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Conserved domains on  [gi|16080691|ref|NP_391519|]
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response regulator aspartate phosphatase [Bacillus subtilis subsp. subtilis str. 168]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 116-281 6.97e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 47.68  E-value: 6.97e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691 116 AEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY-LHQFGYikkvitckLLLAVNYIDQERYEKAEQLF 194
Cdd:COG3914  64 AGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNpDNAEAL--------FNLGNLLLALGRLEEALAAL 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691 195 KEIIkktqQLHDENLlcHAYYNLGFLKATEKKDQEALLYFRKVLKNQEfemNSPVSYLHCvyesVRALFKTGNITEAKAV 274
Cdd:COG3914 136 RRAL----ALNPDFA--EAYLNLGEALRRLGRLEEAIAALRRALELDP---DNAEALNNL----GNALQDLGRLEEAIAA 202


                ....*..
gi 16080691 275 LQKGKEL 281
Cdd:COG3914 203 YRRALEL 209
RapH_N super family cl40096
response regulator aspartate phosphatase H, N terminal; Rap proteins consist of a N-terminal ...
 12-65 1.40e-05

response regulator aspartate phosphatase H, N terminal; Rap proteins consist of a N-terminal 3-helix bundle and a tetratricopeptide domain. This entry represents the conserved region of the C-terminal bundle.


The actual alignment was detected with superfamily member pfam18801:

Pssm-ID: 436748  Cd Length: 62  Bit Score: 42.14  E-value: 1.40e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 16080691    12 NMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIKKNTKLWMRYQLFQARHQLLFE 65
Cdd:pfam18801   9 AKINEWYSCIKKRDVEQAEILKEEVEQLLDEMEEDQDVLLYYSLVEFRHQLMLD 62
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 116-281 6.97e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 47.68  E-value: 6.97e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691 116 AEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY-LHQFGYikkvitckLLLAVNYIDQERYEKAEQLF 194
Cdd:COG3914  64 AGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNpDNAEAL--------FNLGNLLLALGRLEEALAAL 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691 195 KEIIkktqQLHDENLlcHAYYNLGFLKATEKKDQEALLYFRKVLKNQEfemNSPVSYLHCvyesVRALFKTGNITEAKAV 274
Cdd:COG3914 136 RRAL----ALNPDFA--EAYLNLGEALRRLGRLEEAIAALRRALELDP---DNAEALNNL----GNALQDLGRLEEAIAA 202


                ....*..
gi 16080691 275 LQKGKEL 281
Cdd:COG3914 203 YRRALEL 209
RapH_N pfam18801
response regulator aspartate phosphatase H, N terminal; Rap proteins consist of a N-terminal ...
 12-65 1.40e-05

response regulator aspartate phosphatase H, N terminal; Rap proteins consist of a N-terminal 3-helix bundle and a tetratricopeptide domain. This entry represents the conserved region of the C-terminal bundle.


Pssm-ID: 436748  Cd Length: 62  Bit Score: 42.14  E-value: 1.40e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 16080691    12 NMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIKKNTKLWMRYQLFQARHQLLFE 65
Cdd:pfam18801   9 AKINEWYSCIKKRDVEQAEILKEEVEQLLDEMEEDQDVLLYYSLVEFRHQLMLD 62
TPR_12 pfam13424
Tetratricopeptide repeat;
175-242 6.49e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.14  E-value: 6.49e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691   175 LLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDEN--LLCHAYYNLGFLKATEKKDQEALLYFRKVLKNQE 242
Cdd:pfam13424   7 NNLAAVLRRLGRYDEALELLEKALEIARRLLGPDhpLTATTLLNLGRLYLELGRYEEALELLERALALAE 76
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 116-281 6.97e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 47.68  E-value: 6.97e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691 116 AEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY-LHQFGYikkvitckLLLAVNYIDQERYEKAEQLF 194
Cdd:COG3914  64 AGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNpDNAEAL--------FNLGNLLLALGRLEEALAAL 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691 195 KEIIkktqQLHDENLlcHAYYNLGFLKATEKKDQEALLYFRKVLKNQEfemNSPVSYLHCvyesVRALFKTGNITEAKAV 274
Cdd:COG3914 136 RRAL----ALNPDFA--EAYLNLGEALRRLGRLEEAIAALRRALELDP---DNAEALNNL----GNALQDLGRLEEAIAA 202


                ....*..
gi 16080691 275 LQKGKEL 281
Cdd:COG3914 203 YRRALEL 209
RapH_N pfam18801
response regulator aspartate phosphatase H, N terminal; Rap proteins consist of a N-terminal ...
 12-65 1.40e-05

response regulator aspartate phosphatase H, N terminal; Rap proteins consist of a N-terminal 3-helix bundle and a tetratricopeptide domain. This entry represents the conserved region of the C-terminal bundle.


Pssm-ID: 436748  Cd Length: 62  Bit Score: 42.14  E-value: 1.40e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 16080691    12 NMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIKKNTKLWMRYQLFQARHQLLFE 65
Cdd:pfam18801   9 AKINEWYSCIKKRDVEQAEILKEEVEQLLDEMEEDQDVLLYYSLVEFRHQLMLD 62
COG3899 COG3899
Predicted ATPase [General function prediction only];
104-238 5.68e-05

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 45.23  E-value: 5.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691  104 TAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIYLH------QFGYIKKVITCKLLL 177
Cdd:COG3899  719 GAYAEALRYLERALELLPPDPEEEYRLALLLELAEALYLAGRFEEAEALLERALAARALaalaalRHGNPPASARAYANL 798

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16080691  178 AVnyIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLGFLKATEKKDQEALLYFRKVL 238
Cdd:COG3899  799 GL--LLLGDYEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREAL 857
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
117-349 8.29e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.46  E-value: 8.29e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691 117 EQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIYLhqfgyikKVITCKLLLAVNYIDQERYEKAEQLFKE 196
Cdd:COG0457  29 EDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDP-------DDAEALNNLGLALQALGRYEEALEDYDK 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691 197 IIKKTQQLHDenllchAYYNLGFLKATEKKDQEALLYFRKVLknqEFEMNSPVSYlhcvYESVRALFKTGNITEAKAVLQ 276
Cdd:COG0457 102 ALELDPDDAE------ALYNLGLALLELGRYDEAIEAYERAL---ELDPDDADAL----YNLGIALEKLGRYEEALELLE 168

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16080691 277 KGKELSEKVDI---QTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDITEYYKKKDDFEKAAF 349
Cdd:COG0457 169 KLEAAALAALLaaaLGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYR 244
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
130-348 2.12e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.30  E-value: 2.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691 130 ADLYYQTAGAYYLMKSPPLSVQYVKKALHIYlhqfgyiKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDenl 209
Cdd:COG0457   8 AEAYNNLGLAYRRLGRYEEAIEDYEKALELD-------PDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAE--- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691 210 lchAYYNLGFLKATEKKDQEALLYFRKVLknqEFEMNSPVSYLHCVYesvrALFKTGNITEAKAVLQKGKELSEKvDIQT 289
Cdd:COG0457  78 ---ALNNLGLALQALGRYEEALEDYDKAL---ELDPDDAEALYNLGL----ALLELGRYDEAIEAYERALELDPD-DADA 146

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16080691 290 IYLKLKTLEAL--YTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDITEYYKKKDDFEKAA 348
Cdd:COG0457 147 LYNLGIALEKLgrYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQAL 207
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 175-313 3.10e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.56  E-value: 3.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691 175 LLLAVNYIDQERYEKAEQLFKEIIKktqqLHDENLlcHAYYNLGFLKATEKKDQEALLYFRKVLKNQEFEmnspvSYLHC 254
Cdd:COG4783   8 YALAQALLLAGDYDEAEALLEKALE----LDPDNP--EAFALLGEILLQLGDLDEAIVLLHEALELDPDE-----PEARL 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16080691 255 VYesVRALFKTGNITEAKAVLQKGKELSEK-----VDIQTIYLKLKTLEAlytsAEDPYEQLLE 313
Cdd:COG4783  77 NL--GLALLKAGDYDEALALLEKALKLDPEhpeayLRLARAYRALGRPDE----AIAALEKALE 134
TPR_12 pfam13424
Tetratricopeptide repeat;
175-242 6.49e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.14  E-value: 6.49e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691   175 LLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDEN--LLCHAYYNLGFLKATEKKDQEALLYFRKVLKNQE 242
Cdd:pfam13424   7 NNLAAVLRRLGRYDEALELLEKALEIARRLLGPDhpLTATTLLNLGRLYLELGRYEEALELLERALALAE 76
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 113-313 7.06e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.87  E-value: 7.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691 113 FKKAEQ-YLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIYLHQFGYikkvitcKLLLAVNYIDQERYEKAE 191
Cdd:COG2956  92 LDRAEElLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHA-------YCELAELYLEQGDYDEAI 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691 192 QLFKEIIKKTQQLHDenllchAYYNLGFLKATEKKDQEALLYFRKVLKNQEfemnspvSYLHCVYESVRALFKTGNITEA 271
Cdd:COG2956 165 EALEKALKLDPDCAR------ALLLLAELYLEQGDYEEAIAALERALEQDP-------DYLPALPRLAELYEKLGDPEEA 231

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 16080691 272 KAVLQKGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLE 313
Cdd:COG2956 232 LELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQLR 273
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 179-277 1.98e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 37.66  E-value: 1.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691 179 VNYIDQERYEKAEQLFKEIIKKTQqlhDENLLCHAYYNLGFLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYlhcvYES 258
Cdd:COG1729   1 KALLKAGDYDEAIAAFKAFLKRYP---NSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDAL----LKL 73

                        90
                ....*....|....*....
gi 16080691 259 VRALFKTGNITEAKAVLQK 277
Cdd:COG1729  74 GLSYLELGDYDKARATLEE 92
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 175-347 2.21e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.33  E-value: 2.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691 175 LLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDenllchAYYNLGFLKATEKKDQEALLYFRKVLKNQEfemnspvSYLHC 254
Cdd:COG2956  12 YFKGLNYLLNGQPDKAIDLLEEALELDPETVE------AHLALGNLYRRRGEYDRAIRIHQKLLERDP-------DRAEA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691 255 VYESVRALFKTGNITEAKAVLQKGKELSEKvDIQTIYLklktLEALYTSAEDpYEQLLEYVLELEKIEAwvDLEVLLEDI 334
Cdd:COG2956  79 LLELAQDYLKAGLLDRAEELLEKLLELDPD-DAEALRL----LAEIYEQEGD-WEKAIEVLERLLKLGP--ENAHAYCEL 150

                       170
                ....*....|...
gi 16080691 335 TEYYKKKDDFEKA 347
Cdd:COG2956 151 AELYLEQGDYDEA 163
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 175-240 5.61e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 35.00  E-value: 5.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16080691   175 LLLAVNYIDQERYEKAEQLFKEIIKKtqqlHDENLLCH-AYYNLGFLKATEKKDQEALLYFRKVLKN 240
Cdd:pfam13432   1 LALARAALRAGDYDDAAAALEAALAR----FPESPDAAaALLLLGLAALRQGRLAEAAAAYRAALRA 63
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 175-277 6.06e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.52  E-value: 6.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16080691 175 LLLAVNYIDQERYEKAEQLFKEIIkktqQLHDENLLchAYYNLGFLKATEKKDQEALLYFRKVLKNQEfemNSPVSYlhc 254
Cdd:COG4235  21 LLLGRAYLRLGRYDEALAAYEKAL----RLDPDNAD--ALLDLAEALLAAGDTEEAEELLERALALDP---DNPEAL--- 88

                        90       100
                ....*....|....*....|...
gi 16080691 255 vYESVRALFKTGNITEAKAVLQK 277
Cdd:COG4235  89 -YLLGLAAFQQGDYAEAIAAWQK 110
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 174-239 7.85e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.14  E-value: 7.85e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16080691 174 KLLLAVNYIDQERYEKAEQLFKEIIKktqqLHDENLlcHAYYNLGFLKATEKKDQEALLYFRKVLK 239
Cdd:COG4235  54 LLDLAEALLAAGDTEEAEELLERALA----LDPDNP--EALYLLGLAAFQQGDYAEAIAAWQKLLA 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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