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Conserved domains on  [gi|190194321|ref|NP_001121711|]
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transient receptor potential cation channel subfamily M member 5 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TRP_2 super family cl26777
Transient receptor ion channel II; This domain is found in the transient receptor ion channel ...
714-1065 1.44e-05

Transient receptor ion channel II; This domain is found in the transient receptor ion channel (Trp) family of proteins. There is strong evidence that Trp proteins are structural elements of calcium-ion entry channels activated by G protein-coupled receptors. This domain does not tend to appear with the TRP domain (pfam06011) but is often found to the C-terminus of Ankyrin repeats (pfam00023).


The actual alignment was detected with superfamily member TIGR00870:

Pssm-ID: 331598  Cd Length: 743  Bit Score: 48.92  E-value: 1.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194321   714 VFMGNVIMYFAFLILFSYV-----LLLDFRPPPPYGPSAAEIILYfWVFTLVLEEIRQSfftdedmsILKKMKLYVEDNW 788
Cdd:TIGR00870  353 IFHSASYLYFLYLIIFTSVayyrpTRTDLRVTGLQQTPLEMLIVT-WVDGLRLGEEKLI--------WLGGIFEYIHQLW 423
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194321   789 NKCDMVAISLFVVGLSCR-MAMSTYEAGRTVLALDFMVFT-----------------LRLIHIFAIHKQLGPKIIIVERM 850
Cdd:TIGR00870  424 NILDFGMNSFYLATFLDRpFAILFVTQAFLVLREHWLRFDptlieealfafalvlswLNLLYIFRGNQHLGPLQIMIGRM 503
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194321   851 IK-DVFFFLFFLSVWLIAYGV----------TTQAL----LHPNDPRIDWVFRRALYRP----YLHIFGQIPLEEIDAAK 911
Cdd:TIGR00870  504 ILgDILRFLFIYAVVLFGFACglnqlyqyydELKLNecsnPHARSCEKQGNAYSTLFETsqelFWAIIGLGDLLANEHKF 583
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194321   912 MPDDNCTTDVQEIILGTLppcpnIYANwlvilllviyllvtnvlllnLLIAMFSYTFQVVQENADIFWKFQRYNLIVEY- 990
Cdd:TIGR00870  584 TEFVGLLLFGAYNVIMYI-----LLLN--------------------MLIAMMGNTYQLIADDADEEWKFQRAKLWMSYe 638
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 190194321   991 HSRPALAPPFIIISHiTQALLSFIKKTENTQDLLGKELPSGLDQKL-MTWETVqKENYLAKLEHEHRESSGERLRY 1065
Cdd:TIGR00870  639 REGGTCPPPFNIIPG-PKSFVGLFKRIEKHDGKKRQRWCRRVEEVNwTTWERK-AETLIEDGLHYQRVMKRLIKRY 712
 
Name Accession Description Interval E-value
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
714-1065 1.44e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311  Cd Length: 743  Bit Score: 48.92  E-value: 1.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194321   714 VFMGNVIMYFAFLILFSYV-----LLLDFRPPPPYGPSAAEIILYfWVFTLVLEEIRQSfftdedmsILKKMKLYVEDNW 788
Cdd:TIGR00870  353 IFHSASYLYFLYLIIFTSVayyrpTRTDLRVTGLQQTPLEMLIVT-WVDGLRLGEEKLI--------WLGGIFEYIHQLW 423
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194321   789 NKCDMVAISLFVVGLSCR-MAMSTYEAGRTVLALDFMVFT-----------------LRLIHIFAIHKQLGPKIIIVERM 850
Cdd:TIGR00870  424 NILDFGMNSFYLATFLDRpFAILFVTQAFLVLREHWLRFDptlieealfafalvlswLNLLYIFRGNQHLGPLQIMIGRM 503
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194321   851 IK-DVFFFLFFLSVWLIAYGV----------TTQAL----LHPNDPRIDWVFRRALYRP----YLHIFGQIPLEEIDAAK 911
Cdd:TIGR00870  504 ILgDILRFLFIYAVVLFGFACglnqlyqyydELKLNecsnPHARSCEKQGNAYSTLFETsqelFWAIIGLGDLLANEHKF 583
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194321   912 MPDDNCTTDVQEIILGTLppcpnIYANwlvilllviyllvtnvlllnLLIAMFSYTFQVVQENADIFWKFQRYNLIVEY- 990
Cdd:TIGR00870  584 TEFVGLLLFGAYNVIMYI-----LLLN--------------------MLIAMMGNTYQLIADDADEEWKFQRAKLWMSYe 638
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 190194321   991 HSRPALAPPFIIISHiTQALLSFIKKTENTQDLLGKELPSGLDQKL-MTWETVqKENYLAKLEHEHRESSGERLRY 1065
Cdd:TIGR00870  639 REGGTCPPPFNIIPG-PKSFVGLFKRIEKHDGKKRQRWCRRVEEVNwTTWERK-AETLIEDGLHYQRVMKRLIKRY 712
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
721-854 3.47e-04

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 306908  Cd Length: 238  Bit Score: 43.41  E-value: 3.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194321   721 MYFAFLILF-----SYVLLLDFRPPPPYG-PSAAEIILYFWVFTLVLEEIRQsFFTdedmsiLKKMKLYVEDNWNKCDMV 794
Cdd:pfam00520    2 RYFELFILLlillnTIFLALETYFQPEEPlTTVLEILDYVFTGIFTLEMLLK-IIA------AGFKKRYFRSPWNILDFV 74
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194321   795 AISLFVVGLSCRMAMSTYeagrtVLALDFMVFTLRLIHIFAIHKQLGPKIIIVERMIKDV 854
Cdd:pfam00520   75 VVLPSLISLVLSSVGSLS-----GLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSL 129
 
Name Accession Description Interval E-value
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
714-1065 1.44e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311  Cd Length: 743  Bit Score: 48.92  E-value: 1.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194321   714 VFMGNVIMYFAFLILFSYV-----LLLDFRPPPPYGPSAAEIILYfWVFTLVLEEIRQSfftdedmsILKKMKLYVEDNW 788
Cdd:TIGR00870  353 IFHSASYLYFLYLIIFTSVayyrpTRTDLRVTGLQQTPLEMLIVT-WVDGLRLGEEKLI--------WLGGIFEYIHQLW 423
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194321   789 NKCDMVAISLFVVGLSCR-MAMSTYEAGRTVLALDFMVFT-----------------LRLIHIFAIHKQLGPKIIIVERM 850
Cdd:TIGR00870  424 NILDFGMNSFYLATFLDRpFAILFVTQAFLVLREHWLRFDptlieealfafalvlswLNLLYIFRGNQHLGPLQIMIGRM 503
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194321   851 IK-DVFFFLFFLSVWLIAYGV----------TTQAL----LHPNDPRIDWVFRRALYRP----YLHIFGQIPLEEIDAAK 911
Cdd:TIGR00870  504 ILgDILRFLFIYAVVLFGFACglnqlyqyydELKLNecsnPHARSCEKQGNAYSTLFETsqelFWAIIGLGDLLANEHKF 583
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194321   912 MPDDNCTTDVQEIILGTLppcpnIYANwlvilllviyllvtnvlllnLLIAMFSYTFQVVQENADIFWKFQRYNLIVEY- 990
Cdd:TIGR00870  584 TEFVGLLLFGAYNVIMYI-----LLLN--------------------MLIAMMGNTYQLIADDADEEWKFQRAKLWMSYe 638
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 190194321   991 HSRPALAPPFIIISHiTQALLSFIKKTENTQDLLGKELPSGLDQKL-MTWETVqKENYLAKLEHEHRESSGERLRY 1065
Cdd:TIGR00870  639 REGGTCPPPFNIIPG-PKSFVGLFKRIEKHDGKKRQRWCRRVEEVNwTTWERK-AETLIEDGLHYQRVMKRLIKRY 712
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
721-854 3.47e-04

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 306908  Cd Length: 238  Bit Score: 43.41  E-value: 3.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194321   721 MYFAFLILF-----SYVLLLDFRPPPPYG-PSAAEIILYFWVFTLVLEEIRQsFFTdedmsiLKKMKLYVEDNWNKCDMV 794
Cdd:pfam00520    2 RYFELFILLlillnTIFLALETYFQPEEPlTTVLEILDYVFTGIFTLEMLLK-IIA------AGFKKRYFRSPWNILDFV 74
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194321   795 AISLFVVGLSCRMAMSTYeagrtVLALDFMVFTLRLIHIFAIHKQLGPKIIIVERMIKDV 854
Cdd:pfam00520   75 VVLPSLISLVLSSVGSLS-----GLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSL 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.16
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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