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Conserved domains on  [gi|147905925|ref|NP_001085870|]
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ATPase asna1 [Xenopus laevis]

Protein Classification

similar to arsenical pump-driving ATPase (domain architecture ID 11130961)

protein similar to arsenical pump-driving ATPase

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ArsA_ATPase pfam02374
Anion-transporting ATPase; This Pfam family represents a conserved domain, which is sometimes ...
31-334 3.23e-143

Anion-transporting ATPase; This Pfam family represents a conserved domain, which is sometimes repeated, in an anion-transporting ATPase. The ATPase is involved in the removal of arsenate, antimonite, and arsenate from the cell.


:

Pssm-ID: 280525  Cd Length: 304  Bit Score: 411.36  E-value: 3.23e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925   31 LRWIFVGGKGGVGKTTCSCSLAVQLSLVRDSVLIISTDPAHNISDAFDQKFSKVPTKVRGYDNLFAMEIDPSLGVAELPD 110
Cdd:pfam02374   1 MRWIFFGGKGGVGKTTVSCATAVQLSEQGKKVLLVSTDPAHSLSDSFNQKFGHEPTKVKGVENLSAMEIDPQMELEEYRG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925  111 EIFEEDN---MLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPTIVERGLGRLMQI 187
Cdd:pfam02374  81 EVQKPINailGLDMLEGILAEELSSLPGIDEIASFDEFKKYMDEGEYDVVIFDTAPTGHTLRLLSLPTVLSWYLEKIVKL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925  188 KNQISPFISQMCNMlGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCSIDTH 267
Cdd:pfam02374 161 KNQIGPLAKPFKGM-GMGGSCLPEALESLEETKEQIEKAREILSDPERTSFRLVCIPEKMSLYETERAIQELAKYGIDVD 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 147905925  268 NIIVNQlVFPDPEKpCRMCEARHKIQSKYLDQMEDLYEDFHIAKLPLLPHEVRGVENVNTFSKLLLE 334
Cdd:pfam02374 240 AVIVNQ-VLPETEQ-CPFCEARKKIQQKYLKEIEELFSDLPVAKLPLLPEEVVGLEALEKFSQFLYG 304
 
Name Accession Description Interval E-value
ArsA_ATPase pfam02374
Anion-transporting ATPase; This Pfam family represents a conserved domain, which is sometimes ...
31-334 3.23e-143

Anion-transporting ATPase; This Pfam family represents a conserved domain, which is sometimes repeated, in an anion-transporting ATPase. The ATPase is involved in the removal of arsenate, antimonite, and arsenate from the cell.


Pssm-ID: 280525  Cd Length: 304  Bit Score: 411.36  E-value: 3.23e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925   31 LRWIFVGGKGGVGKTTCSCSLAVQLSLVRDSVLIISTDPAHNISDAFDQKFSKVPTKVRGYDNLFAMEIDPSLGVAELPD 110
Cdd:pfam02374   1 MRWIFFGGKGGVGKTTVSCATAVQLSEQGKKVLLVSTDPAHSLSDSFNQKFGHEPTKVKGVENLSAMEIDPQMELEEYRG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925  111 EIFEEDN---MLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPTIVERGLGRLMQI 187
Cdd:pfam02374  81 EVQKPINailGLDMLEGILAEELSSLPGIDEIASFDEFKKYMDEGEYDVVIFDTAPTGHTLRLLSLPTVLSWYLEKIVKL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925  188 KNQISPFISQMCNMlGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCSIDTH 267
Cdd:pfam02374 161 KNQIGPLAKPFKGM-GMGGSCLPEALESLEETKEQIEKAREILSDPERTSFRLVCIPEKMSLYETERAIQELAKYGIDVD 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 147905925  268 NIIVNQlVFPDPEKpCRMCEARHKIQSKYLDQMEDLYEDFHIAKLPLLPHEVRGVENVNTFSKLLLE 334
Cdd:pfam02374 240 AVIVNQ-VLPETEQ-CPFCEARKKIQQKYLKEIEELFSDLPVAKLPLLPEEVVGLEALEKFSQFLYG 304
GET3_arsA_TRC40 TIGR00345
transport-energizing ATPase, TRC40/GET3/ArsA family; Members of this family are ATPases that ...
48-332 4.19e-84

transport-energizing ATPase, TRC40/GET3/ArsA family; Members of this family are ATPases that energize transport, although with different partner proteins for different functions. Recent findings show that TRC40 (GET3 in yeast) in involved in the insertion of tail-anchored membrane proteins in eukaryotes. A similar function is expected for members of this family in archaea. However, the earliest discovery of a function for this protein family is ArsA, an arsenic resistance protein that partners with ArsB (see pfam02040) for As(III) efflux. [Hypothetical proteins, Conserved]


Pssm-ID: 273027  Cd Length: 284  Bit Score: 259.72  E-value: 4.19e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925   48 SCSLAVQLSLVRDSVLIISTDPAHNISDAFDQKFSKVPTKVRGYDNLFAMEIDPSLGVAELPDEIFEEDNMLSMGKKMMQ 127
Cdd:TIGR00345   2 SAATAIRLAEQGKKVLLVSTDPAHSLSDVFEQEIGHTPTKVTGVENLSAVEIDPQAALEEYRAKLVEQIKGNLPDGDMLG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925  128 EAMSAF---PGIDEAMSYAEVMRLVK--GMNFSVVVFDTAPTGHTLRLLNFPTIVERGLGRLMQIKNQISPfisqMCNML 202
Cdd:TIGR00345  82 DQLEGAalsPGIDEIAAFDEFLKHMTdaENEFDVVIFDTAPTGHTLRLLQLPEVLSSFLEKFIKIRSKLGP----MAKLF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925  203 GlGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCSIDTHNIIVNQLVFPDPEkp 282
Cdd:TIGR00345 158 M-GAGEDDEALEKLEELKEQIEAAREILSDPERTSFVLVVIPEKMSLYESERAHKELAKYGIKVDAVIVNQVLPENAQ-- 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 147905925  283 CRMCEARHKIQSKYLDQMEDLYEDFHIAKLPLLPHEVRGVENVNTFSKLL 332
Cdd:TIGR00345 235 DEFCQARWELQQKYLKQIPEKFADLPVAEVPLQKEEMVGLEALKRLSKTL 284
ArsA cd02035
ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ...
47-312 3.20e-72

ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. The pump is composed of two subunits, the catalytic ArsA subunit and the membrane subunit ArsB, which are encoded by arsA and arsB genes respectively. Arsenic efflux in bacteria is catalyzed by either ArsB alone or by ArsAB complex. The ATP-coupled pump, however, is more efficient. ArsA is composed of two homologous halves, A1 and A2, connected by a short linker sequence.


Pssm-ID: 238992  Cd Length: 217  Bit Score: 226.74  E-value: 3.20e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925  47 CSCSLAVQLSLVRDSVLIISTDPAHNISDAfdqkfskvptkvrGYDNLFAM------EIDPSLGVAELPDEIFEEDNMLS 120
Cdd:cd02035   15 IAAATAVRLAEEGKKVLLVSTDPAHNLSDK-------------GLPNLSDAfivedpEIAPNLYREEVDATRRVERAWGG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925 121 MGKkMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLnfptiverglgrlmqiknqispfisqmcn 200
Cdd:cd02035   82 EGG-LMLELAAALPGIEELASLLAVFREFSEGLYDVIVFDTAPTGHTLRLL----------------------------- 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925 201 mlglgdmnadqlaskleetlpvirsVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCSIDTHNIIVNQlVFPDPE 280
Cdd:cd02035  132 -------------------------VRELLTDPERTSFRLVTLPEKLPLYETERAITELALYGIPVDAVVVNR-VLPAEV 185
                        250       260       270
                 ....*....|....*....|....*....|..
gi 147905925 281 KPCRMCEARHKIQSKYLDQMEDLYEDFHIAKL 312
Cdd:cd02035  186 DDDPFLAARRQIQQKYLAEIEELFDDLPIVPV 217
ArsA COG0003
Anion-transporting ATPase, ArsA/GET3 family [Inorganic ion transport and metabolism];
30-332 4.11e-65

Anion-transporting ATPase, ArsA/GET3 family [Inorganic ion transport and metabolism];


Pssm-ID: 223082  Cd Length: 322  Bit Score: 211.83  E-value: 4.11e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925  30 SLRWIFVGGKGGVGKTTCSCSLAVQLSLVRDSVLIISTDPAHNISDAFDQKFSKVPTKVRgyDNLFAMEIDPSL---GVA 106
Cdd:COG0003    1 MTRIVFFTGKGGVGKTTIAAATAVKLAESGKKVLLVSTDPAHSLGDVFDLELGHDPRKVG--PNLDALELDPEKaleEYW 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925 107 ELPDEIFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPTIVERGLGRLmq 186
Cdd:COG0003   79 DEVKDYLARLLRTRGLGGIYADELATLPGIDEALALLKILEYYVSGEYDVIVVDTAPTGHTLRLLSLPEVLGWYLEKL-- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925 187 IKNQISPFISQMCNMLGL--GDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCSI 264
Cdd:COG0003  157 FKPRRKRMVKALKSLSTAagSPLPDDAVLEALEELKERIADVREVLTNPDGTSFRLVSIPEKLSLYETKRAVERLSLYGI 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 147905925 265 DTHNIIVNQlVFPDpEKPCRMCEARHKIQSKYLDQMEDLYEDFHIAKLPLLPHEVRGVENVNTFSKLL 332
Cdd:COG0003  237 PVDAVIVNK-ILPD-EADQPFLEARRKIQQKYLKELEETFSDLAVVKVPLLAEEPVGLEALEKLGDLL 302
 
Name Accession Description Interval E-value
ArsA_ATPase pfam02374
Anion-transporting ATPase; This Pfam family represents a conserved domain, which is sometimes ...
31-334 3.23e-143

Anion-transporting ATPase; This Pfam family represents a conserved domain, which is sometimes repeated, in an anion-transporting ATPase. The ATPase is involved in the removal of arsenate, antimonite, and arsenate from the cell.


Pssm-ID: 280525  Cd Length: 304  Bit Score: 411.36  E-value: 3.23e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925   31 LRWIFVGGKGGVGKTTCSCSLAVQLSLVRDSVLIISTDPAHNISDAFDQKFSKVPTKVRGYDNLFAMEIDPSLGVAELPD 110
Cdd:pfam02374   1 MRWIFFGGKGGVGKTTVSCATAVQLSEQGKKVLLVSTDPAHSLSDSFNQKFGHEPTKVKGVENLSAMEIDPQMELEEYRG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925  111 EIFEEDN---MLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPTIVERGLGRLMQI 187
Cdd:pfam02374  81 EVQKPINailGLDMLEGILAEELSSLPGIDEIASFDEFKKYMDEGEYDVVIFDTAPTGHTLRLLSLPTVLSWYLEKIVKL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925  188 KNQISPFISQMCNMlGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCSIDTH 267
Cdd:pfam02374 161 KNQIGPLAKPFKGM-GMGGSCLPEALESLEETKEQIEKAREILSDPERTSFRLVCIPEKMSLYETERAIQELAKYGIDVD 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 147905925  268 NIIVNQlVFPDPEKpCRMCEARHKIQSKYLDQMEDLYEDFHIAKLPLLPHEVRGVENVNTFSKLLLE 334
Cdd:pfam02374 240 AVIVNQ-VLPETEQ-CPFCEARKKIQQKYLKEIEELFSDLPVAKLPLLPEEVVGLEALEKFSQFLYG 304
GET3_arsA_TRC40 TIGR00345
transport-energizing ATPase, TRC40/GET3/ArsA family; Members of this family are ATPases that ...
48-332 4.19e-84

transport-energizing ATPase, TRC40/GET3/ArsA family; Members of this family are ATPases that energize transport, although with different partner proteins for different functions. Recent findings show that TRC40 (GET3 in yeast) in involved in the insertion of tail-anchored membrane proteins in eukaryotes. A similar function is expected for members of this family in archaea. However, the earliest discovery of a function for this protein family is ArsA, an arsenic resistance protein that partners with ArsB (see pfam02040) for As(III) efflux. [Hypothetical proteins, Conserved]


Pssm-ID: 273027  Cd Length: 284  Bit Score: 259.72  E-value: 4.19e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925   48 SCSLAVQLSLVRDSVLIISTDPAHNISDAFDQKFSKVPTKVRGYDNLFAMEIDPSLGVAELPDEIFEEDNMLSMGKKMMQ 127
Cdd:TIGR00345   2 SAATAIRLAEQGKKVLLVSTDPAHSLSDVFEQEIGHTPTKVTGVENLSAVEIDPQAALEEYRAKLVEQIKGNLPDGDMLG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925  128 EAMSAF---PGIDEAMSYAEVMRLVK--GMNFSVVVFDTAPTGHTLRLLNFPTIVERGLGRLMQIKNQISPfisqMCNML 202
Cdd:TIGR00345  82 DQLEGAalsPGIDEIAAFDEFLKHMTdaENEFDVVIFDTAPTGHTLRLLQLPEVLSSFLEKFIKIRSKLGP----MAKLF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925  203 GlGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCSIDTHNIIVNQLVFPDPEkp 282
Cdd:TIGR00345 158 M-GAGEDDEALEKLEELKEQIEAAREILSDPERTSFVLVVIPEKMSLYESERAHKELAKYGIKVDAVIVNQVLPENAQ-- 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 147905925  283 CRMCEARHKIQSKYLDQMEDLYEDFHIAKLPLLPHEVRGVENVNTFSKLL 332
Cdd:TIGR00345 235 DEFCQARWELQQKYLKQIPEKFADLPVAEVPLQKEEMVGLEALKRLSKTL 284
ArsA cd02035
ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ...
47-312 3.20e-72

ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. The pump is composed of two subunits, the catalytic ArsA subunit and the membrane subunit ArsB, which are encoded by arsA and arsB genes respectively. Arsenic efflux in bacteria is catalyzed by either ArsB alone or by ArsAB complex. The ATP-coupled pump, however, is more efficient. ArsA is composed of two homologous halves, A1 and A2, connected by a short linker sequence.


Pssm-ID: 238992  Cd Length: 217  Bit Score: 226.74  E-value: 3.20e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925  47 CSCSLAVQLSLVRDSVLIISTDPAHNISDAfdqkfskvptkvrGYDNLFAM------EIDPSLGVAELPDEIFEEDNMLS 120
Cdd:cd02035   15 IAAATAVRLAEEGKKVLLVSTDPAHNLSDK-------------GLPNLSDAfivedpEIAPNLYREEVDATRRVERAWGG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925 121 MGKkMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLnfptiverglgrlmqiknqispfisqmcn 200
Cdd:cd02035   82 EGG-LMLELAAALPGIEELASLLAVFREFSEGLYDVIVFDTAPTGHTLRLL----------------------------- 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925 201 mlglgdmnadqlaskleetlpvirsVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCSIDTHNIIVNQlVFPDPE 280
Cdd:cd02035  132 -------------------------VRELLTDPERTSFRLVTLPEKLPLYETERAITELALYGIPVDAVVVNR-VLPAEV 185
                        250       260       270
                 ....*....|....*....|....*....|..
gi 147905925 281 KPCRMCEARHKIQSKYLDQMEDLYEDFHIAKL 312
Cdd:cd02035  186 DDDPFLAARRQIQQKYLAEIEELFDDLPIVPV 217
ArsA COG0003
Anion-transporting ATPase, ArsA/GET3 family [Inorganic ion transport and metabolism];
30-332 4.11e-65

Anion-transporting ATPase, ArsA/GET3 family [Inorganic ion transport and metabolism];


Pssm-ID: 223082  Cd Length: 322  Bit Score: 211.83  E-value: 4.11e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925  30 SLRWIFVGGKGGVGKTTCSCSLAVQLSLVRDSVLIISTDPAHNISDAFDQKFSKVPTKVRgyDNLFAMEIDPSL---GVA 106
Cdd:COG0003    1 MTRIVFFTGKGGVGKTTIAAATAVKLAESGKKVLLVSTDPAHSLGDVFDLELGHDPRKVG--PNLDALELDPEKaleEYW 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925 107 ELPDEIFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPTIVERGLGRLmq 186
Cdd:COG0003   79 DEVKDYLARLLRTRGLGGIYADELATLPGIDEALALLKILEYYVSGEYDVIVVDTAPTGHTLRLLSLPEVLGWYLEKL-- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925 187 IKNQISPFISQMCNMLGL--GDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCSI 264
Cdd:COG0003  157 FKPRRKRMVKALKSLSTAagSPLPDDAVLEALEELKERIADVREVLTNPDGTSFRLVSIPEKLSLYETKRAVERLSLYGI 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 147905925 265 DTHNIIVNQlVFPDpEKPCRMCEARHKIQSKYLDQMEDLYEDFHIAKLPLLPHEVRGVENVNTFSKLL 332
Cdd:COG0003  237 PVDAVIVNK-ILPD-EADQPFLEARRKIQQKYLKELEETFSDLAVVKVPLLAEEPVGLEALEKLGDLL 302
arsen_driv_ArsA TIGR04291
arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family ...
48-323 6.55e-26

arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family belongs consists of transport-energizing ATPases, including to TRC40/GET3 family involved in post-translational insertion of protein C-terminal transmembrane anchors into membranes from the cyotosolic face. This family, however, is restricted to ATPases that energize pumps that export arsenite (or antimonite).


Pssm-ID: 275109  Cd Length: 566  Bit Score: 108.25  E-value: 6.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925   48 SCSLAVQLSLVRDSVLIISTDPAHNISDAFDQKFSKVPTKVRGYDNLFAMEIDPSLGVAE------------LPDEIFEE 115
Cdd:TIGR04291  20 ACATAINLADQGKRVLLVSTDPASNVGQVFGQTIGNKITAIAGVPGLFALEIDPQAAAQAyrarivdpvrgvLPDDVVSS 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925  116 dnmlsmgkkmMQEAMS--------AFPGIDEAMSYAEVMRlvkgmNFSVVVFDTAPTGHTLRLLNFPtiverglgrlmqi 187
Cdd:TIGR04291 100 ----------IEEQLSgactteiaAFDEFTGLLTDAELTQ-----DFDHIIFDTAPTGHTIRLLQLP------------- 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925  188 kNQISPFISQMCNmlglGDMNADQLASkLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCSIDTH 267
Cdd:TIGR04291 152 -GAWSDFLDTNPN----GASCLGPLAG-LEKQRAQYAKAVEALSDPERTRLILVARPQKSTLLEVARTHQELAAIGLKNQ 225
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 147905925  268 NIIVNQLVFPDPEKPCRMCEARHKIQSKYLDQMEDLYEDFHIAKLPLLPHEVRGVE 323
Cdd:TIGR04291 226 YLVINGVLPETEASDDPLAQAIYKREQKALQHMPAILANLPRYTLPLKPYNLVGLE 281
arsen_driv_ArsA TIGR04291
arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family ...
3-318 9.54e-13

arsenical pump-driving ATPase; The broader family (TIGR00345) to which the current family belongs consists of transport-energizing ATPases, including to TRC40/GET3 family involved in post-translational insertion of protein C-terminal transmembrane anchors into membranes from the cyotosolic face. This family, however, is restricted to ATPases that energize pumps that export arsenite (or antimonite).


Pssm-ID: 275109  Cd Length: 566  Bit Score: 68.96  E-value: 9.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925    3 APVDDEFEDAPDVEPLePTLSNVID---QRSLRWIFVGGKGGVGKTTCSCSLAVQLSLVRDSVLIISTDPAHNISDAFDQ 79
Cdd:TIGR04291 291 QPQLSLDITTPQVPDL-PSLSRLIDeiaKSEKGLIMTMGKGGVGKTTVAAAIAVRLANKGLDVHLTTSDPAAHLSVTLTG 369
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925   80 KFskvptkvrgyDNLFAMEIDPSLGVAELPDEIFEE--DNMLSMGKKMMQEAMSAfPGIDEAMSYAEVMRLVKGMNFSVV 157
Cdd:TIGR04291 370 SL----------NNLQVSRIDPKQETERYRQEVLATkgKELDEDGKAYLEEDLRS-PCTEEIAVFQAFSRIIREAGDRFV 438
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925  158 VFDTAPTGHTLRLLNFPTIVERGLGRLMqiknqispfisqmcnmlglgdmnaDQLASKLEETLPvirsvseQFKDPEQTT 237
Cdd:TIGR04291 439 VMDTAPTGHTLLLLDATGAYHREVERKM------------------------GDTPEHVTTPMM-------QLQDPERTK 487
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147905925  238 FICVCIAEFLSLYETERLIQELAKCSIDTHNIIVNQ-LVFPDPEKPCRMCEARHkiQSKYLDQMEDLYEDfHIAKLPLLP 316
Cdd:TIGR04291 488 VLLVTLPETTPVLEAARLQEDLRRAGIEPWWWVINNsLAATNTTSPLLSQRAQN--ELKWIEKVKRIHAD-RYAVIPLQA 564

                  ..
gi 147905925  317 HE 318
Cdd:TIGR04291 565 EE 566
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.16
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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