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Conserved domains on  [gi|147899133|ref|NP_001084892|]
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histone-lysine N-methyltransferase SUV39H1 [Xenopus laevis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 168-421 0e+00

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


:

Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 520.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 168 RDFVYINEYRVGEGVTINRISAGCKCRDCFSD-EGGCCPGAFQHKKAYNNEGQVKVKPGFPIYECNSCCRCGPSCPNRVV 246
Cdd:cd10525    1 RDFVYINEYKVGEGVTLNQVAVGCECQDCLSQpVGGCCPGASKHRFAYNEQGQVKVRPGLPIYECNSRCRCGPDCPNRVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 247 QKGIQYKFCIFRTSDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDYVEDVYTVDAARYGN 326
Cdd:cd10525   81 QKGIQYDLCIFRTDNGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 327 ISHFVNHSCKPNLQVYNVFIDNLDERLPRIAFFATRTIRTGEELTFDYNMQVDPVDVESSKMDSNFGIAGLPASPKKRVR 406
Cdd:cd10525  161 ISHFVNHSCDPNLQVYNVFIDNLDERLPRIALFATRTIRAGEELTFDYNMQVDPVDAESTKMDSNFGLAGLPGSPKKRVR 240

                        250
                 ....*....|....*
gi 147899133 407 VECKCGVSSCRKYLF 421
Cdd:cd10525  241 IECKCGVRSCRKYLF 255
CD_SUV39H1_like cd18639
chromodomain of histone methyltransferase SUV39H1, and similar proteins; CHRomatin ...
 46-94 1.95e-20

chromodomain of histone methyltransferase SUV39H1, and similar proteins; CHRomatin Organization Modifier (chromo) domain of human SUV39H1, a histone lysine methyltransferase (HMT) which catalyzes di- and tri-methylation of lysine 9 of histone H3 (H3K9me2/3), leading to heterochromatin formation and gene silencing. H3K9me2/3 represents a specific mark for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3, and/or CBX5) proteins to methylated histones. SUV39H1 mainly functions in heterochromatin regions. The human SUV39H1/2, histone H3K9 methyltransferases, are the mammalian homologs of Drosophila Su(var)3-9 and Schizosaccharomyces pombe Clr4. SUV39H1 contains a chromodomain at its N-terminus and a SET domain at its C-terminus. Although the SET domain performs the catalytic activity, the chromodomain of SUV39H1 is essential for the catalytic activity of SUV39H1. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


:

Pssm-ID: 349289  Cd Length: 49  Bit Score: 84.11  E-value: 1.95e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 147899133  46 FEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHLKCNNLLKQFHL 94
Cdd:cd18639    1 YEVEYLCDYKKIREQEYYLVKWKGYPDSENTWEPRQNLKCSRLLKQFHK 49
 
Name Accession Description Interval E-value
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 168-421 0e+00

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 520.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 168 RDFVYINEYRVGEGVTINRISAGCKCRDCFSD-EGGCCPGAFQHKKAYNNEGQVKVKPGFPIYECNSCCRCGPSCPNRVV 246
Cdd:cd10525    1 RDFVYINEYKVGEGVTLNQVAVGCECQDCLSQpVGGCCPGASKHRFAYNEQGQVKVRPGLPIYECNSRCRCGPDCPNRVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 247 QKGIQYKFCIFRTSDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDYVEDVYTVDAARYGN 326
Cdd:cd10525   81 QKGIQYDLCIFRTDNGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 327 ISHFVNHSCKPNLQVYNVFIDNLDERLPRIAFFATRTIRTGEELTFDYNMQVDPVDVESSKMDSNFGIAGLPASPKKRVR 406
Cdd:cd10525  161 ISHFVNHSCDPNLQVYNVFIDNLDERLPRIALFATRTIRAGEELTFDYNMQVDPVDAESTKMDSNFGLAGLPGSPKKRVR 240

                        250
                 ....*....|....*
gi 147899133 407 VECKCGVSSCRKYLF 421
Cdd:cd10525  241 IECKCGVRSCRKYLF 255
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 252-375 5.19e-42

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 144.40  E-value: 5.19e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133   252 YKFCIFRtSDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGT--TYLFDLDyveDVYTVDAARYGNISH 329
Cdd:smart00317   1 NKLEVFK-SPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAkaFYLFDID---SDLCIDARRKGNLAR 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 147899133   330 FVNHSCKPNLQVYNVFIDNLDerlpRIAFFATRTIRTGEELTFDYN 375
Cdd:smart00317  77 FINHSCEPNCELLFVEVNGDD----RIVIFALRDIKPGEELTIDYG 118
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 264-375 1.66e-29

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 110.69  E-value: 1.66e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133  264 GWGVRTLEKIRKNSFVMEYVGE-IITSEEAERRGQIYDRQGT-----TYLFDLDyVEDVYTVD--AARYGNISHFVNHSC 335
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLElrlwgPYLFTLD-EDSEYCIDarALYYGNWARFINHSC 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 147899133  336 KPNLQVYNVFIDnldeRLPRIAFFATRTIRTGEELTFDYN 375
Cdd:pfam00856  80 DPNCEVRVVYVN----GGPRIVIFALRDIKPGEELTIDYG 115
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
258-375 4.16e-27

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 105.04  E-value: 4.16e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 258 RTSDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIyDRQGTTYLFDLDyveDVYTVDAARYGNISHFVNHSCKP 337
Cdd:COG2940   11 RPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPH-KEPLHTYLFELD---DDGVIDGALGGNPARFINHSCDP 86

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 147899133 338 NLQvynvfidnLDERLPRIAFFATRTIRTGEELTFDYN 375
Cdd:COG2940   87 NCE--------ADEEDGRIFIVALRDIAAGEELTYDYG 116
CD_SUV39H1_like cd18639
chromodomain of histone methyltransferase SUV39H1, and similar proteins; CHRomatin ...
 46-94 1.95e-20

chromodomain of histone methyltransferase SUV39H1, and similar proteins; CHRomatin Organization Modifier (chromo) domain of human SUV39H1, a histone lysine methyltransferase (HMT) which catalyzes di- and tri-methylation of lysine 9 of histone H3 (H3K9me2/3), leading to heterochromatin formation and gene silencing. H3K9me2/3 represents a specific mark for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3, and/or CBX5) proteins to methylated histones. SUV39H1 mainly functions in heterochromatin regions. The human SUV39H1/2, histone H3K9 methyltransferases, are the mammalian homologs of Drosophila Su(var)3-9 and Schizosaccharomyces pombe Clr4. SUV39H1 contains a chromodomain at its N-terminus and a SET domain at its C-terminus. Although the SET domain performs the catalytic activity, the chromodomain of SUV39H1 is essential for the catalytic activity of SUV39H1. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349289  Cd Length: 49  Bit Score: 84.11  E-value: 1.95e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 147899133  46 FEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHLKCNNLLKQFHL 94
Cdd:cd18639    1 YEVEYLCDYKKIREQEYYLVKWKGYPDSENTWEPRQNLKCSRLLKQFHK 49
Chromo pfam00385
Chromo (CHRromatin organization MOdifier) domain;
46-93 4.09e-10

Chromo (CHRromatin organization MOdifier) domain;


Pssm-ID: 459793 [Multi-domain]  Cd Length: 52  Bit Score: 54.89  E-value: 4.09e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 147899133   46 FEVEYLWNYKKVQDQ-ELYLVKWKYYPDSESTWEPRHHL-KCNNLLKQFH 93
Cdd:pfam00385   1 YEVERILDHRKDKGGkEEYLVKWKGYPYDENTWEPEENLsKCPELIEEFK 50
CHROMO smart00298
Chromatin organization modifier domain;
45-93 3.52e-07

Chromatin organization modifier domain;


Pssm-ID: 214605 [Multi-domain]  Cd Length: 55  Bit Score: 46.82  E-value: 3.52e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 147899133    45 DFEVEYLWNYKKVQD-QELYLVKWKYYPDSESTWEPRHHLK-CNNLLKQFH 93
Cdd:smart00298   1 EYEVEKILDHRWKKKgELEYLVKWKGYSYSEDTWEPEENLLnCSKKLDNYK 51
 
Name Accession Description Interval E-value
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 168-421 0e+00

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 520.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 168 RDFVYINEYRVGEGVTINRISAGCKCRDCFSD-EGGCCPGAFQHKKAYNNEGQVKVKPGFPIYECNSCCRCGPSCPNRVV 246
Cdd:cd10525    1 RDFVYINEYKVGEGVTLNQVAVGCECQDCLSQpVGGCCPGASKHRFAYNEQGQVKVRPGLPIYECNSRCRCGPDCPNRVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 247 QKGIQYKFCIFRTSDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDYVEDVYTVDAARYGN 326
Cdd:cd10525   81 QKGIQYDLCIFRTDNGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 327 ISHFVNHSCKPNLQVYNVFIDNLDERLPRIAFFATRTIRTGEELTFDYNMQVDPVDVESSKMDSNFGIAGLPASPKKRVR 406
Cdd:cd10525  161 ISHFVNHSCDPNLQVYNVFIDNLDERLPRIALFATRTIRAGEELTFDYNMQVDPVDAESTKMDSNFGLAGLPGSPKKRVR 240

                        250
                 ....*....|....*
gi 147899133 407 VECKCGVSSCRKYLF 421
Cdd:cd10525  241 IECKCGVRSCRKYLF 255
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 169-420 6.89e-138

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 394.35  E-value: 6.89e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 169 DFVYINEYRVGEGVTINR-ISAGCKCR-DCFSDEGGCCPGAFQHKKAYNNEGQVKVKPGFPIYECNSCCRCGPSCPNRVV 246
Cdd:cd10542    2 NFQYINDYIPGDGVKIPEdFLVGCECTeDCHNNNPTCCPAESGVKFAYDKQGRLRLPPGTPIYECNSRCKCGPDCPNRVV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 247 QKGIQYKFCIFRTSDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDYVED--VYTVDAARY 324
Cdd:cd10542   82 QRGRKVPLCIFRTSNGRGWGVKTLEDIKKGTFVMEYVGEIITSEEAERRGKIYDANGRTYLFDLDYNDDdcEYTVDAAYY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 325 GNISHFVNHSCKPNLQVYNVFIDNLDERLPRIAFFATRTIRTGEELTFDYNMQVDPVDVESSKmdsnfgiaglpaSPKKR 404
Cdd:cd10542  162 GNISHFINHSCDPNLAVYAVWINHLDPRLPRIAFFAKRDIKAGEELTFDYLMTGTGGSSESTI------------PKPKD 229

                        250
                 ....*....|....*.
gi 147899133 405 VRVECKCGVSSCRKYL 420
Cdd:cd10542  230 VRVPCLCGSKNCRKYL 245
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 169-420 1.58e-128

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 370.38  E-value: 1.58e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 169 DFVYINEYRVGEGV-TINRISAGCKCRDCFSdeGGCCPGAFQHKKAYNNEGQVKVKPGFPIYECNSCCRCGPSCPNRVVQ 247
Cdd:cd10532    2 DFYYINEYKPAPGInLDNEATVGCDCSDCFF--GKCCPAEAGVLFAYNEHGQLKIPPGTPIYECNSRCKCGPDCPNRVVQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 248 KGIQYKFCIFRTSDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDYVEDVYTVDAARYGNI 327
Cdd:cd10532   80 KGTQYSLCIFRTSNGRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQFYDSKGITYLFDLDYESDEFTVDAARYGNV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 328 SHFVNHSCKPNLQVYNVFIDNLDERLPRIAFFATRTIRTGEELTFDYNMQvDPVDVESSKMDSnfgiaglpASPKKRVRV 407
Cdd:cd10532  160 SHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTIKAGEELTFDYQMK-GSGDLSSDSIDN--------SPAKKRVRT 230

                        250
                 ....*....|...
gi 147899133 408 ECKCGVSSCRKYL 420
Cdd:cd10532  231 VCKCGAVTCRGYL 243
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 169-375 1.35e-82

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 252.68  E-value: 1.35e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 169 DFVYINEYRVGEGVTINRISA---GCKCRD-CFSdeGGC-CPGAFQHKKAYNNEGQVKV-KPGFPIYECNSCCRCGPSCP 242
Cdd:cd10538    2 SFTYIKDNIVGKNVQPFSNIIdsvGCKCKDdCLD--SKCaCAAESDGIFAYTKNGLLRLnNSPPPIFECNSKCSCDDDCK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 243 NRVVQKGIQYKFCIFRTSDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDYVEDV------ 316
Cdd:cd10538   80 NRVVQRGLQARLQVFRTSK-KGWGVRSLEFIPKGSFVCEYVGEVITTSEADRRGKIYDKSGGSYLFDLDEFSDSdgdgee 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 147899133 317 YTVDAARYGNISHFVNHSCKPNLQVYNVFIDNLDERLPRIAFFATRTIRTGEELTFDYN 375
Cdd:cd10538  159 LCVDATFCGNVSRFINHSCDPNLFPFNVVIDHDDLRYPRIALFATRDILPGEELTFDYG 217
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 169-421 6.36e-66

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 211.28  E-value: 6.36e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 169 DFVYINEYRVGEGVTI--NRISAGCKCrdcfSDEGGC---------CPGAFQHKK-AYNNEGQVKVKPGFPIYECNSCCR 236
Cdd:cd20073    2 DFEFITSYRYGLGIEPpdPLFISGCSC----SKLGGCdlnnpgscqCLEDSNEKSfAYDEYGRVRANTGSIIYECNENCD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 237 CGPSCPNRVVQKGIQYKFCIFRTSDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDYVEDV 316
Cdd:cd20073   78 CGINCPNRVVQRGRKLPLEIFKTKH-KGWGLRCPRFIKAGTFIGVYLGEVITQSEAEIRGKKYDNVGVTYLFDLDLFEDQ 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 317 ----YTVDAARYGNISHFVNHSCKPNLQVYNVFIDNLDERLPRIAFFATRTIRTGEELTFDYNmqvdpvdveSSKMDSNF 392
Cdd:cd20073  157 vdeyYTVDAQYCGDVTRFINHSCDPNLAIYSVLRDKSDSKIYDLAFFAIKDIPALEELTFDYS---------GRNNFDQL 227

                        250       260       270
                 ....*....|....*....|....*....|..
gi 147899133 393 GIAGLPASPKKRV---RVECKCGVSSCRKYLF 421
Cdd:cd20073  228 GFIGNRSNSKYINlknKRPCYCGSANCRGWLF 259
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 168-374 3.78e-63

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 202.95  E-value: 3.78e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 168 RDFVYINEYRVGEGVTINRISA---GCKCRD-CFSDegGCCPGAFQHKKAYNNEGqvKVKPGFP------IYECNSCCRC 237
Cdd:cd10543    1 PDFLYVTENCETSPLNIDRNITslqTCSCRDdCSSD--NCVCGRLSVRCWYDKEG--RLLPDFNkldpplIFECNRACSC 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 238 GPSCPNRVVQKGIQYKFCIFRTsDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRgqiydrQGTTYLFDLDYVE-DV 316
Cdd:cd10543   77 WRNCRNRVVQNGIRYRLQLFRT-RGMGWGVRALQDIPKGTFVCEYIGELISDSEADSR------EDDSYLFDLDNKDgET 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 147899133 317 YTVDAARYGNISHFVNHSCKPNLQVYNVFIDNLDERLPRIAFFATRTIRTGEELTFDY 374
Cdd:cd10543  150 YCIDARRYGNISRFINHLCEPNLIPVRVFVEHQDLRFPRIAFFASRDIKAGEELGFDY 207
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 155-420 2.81e-62

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 202.52  E-value: 2.81e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 155 ILVENEVDLEGPPrDFVYINEYRVGEGVTINR-----ISAGCK--CRDCFS--------DEGGCCPGA-------FQHKK 212
Cdd:cd10517   18 IPCVNEIDNSSPP-YVEYSKERIPGKGVNINLdpdflVGCDCTdgCRDKSKcacqqltiEATAATPGGqinpsagYQYRR 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 213 AYNnegqvKVKPGfpIYECNSCCRCGPSCPNRVVQKGIQYKFCIFRTSDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEA 292
Cdd:cd10517   97 LME-----KLPTG--VYECNSRCKCDKRCYNRVVQNGLQVRLQVFKTEK-KGWGIRCLDDIPKGSFVCIYAGQILTEDEA 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 293 ERRGQIYDRQgttYLFDLDYVEDV---------------YTVDAARYGNISHFVNHSCKPNLQVYNVFIDNLDERLPRIA 357
Cdd:cd10517  169 NEEGLQYGDE---YFAELDYIEVVeklkegyesdveehcYIIDAKSEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVA 245

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 147899133 358 FFATRTIRTGEELTFDYNMQVDPVdvesskmdsnfgiaglpasPKKrvRVECKCGVSSCRKYL 420
Cdd:cd10517  246 FFASRYIRAGTELTWDYNYEVGSV-------------------PGK--VLYCYCGSSNCRGRL 287
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 169-420 4.21e-60

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 196.77  E-value: 4.21e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 169 DFVYINEYRVGEGVTINRIS--AGCKCRD----------CFSD---EGGCCPGAFqhKKAYNNEGQVK-------VKPGF 226
Cdd:cd19473    2 DFRFIEKSILGEGVELADEEfrSGCECTDdedcmysgclCLQDvdpDDDRDPGKK--KNAYHSSGAKKgclrghmLNSRL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 227 PIYECNSCCRCGPSCPNRVVQKGIQYKFCIFRTSDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERR--GQIYDRQGT 304
Cdd:cd19473   80 PIYECHEGCACSDDCPNRVVERGRKVPLQIFRTSDGRGWGVRSTVDIKRGQFVDCYVGEIITPEEAQRRrdAATIAQRKD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 305 TYLFDLDYVEDV-----------YTVDAARYGNISHFVNHSCKPNLQVYNVFIDNLDERLPRIAFFATRTIRTGEELTFD 373
Cdd:cd19473  160 VYLFALDKFSDPdsldprlrgdpYEIDGEFMSGPTRFINHSCDPNLRIFARVGDHADKHIHDLAFFAIKDIPRGTELTFD 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 147899133 374 YnmqVDPVDVESSKMDSNFGIAGLpaspkkrvrVECKCGVSSCRKYL 420
Cdd:cd19473  240 Y---VDGVTGLDDDAGDEEKEKEM---------TKCLCGSPKCRGYL 274
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 190-420 2.87e-55

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 183.27  E-value: 2.87e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 190 GCKCRD--CFSDEggcCPGAFQHKKAYNNEGQVKVKPGF---PIYECNSCCRCGPSCPNRVVQKGIQYKFCIFRTSDgRG 264
Cdd:cd10544   26 GCDCKTssCEPET---CSCLRKYGPNYDDDGCLLDFDGKysgPVFECNSMCKCSESCQNRVVQNGLQFKLQVFKTPK-KG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 265 WGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDyvEDVYT-------VDAARYGNISHFVNHSCKP 337
Cdd:cd10544  102 WGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSQTKGDMNYIIVLR--EHLSSgkvletfVDPTYIGNIGRFLNHSCEP 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 338 NLQVYNVFIDNLderLPRIAFFATRTIRTGEELTFDYNMQVDPvdvesSKMDSNFGIAGLPASPKKrvrveCKCGVSSCR 417
Cdd:cd10544  180 NLFMVPVRVDSM---VPKLALFAARDIVAGEELSFDYSGEFSN-----SVESVTLARQDESKSRKP-----CLCGAENCR 246


                 ...
gi 147899133 418 KYL 420
Cdd:cd10544  247 GFL 249
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 169-375 2.95e-51

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 172.20  E-value: 2.95e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 169 DFVYINEYRVGEGVTINRISAGCKCRD-CFSDEGGC-----CPGAFqhkkAYNNEGQVKV-KPGfpIYECNSCCRCGPSC 241
Cdd:cd10545    2 GFTYTVKLIIPPGVSLPVPSTGCDCKNrCTDGASDCacvkkNGGEI----PYNFNGRLIRaKPA--IYECGPLCKCPPSC 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 242 PNRVVQKGIQYKFCIFRTSDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDrqgttYLFDLDYVEDV----- 316
Cdd:cd10545   76 YNRVTQKGLRYRLEVFKTAE-RGWGVRSWDSIPAGSFICEYVGELLDTSEADTRSGNDD-----YLFDIDNRQTNrgwdg 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 317 -----------------------YTVDAARYGNISHFVNHSCKPNLQVYNVFIDNLDERLPRIAFFATRTIRTGEELTFD 373
Cdd:cd10545  150 gqrldvgmsdgerssaedeesseFTIDAGSFGNVARFINHSCSPNLFVQCVLYDHNDLRLPRVMLFAADNIPPLQELTYD 229


                 ..
gi 147899133 374 YN 375
Cdd:cd10545  230 YG 231
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 191-374 3.34e-46

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 158.94  E-value: 3.34e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 191 CKCRD-CFSDEggCCPGAFQHKKAYNNEGQV-----KVKPGFpIYECNSCCRCGPSCPNRVVQKGIQYKFCIFRTSDgRG 264
Cdd:cd10535   27 CVCIDdCSSSN--CMCGQLSMRCWYDKDGRLlpefnMAEPPL-IFECNHACSCWRNCRNRVVQNGLRARLQLYRTRD-MG 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 265 WGVRTLEKIRKNSFVMEYVGEIITSEEAERRgqiydrQGTTYLFDLDYVE-DVYTVDAARYGNISHFVNHSCKPNLQVYN 343
Cdd:cd10535  103 WGVRSLQDIPPGTFVCEYVGELISDSEADVR------EEDSYLFDLDNKDgEVYCIDARFYGNVSRFINHHCEPNLVPVR 176

                        170       180       190
                 ....*....|....*....|....*....|.
gi 147899133 344 VFIDNLDERLPRIAFFATRTIRTGEELTFDY 374
Cdd:cd10535  177 VFMAHQDLRFPRIAFFSTRLIEAGEQLGFDY 207
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 169-374 6.92e-45

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 155.95  E-value: 6.92e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 169 DFVYINEYRVGEGVTINR-IS--AGCKCRDCFSDEGGCCpGAFQHKKAYNNEGQV-----KVKPGFpIYECNSCCRCGPS 240
Cdd:cd10533    2 DYKYISENCETSTMNIDRnIThlQHCTCVDDCSSSNCLC-GQLSIRCWYDKDGRLlqefnKIEPPL-IFECNQACSCWRN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 241 CPNRVVQKGIQYKFCIFRTSDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRgqiydrQGTTYLFDLDYVE-DVYTV 319
Cdd:cd10533   80 CKNRVVQSGIKVRLQLYRTAK-MGWGVRALQTIPQGTFICEYVGELISDAEADVR------EDDSYLFDLDNKDgEVYCI 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 147899133 320 DAARYGNISHFVNHSCKPNLQVYNVFIDNLDERLPRIAFFATRTIRTGEELTFDY 374
Cdd:cd10533  153 DARYYGNISRFINHLCDPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDY 207
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 191-420 4.11e-42

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 148.46  E-value: 4.11e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 191 CKCRDCFSDEGGCCPGA-------FQHKKAynnegQVKVKPGfpIYECNSCCRCGPS-CPNRVVQKGIQYKFCIFRTSDg 262
Cdd:cd10541   30 CACHQLTIQATACTPGGqdnptagYQYKRL-----EECLPTG--VYECNKLCKCDPNmCQNRLVQHGLQVRLQLFKTQN- 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 263 RGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIydrQGTTYLFDLDYVED-VYTVDAARYGNISHFVNHSCKPNLQV 341
Cdd:cd10541  102 KGWGIRCLDDIAKGTFVCIYAGKILTDDFADKEGLE---MGDEYFANLDHIEEsCYIIDAKLEGNLGRYLNHSCSPNLFV 178

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 147899133 342 YNVFIDNLDERLPRIAFFATRTIRTGEELTFDYNMQVDPVdvesskmdsnfgiaglpasPKKRVRveCKCGVSSCRKYL 420
Cdd:cd10541  179 QNVFVDTHDLRFPWVAFFASKRIKAGTELTWDYNYEVGSV-------------------EGKELL--CCCGSNECRGRL 236
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 252-375 5.19e-42

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 144.40  E-value: 5.19e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133   252 YKFCIFRtSDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGT--TYLFDLDyveDVYTVDAARYGNISH 329
Cdd:smart00317   1 NKLEVFK-SPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAkaFYLFDID---SDLCIDARRKGNLAR 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 147899133   330 FVNHSCKPNLQVYNVFIDNLDerlpRIAFFATRTIRTGEELTFDYN 375
Cdd:smart00317  77 FINHSCEPNCELLFVEVNGDD----RIVIFALRDIKPGEELTIDYG 118
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 260-374 3.99e-37

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 131.21  E-value: 3.99e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 260 SDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDyveDVYTVDAARYGNISHFVNHSCKPNL 339
Cdd:cd10519    8 SDVAGWGLFLKEPIKKDEFIGEYTGELISQDEADRRGKIYDKYNSSYLFNLN---DQFVVDATRKGNKIRFANHSSNPNC 84

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 147899133 340 QVyNVFIDNLDErlpRIAFFATRTIRTGEELTFDY 374
Cdd:cd10519   85 YA-KVMMVNGDH---RIGIFAKRDIEAGEELFFDY 115
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 256-420 1.48e-34

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 125.39  E-value: 1.48e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 256 IFRTsDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTT--YLFDLDYVEdvyTVDAARYGNISHFVNH 333
Cdd:cd19172    6 VFRT-EKKGWGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKEYAREGNRhyYFMALKSDE---IIDATKKGNLSRFINH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 334 SCKPN--LQVYNVfidnldERLPRIAFFATRTIRTGEELTFDYNMQVdpvdvesskmdsnFGiaglpASPKKrvrveCKC 411
Cdd:cd19172   82 SCEPNceTQKWTV------NGELRVGFFAKRDIPAGEELTFDYQFER-------------YG-----KEAQK-----CYC 132


                 ....*....
gi 147899133 412 GVSSCRKYL 420
Cdd:cd19172  133 GSPNCRGYI 141
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 256-417 4.11e-34

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 123.90  E-value: 4.11e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 256 IFRTSDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRgQIYDRQGTTYLFDLDYVEDVYTVDAARYGNISHFVNHSC 335
Cdd:cd10531    4 LFRTEK-KGWGVKAKEDIQKGEFIIEYVGEVIDKKEFKER-LDEYEELGKSNFYILSLSDDVVIDATRKGNLSRFINHSC 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 336 KPNL--QVYNVFIDnlderlPRIAFFATRTIRTGEELTFDYNMQvdpvdvesskmdsNFGIAGlpaspkkrvrVECKCGV 413
Cdd:cd10531   82 EPNCetQKWIVNGE------YRIGIFALRDIPAGEELTFDYNFV-------------NYNEAK----------QVCLCGA 132


                 ....
gi 147899133 414 SSCR 417
Cdd:cd10531  133 QNCR 136
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 228-420 1.31e-33

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 126.48  E-value: 1.31e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 228 IYECNSCCRCGPS-CPNRVVQKGIQYKFCIFRTSDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGT-- 304
Cdd:cd10523   83 LYECNVSCKCNRMlCQNRVVQHGLQVRLQVFKTEK-KGWGVRCLDDIDKGTFVCIYAGRVLSRARSPTEPLPPKLELPse 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 305 ---------TYLFDLDYVED-VYTVDAARYGNISHFVNHSCKPNLQVYNVFIDNLDERLPRIAFFATRTIRTGEELTFDY 374
Cdd:cd10523  162 nevevvtswLILSKKRKLREnVCFLDASKEGNVGRFLNHSCCPNLFVQNVFVDTHDKNFPWVAFFTNRVVKAGTELTWDY 241

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 147899133 375 NMQvdpvdvesskmdsnfgiAGlpASPKKrvRVECKCGVSSCRKYL 420
Cdd:cd10523  242 SYD-----------------AG--TSPEQ--EIPCLCGVNKCQKKI 266
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 257-420 2.01e-33

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 122.02  E-value: 2.01e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 257 FRTSDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRG-QIYDRQGTTYLFDLDYVEdvyTVDAARYGNISHFVNHSC 335
Cdd:cd19174    5 FRTED-KGWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRMiEQYHNHSHHYCLNLDSGM---VIDGYRMGNEARFVNHSC 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 336 KPN--LQVYNVfidnldERLPRIAFFATRTIRTGEELTFDYNMqvDPVDVESSKmdsnfgiaglpaspkkrvrvECKCGV 413
Cdd:cd19174   81 DPNceMQKWSV------NGVYRIGLFALKDIPAGEELTYDYNF--HSFNVEKQQ--------------------PCKCGS 132


                 ....*..
gi 147899133 414 SSCRKYL 420
Cdd:cd19174  133 PNCRGVI 139
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 257-417 4.58e-31

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 116.16  E-value: 4.58e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 257 FRTSDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGT--TYLFDLDyveDVYTVDAARYGNISHFVNHS 334
Cdd:cd10518   18 VGKSGIHGWGLFAKRPIAAGEMVIEYVGEVIRPIVADKREKRYDEEGGggTYMFRID---EDLVIDATKKGNIARFINHS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 335 CKPNLQVYNVFIDNLDerlpRIAFFATRTIRTGEELTFDYNMQVDPVDvesskmdsnfgiaglpaspkkrvRVECKCGVS 414
Cdd:cd10518   95 CDPNCYAKIITVDGEK----HIVIFAKRDIAPGEELTYDYKFPIEDEE-----------------------KIPCLCGAP 147


                 ...
gi 147899133 415 SCR 417
Cdd:cd10518  148 NCR 150
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 264-375 1.66e-29

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 110.69  E-value: 1.66e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133  264 GWGVRTLEKIRKNSFVMEYVGE-IITSEEAERRGQIYDRQGT-----TYLFDLDyVEDVYTVD--AARYGNISHFVNHSC 335
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLElrlwgPYLFTLD-EDSEYCIDarALYYGNWARFINHSC 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 147899133  336 KPNLQVYNVFIDnldeRLPRIAFFATRTIRTGEELTFDYN 375
Cdd:pfam00856  80 DPNCEVRVVYVN----GGPRIVIFALRDIKPGEELTIDYG 115
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 256-420 1.32e-27

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 106.63  E-value: 1.32e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 256 IFRTSDgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTT--YLFDLDyvEDVYtVDAARYGNISHFVNH 333
Cdd:cd19173    6 PFKTGD-RGWGLRTKRDIKKGDFVIEYVGELIDEEECRRRLKKAHENNITnfYMLTLD--KDRI-IDAGPKGNLSRFMNH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 334 SCKPNL--QVYNVFIDnlderlPRIAFFATRTIRTGEELTFDYNMQVdpvdvesskmdsnFGiaglpaspkkRVRVECKC 411
Cdd:cd19173   82 SCQPNCetQKWTVNGD------TRVGLFAVRDIPAGEELTFNYNLDC-------------LG----------NEKKVCRC 132


                 ....*....
gi 147899133 412 GVSSCRKYL 420
Cdd:cd19173  133 GAPNCSGFL 141
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 253-374 1.44e-27

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 105.77  E-value: 1.44e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 253 KFCIFRTSDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDyveDVYTVDAARYGNISHFVN 332
Cdd:cd19218    4 KHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLN---NDFVVDATRKGNKIRFAN 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 147899133 333 HSCKPNLQVyNVFIDNLDErlpRIAFFATRTIRTGEELTFDY 374
Cdd:cd19218   81 HSVNPNCYA-KVMMVNGDH---RIGIFAKRAIQTGEELFFDY 118
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
258-375 4.16e-27

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 105.04  E-value: 4.16e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 258 RTSDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIyDRQGTTYLFDLDyveDVYTVDAARYGNISHFVNHSCKP 337
Cdd:COG2940   11 RPSPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERREPH-KEPLHTYLFELD---DDGVIDGALGGNPARFINHSCDP 86

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 147899133 338 NLQvynvfidnLDERLPRIAFFATRTIRTGEELTFDYN 375
Cdd:COG2940   87 NCE--------ADEEDGRIFIVALRDIAAGEELTYDYG 116
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 264-420 2.19e-25

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 100.57  E-value: 2.19e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 264 GWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDYVEDVyTVDAARYGNISHFVNHSCKPNLQVYN 343
Cdd:cd19175   11 GWGLVADEDINAGEFIIEYVGEVIDDKTCEERLWDMKHKGEKNFYMCEIDKDM-VIDATFKGNLSRFINHSCDPNCELQK 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 147899133 344 VFIDNLDerlpRIAFFATRTIRTGEELTFDYNMqvdpvdvesskmdSNFGIAglpaspkkrvrVECKCGVSSCRKYL 420
Cdd:cd19175   90 WQVDGET----RIGVFAIRDIKKGEELTYDYQF-------------VQFGAD-----------QDCHCGSKNCRGKL 138
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 247-374 3.65e-25

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 99.76  E-value: 3.65e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 247 QKGIQyKFCIFRTSDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDyveDVYTVDAARYGN 326
Cdd:cd19217    1 QRGLK-KHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLN---NDFVVDATRKGN 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 147899133 327 ISHFVNHSCKPNLQVYNVFIdNLDErlpRIAFFATRTIRTGEELTFDY 374
Cdd:cd19217   77 KIRFANHSVNPNCYAKVVMV-NGDH---RIGIFAKRAIQQGEELFFDY 120
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 264-375 3.79e-25

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 99.34  E-value: 3.79e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 264 GWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQiyDRQGTTYLFDLDYveDVYTVDAARYGNISHFVNHSCKPNLQVYN 343
Cdd:cd10522   14 GLGLFAAETIAKGEFVGEYTGEVLDRWEEDRDSV--YHYDPLYPFDLNG--DILVIDAGKKGNLTRFINHSDQPNLELIV 89

                         90       100       110
                 ....*....|....*....|....*....|..
gi 147899133 344 VFidnlDERLPRIAFFATRTIRTGEELTFDYN 375
Cdd:cd10522   90 RT----LKGEQHIGFVAIRDIKPGEELFISYG 117
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 257-417 3.13e-23

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 94.71  E-value: 3.13e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 257 FRTSDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQ--GTTYLFDLDyveDVYTVDAARYGNISHFVNHS 334
Cdd:cd19169   17 FAKSRIHDWGLFALEPIAADEMVIEYVGQVIRQSVADEREKRYEAIgiGSSYLFRVD---DDTIIDATKCGNLARFINHS 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 335 CKPNL--QVYNVfidnldERLPRIAFFATRTIRTGEELTFDYNMqvdpvdvesskmdsnfgiaglpasPKKRVRVECKCG 412
Cdd:cd19169   94 CNPNCyaKIITV------ESQKKIVIYSKRPIAVNEEITYDYKF------------------------PIEDEKIPCLCG 143


                 ....*
gi 147899133 413 VSSCR 417
Cdd:cd19169  144 APQCR 148
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 256-420 6.01e-23

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 94.38  E-value: 6.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 256 IFRtSDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGT-TYLFDLDyveDVYTVDAARYGNISHFVNHS 334
Cdd:cd19170   18 VYR-SPIHGRGLFCKRNIDAGEMVIEYAGEVIRSVLTDKREKYYESKGIgCYMFRID---DDEVVDATMHGNAARFINHS 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 335 CKPNLQVYNVFIDNLDerlpRIAFFATRTIRTGEELTFDYNMqvdpvdvesskmdsnfgiaglpasPKKRVRVECKCGVS 414
Cdd:cd19170   94 CEPNCYSRVVNIDGKK----HIVIFALRRILRGEELTYDYKF------------------------PIEDVKIPCTCGSK 145


                 ....*.
gi 147899133 415 SCRKYL 420
Cdd:cd19170  146 KCRKYL 151
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 257-417 2.11e-22

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 92.49  E-value: 2.11e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 257 FRTSDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQG--TTYLFDLDyvEDVyTVDAARYGNISHFVNHS 334
Cdd:cd20072   17 FARSAIHNWGLYAMENISAKDMVIEYVGEVIRQQVADEREKRYLRQGigSSYLFRID--DDT-VVDATKKGNIARFINHC 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 335 CKPNLQVYNVFIDNldERlpRIAFFATRTIRTGEELTFDYNMQVDpvdvesskmdsnfgiaglpaspkkRVRVECKCGVS 414
Cdd:cd20072   94 CDPNCTAKIIKVEG--EK--RIVIYAKRDIAAGEELTYDYKFPRE------------------------EDKIPCLCGAP 145


                 ...
gi 147899133 415 SCR 417
Cdd:cd20072  146 NCR 148
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 155-244 2.26e-22

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 90.94  E-value: 2.26e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133  155 ILVENEVDLEGPPRDFVYINEYRVGEGVtINRISAGCKCRDCFSDEGGCCPGAFQHKK-AYNNEGQVKVKPGFPIYECNS 233
Cdd:pfam05033  10 IPVVNEVDDEPPPPDFTYITSYIYPKEF-LLIIPQGCDCGDCSSEKCSCAQLNGGEFRfPYDKDGLLVPESKPPIYECNP 88

                          90
                  ....*....|.
gi 147899133  234 CCRCGPSCPNR 244
Cdd:pfam05033  89 LCGCPPSCPNR 99
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 264-420 2.76e-22

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 92.49  E-value: 2.76e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 264 GWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGT-TYLFDLDyveDVYTVDAARYGNISHFVNHSCKPNL--Q 340
Cdd:cd19171   25 GLGLYAARDIEKHTMVIEYIGEIIRNEVANRREKIYESQNRgIYMFRID---NDWVIDATMTGGPARYINHSCNPNCvaE 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 341 VYNVfidnldERLPRIAFFATRTIRTGEELTFDYNMqvdpvDVESskmDSNfgiaglpaspkkrvRVECKCGVSSCRKYL 420
Cdd:cd19171  102 VVTF------DKEKKIIIISNRRIAKGEELTYDYKF-----DFED---DQH--------------KIPCLCGAPNCRKWM 153
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 256-420 4.17e-22

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 91.53  E-value: 4.17e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 256 IFRTsDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDYVEDvYTVDAARYGNISHFVNHSC 335
Cdd:cd19212    6 IIKT-ERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKD-RIIDAGPKGNYSRFMNHSC 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 336 KPN--LQVYNVFIDNlderlpRIAFFATRTIRTGEELTFDYNMQVdpvdvesskmdsnFGIAglpaspkkrvRVECKCGV 413
Cdd:cd19212   84 NPNceTQKWTVNGDV------RVGLFALCDIPAGMELTFNYNLDC-------------LGNG----------RTECHCGA 134


                 ....*..
gi 147899133 414 SSCRKYL 420
Cdd:cd19212  135 DNCSGFL 141
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 264-374 2.65e-21

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 88.79  E-value: 2.65e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 264 GWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDyveDVYTVDAARYGNISHFVNHSCKP----NL 339
Cdd:cd19168   13 GLGLFAAEDIKEGEFVIEYTGELISHDEGVRREHRRGDVSYLYLFEEQ---EGIWVDAAIYGNLSRYINHATDKvktgNC 89

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 147899133 340 QVYNVFidnlDERLPRIAFFATRTIRTGEELTFDY 374
Cdd:cd19168   90 MPKIMY----VNHEWRIKFTAIKDIKIGEELFFNY 120
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 261-374 8.30e-21

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 88.02  E-value: 8.30e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 261 DGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTT--YLFDLDYVEDVYTVDAA----RYGNIshfVNHS 334
Cdd:cd10528   25 DGKGRGVIATRPFEKGDFVVEYHGDLITITEAKKREALYAKDPSTgcYMYYFQYKGKTYCVDATkesgRLGRL---INHS 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 147899133 335 CK-PNLQVYNVFIDNlderLPRIAFFATRTIRTGEELTFDY 374
Cdd:cd10528  102 KKkPNLKTKLLVIDG----VPHLILVAKRDIKPGEELLYDY 138
CD_SUV39H1_like cd18639
chromodomain of histone methyltransferase SUV39H1, and similar proteins; CHRomatin ...
 46-94 1.95e-20

chromodomain of histone methyltransferase SUV39H1, and similar proteins; CHRomatin Organization Modifier (chromo) domain of human SUV39H1, a histone lysine methyltransferase (HMT) which catalyzes di- and tri-methylation of lysine 9 of histone H3 (H3K9me2/3), leading to heterochromatin formation and gene silencing. H3K9me2/3 represents a specific mark for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3, and/or CBX5) proteins to methylated histones. SUV39H1 mainly functions in heterochromatin regions. The human SUV39H1/2, histone H3K9 methyltransferases, are the mammalian homologs of Drosophila Su(var)3-9 and Schizosaccharomyces pombe Clr4. SUV39H1 contains a chromodomain at its N-terminus and a SET domain at its C-terminus. Although the SET domain performs the catalytic activity, the chromodomain of SUV39H1 is essential for the catalytic activity of SUV39H1. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349289  Cd Length: 49  Bit Score: 84.11  E-value: 1.95e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 147899133  46 FEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHLKCNNLLKQFHL 94
Cdd:cd18639    1 YEVEYLCDYKKIREQEYYLVKWKGYPDSENTWEPRQNLKCSRLLKQFHK 49
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 256-420 2.96e-20

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 86.58  E-value: 2.96e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 256 IFRTSdGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDYVEDvYTVDAARYGNISHFVNHSC 335
Cdd:cd19211    6 IIKTE-GKGWGLIAKRDIKKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKD-RIIDAGPKGNYSRFMNHSC 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 336 KPN--LQVYNVFIDNlderlpRIAFFATRTIRTGEELTFDYNMqvDPVDVEsskmdsnfgiaglpaspkkrvRVECKCGV 413
Cdd:cd19211   84 QPNceTQKWTVNGDT------RVGLFAVCDIPAGTELTFNYNL--DCLGNE---------------------KTVCRCGA 134


                 ....*..
gi 147899133 414 SSCRKYL 420
Cdd:cd19211  135 PNCSGFL 141
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 256-420 3.73e-20

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 86.13  E-value: 3.73e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 256 IFRTSdGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDYVEDvYTVDAARYGNISHFVNHSC 335
Cdd:cd19210    6 IFRTL-GRGWGLRCKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKD-RIIDAGPKGNYARFMNHCC 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 336 KPN--LQVYNVFIDNlderlpRIAFFATRTIRTGEELTFDYNMQVdpvdvesskmdsnFGIAglpaspkkrvRVECKCGV 413
Cdd:cd19210   84 QPNceTQKWTVNGDT------RVGLFALCDIKAGTELTFNYNLEC-------------LGNG----------KTVCKCGA 134


                 ....*..
gi 147899133 414 SSCRKYL 420
Cdd:cd19210  135 PNCSGFL 141
PreSET smart00468
N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal ...
 145-236 1.30e-18

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal to some SET domains. Function is unknown. Unpublished.


Pssm-ID: 128744 [Multi-domain]  Cd Length: 98  Bit Score: 80.54  E-value: 1.30e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133   145 LNAKRSHLGLILVeNEVDLEGPPRDFVYINEYRVGEGVTINRISA---GCKC-RDCFSDEGGCCPGAFQHKKAYNNEGQV 220
Cdd:smart00468   4 ISNGKENVPVPLV-NEVDEDPPPPDFEYISEYIYGQGVPIDRSPSplvGCSCsGDCSSSNKCECARKNGGEFAYELNGGL 82

                           90
                   ....*....|....*.
gi 147899133   221 KVKPGFPIYECNSCCR 236
Cdd:smart00468  83 RLKRKPLIYECNSRCS 98
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 264-420 1.80e-18

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 81.99  E-value: 1.80e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 264 GWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGT-TYLFDLDyveDVYTVDAARYGNISHFVNHSCKPNLQVY 342
Cdd:cd19206   25 GRGLFCKRNIDAGEMVIEYSGNVIRSILTDKREKYYDSKGIgCYMFRID---DSEVVDATMHGNAARFINHSCEPNCYSR 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 147899133 343 NVFIDNLDErlprIAFFATRTIRTGEELTFDYNMqvdPVDVESSKMdsnfgiaglpaspkkrvrvECKCGVSSCRKYL 420
Cdd:cd19206  102 VINIDGQKH----IVIFAMRKIYRGEELTYDYKF---PIEDASNKL-------------------PCNCGAKKCRKFL 153
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 266-376 3.92e-17

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 77.31  E-value: 3.92e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 266 GVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGT-TYLFDLDYVEDVYtVDAARYGNISHFVNHSCKPNLQVYNV 344
Cdd:cd10529   18 GLVATEDISPGEPILEYKGEVSLRSEFKEDNGFFKRPSPfVFFYDGFEGLPLC-VDARKYGNEARFIRRSCRPNAELRHV 96

                         90       100       110
                 ....*....|....*....|....*....|....
gi 147899133 345 FIDNldERLpRIAFFATRTIRTGEELT--FDYNM 376
Cdd:cd10529   97 VVSN--GEL-RLFIFALKDIRKGTEITipFDYDY 127
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 263-420 2.33e-15

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 73.19  E-value: 2.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 263 RGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGT-TYLFDLDyveDVYTVDAARYGNISHFVNHSCKPNLQV 341
Cdd:cd19209   26 QGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRgIYMFRIN---NEHVIDATLTGGPARYINHSCAPNCVA 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 147899133 342 YNVFIDNLDerlpRIAFFATRTIRTGEELTFDYNMqvdpvDVESSKMDsnfgiaglpaspkkrvrVECKCGVSSCRKYL 420
Cdd:cd19209  103 EVVTFDKED----KIIIISSRRIPKGEELTYDYQF-----DFEDDQHK-----------------IPCHCGAWNCRKWM 155
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 265-420 3.52e-15

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 72.36  E-value: 3.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 265 WGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQG--TTYLFDLDYVEdvyTVDAARYGNISHFVNHSCKPNLQVY 342
Cdd:cd19204   26 WGLFAMEPIAADEMVIEYVGQNIRQVVADMREKRYVQEGigSSYLFRVDHDT---IIDATKCGNLARFINHCCTPNCYAK 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 147899133 343 NVFIdnldERLPRIAFFATRTIRTGEELTFDYNMqvdpvdvesskmdsnfgiaglpasPKKRVRVECKCGVSSCRKYL 420
Cdd:cd19204  103 VITI----ESQKKIVIYSKQPIGVNEEITYDYKF------------------------PIEDNKIPCLCGTENCRGTL 152
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 263-420 7.32e-15

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 71.58  E-value: 7.32e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 263 RGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGT-TYLFDLDyveDVYTVDAARYGNISHFVNHSCKPNLQV 341
Cdd:cd19208   25 QGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRgVYMFRID---NDHVIDATLTGGPARYINHSCAPNCVA 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 147899133 342 YNVFIdnldERLPRIAFFATRTIRTGEELTFDYNMqvdpvDVESSKMdsnfgiaglpaspkkrvRVECKCGVSSCRKYL 420
Cdd:cd19208  102 EVVTF----EKGHKIIISSSRRIQKGEELCYDYKF-----DFEDDQH-----------------KIPCHCGAVNCRKWM 154
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 264-420 5.64e-14

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 69.28  E-value: 5.64e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 264 GWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGT-TYLFDLDyveDVYTVDAARYGNISHFVNHSCKPNLQVY 342
Cdd:cd19207   25 GRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDSKGIgCYMFRID---DFDVVDATMHGNAARFINHSCEPNCYSR 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 147899133 343 NVFIdnldERLPRIAFFATRTIRTGEELTFDYNMqvdPVDVESSKMdsnfgiaglpaspkkrvrvECKCGVSSCRKYL 420
Cdd:cd19207  102 VIHV----EGQKHIVIFALRKIYRGEELTYDYKF---PIEDASNKL-------------------PCNCGAKRCRRFL 153
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 253-420 2.20e-13

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 67.39  E-value: 2.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 253 KFCIFRTSDgrgWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQG--TTYLFDLDYVEdvyTVDAARYGNISHF 330
Cdd:cd19205   17 KFCKSHIHD---WGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGigSSYMFRVDHDT---IIDATKCGNFARF 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 331 VNHSCKPNLQVYNVFIdnldERLPRIAFFATRTIRTGEELTFDYNMqvdPVDVEsskmdsnfgiaglpaspkkrvRVECK 410
Cdd:cd19205   91 INHSCNPNCYAKVITV----ESQKKIVIYSKQHINVNEEITYDYKF---PIEDV---------------------KIPCL 142

                        170
                 ....*....|
gi 147899133 411 CGVSSCRKYL 420
Cdd:cd19205  143 CGSENCRGTL 152
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 258-375 6.11e-13

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 63.42  E-value: 6.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 258 RTSDGRGWGVRTLEKIRKNSFVMeyvgeiitseeaerrgqiydrqgttylfdldyvedvytvdaarygnISHFVNHSCKP 337
Cdd:cd08161    5 STIPGAGFGLFATRDIPKGEVIG----------------------------------------------LARFINHSCEP 38

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 147899133 338 NLQVYNVFIDnldeRLPRIAFFATRTIRTGEELTFDYN 375
Cdd:cd08161   39 NCEFEEVYVG----GKPRVFIVALRDIKAGEELTVDYG 72
CD_CSD cd00024
CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains; Members of this ...
 46-93 3.22e-11

CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains; Members of this group are chromodomains or chromo shadow domains; these are SH3-fold-beta-barrel domains of the chromo-like superfamily. Chromodomains lack the first strand of the SH3-fold-beta-barrel, this first strand is altered by insertion in the chromo shadow domains. The chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. Chromodomain-containing proteins include: i) those having an N-terminal chromodomain followed by a related chromo shadow domain, such as Drosophila and human heterochromatin protein Su(var)205 (HP1), and mammalian modifier 1 and 2; ii) those having a single chromodomain, such as Drosophila protein Polycomb (Pc), mammalian modifier 3, human Mi-2 autoantigen, and several yeast and Caenorhabditis elegans proteins of unknown function; iii) those having paired tandem chromodomains, such as mammalian DNA-binding/helicase proteins CHD-1 to CHD-4 and yeast protein CHD1; (iv) and elongation factor eEF3, a member of the ATP-binding cassette (ABC) family of proteins, that serves an essential function in the translation cycle of fungi. eEF3 is a soluble factor lacking a transmembrane domain and having two ABC domains arranged in tandem, with a unique chromodomain inserted within the ABC2 domain.


Pssm-ID: 349274 [Multi-domain]  Cd Length: 50  Bit Score: 57.87  E-value: 3.22e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 147899133  46 FEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHLK-CNNLLKQFH 93
Cdd:cd00024    1 YEVEKILDHRVRKGKLEYLVKWKGYPPEENTWEPEENLTnAPELIKEYE 49
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 256-375 1.01e-10

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 58.42  E-value: 1.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 256 IFRTSDGRGWGVRTLEKIRKNSFVmEYVGEIITSEEAERRGQiydrqgTTYLFDLDYV-EDVYTVDAARYGniSHFvNHS 334
Cdd:cd10540    3 EVKPSTLKGRGVFATRPIKKGEVI-EEAPVIVLPKEEYQHLC------KTVLDHYVFSwGDGCLALALGYG--SMF-NHS 72

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 147899133 335 CKPNLQVYnvfidnLDERLPRIAFFATRTIRTGEELTFDYN 375
Cdd:cd10540   73 YTPNAEYE------IDFENQTIVFYALRDIEAGEELTINYG 107
Chromo pfam00385
Chromo (CHRromatin organization MOdifier) domain;
46-93 4.09e-10

Chromo (CHRromatin organization MOdifier) domain;


Pssm-ID: 459793 [Multi-domain]  Cd Length: 52  Bit Score: 54.89  E-value: 4.09e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 147899133   46 FEVEYLWNYKKVQDQ-ELYLVKWKYYPDSESTWEPRHHL-KCNNLLKQFH 93
Cdd:pfam00385   1 YEVERILDHRKDKGGkEEYLVKWKGYPYDENTWEPEENLsKCPELIEEFK 50
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 273-374 4.37e-10

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 58.57  E-value: 4.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 273 IRKNSFVMEYVGEIITSEE--AERRGQiYDRQGTTYLFDLDYVEDVYTVDAARYGNISHFVNHSCKPNLQVYNVFIDNLd 350
Cdd:cd19183   22 IPAGDPIQELLGEIGLQSEyiADPENQ-YQILGAPKPHVFFHPQSPLYIDTRRSGSVARFIRRSCRPNAELVTVASDSG- 99

                         90       100
                 ....*....|....*....|....
gi 147899133 351 eRLPRIAFFATRTIRTGEELTFDY 374
Cdd:cd19183  100 -SVLKFVLYASRDISPGEEITIGW 122
chromodomain cd18968
CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain ...
 45-92 1.44e-09

CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain. Chromodomains belong to the chromo-like superfamily of SH3-fold-beta-barrel domains which includes chromo shadow domains and chromo barrel domains. Chromodomains differ from these in that they lack the first strand of the SH3-fold-beta-barrel. This first strand is altered by insertion in the chromo shadow domains, and chromo barrel domains are typical SH3-fold-beta-barrel domains with sequence similarity to the canonical chromo domain.


Pssm-ID: 349324  Cd Length: 57  Bit Score: 53.50  E-value: 1.44e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 147899133  45 DFEVEYLWNYKKVQDQE------LYLVKWKYYPDSESTWEPRHHLK-CNNLLKQF 92
Cdd:cd18968    1 EYEVEVILAARVVKDAEsrkkgwKYLVKWAGYPDEENTWEPEESFDgCDDLLERF 55
chromodomain cd18966
CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain ...
 46-91 7.44e-08

CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain. Chromodomains belong to the chromo-like superfamily of SH3-fold-beta-barrel domains which includes chromo shadow domains and chromo barrel domains. Chromodomains differ from these in that they lack the first strand of the SH3-fold-beta-barrel. This first strand is altered by insertion in the chromo shadow domains, and chromo barrel domains are typical SH3-fold-beta-barrel domains with sequence similarity to the canonical chromo domain.


Pssm-ID: 349322  Cd Length: 49  Bit Score: 48.43  E-value: 7.44e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 147899133  46 FEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHLKCNNLLKQ 91
Cdd:cd18966    1 YEVERILAERRDDGGKRYLVKWEGYPLEEATWEPEENIGDEELLKE 46
CD_HP1_like cd18631
chromodomain of heterochromatin protein 1 proteins, including HP1alpha, HP1beta, and HP1gamma; ...
 45-92 7.55e-08

chromodomain of heterochromatin protein 1 proteins, including HP1alpha, HP1beta, and HP1gamma; CHRomatin Organization Modifier (chromo) domain of mammalian HP1alpha (Cbx5), HP1beta (Cbx1), HP1gamma (Cbx5), and similar proteins. HP1 has diverse functions in heterochromatin formation and impacts both gene expression and gene silencing. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. There are three human homologs of HP1 proteins: HP1alpha (also known as Cbx5), HP1beta (also known as Cbx1), and HP1gamma (also known as Cbx3).


Pssm-ID: 349281  Cd Length: 50  Bit Score: 48.59  E-value: 7.55e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 147899133  45 DFEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHLKCNNLLKQF 92
Cdd:cd18631    1 EYVVEKVLDRRVVKGKVEYLLKWKGYPDEDNTWEPEENLDCPDLIAEF 48
CD_MarY1_POL_like cd18975
chromodomain of Tricholoma matsutake polyprotein, and similar proteins; This subgroup includes ...
 46-94 9.56e-08

chromodomain of Tricholoma matsutake polyprotein, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in the polyprotein from the MarY1 Ty3/Gypsy long terminal repeat (LTR) retroelement from the from the Ectomycorrhizal Basidiomycete Tricholoma matsutake. The pol gene in TY3/gypsy elements generally encodes domains in the following order: prt-reverse transcriptase-RNase H-integrase, in marY1 POL the chromodomain is found at the C-terminus of the integrase domain. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349331  Cd Length: 49  Bit Score: 48.31  E-value: 9.56e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 147899133  46 FEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHLKCNNLLKQFHL 94
Cdd:cd18975    1 YEVESILNSRLHRGKLQYLIQWKGYPLEEASWELEDNIKNPRLIEEFHK 49
CD_Tf2-1_POL_like cd18973
chromodomain of Rhizoctonia solani AG-1 IB retrotransposable element Tf2 155 kDa protein type ...
 46-93 1.07e-07

chromodomain of Rhizoctonia solani AG-1 IB retrotransposable element Tf2 155 kDa protein type 1, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in Rhizoctonia solani AG-1 IB retrotransposable element Tf2 155 kDa protein type 1 (Tf2-1), and similar proteins. It belongs to the Ty3/gypsy family of long terminal repeat (LTR) retrotransposons. The pol gene in TY3/gypsy elements generally encodes domains in the following order: an aspartyl protease, a reverse transcriptase, RNase H, and an integrase, here the chromodomain is found at the C-terminus of the integrase domain. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349329  Cd Length: 50  Bit Score: 48.01  E-value: 1.07e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 147899133  46 FEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHLK-CNNLLKQFH 93
Cdd:cd18973    1 YVVEAILDNKRRKGKWLYLVKWKGYGPEHNTWEPRENLEhAQKLLKKYY 49
CD_POL_like cd18976
chromodomain of uncharacterized putative retroelement polyprotein proteins; This subgroup ...
 48-92 1.86e-07

chromodomain of uncharacterized putative retroelement polyprotein proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in uncharacterized putative retrotransposon proteins, and similar proteins. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349332  Cd Length: 51  Bit Score: 47.56  E-value: 1.86e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 147899133  48 VEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHL--KCNNLLKQF 92
Cdd:cd18976    3 VESLLDRRKVRGQVQYLVKWRGFPRSEATWEPREELmrRCAELVAAY 49
CD_HP1a_insect cd18653
chromodomain of insect HP1a; CHRomatin Organization Modifier (chromo) domain of insect HP1a. ...
 45-94 2.05e-07

chromodomain of insect HP1a; CHRomatin Organization Modifier (chromo) domain of insect HP1a. HP1a is a member of the heterochromatin protein family, and is enriched in the heterochromatin and associated with centromeres. HP1 has diverse functions in heterochromatin formation and impacts both gene expression and gene silencing. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. In Drosophila, there are at least five HP1 family proteins, this subgroup includes the CD of Drosophila melanogaster HP1a.


Pssm-ID: 349300  Cd Length: 50  Bit Score: 47.33  E-value: 2.05e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 147899133  45 DFEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHLKCNNLLKQFHL 94
Cdd:cd18653    1 EYAVEKICDRRVRKGKVEYYLKWKGYPETENTWEPEENLDCQDLIQQYEA 50
CHROMO smart00298
Chromatin organization modifier domain;
45-93 3.52e-07

Chromatin organization modifier domain;


Pssm-ID: 214605 [Multi-domain]  Cd Length: 55  Bit Score: 46.82  E-value: 3.52e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 147899133    45 DFEVEYLWNYKKVQD-QELYLVKWKYYPDSESTWEPRHHLK-CNNLLKQFH 93
Cdd:smart00298   1 EYEVEKILDHRWKKKgELEYLVKWKGYSYSEDTWEPEENLLnCSKKLDNYK 51
CD_HP1_like cd18960
chromodomain of heterochromatin protein 1 proteins, including HP1alpha, HP1beta, and HP1gamma; ...
 46-92 4.53e-07

chromodomain of heterochromatin protein 1 proteins, including HP1alpha, HP1beta, and HP1gamma; uncharacterized subgroup; CHRomatin Organization Modifier (chromo) domain of mammalian HP1alpha (Cbx5), HP1beta (Cbx1), HP1gamma (Cbx5), and similar proteins. HP1 has diverse functions in heterochromatin formation and impacts both gene expression and gene silencing. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. There are three human homologs of HP1 proteins: HP1alpha (also known as Cbx5), HP1beta (also known as Cbx1), and HP1gamma (also known as Cbx3).


Pssm-ID: 349316  Cd Length: 51  Bit Score: 46.40  E-value: 4.53e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 147899133  46 FEVEYLWNYKKVQD-QELYLVKWKYYPDSESTWEPRHHLKCNNLLKQF 92
Cdd:cd18960    2 FVVERILDKRLGRNgGEEFLIKWQGFPESDSSWEPRENLQCDEMLEEF 49
SET_SETD5 cd19181
SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and ...
 267-379 5.55e-07

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. SETD5 loss-of-function mutations are a likely cause of a familial syndromic intellectual disability with variable phenotypic expression.


Pssm-ID: 380958  Cd Length: 150  Bit Score: 48.85  E-value: 5.55e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 267 VRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDYVEDVYTVDAARYGNISHFVNHSCKPNLQVYNVFI 346
Cdd:cd19181   21 LRAARDLALDTLIIEYRGKVMLRQQFEVNGHFFKRPYPFVLFYSKFNGVEMCVDARTFGNDARFIRRSCTPNAEVRHMIA 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 147899133 347 DNlderLPRIAFFATRTIRTGEELT--FDY-----NMQVD 379
Cdd:cd19181  101 DG----MIHLCIYAVAAIAKDAEVTiaFDYeysncNYKVD 136
CD_DDE_transposase_like cd18978
chromodomain of Rhizopus microsporus putative DDE transposases, and similar proteins; This ...
 45-93 6.06e-07

chromodomain of Rhizopus microsporus putative DDE transposases, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in Rhizopus microsporus putative DDE transposases, and similar proteins. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349334  Cd Length: 52  Bit Score: 46.16  E-value: 6.06e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 147899133  45 DFEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHLKCNNLLKQFH 93
Cdd:cd18978    3 SYEVEKIINHRGEKNRRKYLVKWKGYDDTDNSWVTQEDFNDKDMIDEYE 51
CD_HP1beta_Cbx1 cd18650
chromodomain of heterochromatin protein 1 homolog beta; CHRomatin Organization Modifier ...
 45-92 9.28e-07

chromodomain of heterochromatin protein 1 homolog beta; CHRomatin Organization Modifier (chromo) domain of heterochromatin protein 1 homolog beta (also known as HP1beta, CBX1, and chromobox 1), and related proteins. HP1beta is a highly conserved non-histone protein, which is a member of the heterochromatin protein family, and is enriched in the heterochromatin and associated with centromeres. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. There are three human homologs of HP1 proteins: HP1alpha (also known as Cbx5), HP1beta, and HP1gamma (also known as Cbx3).


Pssm-ID: 349297  Cd Length: 50  Bit Score: 45.32  E-value: 9.28e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 147899133  45 DFEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHLKCNNLLKQF 92
Cdd:cd18650    1 EYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDCPDLIAEF 48
SET_KMT2E cd19182
SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar ...
 276-375 1.28e-06

SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; KMT2E (also termed inactive lysine N-methyltransferase 2E, myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. It associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Lack of key residues in the SET domain as well as the presence of an unusually large loop in the SET-I subdomain preclude the interaction of MLL5 SET with its cofactor and substrate thus making MLL5 devoid of any in vitro methyltransferase activity on full-length histones and histone H3 peptide.


Pssm-ID: 380959  Cd Length: 129  Bit Score: 47.19  E-value: 1.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 276 NSFVMEYVGEIITSEEAERRGQIYDRQGTTYLFDLDYVEDVYTVDAARYGNISHFVNHSCKPNLQVYNVfidnLDERLPR 355
Cdd:cd19182   30 DTLIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLEMCVDARTFGNEARFIRRSCTPNAEVRHV----IEDGTIH 105

                         90       100
                 ....*....|....*....|..
gi 147899133 356 IAFFATRTIRTGEELT--FDYN 375
Cdd:cd19182  106 LYIYSIRSIPKGTEITiaFDFD 127
CD_MMP8 cd18633
chromodomain of M-phase phosphoprotein 8; The chromodomain of M-phase phosphoprotein 8 (MPP8), ...
 46-92 4.78e-06

chromodomain of M-phase phosphoprotein 8; The chromodomain of M-phase phosphoprotein 8 (MPP8), a component of the RanBPM-containing large protein complex, binds methylated H3K9. This may in turn recruit the H3K9 methyltransferases GLP and ESET, and DNA methyltransferase 3A to the promoter of the E-cadherin gene, mediating the E-cadherin gene silencing and promoting tumor cell motility and invasion. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349283  Cd Length: 51  Bit Score: 43.43  E-value: 4.78e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 147899133  46 FEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHLK-CNNLLKQF 92
Cdd:cd18633    2 FEVEKILDMKTEGGKVLYKVRWKGYTSDDDTWEPEVHLEdCKEVLLEF 49
CD_HP1gamma_Cbx3 cd18652
chromodomain of heterochromatin protein 1 homolog gamma; CHRomatin Organization Modifier ...
 45-92 5.30e-06

chromodomain of heterochromatin protein 1 homolog gamma; CHRomatin Organization Modifier (chromo) domain of heterochromatin protein 1 homolog gamma (also known as HP1gamma, Cbx3, and Chromobox 3), and related proteins. HP1gamma is a highly conserved non-histone protein, which is a member of the heterochromatin protein family, and is enriched in the heterochromatin and associated with centromeres. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. In addition to being involved in transcriptional silencing in heterochromatin-like complexes, HP1gamma also binds lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the protein may explain the association of heterochromatin with the inner nuclear membrane. HP1gamma is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. There are three human homologs of HP1 proteins: HP1alpha (also known as Cbx5), HP1beta (also known as Cbx1), and HP1gamma.


Pssm-ID: 349299  Cd Length: 50  Bit Score: 43.46  E-value: 5.30e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 147899133  45 DFEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHLKCNNLLKQF 92
Cdd:cd18652    1 EFVVEKVLDRRVVNGKVEYFLKWKGFTDADNTWEPEENLDCPELIEAF 48
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 324-380 1.04e-05

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 44.68  E-value: 1.04e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 147899133 324 YGNISHFvNHSCKPNLQVynVFIDNlderlPRIAFFATRTIRTGEELTFDYNMQVDP 380
Cdd:cd20071   53 FPLASLL-NHSCDPNAVV--VFDGN-----GTLRVRALRDIKAGEELTISYIDPLLP 101
CD_NC-like cd18980
chromodomain of a Tasahii var. asahii CBS 8904 retrotransposon nucleocapsid protein, and ...
 45-93 1.19e-05

chromodomain of a Tasahii var. asahii CBS 8904 retrotransposon nucleocapsid protein, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in Trichosporon asahii var. asahii CBS 8904 retrotransposon nucleocapsid protein, and similar proteins. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349336  Cd Length: 56  Bit Score: 42.56  E-value: 1.19e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 147899133  45 DFEVEYLWNYK---KVQDQELYLVKWKYYPDSESTWEPRHHLK-CNNLLKQFH 93
Cdd:cd18980    3 EYEVEAILDHKvdrRYRDPNFYLVRWRGYGPSHDSWEPTSALEnAQDLLREFW 55
CD_HP1alpha_Cbx5 cd18651
chromodomain of heterochromatin protein 1 homolog alpha; CHRomatin Organization Modifier ...
 45-92 1.35e-05

chromodomain of heterochromatin protein 1 homolog alpha; CHRomatin Organization Modifier (chromo) domain of heterochromatin protein 1 homolog alpha (also known as HP1alpha, Cbx5, and Chromobox 5), and related proteins. HP1alpha has diverse functions in heterochromatin formation, gene regulation, and mitotic progression, and forms complex networks of gene, RNA, and protein interactions. HP1 has two conserved protein-protein interaction domains, a single N-terminal chromodomain (CD) which can bind to histone proteins via methylated lysine residues, and a related C-terminal chromo shadow domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated non-histone proteins; a flexible hinge region separates the CD and CSD and may bind nucleic acid. HP1 is a highly conserved non-histone chromosomal protein that is evolutionarily conserved from fission yeast to plants and animals. There are three human homologs of HP1 proteins: HP1alpha, HP1beta (also known as Cbx1), and HP1gamma (also known as Cbx3).


Pssm-ID: 349298  Cd Length: 50  Bit Score: 42.29  E-value: 1.35e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 147899133  45 DFEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHLKCNNLLKQF 92
Cdd:cd18651    1 EYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCPELISEF 48
chromodomain cd18964
CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain ...
 62-92 2.54e-05

CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain. Chromodomains belong to the chromo-like superfamily of SH3-fold-beta-barrel domains which includes chromo shadow domains and chromo barrel domains. Chromodomains differ from these in that they lack the first strand of the SH3-fold-beta-barrel. This first strand is altered by insertion in the chromo shadow domains, and chromo barrel domains are typical SH3-fold-beta-barrel domains with sequence similarity to the canonical chromo domain.


Pssm-ID: 349320  Cd Length: 54  Bit Score: 41.55  E-value: 2.54e-05
                         10        20        30
                 ....*....|....*....|....*....|..
gi 147899133  62 LYLVKWKYYPDSESTWEPRHHL-KCNNLLKQF 92
Cdd:cd18964   21 LWLVKWDGYPIEDATWEPPENLgEHAKLIEDF 52
CD_EhHp1_like cd18638
chromodomain of Entamoeba histolytica heterochromatin protein 1, and similar proteins; This ...
 46-92 3.39e-05

chromodomain of Entamoeba histolytica heterochromatin protein 1, and similar proteins; This subgroup includes the N-terminal CHRomatin Organization Modifier (chromo) domain of heterochromatin protein 1 (HP1)-like protein from Entamoeba histolytica, and similar proteins. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349288  Cd Length: 52  Bit Score: 41.09  E-value: 3.39e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 147899133  46 FEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHLK--CNNLLKQF 92
Cdd:cd18638    2 FEVEKIVKKKTVKGGTEYFVKWKGYSAKENTWETEDNLEksYKEMIDEF 50
CD_POL_like cd18972
chromodomain of a Moniliophthora perniciosa FA553 putative retrotransposon polyprotein, and ...
 46-92 3.98e-05

chromodomain of a Moniliophthora perniciosa FA553 putative retrotransposon polyprotein, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in a Moniliophthora perniciosa FA553 putative retrotelement polyprotein, which includes domains in the following order: a reverse transcriptase, RNase H, and an integrase, here the chromodomain is found at the C-terminus of the integrase domain. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related "chromo shadow" domain


Pssm-ID: 349328  Cd Length: 50  Bit Score: 40.96  E-value: 3.98e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 147899133  46 FEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHLK-CNNLLKQF 92
Cdd:cd18972    1 YEVEAIVGHKPKKKPRQFLVSWLGYDSSHNEWKQKEELEnARELLQDY 48
CD_POL_like cd18974
chromodomain of Penicillium solitum protein PENSOL_c198G03123; This subgroup includes the ...
 46-83 5.47e-05

chromodomain of Penicillium solitum protein PENSOL_c198G03123; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in Penicillium solitum protein PENSOL_c198G03123 a putative polyprotein from a Ty3/Gypsy long terminal repeat (LTR) retroelement. The pol gene in TY3/gypsy elements generally encodes domains in the following order: an aspartyl protease, a reverse transcriptase, RNase H, and an integrase, here the chromodomain is found at the C-terminus of the integrase domain. The chromodomain, is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349330  Cd Length: 50  Bit Score: 40.54  E-value: 5.47e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 147899133  46 FEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHL 83
Cdd:cd18974    1 WEVEEIVDEKMIDDELHYLVKWKGWPAEYNQWEPEDDM 38
CD_MT_like cd18962
chromodomain of a putative Coemansia reversa NRRL 1564 methyltransferase, and similar proteins; ...
 48-92 1.83e-04

chromodomain of a putative Coemansia reversa NRRL 1564 methyltransferase, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in a Coemansia reversa NRRL 1564 SET (Su(var)3-9, enhancer-of-zeste, trithorax) domain-containing protein, and similar proteins. The SU(VAR)3-9 protein is the main chromocenter-specific histone H3-K9 methyltransferase (HMTase) in Drosophila where it plays a role in heterochromatic gene silencing. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349318  Cd Length: 52  Bit Score: 39.09  E-value: 1.83e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 147899133  48 VEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHLKCNNLLKQF 92
Cdd:cd18962    6 VEAIVNDVLIDGKHMYEVKWEGYPSDHNNWVAEWDLNDKEILRKY 50
CD_CDY cd18634
chromodomain of the Chromodomain Y-like protein family; This group includes the chromodomain ...
 46-94 3.16e-04

chromodomain of the Chromodomain Y-like protein family; This group includes the chromodomain found in the mammalian chromodomain Y-like (CDY) protein family, and similar proteins. The human CDY family includes 6 proteins: the genes encoding four of these: two copies of CDY1 (CDY1a, CDY1a) and two copies of CDY2(CDY2a and CDY2b), are located on chromosome Y, and the genes encoding the other two members (CDYL and CDYL2) are located on autosomes. The chromosomal genes are only present in primates, whereas the CDYL and CDYL2 genes exist in most mammalian species. The CDY family proteins contain two functional domains: a chromodomain involved in chromatin binding and a catalytic domain found in many coenzyme A (CoA)- dependent acylation enzymes. CDYL is ubiquitously expressed, whereas CDYL2 shows selective expression in tissues of testis, prostate, spleen, and leukocyte. The CDYL genes are ubiquitously expressed, the CDY genes are only expressed in the testis. Deletion of the CDY1b gene has been shown to be a risk factor for male infertility. Impairments in CDY2 expression could be implicated in the pathogenesis of maturation arrest (a failure of germ cell development).


Pssm-ID: 349284  Cd Length: 52  Bit Score: 38.20  E-value: 3.16e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 147899133  46 FEVEYLWNYKKVQDQEL-YLVKWKYYPDSESTWEPRHHLK-CNNLLKQFHL 94
Cdd:cd18634    2 YEVERIVDKRKNKKGKTeYLVRWKGYDSEDDTWEPEQHLLnCEEFIHDFNR 52
CD_CMT3_like cd18635
chromodomain of chromomethylase 3, and similar proteins; CHRomatin Organization Modifier ...
 46-92 5.41e-04

chromodomain of chromomethylase 3, and similar proteins; CHRomatin Organization Modifier (chromo) domain of DNA (cytosine-5)-methyltransferase chromomethylase 3 (CMT3, EC:2.1.1.37), and similar proteins. CMT3 is primarily a CHG (where H is either A, T or C) methyltransferase and is predominantly expressed in actively replicating cells. The protein is involved in preferentially methylating transposon-related sequences, reducing their mobility. Studies suggest that in order to target DNA methylation, CMT3 associates with H3K9me2-containing nucleosomes through binding of its BAH- and chromo-domains to H3K9me2. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349285  Cd Length: 57  Bit Score: 37.68  E-value: 5.41e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 147899133  46 FEVEYLWNYKKVQDQE-----LYL-VKWKYYPDSESTWEPRHHL-KCNNLLKQF 92
Cdd:cd18635    2 FEVEKLVGICYGDPKKtgergLYFkVRWKGYGPEEDTWEPIEGLsNCPEKIKEF 55
CD_Chro-like cd18640
chromodomain of Drosophila melanogaster chromator chromodomain protein, and similar proteins; ...
 63-92 6.53e-04

chromodomain of Drosophila melanogaster chromator chromodomain protein, and similar proteins; This subgroup includes the CHROMO (CHRromatin Organization Modifier) domain found in chromodomain of Drosophila melanogaster chromator (also known as Chriz/Chro) chromodomain protein, and similar proteins. Chromator is a nuclear protein that plays a role in proper spindle dynamics during mitosis. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349290  Cd Length: 52  Bit Score: 37.66  E-value: 6.53e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 147899133  63 YLVKWKYYPDSESTWEPRHHL-KCNNLLKQF 92
Cdd:cd18640   20 YLVKWENRSHHENTWEPMANLeRCKYLLQMF 50
chromodomain cd18969
CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; for most members ...
 44-77 1.32e-03

CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; for most members of this subgroup, the chromodomain is followed by a chromo shadow domain; The chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain. Chromodomains belong to the chromo-like superfamily of SH3-fold-beta-barrel domains which includes chromo shadow domains and chromo barrel domains. Chromodomains differ from these in that they lack the first strand of the SH3-fold-beta-barrel. This first strand is altered by insertion in the chromo shadow domains, and chromo barrel domains are typical SH3-fold-beta-barrel domains with sequence similarity to the canonical chromo domain. For the majority of members of this subgroup, the chromodomain is followed by a chromo shadow domain (CSD).


Pssm-ID: 349325  Cd Length: 56  Bit Score: 36.73  E-value: 1.32e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 147899133  44 SDFEVEYLWNYKK---VQDQELYLVKWKYYPDSESTW 77
Cdd:cd18969    2 EEYEIEEILDVKKggfEDGKLAYFVKWKGYPSSENSW 38
CD_Cbx7 cd18646
chromodomain of chromobox homolog 7; CHRomatin Organization Modifier (chromo) domain of ...
 46-83 1.76e-03

chromodomain of chromobox homolog 7; CHRomatin Organization Modifier (chromo) domain of chromobox homolog 7 (CBX7), a component of the PcG repressive complex PRC1, one of the two classes of PRCs. PcG proteins form large multiprotein complexes (PcG bodies) which are involved in the stable repression of genes involved in development, signaling or cancer via chromatin-based epigenetic modifications. Mammalian PRC1 includes canonical (cPRC1) and non-canonical complexes; cPRC1, contains four core subunits including one CBX protein (CBX2, CBX4, and CBX6-CBX8) that binds H3K27me3. CBX family members have different affinity for H3K27me3, with CBX7 having the highest binding capability. The human CBX proteins show distinct nuclear localizations and contribute differently to transcriptional repression. Some CBX proteins of the PRC1 complex have been implicated in transcriptional activation as well as in PRC1-independent roles in embryonic stem cells and in somatic cells. CBX proteins may act as an oncogene or tumor suppressor in a cell-type-dependent manner, for example CBX8 promotes proliferation while suppressing metastasis, in colorectal carcinoma progression. CBX7 has been shown to function as a tumor suppressor in lung carcinoma and an oncogene in gastric cancer and lymphoma.


Pssm-ID: 349293  Cd Length: 56  Bit Score: 36.61  E-value: 1.76e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 147899133  46 FEVEYLWNYKKVQDQELYLVKWKYYPDSESTWEPRHHL 83
Cdd:cd18646    5 FAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHI 42
CD_Rhino cd18630
chromodomain of Drosophila melanogaster Rhino, and similar proteins; N-terminal CHRomatin ...
 63-92 2.02e-03

chromodomain of Drosophila melanogaster Rhino, and similar proteins; N-terminal CHRomatin Organization Modifier (chromo) domain of Drosophila melanogaster Rhino (also known as heterochromatin protein 1-like), and similar proteins. Rhino is a female-specific protein that affects chromosome structure and egg polarity that is required for germline PIWI-interacting RNA (piRNA) production. In Drosophila the RDC (rhino, deadlock, and cutoff) complex, composed of rhino, the protein deadlock (Del) and the Rai1-like transcription termination cofactor cutoff (Cuff) binds to chromatin of dual-strand piRNA clusters, special genomic regions, which encode piRNA precursors. The RDC complex is anchored to H3K9me3-marked chromatin in part via the H3K9me3-binding activity of Rhino, and is required for transcription of piRNA precursors. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349280  Cd Length: 51  Bit Score: 35.96  E-value: 2.02e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 147899133  63 YLVKWKYYPDSESTWEPRHHL-KCNNLLKQF 92
Cdd:cd18630   19 VLVKWSGFPNENNTWEPLENLgNCMKLVADY 49
CD_Clr4_like cd18632
N-terminal chromodomain of the fission yeast histone methyltransferase Clr4, and similar ...
 45-94 2.33e-03

N-terminal chromodomain of the fission yeast histone methyltransferase Clr4, and similar proteins; N-terminal CHRomatin Organization Modifier (chromo) domain of cryptic loci regulator 4 (Clr4), a histone H3 lysine methyltransferase which targets H3K9. Clr4 regulates silencing and switching at the mating-type loci and affects chromatin structure at centromeres. Clr4 is a catalytic component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. A chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins, and which appears to play a role in the functional organization of the eukaryotic nucleus. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain.


Pssm-ID: 349282  Cd Length: 55  Bit Score: 35.94  E-value: 2.33e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 147899133  45 DFEVEYLWNYKKVQD--QELYLVKWKYYPDSESTWEPRHHLK-CNNLLKQFHL 94
Cdd:cd18632    1 EYEVEKIVDEKTDRNtaEPLYLVRWKNYSKNHDTWEPAENLSgCQAVLEKWKR 53
SET_ATXR5_6-like cd10539
SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The ...
 264-375 3.13e-03

SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The family includes Arabidopsis thaliana ATXR5 and ATXR6. Both ATXR5 (also termed protein SET DOMAIN GROUP 15, or TRX-related protein 5) and ATXR6 (also termed protein SET DOMAIN GROUP 34, or TRX-related protein 6) function as histone methyltransferase that specifically monomethylates 'Lys-37' of histone H3 (H3K27me1). They are required for chromatin structure and gene silencing.


Pssm-ID: 380937  Cd Length: 138  Bit Score: 37.77  E-value: 3.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147899133 264 GWGVRTLEKIRKNSFVMEYVGEIITSeeaerRGQIYDRQGT--TYLFDLDYVEDVYTVdAARYGNISHFV----NHSC-- 335
Cdd:cd10539   15 GFTVEADGFIKDLTIIAEYTGDVDYI-----RNREFDDNDSimTLLLAGDPSKSLVIC-PDKRGNIARFIsginNHTKdg 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 147899133 336 --KPNLQVYNVFIDNLderlPRIAFFATRTIRTGEELTFDYN 375
Cdd:cd10539   89 kkKQNCKCVRYSINGE----ARVLLVATRDIAKGERLYYDYN 126
CD_polycomb_like cd18627
chromodomain of polycomb and chromobox family proteins; CHRomatin Organization Modifier ...
 63-93 4.77e-03

chromodomain of polycomb and chromobox family proteins; CHRomatin Organization Modifier (chromo) domain of Polycomb and Polycomb-group (PcG) chromobox (CBX) family proteins such as CBX2, CBX4, CBX6, CBX7, and CBX8. These CBX proteins are components of the PcG repressive complex PRC1, one of the two classes of PRCs. PcG proteins form large multiprotein complexes (PcG bodies) which are involved in the stable repression of genes involved in development, signaling or cancer via chromatin-based epigenetic modifications. Mammalian PRC1 includes canonical (cPRC1) and non-canonical complexes; cPRC1, contains four core subunits including one CBX protein (CBX2, CBX4, and CBX6-CBX8) that binds H3K27me3. CBX family members have different affinity for H3K27me3, with CBX7 having the highest binding capability. The human CBX proteins show distinct nuclear localizations and contribute differently to transcriptional repression. Some CBX proteins of the PRC1 complex have been implicated in transcriptional activation as well as in PRC1-independent roles in embryonic stem cells and in somatic cells.


Pssm-ID: 349277  Cd Length: 49  Bit Score: 35.06  E-value: 4.77e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 147899133  63 YLVKWKYYPDSESTWEPRHHLKCNNLLKQFH 93
Cdd:cd18627   18 YLVKWKGWSQKYNTWEPEENILDPRLLAAFE 48
chromodomain cd18965
CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain ...
 48-78 5.05e-03

CHROMO (CHRromatin Organization Modifier) domain; uncharacterized subgroup; The chromodomain is a conserved region of about 50 amino acids, found in a variety of chromosomal proteins. The chromodomain is implicated in the binding, of the proteins in which it is found, to methylated histone tails and maybe RNA. A chromodomain may occur as a single instance, in a tandem arrangement, or followed by a related chromo shadow domain. Chromodomains belong to the chromo-like superfamily of SH3-fold-beta-barrel domains which includes chromo shadow domains and chromo barrel domains. Chromodomains differ from these in that they lack the first strand of the SH3-fold-beta-barrel. This first strand is altered by insertion in the chromo shadow domains, and chromo barrel domains are typical SH3-fold-beta-barrel domains with sequence similarity to the canonical chromo domain.


Pssm-ID: 349321  Cd Length: 53  Bit Score: 35.14  E-value: 5.05e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 147899133  48 VEYLWNYKKVQDQELYLVKWKYYPDSESTWE 78
Cdd:cd18965    3 IEALLKKRQFNRKLEYLVKWHGLPESENTWE 33
CD_polycomb cd18644
chromodomain of polycomb; CHRomatin Organization Modifier (chromo) domain of the PcG ...
 63-92 9.33e-03

chromodomain of polycomb; CHRomatin Organization Modifier (chromo) domain of the PcG (polycomb-group) chromodomain protein Polycomb (Pc) from Drosophila melanogaster, anthropod, worm, and sea cucumber, and similar proteins. Pc is a component of the Polycomb-group (PcG) multiprotein PRC1 complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The core subunits of PRC1 are polycomb (Pc), polyhomeotic (Ph), posterior sex combs (Psc), and sex comb extra (Sce, also known as dRing). Polycomb (Pc) plays a role in modulating life span in flies, it negatively regulates longevity.


Pssm-ID: 349291  Cd Length: 54  Bit Score: 34.36  E-value: 9.33e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 147899133  63 YLVKWKYYPDSESTWEPRHHLKCNNLLKQF 92
Cdd:cd18644   21 YLVKWKGWSNKHNTWEPEENILDRRLIEIF 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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