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Conserved domains on  [gi|148233336|ref|NP_001081444|]
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integrin alpha-4 precursor [Xenopus laevis]

Protein Classification

integrin alpha( domain architecture ID 12192572)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 super family cl26747
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 463-900 4.11e-76

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


The actual alignment was detected with superfamily member pfam08441:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 257.63  E-value: 4.11e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148233336   463 RPVIIIDAFLKL-PSTVNKTKFECMENGVAVVCMNVTVCFAYQGLDVP-GYIVMFYNITSDVRRKSGTPARFYFVSNGSS 540
Cdd:pfam08441    1 RPVVSVSASLQVePNSINPEKKNCTLTGTPVSCFTVRACFSYTGKPIPnPSLVLNYELELDRQKKKGLPPRVLFLDSQQP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148233336   541 DVISGTVEIRQKSANCKTHQAFMRKDTRDIFTPIHMESSYYLGkhiVSKRSADDFQPLQPVLQQKEgkGNVITNKVYFAR 620
Cdd:pfam08441   81 SLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR---VDPRAPSDLPGLKPILDQNQ--PSTVQEQANFLK 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148233336   621 YC---NLpnCSADLQITGKrsfPKPFESKTYLAVGGMKSLMINITLFNGGDDAFQTVLRLRLPKGLYFVKV-FDLLEKEI 696
Cdd:pfam08441  156 DCgedNV--CVPDLQLSAK---FDSRESDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVrREGSEKQL 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148233336   697 NCAVNKeENEQTRLDCSVGHFYVdAFSKQEFSFLLDSSALIRAEEDLVINATVACANEliqDTMWNNEVSFIVPTRYEID 776
Cdd:pfam08441  231 SCTAKK-ENSTRQVVCDLGNPMK-RGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNE---QNSNSNPVSLKVPVVAEAQ 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148233336   777 LNVLGTVSPFSFVFGPREDKPDDSCIMEE-----IEYTFNVINAGSSLVPAAKLQISLPNTFAPNDiKLFNILAVKTTV- 850
Cdd:pfam08441  306 LSLSGVSKPDQVVGGSVKGESAMKPRSEEdigplVEHTYEVINNGPSTVSGASLEISWPYELSNGK-WLLYLLDVQGQGk 384

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 148233336   851 GECYFDNSTRDC--ETPKNTRSKIGDLFAFFSRPDKRWLYCIKDDPSCLQIL 900
Cdd:pfam08441  385 GECSPQNEINPLnlTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTASVLL 436
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 365-417 4.63e-12

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 61.62  E-value: 4.63e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 148233336    365 ARFGETIANLGDIDNDGFEDVAIAAPQEGDLE--GAVYIYNGREKGITPSFSQRL 417
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGetGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 303-349 5.74e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 5.74e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 148233336    303 GSYFGAAVCAA-DLNGDGLSDLLVGAPIQSTIREEGRVFVYMNTGSGA 349
Cdd:smart00191    2 GSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGG 49
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 428-471 1.12e-06

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 46.60  E-value: 1.12e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 148233336    428 MFGQSLSNVLDIDGNGYQDVAIGAFLSDSAVLLRTRPVIIIDAF 471
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 247-284 8.26e-06

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 43.90  E-value: 8.26e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 148233336    247 FGSYLGYSVGAGHFRTPNGY-DVIGGAPQQEQ---TGRVYIF 284
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYpDLLVGAPRANDageTGAVYVY 42
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 49-99 5.23e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.90  E-value: 5.23e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 148233336     49 PGSLFGFSVVLHS--NGEG-NWIVVGAPQSswttKNVSNPGAILKCKIQQNPNR 99
Cdd:smart00191    1 PGSYFGYSVAGVGdvNGDGyPDLLVGAPRA----NDAGETGAVYVYFGSSGGGN 50
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 463-900 4.11e-76

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 257.63  E-value: 4.11e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148233336   463 RPVIIIDAFLKL-PSTVNKTKFECMENGVAVVCMNVTVCFAYQGLDVP-GYIVMFYNITSDVRRKSGTPARFYFVSNGSS 540
Cdd:pfam08441    1 RPVVSVSASLQVePNSINPEKKNCTLTGTPVSCFTVRACFSYTGKPIPnPSLVLNYELELDRQKKKGLPPRVLFLDSQQP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148233336   541 DVISGTVEIRQKSANCKTHQAFMRKDTRDIFTPIHMESSYYLGkhiVSKRSADDFQPLQPVLQQKEgkGNVITNKVYFAR 620
Cdd:pfam08441   81 SLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR---VDPRAPSDLPGLKPILDQNQ--PSTVQEQANFLK 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148233336   621 YC---NLpnCSADLQITGKrsfPKPFESKTYLAVGGMKSLMINITLFNGGDDAFQTVLRLRLPKGLYFVKV-FDLLEKEI 696
Cdd:pfam08441  156 DCgedNV--CVPDLQLSAK---FDSRESDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVrREGSEKQL 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148233336   697 NCAVNKeENEQTRLDCSVGHFYVdAFSKQEFSFLLDSSALIRAEEDLVINATVACANEliqDTMWNNEVSFIVPTRYEID 776
Cdd:pfam08441  231 SCTAKK-ENSTRQVVCDLGNPMK-RGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNE---QNSNSNPVSLKVPVVAEAQ 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148233336   777 LNVLGTVSPFSFVFGPREDKPDDSCIMEE-----IEYTFNVINAGSSLVPAAKLQISLPNTFAPNDiKLFNILAVKTTV- 850
Cdd:pfam08441  306 LSLSGVSKPDQVVGGSVKGESAMKPRSEEdigplVEHTYEVINNGPSTVSGASLEISWPYELSNGK-WLLYLLDVQGQGk 384

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 148233336   851 GECYFDNSTRDC--ETPKNTRSKIGDLFAFFSRPDKRWLYCIKDDPSCLQIL 900
Cdd:pfam08441  385 GECSPQNEINPLnlTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTASVLL 436
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 365-417 4.63e-12

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 61.62  E-value: 4.63e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 148233336    365 ARFGETIANLGDIDNDGFEDVAIAAPQEGDLE--GAVYIYNGREKGITPSFSQRL 417
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGetGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 303-349 5.74e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 5.74e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 148233336    303 GSYFGAAVCAA-DLNGDGLSDLLVGAPIQSTIREEGRVFVYMNTGSGA 349
Cdd:smart00191    2 GSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGG 49
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 306-342 9.56e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.74  E-value: 9.56e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 148233336   306 FGAAVCAADLNGDGLSDLLVGAPiQSTIREEGRVFVY 342
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAP-GEGGAGAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 367-402 3.41e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 47.51  E-value: 3.41e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 148233336   367 FGETIAnLGDIDNDGFEDVAIAAPQEGDLE-GAVYIY 402
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGaGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 428-471 1.12e-06

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 46.60  E-value: 1.12e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 148233336    428 MFGQSLSNVLDIDGNGYQDVAIGAFLSDSAVLLRTRPVIIIDAF 471
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 247-284 8.26e-06

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 43.90  E-value: 8.26e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 148233336    247 FGSYLGYSVGAGHFRTPNGY-DVIGGAPQQEQ---TGRVYIF 284
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYpDLLVGAPRANDageTGAVYVY 42
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 49-99 5.23e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.90  E-value: 5.23e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 148233336     49 PGSLFGFSVVLHS--NGEG-NWIVVGAPQSswttKNVSNPGAILKCKIQQNPNR 99
Cdd:smart00191    1 PGSYFGYSVAGVGdvNGDGyPDLLVGAPRA----NDAGETGAVYVYFGSSGGGN 50
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 429-451 5.21e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 35.56  E-value: 5.21e-03
                           10        20
                   ....*....|....*....|...
gi 148233336   429 FGQSLSnVLDIDGNGYQDVAIGA 451
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGA 22
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 463-900 4.11e-76

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 257.63  E-value: 4.11e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148233336   463 RPVIIIDAFLKL-PSTVNKTKFECMENGVAVVCMNVTVCFAYQGLDVP-GYIVMFYNITSDVRRKSGTPARFYFVSNGSS 540
Cdd:pfam08441    1 RPVVSVSASLQVePNSINPEKKNCTLTGTPVSCFTVRACFSYTGKPIPnPSLVLNYELELDRQKKKGLPPRVLFLDSQQP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148233336   541 DVISGTVEIRQKSANCKTHQAFMRKDTRDIFTPIHMESSYYLGkhiVSKRSADDFQPLQPVLQQKEgkGNVITNKVYFAR 620
Cdd:pfam08441   81 SLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR---VDPRAPSDLPGLKPILDQNQ--PSTVQEQANFLK 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148233336   621 YC---NLpnCSADLQITGKrsfPKPFESKTYLAVGGMKSLMINITLFNGGDDAFQTVLRLRLPKGLYFVKV-FDLLEKEI 696
Cdd:pfam08441  156 DCgedNV--CVPDLQLSAK---FDSRESDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVrREGSEKQL 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148233336   697 NCAVNKeENEQTRLDCSVGHFYVdAFSKQEFSFLLDSSALIRAEEDLVINATVACANEliqDTMWNNEVSFIVPTRYEID 776
Cdd:pfam08441  231 SCTAKK-ENSTRQVVCDLGNPMK-RGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNE---QNSNSNPVSLKVPVVAEAQ 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148233336   777 LNVLGTVSPFSFVFGPREDKPDDSCIMEE-----IEYTFNVINAGSSLVPAAKLQISLPNTFAPNDiKLFNILAVKTTV- 850
Cdd:pfam08441  306 LSLSGVSKPDQVVGGSVKGESAMKPRSEEdigplVEHTYEVINNGPSTVSGASLEISWPYELSNGK-WLLYLLDVQGQGk 384

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 148233336   851 GECYFDNSTRDC--ETPKNTRSKIGDLFAFFSRPDKRWLYCIKDDPSCLQIL 900
Cdd:pfam08441  385 GECSPQNEINPLnlTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTASVLL 436
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 365-417 4.63e-12

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 61.62  E-value: 4.63e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 148233336    365 ARFGETIANLGDIDNDGFEDVAIAAPQEGDLE--GAVYIYNGREKGITPSFSQRL 417
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGetGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 303-349 5.74e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.84  E-value: 5.74e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 148233336    303 GSYFGAAVCAA-DLNGDGLSDLLVGAPIQSTIREEGRVFVYMNTGSGA 349
Cdd:smart00191    2 GSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGG 49
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 306-342 9.56e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.74  E-value: 9.56e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 148233336   306 FGAAVCAADLNGDGLSDLLVGAPiQSTIREEGRVFVY 342
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAP-GEGGAGAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 367-402 3.41e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 47.51  E-value: 3.41e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 148233336   367 FGETIAnLGDIDNDGFEDVAIAAPQEGDLE-GAVYIY 402
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGaGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 314-387 4.76e-07

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 47.61  E-value: 4.76e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148233336   314 DLNGDGLSDLLVGapiqstirEEGRVFVYMNTGSGameelKFELSGSDLYAARFGETIANLGDIDNDGFEDVAI 387
Cdd:pfam13517    1 DLDGDGKLDLVVA--------NDGGLRLYLNNGDG-----TFTFITSVSLGGGGGGLSVAVGDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 428-471 1.12e-06

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 46.60  E-value: 1.12e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 148233336    428 MFGQSLSNVLDIDGNGYQDVAIGAFLSDSAVLLRTRPVIIIDAF 471
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 247-284 8.26e-06

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 43.90  E-value: 8.26e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 148233336    247 FGSYLGYSVGAGHFRTPNGY-DVIGGAPQQEQ---TGRVYIF 284
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYpDLLVGAPRANDageTGAVYVY 42
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 376-449 4.09e-04

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 39.52  E-value: 4.09e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148233336   376 DIDNDGFEDVAIAAPqegdleGAVYIYNGREKGiTPSFSQRLQGSKFGYGLRMFgqslsnVLDIDGNGYQDVAI 449
Cdd:pfam13517    1 DLDGDGKLDLVVAND------GGLRLYLNNGDG-TFTFITSVSLGGGGGGLSVA------VGDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 49-99 5.23e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.90  E-value: 5.23e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 148233336     49 PGSLFGFSVVLHS--NGEG-NWIVVGAPQSswttKNVSNPGAILKCKIQQNPNR 99
Cdd:smart00191    1 PGSYFGYSVAGVGdvNGDGyPDLLVGAPRA----NDAGETGAVYVYFGSSGGGN 50
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 429-451 5.21e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 35.56  E-value: 5.21e-03
                           10        20
                   ....*....|....*....|...
gi 148233336   429 FGQSLSnVLDIDGNGYQDVAIGA 451
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGA 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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