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Conserved domains on  [gi|254692924|ref|NP_001157105|]
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protein Wnt-7b isoform 3 [Mus musculus]

Protein Classification

wnt domain-containing protein (domain architecture ID 10443547)

wnt domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
1-282 3.49e-165

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


:

Pssm-ID: 306592  Cd Length: 304  Bit Score: 464.70  E-value: 3.49e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692924    1 MGIDECQHQFRFGRWNCSALGEK-TVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQGYyNQAEG 79
Cdd:pfam00110  29 LAISECQHQFRNRRWNCSTLEDRnAVFGKVLKRGTRETAFVYAISSAGVVHAVTRACSSGELTSCGCDRSPRGR-SPGED 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692924   80 WKWGGCSADVRYGIDFSRRFVDAREI-KKNARRLMNLHNNEAGRKVLEDRMKLECKCHGVSGSCTTKTCWTTLPKFREVG 158
Cdd:pfam00110 108 WEWGGCSDNIDYGMRFSRKFLDARERkGRDARALMNLHNNEAGRKAVKKNMRRECKCHGVSGSCSVKTCWKQLPDFREVG 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692924  159 HLLKEKYNAAVQVEVVRASRLRQPTflrikqlRSYQKPMETDLVYIEKSPNYCEEDAATGSVGTQGRLCNRTSPGADGCD 238
Cdd:pfam00110 188 DRLKEKYDGAVKVVNNRGTRLRPRN-------SRFKPPTKTDLVYLEKSPDYCERDPKLGSLGTQGRECNKTSTGPDGCD 260
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 254692924  239 TMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK 282
Cdd:pfam00110 261 LLCCGRGYNTRTVTRTERCNCKFHWCCYVKCKTCTRTVEVHTCK 304
 
Name Accession Description Interval E-value
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
1-282 3.49e-165

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 306592  Cd Length: 304  Bit Score: 464.70  E-value: 3.49e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692924    1 MGIDECQHQFRFGRWNCSALGEK-TVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQGYyNQAEG 79
Cdd:pfam00110  29 LAISECQHQFRNRRWNCSTLEDRnAVFGKVLKRGTRETAFVYAISSAGVVHAVTRACSSGELTSCGCDRSPRGR-SPGED 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692924   80 WKWGGCSADVRYGIDFSRRFVDAREI-KKNARRLMNLHNNEAGRKVLEDRMKLECKCHGVSGSCTTKTCWTTLPKFREVG 158
Cdd:pfam00110 108 WEWGGCSDNIDYGMRFSRKFLDARERkGRDARALMNLHNNEAGRKAVKKNMRRECKCHGVSGSCSVKTCWKQLPDFREVG 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692924  159 HLLKEKYNAAVQVEVVRASRLRQPTflrikqlRSYQKPMETDLVYIEKSPNYCEEDAATGSVGTQGRLCNRTSPGADGCD 238
Cdd:pfam00110 188 DRLKEKYDGAVKVVNNRGTRLRPRN-------SRFKPPTKTDLVYLEKSPDYCERDPKLGSLGTQGRECNKTSTGPDGCD 260
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 254692924  239 TMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK 282
Cdd:pfam00110 261 LLCCGRGYNTRTVTRTERCNCKFHWCCYVKCKTCTRTVEVHTCK 304
WNT1 smart00097
found in Wnt-1;
1-282 1.88e-162

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 457.55  E-value: 1.88e-162
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692924     1 MGIDECQHQFRFGRWNCSALGEKTVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQGYYNqAEGW 80
Cdd:smart00097  29 EGIEECQHQFRFRRWNCSTLDNASVFGKVLRQGTRETAFVYAISSAGVAHAVTRACSEGELDSCGCDYRKRGRAG-GRGW 107
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692924    81 KWGGCSADVRYGIDFSRRFVDAREIKKNARRLMNLHNNEAGRKVLEDRMKLECKCHGVSGSCTTKTCWTTLPKFREVGHL 160
Cdd:smart00097 108 KWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKRECKCHGVSGSCTVKTCWLQLPDFRKVGDY 187
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692924   161 LKEKYNAAVQVEVVRASRLRQPTFlrikQLRSYQKPMETDLVYIEKSPNYCEEDAATGSVGTQGRLCNRTSPGADGCDTM 240
Cdd:smart00097 188 LKEKYDGASEVEVDKRGTNKAPVP----KNSTFKPPTETDLVYLESSPDFCEKNPKTGSLGTQGRQCNKTSKGLDGCDLL 263
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 254692924   241 CCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK 282
Cdd:smart00097 264 CCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
 
Name Accession Description Interval E-value
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
1-282 3.49e-165

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 306592  Cd Length: 304  Bit Score: 464.70  E-value: 3.49e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692924    1 MGIDECQHQFRFGRWNCSALGEK-TVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQGYyNQAEG 79
Cdd:pfam00110  29 LAISECQHQFRNRRWNCSTLEDRnAVFGKVLKRGTRETAFVYAISSAGVVHAVTRACSSGELTSCGCDRSPRGR-SPGED 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692924   80 WKWGGCSADVRYGIDFSRRFVDAREI-KKNARRLMNLHNNEAGRKVLEDRMKLECKCHGVSGSCTTKTCWTTLPKFREVG 158
Cdd:pfam00110 108 WEWGGCSDNIDYGMRFSRKFLDARERkGRDARALMNLHNNEAGRKAVKKNMRRECKCHGVSGSCSVKTCWKQLPDFREVG 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692924  159 HLLKEKYNAAVQVEVVRASRLRQPTflrikqlRSYQKPMETDLVYIEKSPNYCEEDAATGSVGTQGRLCNRTSPGADGCD 238
Cdd:pfam00110 188 DRLKEKYDGAVKVVNNRGTRLRPRN-------SRFKPPTKTDLVYLEKSPDYCERDPKLGSLGTQGRECNKTSTGPDGCD 260
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 254692924  239 TMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK 282
Cdd:pfam00110 261 LLCCGRGYNTRTVTRTERCNCKFHWCCYVKCKTCTRTVEVHTCK 304
WNT1 smart00097
found in Wnt-1;
1-282 1.88e-162

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 457.55  E-value: 1.88e-162
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692924     1 MGIDECQHQFRFGRWNCSALGEKTVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDREKQGYYNqAEGW 80
Cdd:smart00097  29 EGIEECQHQFRFRRWNCSTLDNASVFGKVLRQGTRETAFVYAISSAGVAHAVTRACSEGELDSCGCDYRKRGRAG-GRGW 107
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692924    81 KWGGCSADVRYGIDFSRRFVDAREIKKNARRLMNLHNNEAGRKVLEDRMKLECKCHGVSGSCTTKTCWTTLPKFREVGHL 160
Cdd:smart00097 108 KWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKRECKCHGVSGSCTVKTCWLQLPDFRKVGDY 187
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254692924   161 LKEKYNAAVQVEVVRASRLRQPTFlrikQLRSYQKPMETDLVYIEKSPNYCEEDAATGSVGTQGRLCNRTSPGADGCDTM 240
Cdd:smart00097 188 LKEKYDGASEVEVDKRGTNKAPVP----KNSTFKPPTETDLVYLESSPDFCEKNPKTGSLGTQGRQCNKTSKGLDGCDLL 263
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 254692924   241 CCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK 282
Cdd:smart00097 264 CCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.16
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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