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Conserved domains on  [gi|242397432|ref|NP_076142|]
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protein Wnt-2 precursor [Mus musculus]

Protein Classification

wnt domain-containing protein (domain architecture ID 10443547)

wnt domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
43-349 0e+00

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


:

Pssm-ID: 306592  Cd Length: 304  Bit Score: 512.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397432   43 NVPGLVSRQRQLCHRHPDVMRAIGLGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLLRSSRESAFVYAISSAGVVFA 122
Cdd:pfam00110   1 RLPGLSRRQRRLCRRNPDVMASIAEGARLAISECQHQFRNRRWNCSTLEDRNAVFGKVLKRGTRETAFVYAISSAGVVHA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397432  123 ITRACSQGELKSCSCDPKKKGsaKDSKGTFDWGGCSDNIDYGIKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFL 202
Cdd:pfam00110  81 VTRACSSGELTSCGCDRSPRG--RSPGEDWEWGGCSDNIDYGMRFSRKFLDARERKGRDARALMNLHNNEAGRKAVKKNM 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397432  203 KQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVmNQDGTGFTVANKRFKKPTKNDLVYFENSPDYCIRDR 282
Cdd:pfam00110 159 RRECKCHGVSGSCSVKTCWKQLPDFREVGDRLKEKYDGAVKVV-NNRGTRLRPRNSRFKPPTKTDLVYLEKSPDYCERDP 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 242397432  283 EAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCECKFHWCCAVRCQDCLEALDVHTCK 349
Cdd:pfam00110 238 KLGSLGTQGRECNKTSTGPDGCDLLCCGRGYNTRTVTRTERCNCKFHWCCYVKCKTCTRTVEVHTCK 304
 
Name Accession Description Interval E-value
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
43-349 0e+00

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 306592  Cd Length: 304  Bit Score: 512.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397432   43 NVPGLVSRQRQLCHRHPDVMRAIGLGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLLRSSRESAFVYAISSAGVVFA 122
Cdd:pfam00110   1 RLPGLSRRQRRLCRRNPDVMASIAEGARLAISECQHQFRNRRWNCSTLEDRNAVFGKVLKRGTRETAFVYAISSAGVVHA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397432  123 ITRACSQGELKSCSCDPKKKGsaKDSKGTFDWGGCSDNIDYGIKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFL 202
Cdd:pfam00110  81 VTRACSSGELTSCGCDRSPRG--RSPGEDWEWGGCSDNIDYGMRFSRKFLDARERKGRDARALMNLHNNEAGRKAVKKNM 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397432  203 KQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVmNQDGTGFTVANKRFKKPTKNDLVYFENSPDYCIRDR 282
Cdd:pfam00110 159 RRECKCHGVSGSCSVKTCWKQLPDFREVGDRLKEKYDGAVKVV-NNRGTRLRPRNSRFKPPTKTDLVYLEKSPDYCERDP 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 242397432  283 EAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCECKFHWCCAVRCQDCLEALDVHTCK 349
Cdd:pfam00110 238 KLGSLGTQGRECNKTSTGPDGCDLLCCGRGYNTRTVTRTERCNCKFHWCCYVKCKTCTRTVEVHTCK 304
WNT1 smart00097
found in Wnt-1;
43-349 7.80e-170

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 479.89  E-value: 7.80e-170
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397432    43 NVPGLVSRQRQLCHRHPDVMRAIGLGVAEWTAECQHQFRQHRWNCNTLDrDHSLFGRVLLRSSRESAFVYAISSAGVVFA 122
Cdd:smart00097   1 SLPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLD-NASVFGKVLRQGTRETAFVYAISSAGVAHA 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397432   123 ITRACSQGELKSCSCDPKKKGSAkdSKGTFDWGGCSDNIDYGIKFARAFVDAKERkGKDARALMNLHNNRAGRKAVKRFL 202
Cdd:smart00097  80 VTRACSEGELDSCGCDYRKRGRA--GGRGWKWGGCSDNIDFGIRFSREFVDARER-GKDARALMNLHNNEAGRLAVKKTM 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397432   203 KQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVA--NKRFKKPTKNDLVYFENSPDYCIR 280
Cdd:smart00097 157 KRECKCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPVpkNSTFKPPTETDLVYLESSPDFCEK 236
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 242397432   281 DREAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCECKFHWCCAVRCQDCLEALDVHTCK 349
Cdd:smart00097 237 NPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
 
Name Accession Description Interval E-value
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
43-349 0e+00

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 306592  Cd Length: 304  Bit Score: 512.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397432   43 NVPGLVSRQRQLCHRHPDVMRAIGLGVAEWTAECQHQFRQHRWNCNTLDRDHSLFGRVLLRSSRESAFVYAISSAGVVFA 122
Cdd:pfam00110   1 RLPGLSRRQRRLCRRNPDVMASIAEGARLAISECQHQFRNRRWNCSTLEDRNAVFGKVLKRGTRETAFVYAISSAGVVHA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397432  123 ITRACSQGELKSCSCDPKKKGsaKDSKGTFDWGGCSDNIDYGIKFARAFVDAKERKGKDARALMNLHNNRAGRKAVKRFL 202
Cdd:pfam00110  81 VTRACSSGELTSCGCDRSPRG--RSPGEDWEWGGCSDNIDYGMRFSRKFLDARERKGRDARALMNLHNNEAGRKAVKKNM 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397432  203 KQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVmNQDGTGFTVANKRFKKPTKNDLVYFENSPDYCIRDR 282
Cdd:pfam00110 159 RRECKCHGVSGSCSVKTCWKQLPDFREVGDRLKEKYDGAVKVV-NNRGTRLRPRNSRFKPPTKTDLVYLEKSPDYCERDP 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 242397432  283 EAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCECKFHWCCAVRCQDCLEALDVHTCK 349
Cdd:pfam00110 238 KLGSLGTQGRECNKTSTGPDGCDLLCCGRGYNTRTVTRTERCNCKFHWCCYVKCKTCTRTVEVHTCK 304
WNT1 smart00097
found in Wnt-1;
43-349 7.80e-170

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 479.89  E-value: 7.80e-170
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397432    43 NVPGLVSRQRQLCHRHPDVMRAIGLGVAEWTAECQHQFRQHRWNCNTLDrDHSLFGRVLLRSSRESAFVYAISSAGVVFA 122
Cdd:smart00097   1 SLPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLD-NASVFGKVLRQGTRETAFVYAISSAGVAHA 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397432   123 ITRACSQGELKSCSCDPKKKGSAkdSKGTFDWGGCSDNIDYGIKFARAFVDAKERkGKDARALMNLHNNRAGRKAVKRFL 202
Cdd:smart00097  80 VTRACSEGELDSCGCDYRKRGRA--GGRGWKWGGCSDNIDFGIRFSREFVDARER-GKDARALMNLHNNEAGRLAVKKTM 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 242397432   203 KQECKCHGVSGSCTLRTCWLAMADFRKTGDYLWRKYNGAIQVVMNQDGTGFTVA--NKRFKKPTKNDLVYFENSPDYCIR 280
Cdd:smart00097 157 KRECKCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPVpkNSTFKPPTETDLVYLESSPDFCEK 236
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 242397432   281 DREAGSLGTAGRVCNLTSRGMDSCEVMCCGRGYDTSHVTRMTKCECKFHWCCAVRCQDCLEALDVHTCK 349
Cdd:smart00097 237 NPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.16
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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