFALKKLDAATYQVTyQLKILTTAIFSVTMLGKSLHRYNWMALILLTAGVALVQYPSgdsttsk 174
Cdd:TIGR00803   1 KLSVPIHIIFKQNNLVLIALGNLLAAGKQVT-QLKILSTALMTLGSLVASLGDDQWFSLKLLKLGVAIVQMVQ------- 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044   175 STAAEHDASDNILGLGAVLAACFSSGFAGVYFEKILKTSKVSLWIRNIQLAFFSVFGALLVCWLYDWQAISDDGFLRGYN 254
Cdd:TIGR00803  73 SSAKTLMFGNPVVGLSAVLSALLSSGFAGVYFEKILKDGDTMFWSRNLQLPLFGLFSTFSVLLWSDGTLISNFGFFIGYP 152
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32565044   255 GVIWIVVLLQAYGGLVIALVVKYADNILKGFAVSLSIILSSFTSwLVLGDLTITTTFAIGATVVIFATFLY 325
Cdd:TIGR00803 153 TAVWIVGLLNVGGGLCIGGVVRYADNTTKSFVTALSIILSTLAS-VRLFDAKISSTFYLGAILVFLATFLY 222
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
75-331 4.03e-06

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 223769 [Multi-domain]  Cd Length: 292  Bit Score: 47.55  E-value: 4.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044  75 MLNELNREIFASPQTRADSLKVAVPAIMYVIQNNLLFFALKKLDAATYQVTYQLKILTTAIFSVTML-GKSLHRYNWMAL 153
Cdd:COG0697  52 LPLLLLEPRGLRPALRPWLLLLLLALLGLALPFLLLFLALKYTSASVASLIIGLLPLFTALLAVLLLlGERLSLLQILGI 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044 154 ILLTAGVALVQYPSGDSTTSkstaaehdasdNILGLGAVLAACFSSGFAGVYFEKILKTSKVSLwirniqLAFFSVFGAL 233
Cdd:COG0697 132 LLALAGVLLILLGGGGGGIL-----------SLLGLLLALAAALLWALYTALVKRLSRLGPVTL------ALLLQLLLAL 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044 234 LVCWLYDWQAISDDGFLRGYNGVIWIVVLLQAYGGLVIALVVKYADNILKGFAVSLSIILSSFTSWLVLGDlTITTTFAI 313
Cdd:COG0697 195 LLLLLFFLSGFGAPILSRAWLLLLYLGVFSTGLAYLLWYYALRLLGASLVALLSLLEPVFAALLGVLLLGE-PLSPAQLL 273
                       250
                ....*....|....*...
gi 32565044 314 GATVVIFATFLYGHEPKS 331
Cdd:COG0697 274 GAALVVLGVLLASLRARR 291
 
Name Accession Description Interval E-value
Nuc_sug_transp pfam04142
Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars ...
7-326 4.40e-165

Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars from the cytoplasm into Golgi vesicles. SSLC35A1 transports CMP-sialic acid, SLC35A2 transports UDP-galactose and SLC35A3 transports UDP-GlcNAc.


Pssm-ID: 282054  Cd Length: 315  Bit Score: 462.58  E-value: 4.40e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044     7 TSSNLKLISLVVLIVQTTALVLTLRYSQTQKsEGPRYLSSTAVVCAEIIKLITCFFVIYRNNGYRFSGMLNELNREIFAS 86
Cdd:pfam04142   1 NSSTFKYISLAVLTVQNASLVLTLRYSRTRK-DGPRYFSTTAVLMAEIIKLVVCFLLLYKETKSDARKFLRELHKEIFNS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044    87 PqtrADSLKVAVPAIMYVIQNNLLFFALKKLDAATYQVTYQLKILTTAIFSVTMLGKSLHRYNWMALILLTAGVALVQYP 166
Cdd:pfam04142  80 P---RDTLKVAVPSLIYTLQNNLLYVALSNLDAATYQVTYQLKILTTAIFSVLMLGRKLSTLQWMSLFLLMAGVALVQYQ 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044   167 SGDSTTSKSTAAEHDASDNILGLGAVLAACFSSGFAGVYFEKILKTSKVSLWIRNIQLAFFSVFGALLVCWLYDWQAISD 246
Cdd:pfam04142 157 QASSPESESAAAAAVEQNPILGLSAVLAACFSSGFAGVYFEKILKGSNVSLWIRNIQLALFGIIFALLGAWLYDGSRISE 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044   247 DGFLRGYNGVIWIVVLLQAYGGLVIALVVKYADNILKGFAVSLSIILSSFTSWLVLgDLTITTTFAIGATVVIFATFLYG 326
Cdd:pfam04142 237 KGFFFGYTDVVWIVVLLQAVGGLVIAVVVKYADNILKGFATSLSIILSTVASVLLF-DFFITLTFLLGAILVIAAIFLYG 315
nst TIGR00803
UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10) ...
95-325 4.71e-55

UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10)Nucleotide-sugar transporters (NSTs) are found in the Golgi apparatus and the endoplasmic reticulum of eukaryotic cells. Members of the family have been sequenced from yeast, protozoans and animals. Animals such as C. elegans possess many of these transporters. Humans have at least two closely related isoforms of the UDP-galactose:UMP exchange transporter.NSTs generally appear to function by antiport mechanisms, exchanging a nucleotide-sugar for a nucleotide. Thus, CMP-sialic acid is exchanged for CMP; GDP-mannose is preferentially exchanged for GMP, and UDP-galactose and UDP-N-acetylglucosamine are exchanged for UMP (or possibly UDP). Other nucleotide sugars (e.g., GDP-fucose, UDP-xylose, UDP-glucose, UDP-N-acetylgalactosamine, etc.) may also be transported in exchange for various nucleotides, but their transporters have not been molecularly characterized. Each compound appears to be translocated by its own transport protein. Transport allows the compound, synthesized in the cytoplasm, to be exported to the lumen of the Golgi apparatus or the endoplasmic reticulum where it is used for the synthesis of glycoproteins and glycolipids.


Pssm-ID: 129885  Cd Length: 222  Bit Score: 179.09  E-value: 4.71e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044    95 KVAVPAIMYVIQNNLLFFALKKLDAATYQVTyQLKILTTAIFSVTMLGKSLHRYNWMALILLTAGVALVQYPSgdsttsk 174
Cdd:TIGR00803   1 KLSVPIHIIFKQNNLVLIALGNLLAAGKQVT-QLKILSTALMTLGSLVASLGDDQWFSLKLLKLGVAIVQMVQ------- 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044   175 STAAEHDASDNILGLGAVLAACFSSGFAGVYFEKILKTSKVSLWIRNIQLAFFSVFGALLVCWLYDWQAISDDGFLRGYN 254
Cdd:TIGR00803  73 SSAKTLMFGNPVVGLSAVLSALLSSGFAGVYFEKILKDGDTMFWSRNLQLPLFGLFSTFSVLLWSDGTLISNFGFFIGYP 152
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32565044   255 GVIWIVVLLQAYGGLVIALVVKYADNILKGFAVSLSIILSSFTSwLVLGDLTITTTFAIGATVVIFATFLY 325
Cdd:TIGR00803 153 TAVWIVGLLNVGGGLCIGGVVRYADNTTKSFVTALSIILSTLAS-VRLFDAKISSTFYLGAILVFLATFLY 222
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
75-331 4.03e-06

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 223769 [Multi-domain]  Cd Length: 292  Bit Score: 47.55  E-value: 4.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044  75 MLNELNREIFASPQTRADSLKVAVPAIMYVIQNNLLFFALKKLDAATYQVTYQLKILTTAIFSVTML-GKSLHRYNWMAL 153
Cdd:COG0697  52 LPLLLLEPRGLRPALRPWLLLLLLALLGLALPFLLLFLALKYTSASVASLIIGLLPLFTALLAVLLLlGERLSLLQILGI 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044 154 ILLTAGVALVQYPSGDSTTSkstaaehdasdNILGLGAVLAACFSSGFAGVYFEKILKTSKVSLwirniqLAFFSVFGAL 233
Cdd:COG0697 132 LLALAGVLLILLGGGGGGIL-----------SLLGLLLALAAALLWALYTALVKRLSRLGPVTL------ALLLQLLLAL 194
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32565044 234 LVCWLYDWQAISDDGFLRGYNGVIWIVVLLQAYGGLVIALVVKYADNILKGFAVSLSIILSSFTSWLVLGDlTITTTFAI 313
Cdd:COG0697 195 LLLLLFFLSGFGAPILSRAWLLLLYLGVFSTGLAYLLWYYALRLLGASLVALLSLLEPVFAALLGVLLLGE-PLSPAQLL 273
                       250
                ....*....|....*...
gi 32565044 314 GATVVIFATFLYGHEPKS 331
Cdd:COG0697 274 GAALVVLGVLLASLRARR 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.17
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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