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Conserved domains on  [gi|223468670|ref|NP_001138606|]
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carnitine O-palmitoyltransferase 1, muscle isoform isoform c [Homo sapiens]

Protein Classification

CPT_N and Carn_acyltransf domain-containing protein (domain architecture ID 11243103)

CPT_N and Carn_acyltransf domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Carn_acyltransf pfam00755
Choline/Carnitine o-acyltransferase;
154-724 0e+00

Choline/Carnitine o-acyltransferase;


:

Pssm-ID: 307070  Cd Length: 571  Bit Score: 721.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  154 YLESVRPLLDDEEYYRMELLAKEFQDKTAPRLQKYLVLKSWWASNYVSDWWEEYIYLRGRSPLMVNSNYYVMDLVLIKNT 233
Cdd:pfam00755  16 YLESVKPLLDEEEYERTEKLVEEFLKGGGPKLQERLLERAKASKNWLSDWWLDYAYLEYRDPLVLNSNYFFVLPGDPDPP 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  234 DV-QAARLGNIIHAMIMYRRKLDREEIKPVMALgiVPMCSYQMERMFNTTRIPGKDTD--VLQHLSDSRHVAVYHKGRFF 310
Cdd:pfam00755  96 TRnQQERAANLIHSALEFKRLLRRETLPPEVLG--GPLCMSQYKRLFNTTRIPGKERDtlTLQDGPDSRHIVVLRKGQFY 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  311 KLWLY--EGARLLKPQDLEMQFQRILDDPSPPQPGEEKLAALTAGGRVEWAQARQAFFSSGKNKAALEAIERAAFFVALD 388
Cdd:pfam00755 174 KVDVLsdDGGRLLSPAELEAQLQRILDSDSDKTPPGPPVGALTTENRDTWAKAREELLKDPTNAESLEAIESALFVVCLD 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  389 EESYSYDPEDEaslslYGKALLHGNcYNRWFDKSFTLISFKNGQLGLNAEHAWADAPIIGHLWEFVLGTDSFHLGYTETG 468
Cdd:pfam00755 254 DASPEPTDEEE-----LARQLLHGG-TNRWFDKSLQLIVTKNGRAGFNGEHSPADGTPVLRLNDYVLTDIIEKPAVDPNE 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  469 HclgKPNPALAPPTRLQWDIPKQCQAVIESSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDR 548
Cdd:pfam00755 328 S---APSSPAPSPEKLEFNLDDELKEAIEEAKTRFDKLISDLDLHVLEFTDYGKNFIKKFKLSPDAFIQMALQLAYYRLY 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  549 GKFCLTYEASMTRMFREGRTETVRSCTSESTAFVQAMMEGSHTKADL-RDLFQKAAKKHQNMYRLAMTGAGIDRHLFCLY 627
Cdd:pfam00755 405 GKFAATYESASTRKFRHGRTETIRSVTPESVAFVKAMTDPSASDEEKvLELLRAAVKAHVKLTKEAATGQGVDRHLFGLK 484
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  628 LVSKYLGVSSP-FLAEVLSEP---WRLSTSQIPQSQIRmfdpeqhpnhlgaGGGFGPVADDGYGVSYMIaGENTIFFHIS 703
Cdd:pfam00755 485 LLAKELGLPLPeLFTDPAYAKsnhWVLSTSQLPSPAFR-------------GGGFGPVVPDGYGIGYNI-GDDSISFCIS 550
                         570       580
                  ....*....|....*....|.
gi 223468670  704 SKFSSSETNAQRFGNHIRKAL 724
Cdd:pfam00755 551 SKKSCPETDAERFAKALEEAL 571
CPT_N pfam16484
Carnitine O-palmitoyltransferase N-terminus; This domain is found at the N-terminus of ...
1-46 3.13e-23

Carnitine O-palmitoyltransferase N-terminus; This domain is found at the N-terminus of carnitine O-palmitoyltransferases. It functions as a regulatory domain and is linked to the catalytic domain (pfam00755) via two transmembrane regions.


:

Pssm-ID: 318644  Cd Length: 46  Bit Score: 94.99  E-value: 3.13e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 223468670    1 MAEAHQAVAFQFTVTPDGVDFRLSREALKHVYLSGINSWKKRLIRI 46
Cdd:pfam16484   1 MAEAHQAVAFQFTVTPDGIDVQLSHEALKEIYLSGVRSWKKRLIRF 46
 
Name Accession Description Interval E-value
Carn_acyltransf pfam00755
Choline/Carnitine o-acyltransferase;
154-724 0e+00

Choline/Carnitine o-acyltransferase;


Pssm-ID: 307070  Cd Length: 571  Bit Score: 721.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  154 YLESVRPLLDDEEYYRMELLAKEFQDKTAPRLQKYLVLKSWWASNYVSDWWEEYIYLRGRSPLMVNSNYYVMDLVLIKNT 233
Cdd:pfam00755  16 YLESVKPLLDEEEYERTEKLVEEFLKGGGPKLQERLLERAKASKNWLSDWWLDYAYLEYRDPLVLNSNYFFVLPGDPDPP 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  234 DV-QAARLGNIIHAMIMYRRKLDREEIKPVMALgiVPMCSYQMERMFNTTRIPGKDTD--VLQHLSDSRHVAVYHKGRFF 310
Cdd:pfam00755  96 TRnQQERAANLIHSALEFKRLLRRETLPPEVLG--GPLCMSQYKRLFNTTRIPGKERDtlTLQDGPDSRHIVVLRKGQFY 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  311 KLWLY--EGARLLKPQDLEMQFQRILDDPSPPQPGEEKLAALTAGGRVEWAQARQAFFSSGKNKAALEAIERAAFFVALD 388
Cdd:pfam00755 174 KVDVLsdDGGRLLSPAELEAQLQRILDSDSDKTPPGPPVGALTTENRDTWAKAREELLKDPTNAESLEAIESALFVVCLD 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  389 EESYSYDPEDEaslslYGKALLHGNcYNRWFDKSFTLISFKNGQLGLNAEHAWADAPIIGHLWEFVLGTDSFHLGYTETG 468
Cdd:pfam00755 254 DASPEPTDEEE-----LARQLLHGG-TNRWFDKSLQLIVTKNGRAGFNGEHSPADGTPVLRLNDYVLTDIIEKPAVDPNE 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  469 HclgKPNPALAPPTRLQWDIPKQCQAVIESSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDR 548
Cdd:pfam00755 328 S---APSSPAPSPEKLEFNLDDELKEAIEEAKTRFDKLISDLDLHVLEFTDYGKNFIKKFKLSPDAFIQMALQLAYYRLY 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  549 GKFCLTYEASMTRMFREGRTETVRSCTSESTAFVQAMMEGSHTKADL-RDLFQKAAKKHQNMYRLAMTGAGIDRHLFCLY 627
Cdd:pfam00755 405 GKFAATYESASTRKFRHGRTETIRSVTPESVAFVKAMTDPSASDEEKvLELLRAAVKAHVKLTKEAATGQGVDRHLFGLK 484
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  628 LVSKYLGVSSP-FLAEVLSEP---WRLSTSQIPQSQIRmfdpeqhpnhlgaGGGFGPVADDGYGVSYMIaGENTIFFHIS 703
Cdd:pfam00755 485 LLAKELGLPLPeLFTDPAYAKsnhWVLSTSQLPSPAFR-------------GGGFGPVVPDGYGIGYNI-GDDSISFCIS 550
                         570       580
                  ....*....|....*....|.
gi 223468670  704 SKFSSSETNAQRFGNHIRKAL 724
Cdd:pfam00755 551 SKKSCPETDAERFAKALEEAL 571
CPT_N pfam16484
Carnitine O-palmitoyltransferase N-terminus; This domain is found at the N-terminus of ...
1-46 3.13e-23

Carnitine O-palmitoyltransferase N-terminus; This domain is found at the N-terminus of carnitine O-palmitoyltransferases. It functions as a regulatory domain and is linked to the catalytic domain (pfam00755) via two transmembrane regions.


Pssm-ID: 318644  Cd Length: 46  Bit Score: 94.99  E-value: 3.13e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 223468670    1 MAEAHQAVAFQFTVTPDGVDFRLSREALKHVYLSGINSWKKRLIRI 46
Cdd:pfam16484   1 MAEAHQAVAFQFTVTPDGIDVQLSHEALKEIYLSGVRSWKKRLIRF 46
 
Name Accession Description Interval E-value
Carn_acyltransf pfam00755
Choline/Carnitine o-acyltransferase;
154-724 0e+00

Choline/Carnitine o-acyltransferase;


Pssm-ID: 307070  Cd Length: 571  Bit Score: 721.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  154 YLESVRPLLDDEEYYRMELLAKEFQDKTAPRLQKYLVLKSWWASNYVSDWWEEYIYLRGRSPLMVNSNYYVMDLVLIKNT 233
Cdd:pfam00755  16 YLESVKPLLDEEEYERTEKLVEEFLKGGGPKLQERLLERAKASKNWLSDWWLDYAYLEYRDPLVLNSNYFFVLPGDPDPP 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  234 DV-QAARLGNIIHAMIMYRRKLDREEIKPVMALgiVPMCSYQMERMFNTTRIPGKDTD--VLQHLSDSRHVAVYHKGRFF 310
Cdd:pfam00755  96 TRnQQERAANLIHSALEFKRLLRRETLPPEVLG--GPLCMSQYKRLFNTTRIPGKERDtlTLQDGPDSRHIVVLRKGQFY 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  311 KLWLY--EGARLLKPQDLEMQFQRILDDPSPPQPGEEKLAALTAGGRVEWAQARQAFFSSGKNKAALEAIERAAFFVALD 388
Cdd:pfam00755 174 KVDVLsdDGGRLLSPAELEAQLQRILDSDSDKTPPGPPVGALTTENRDTWAKAREELLKDPTNAESLEAIESALFVVCLD 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  389 EESYSYDPEDEaslslYGKALLHGNcYNRWFDKSFTLISFKNGQLGLNAEHAWADAPIIGHLWEFVLGTDSFHLGYTETG 468
Cdd:pfam00755 254 DASPEPTDEEE-----LARQLLHGG-TNRWFDKSLQLIVTKNGRAGFNGEHSPADGTPVLRLNDYVLTDIIEKPAVDPNE 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  469 HclgKPNPALAPPTRLQWDIPKQCQAVIESSYQVAKALADDVELYCFQFLPFGKGLIKKCRTSPDAFVQIALQLAHFRDR 548
Cdd:pfam00755 328 S---APSSPAPSPEKLEFNLDDELKEAIEEAKTRFDKLISDLDLHVLEFTDYGKNFIKKFKLSPDAFIQMALQLAYYRLY 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  549 GKFCLTYEASMTRMFREGRTETVRSCTSESTAFVQAMMEGSHTKADL-RDLFQKAAKKHQNMYRLAMTGAGIDRHLFCLY 627
Cdd:pfam00755 405 GKFAATYESASTRKFRHGRTETIRSVTPESVAFVKAMTDPSASDEEKvLELLRAAVKAHVKLTKEAATGQGVDRHLFGLK 484
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223468670  628 LVSKYLGVSSP-FLAEVLSEP---WRLSTSQIPQSQIRmfdpeqhpnhlgaGGGFGPVADDGYGVSYMIaGENTIFFHIS 703
Cdd:pfam00755 485 LLAKELGLPLPeLFTDPAYAKsnhWVLSTSQLPSPAFR-------------GGGFGPVVPDGYGIGYNI-GDDSISFCIS 550
                         570       580
                  ....*....|....*....|.
gi 223468670  704 SKFSSSETNAQRFGNHIRKAL 724
Cdd:pfam00755 551 SKKSCPETDAERFAKALEEAL 571
CPT_N pfam16484
Carnitine O-palmitoyltransferase N-terminus; This domain is found at the N-terminus of ...
1-46 3.13e-23

Carnitine O-palmitoyltransferase N-terminus; This domain is found at the N-terminus of carnitine O-palmitoyltransferases. It functions as a regulatory domain and is linked to the catalytic domain (pfam00755) via two transmembrane regions.


Pssm-ID: 318644  Cd Length: 46  Bit Score: 94.99  E-value: 3.13e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 223468670    1 MAEAHQAVAFQFTVTPDGVDFRLSREALKHVYLSGINSWKKRLIRI 46
Cdd:pfam16484   1 MAEAHQAVAFQFTVTPDGIDVQLSHEALKEIYLSGVRSWKKRLIRF 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.16
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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