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Conserved domains on  [gi|148230246|ref|NP_001089102|]
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MDS1 and EVI1 complex locus [Xenopus laevis]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
747-771 1.18e-04

Zinc-finger double domain;


:

Pssm-ID: 316026  Cd Length: 26  Bit Score: 41.95  E-value: 1.18e-04
                           10        20
                   ....*....|....*....|....*
gi 148230246   747 NLTRHLRTHTGEQPYRCKYCDRSFS 771
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2_8 super family cl25789
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
166-245 3.33e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


The actual alignment was detected with superfamily member pfam15909:

Pssm-ID: 318181  Cd Length: 98  Bit Score: 38.51  E-value: 3.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230246   166 CGKTFATSSGLKQHKHIH------SSVKPFVCEV--CHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHR 237
Cdd:pfam15909    7 CRLAFPNPRELAQHLHSHlqptqsLEGKLFRCSTlsCTETFPSMQELMAHTKLHYKPNRYFKCENCLLRFRTHRSLFKHL 86

                   ....*...
gi 148230246   238 RFCEGKNH 245
Cdd:pfam15909   87 HVCSDQSH 94
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
761-786 6.84e-03

C2H2-type zinc-finger domain;


:

Pssm-ID: 316431  Cd Length: 26  Bit Score: 36.80  E-value: 6.84e-03
                           10        20
                   ....*....|....*....|....*.
gi 148230246   761 YRCKYCDRSFSISSNLQRHVRNIHNK 786
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRRKHTG 26
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
747-771 1.18e-04

Zinc-finger double domain;


Pssm-ID: 316026  Cd Length: 26  Bit Score: 41.95  E-value: 1.18e-04
                           10        20
                   ....*....|....*....|....*
gi 148230246   747 NLTRHLRTHTGEQPYRCKYCDRSFS 771
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
166-245 3.33e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 318181  Cd Length: 98  Bit Score: 38.51  E-value: 3.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230246   166 CGKTFATSSGLKQHKHIH------SSVKPFVCEV--CHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHR 237
Cdd:pfam15909    7 CRLAFPNPRELAQHLHSHlqptqsLEGKLFRCSTlsCTETFPSMQELMAHTKLHYKPNRYFKCENCLLRFRTHRSLFKHL 86

                   ....*...
gi 148230246   238 RFCEGKNH 245
Cdd:pfam15909   87 HVCSDQSH 94
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
761-786 6.84e-03

C2H2-type zinc-finger domain;


Pssm-ID: 316431  Cd Length: 26  Bit Score: 36.80  E-value: 6.84e-03
                           10        20
                   ....*....|....*....|....*.
gi 148230246   761 YRCKYCDRSFSISSNLQRHVRNIHNK 786
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRRKHTG 26
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
747-771 1.18e-04

Zinc-finger double domain;


Pssm-ID: 316026  Cd Length: 26  Bit Score: 41.95  E-value: 1.18e-04
                           10        20
                   ....*....|....*....|....*
gi 148230246   747 NLTRHLRTHTGEQPYRCKYCDRSFS 771
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
166-245 3.33e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 318181  Cd Length: 98  Bit Score: 38.51  E-value: 3.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148230246   166 CGKTFATSSGLKQHKHIH------SSVKPFVCEV--CHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHR 237
Cdd:pfam15909    7 CRLAFPNPRELAQHLHSHlqptqsLEGKLFRCSTlsCTETFPSMQELMAHTKLHYKPNRYFKCENCLLRFRTHRSLFKHL 86

                   ....*...
gi 148230246   238 RFCEGKNH 245
Cdd:pfam15909   87 HVCSDQSH 94
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
761-786 6.84e-03

C2H2-type zinc-finger domain;


Pssm-ID: 316431  Cd Length: 26  Bit Score: 36.80  E-value: 6.84e-03
                           10        20
                   ....*....|....*....|....*.
gi 148230246   761 YRCKYCDRSFSISSNLQRHVRNIHNK 786
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRRKHTG 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
189-211 8.13e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 306579  Cd Length: 23  Bit Score: 36.90  E-value: 8.13e-03
                           10        20
                   ....*....|....*....|...
gi 148230246   189 FVCEVCHKSYTQFSNLCRHKRMH 211
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.16
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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