NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|672084811|ref|XP_008770714|]
View 

solute carrier family 12 member 4 isoform X3 [Rattus norvegicus]

Protein Classification

solute carrier family 12 protein( domain architecture ID 11489985)

solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis, or human kidney-specific Na-K-Cl symporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
63-1080 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


:

Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1323.95  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811    63 TRMEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGGRRRA-AKAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVG 141
Cdd:TIGR00930   27 SLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPpAGAVKFGWVMGVLVPCLLNIWGVILFLRLSWIVG 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   142 TAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLT 221
Cdd:TIGR00930  107 QAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVLD 186
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   222 yiappaaIFYPSGtHDMSSATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYVGGIKSAFDPPVFP 301
Cdd:TIGR00930  187 -------LLRENG-SKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSILNIFVGTIIPAFDKPAKG 258
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   302 VCMLGNRTLSRDqfdicaktvvvdnetvatrlwtffchspnltadscdpyfllnnvtEIPGIPGAAAGvlqenlwsayle 381
Cdd:TIGR00930  259 FFGLGNEIFSEN---------------------------------------------FIPGIPGPEGG------------ 281
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   382 kgevvekhglpstdtlglkeslslyvvadiatsFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIVTTSLVY 461
Cdd:TIGR00930  282 ---------------------------------FFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLAILTTTVVY 328
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   462 FSSVILFGACIEGVVLRDKYGDGVS---------------------RNLVVGTLAWPSPWVIVVGSFFSTCGAGLQSLTG 520
Cdd:TIGR00930  329 LGSVVLFGACVVRDATGDKNDTLVTnctsaacfsecahntcsyglmNNLQVMSLVSPFPPLITAGIFSATLSSALASLVS 408
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   521 APRLLQAIAKDNIIPFLRVFGHGKA-NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRT 599
Cdd:TIGR00930  409 APRLFQALCKDNIYPFLQFFGKGYGkNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLASYALINFSCFHASLLRS 488
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   600 PNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGP 679
Cdd:TIGR00930  489 PGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQALSYSLALYSLLRLEEVE 568
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   680 PHTKNWRPQLLVLLKLDedlhVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQV 759
Cdd:TIGR00930  569 DHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQTWLEKNKVKAFYAV 644
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   760 VVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEdPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNH------ 833
Cdd:TIGR00930  645 VVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAE-PRAWETYIGIIHDAFDAHLAVVVVRNSEGLPISVlqvqee 723
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   834 --------------------------------ERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWKKCRMRIFTVAQMDD 881
Cdd:TIGR00930  724 lendcsedsielndgkistqpdmhleastqfqKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAQKDD 803
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   882 NSIQMKKDLAIFLYHLRLEAEVEVVEMhnsDISAytYERTLMMEQRSQMLRQMRLTKTERDREAqlvKDRHsalrlesly 961
Cdd:TIGR00930  804 RSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPFRLHKTEKDREA---KDPK--------- 866
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   962 sdeedesvtgadkiqMTWTRDKYMAEpwdpshapdnfrelvhiKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGP 1041
Cdd:TIGR00930  867 ---------------MTWTKPWKITD-----------------AELQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVP 914
                         1050      1060      1070
                   ....*....|....*....|....*....|....*....
gi 672084811  1042 PKNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1080
Cdd:TIGR00930  915 RKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
63-1080 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1323.95  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811    63 TRMEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGGRRRA-AKAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVG 141
Cdd:TIGR00930   27 SLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPpAGAVKFGWVMGVLVPCLLNIWGVILFLRLSWIVG 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   142 TAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLT 221
Cdd:TIGR00930  107 QAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVLD 186
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   222 yiappaaIFYPSGtHDMSSATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYVGGIKSAFDPPVFP 301
Cdd:TIGR00930  187 -------LLRENG-SKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSILNIFVGTIIPAFDKPAKG 258
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   302 VCMLGNRTLSRDqfdicaktvvvdnetvatrlwtffchspnltadscdpyfllnnvtEIPGIPGAAAGvlqenlwsayle 381
Cdd:TIGR00930  259 FFGLGNEIFSEN---------------------------------------------FIPGIPGPEGG------------ 281
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   382 kgevvekhglpstdtlglkeslslyvvadiatsFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIVTTSLVY 461
Cdd:TIGR00930  282 ---------------------------------FFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLAILTTTVVY 328
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   462 FSSVILFGACIEGVVLRDKYGDGVS---------------------RNLVVGTLAWPSPWVIVVGSFFSTCGAGLQSLTG 520
Cdd:TIGR00930  329 LGSVVLFGACVVRDATGDKNDTLVTnctsaacfsecahntcsyglmNNLQVMSLVSPFPPLITAGIFSATLSSALASLVS 408
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   521 APRLLQAIAKDNIIPFLRVFGHGKA-NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRT 599
Cdd:TIGR00930  409 APRLFQALCKDNIYPFLQFFGKGYGkNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLASYALINFSCFHASLLRS 488
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   600 PNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGP 679
Cdd:TIGR00930  489 PGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQALSYSLALYSLLRLEEVE 568
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   680 PHTKNWRPQLLVLLKLDedlhVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQV 759
Cdd:TIGR00930  569 DHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQTWLEKNKVKAFYAV 644
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   760 VVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEdPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNH------ 833
Cdd:TIGR00930  645 VVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAE-PRAWETYIGIIHDAFDAHLAVVVVRNSEGLPISVlqvqee 723
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   834 --------------------------------ERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWKKCRMRIFTVAQMDD 881
Cdd:TIGR00930  724 lendcsedsielndgkistqpdmhleastqfqKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAQKDD 803
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   882 NSIQMKKDLAIFLYHLRLEAEVEVVEMhnsDISAytYERTLMMEQRSQMLRQMRLTKTERDREAqlvKDRHsalrlesly 961
Cdd:TIGR00930  804 RSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPFRLHKTEKDREA---KDPK--------- 866
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   962 sdeedesvtgadkiqMTWTRDKYMAEpwdpshapdnfrelvhiKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGP 1041
Cdd:TIGR00930  867 ---------------MTWTKPWKITD-----------------AELQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVP 914
                         1050      1060      1070
                   ....*....|....*....|....*....|....*....
gi 672084811  1042 PKNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1080
Cdd:TIGR00930  915 RKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
AA_permease pfam00324
Amino acid permease;
118-690 4.40e-50

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 184.45  E-value: 4.40e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   118 GVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVpAGGSYFMISRSLGPEFGGAVG 197
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   198 L--CFYLGTTFAAAmyiLGAIEILLTYIAPPAAIFYPSGThdmssatlnnmrvyGTIFLTFMTLVVFVGVKYVNKFASLF 275
Cdd:pfam00324   80 WnyWLSWITVLALE---LTAASILIQFWELVPDIPYLWVW--------------GAVFLVLLTIINLVGVKWYGEAEFWF 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   276 LACVIISILSIYVGGIKSAFDPpvfpvcmlgnrtlsrdqfdicaktvvvdnetvatrlwtffchspnltadscdpyflln 355
Cdd:pfam00324  143 ALIKIIAIIGFIIVGIILLSGG---------------------------------------------------------- 164
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   356 nvteipgipGAAAGVLQENLWSAYLEKgevvekhglpstdtlglkeslslYVVADIATSFTVLVGIFFPSVTGIMAGSNR 435
Cdd:pfam00324  165 ---------NPNDGAIFRYLGDNGGKN-----------------------NFPPGFGKGFISVFVIAFFAFTGIELVGIA 212
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   436 SGDLRDAQKSIPVGTILAIVTTSLVYFSSVILFGACIEGVVLRDKYGDGVSRNLVV------GTLAWPSpwVIVVGSFFS 509
Cdd:pfam00324  213 AGEVKNPEKSIPKAILQVIWRITIFYILSLLAIGLLVPWNDPGLLNDSASAASPFViffkflGISGLAP--LINAVILTA 290
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   510 TCGAGLQSLTGAPRLLQAIAKDNIIPFlrVFGHGKANGEPTWALLLTALIAELGILIASLdmVAPILSMFFLMCYLFVNL 589
Cdd:pfam00324  291 ALSAANSSLYSGSRMLYSLARDGLAPK--FLKKVDKRGVPLRAILVSMVISLLALLLASL--NPAIVFNFLLAISGLSGL 366
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   590 ACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR 669
Cdd:pfam00324  367 IVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGAGSFAAAYLIVL 446
                          570       580
                   ....*....|....*....|.
gi 672084811   670 YALLRLEEGPPHTKNWRPQLL 690
Cdd:pfam00324  447 LFLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
126-650 4.03e-33

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 133.87  E-value: 4.03e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811  126 NIFGVILFLRLTWMVGTAGvLQALLIVLICCCCTLLTAISMSAIATNgvVP-AGGSYFMISRSLGPEFGGAVGLCFYLGT 204
Cdd:COG0531    25 AIIGAGIFVLPGLAAGLAG-PAAILAWLIAGLLALLVALSYAELASA--FPrAGGAYTYARRALGPLLGFLAGWALLLSY 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811  205 TFAAAMYILGAIEILltyiappaAIFYPSGTHDmssatlnnmrVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISIL 284
Cdd:COG0531   102 VLAVAAVAVAFGGYL--------SSLFPAGGSV----------LIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811  285 SIYVGGIksafdppvfpvcmlgnrtlsrdqfdicaktvvvdnetvatrlwtffchspnltadscdPYFLLNNVTEIPGIP 364
Cdd:COG0531   164 LFIVVGL----------------------------------------------------------FAFDPANFTPFLPAG 185
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811  365 GAAAGVlqenlwsaylekgevvekhglpstdtlglkeslslyvvadiatsFTVLVGIFFpSVTGIMAGSNRSGDLRDAQK 444
Cdd:COG0531   186 GGLSGV--------------------------------------------LAALALAFF-AFTGFEAIANLAEEAKNPKR 220
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811  445 SIPVGTILAIVTTSLVYFSSVILFGacieGVVLRDKYGDGVSRNLVVGTLAWPSP--WVIVVGSFFSTCGAGLQSLTGAP 522
Cdd:COG0531   221 NIPRAIILSLLIVGVLYILVSLALT----GVVPYDELAASGAPLADAAEAVFGPWgaILIALGALLSLLGALNASILGAS 296
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811  523 RLLQAIAKDNIIPflRVFGH-GKANGEPTWALLLTALIAELGILI--ASLDMVAPILSMFFLMCYLFVNLACAVQtLLRT 599
Cdd:COG0531   297 RLLYAMARDGLLP--KVFAKvHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALAVIVL-RRRR 373
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 672084811  600 PNWRPRFKYYHWALSFLGMSLCLALMFVS---SWYYALVAMVIAGMIYKYIEYQ 650
Cdd:COG0531   374 PDLPRPFRVPLPLIPILGILLCLFLLYLLgpgALLIGLVLLAIGLLLYLLYRRR 427
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
63-1080 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1323.95  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811    63 TRMEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGGRRRA-AKAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVG 141
Cdd:TIGR00930   27 SLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDAEGTKEKPpAGAVKFGWVMGVLVPCLLNIWGVILFLRLSWIVG 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   142 TAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLT 221
Cdd:TIGR00930  107 QAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVLD 186
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   222 yiappaaIFYPSGtHDMSSATLNNMRVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISILSIYVGGIKSAFDPPVFP 301
Cdd:TIGR00930  187 -------LLRENG-SKIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSILNIFVGTIIPAFDKPAKG 258
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   302 VCMLGNRTLSRDqfdicaktvvvdnetvatrlwtffchspnltadscdpyfllnnvtEIPGIPGAAAGvlqenlwsayle 381
Cdd:TIGR00930  259 FFGLGNEIFSEN---------------------------------------------FIPGIPGPEGG------------ 281
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   382 kgevvekhglpstdtlglkeslslyvvadiatsFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIVTTSLVY 461
Cdd:TIGR00930  282 ---------------------------------FFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLLAILTTTVVY 328
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   462 FSSVILFGACIEGVVLRDKYGDGVS---------------------RNLVVGTLAWPSPWVIVVGSFFSTCGAGLQSLTG 520
Cdd:TIGR00930  329 LGSVVLFGACVVRDATGDKNDTLVTnctsaacfsecahntcsyglmNNLQVMSLVSPFPPLITAGIFSATLSSALASLVS 408
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   521 APRLLQAIAKDNIIPFLRVFGHGKA-NGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRT 599
Cdd:TIGR00930  409 APRLFQALCKDNIYPFLQFFGKGYGkNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLASYALINFSCFHASLLRS 488
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   600 PNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGP 679
Cdd:TIGR00930  489 PGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQALSYSLALYSLLRLEEVE 568
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   680 PHTKNWRPQLLVLLKLDedlhVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQV 759
Cdd:TIGR00930  569 DHVKNWRPQCLVLTGPP----VCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQTWLEKNKVKAFYAV 644
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   760 VVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEdPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNH------ 833
Cdd:TIGR00930  645 VVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAE-PRAWETYIGIIHDAFDAHLAVVVVRNSEGLPISVlqvqee 723
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   834 --------------------------------ERYLEGHIDVWWIVHDGGMLMLLPFLLRQHKVWKKCRMRIFTVAQMDD 881
Cdd:TIGR00930  724 lendcsedsielndgkistqpdmhleastqfqKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAQKDD 803
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   882 NSIQMKKDLAIFLYHLRLEAEVEVVEMhnsDISAytYERTLMMEQRSQMLRQMRLTKTERDREAqlvKDRHsalrlesly 961
Cdd:TIGR00930  804 RSEQEKKDMATLLYKFRIDAEVIVVLM---DINA--KPQTESMEAFEEMIRPFRLHKTEKDREA---KDPK--------- 866
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   962 sdeedesvtgadkiqMTWTRDKYMAEpwdpshapdnfrelvhiKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGP 1041
Cdd:TIGR00930  867 ---------------MTWTKPWKITD-----------------AELQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVP 914
                         1050      1060      1070
                   ....*....|....*....|....*....|....*....
gi 672084811  1042 PKNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1080
Cdd:TIGR00930  915 RKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
AA_permease pfam00324
Amino acid permease;
118-690 4.40e-50

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 184.45  E-value: 4.40e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   118 GVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVpAGGSYFMISRSLGPEFGGAVG 197
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   198 L--CFYLGTTFAAAmyiLGAIEILLTYIAPPAAIFYPSGThdmssatlnnmrvyGTIFLTFMTLVVFVGVKYVNKFASLF 275
Cdd:pfam00324   80 WnyWLSWITVLALE---LTAASILIQFWELVPDIPYLWVW--------------GAVFLVLLTIINLVGVKWYGEAEFWF 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   276 LACVIISILSIYVGGIKSAFDPpvfpvcmlgnrtlsrdqfdicaktvvvdnetvatrlwtffchspnltadscdpyflln 355
Cdd:pfam00324  143 ALIKIIAIIGFIIVGIILLSGG---------------------------------------------------------- 164
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   356 nvteipgipGAAAGVLQENLWSAYLEKgevvekhglpstdtlglkeslslYVVADIATSFTVLVGIFFPSVTGIMAGSNR 435
Cdd:pfam00324  165 ---------NPNDGAIFRYLGDNGGKN-----------------------NFPPGFGKGFISVFVIAFFAFTGIELVGIA 212
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   436 SGDLRDAQKSIPVGTILAIVTTSLVYFSSVILFGACIEGVVLRDKYGDGVSRNLVV------GTLAWPSpwVIVVGSFFS 509
Cdd:pfam00324  213 AGEVKNPEKSIPKAILQVIWRITIFYILSLLAIGLLVPWNDPGLLNDSASAASPFViffkflGISGLAP--LINAVILTA 290
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   510 TCGAGLQSLTGAPRLLQAIAKDNIIPFlrVFGHGKANGEPTWALLLTALIAELGILIASLdmVAPILSMFFLMCYLFVNL 589
Cdd:pfam00324  291 ALSAANSSLYSGSRMLYSLARDGLAPK--FLKKVDKRGVPLRAILVSMVISLLALLLASL--NPAIVFNFLLAISGLSGL 366
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   590 ACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAAR 669
Cdd:pfam00324  367 IVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGAGSFAAAYLIVL 446
                          570       580
                   ....*....|....*....|.
gi 672084811   670 YALLRLEEGPPHTKNWRPQLL 690
Cdd:pfam00324  447 LFLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
126-650 4.03e-33

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 133.87  E-value: 4.03e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811  126 NIFGVILFLRLTWMVGTAGvLQALLIVLICCCCTLLTAISMSAIATNgvVP-AGGSYFMISRSLGPEFGGAVGLCFYLGT 204
Cdd:COG0531    25 AIIGAGIFVLPGLAAGLAG-PAAILAWLIAGLLALLVALSYAELASA--FPrAGGAYTYARRALGPLLGFLAGWALLLSY 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811  205 TFAAAMYILGAIEILltyiappaAIFYPSGTHDmssatlnnmrVYGTIFLTFMTLVVFVGVKYVNKFASLFLACVIISIL 284
Cdd:COG0531   102 VLAVAAVAVAFGGYL--------SSLFPAGGSV----------LIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811  285 SIYVGGIksafdppvfpvcmlgnrtlsrdqfdicaktvvvdnetvatrlwtffchspnltadscdPYFLLNNVTEIPGIP 364
Cdd:COG0531   164 LFIVVGL----------------------------------------------------------FAFDPANFTPFLPAG 185
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811  365 GAAAGVlqenlwsaylekgevvekhglpstdtlglkeslslyvvadiatsFTVLVGIFFpSVTGIMAGSNRSGDLRDAQK 444
Cdd:COG0531   186 GGLSGV--------------------------------------------LAALALAFF-AFTGFEAIANLAEEAKNPKR 220
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811  445 SIPVGTILAIVTTSLVYFSSVILFGacieGVVLRDKYGDGVSRNLVVGTLAWPSP--WVIVVGSFFSTCGAGLQSLTGAP 522
Cdd:COG0531   221 NIPRAIILSLLIVGVLYILVSLALT----GVVPYDELAASGAPLADAAEAVFGPWgaILIALGALLSLLGALNASILGAS 296
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811  523 RLLQAIAKDNIIPflRVFGH-GKANGEPTWALLLTALIAELGILI--ASLDMVAPILSMFFLMCYLFVNLACAVQtLLRT 599
Cdd:COG0531   297 RLLYAMARDGLLP--KVFAKvHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALAVIVL-RRRR 373
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 672084811  600 PNWRPRFKYYHWALSFLGMSLCLALMFVS---SWYYALVAMVIAGMIYKYIEYQ 650
Cdd:COG0531   374 PDLPRPFRVPLPLIPILGILLCLFLLYLLgpgALLIGLVLLAIGLLLYLLYRRR 427
SLC12 pfam03522
Solute carrier family 12;
704-1080 5.42e-24

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 106.16  E-value: 5.42e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   704 PRLLTFASQLKAGKGLTIVGSVIQGSFleSYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRH 783
Cdd:pfam03522    2 PALVDFAHLITKNVSLMICGHVVKGRL--SQKLRSELQKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLKP 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   784 NSVVLGWPYGWRQSE----------------------------------------------------------------- 798
Cdd:pfam03522   80 NILLMGYKSDWRTCDkeeleeyfnvihdafdlqyavailrlpegldvshllqdqdteelglgdetnssyaeqsseeqsts 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   799 DPRAWKTFIDTVRCTTAAHLALLV--------------------PKNIAFYPSNHERYLE-----------GHIDVWWIV 847
Cdd:pfam03522  160 NSKQDDDKSKLSKKDSNLSLSPDKstknpsgkdssksdklkkksPSIILRTASNEKEILNnitqfqkkqkkGTIDVWWLY 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   848 HDGGMLMLLPFLLRQHKVWKKCRMRIFTVAQMDDNSIQMKKDLAIFLYHLRLE-AEVEVVemhnSDISAYTYERTLMMEQ 926
Cdd:pfam03522  240 DDGGLTLLLPYILSTRSKWSDCKLRVFALGNRKDELEEEQRNMASLLSKFRIDySDLTVI----PDITKKPKKETKKFFD 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   927 rsQMLRQMRLTKTErdreaqlvKDRHSALRLeslySDEEDESVtgadkiqmtwtRDKymaepwdpshapdNFRELvhikp 1006
Cdd:pfam03522  316 --ELIEPFRLHEDD--------KEEESAEKI----TDSELEAL-----------KEK-------------TNRQL----- 352
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672084811  1007 dqsnvrrmhtavKLNEVIVTRSHDARLVLLNMPGPPKNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS 1080
Cdd:pfam03522  353 ------------RLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWLETLTKDLPPFLLVRGNQTSVLTFYS 414
AA_permease_2 pfam13520
Amino acid permease;
406-647 2.55e-13

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 73.50  E-value: 2.55e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   406 YVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRdaQKSIPVGTILAIVTTSLVYFSSVILFGACI--EGVVLRDKYGD 483
Cdd:pfam13520  181 TFFPDGWPGVFAGFLGVLWSFTGFESAANVSEEVK--KRNVPKAIFIGVIIVGVLYILVNIAFFGVVpdDEIALSSGLGQ 258
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   484 GVS---RNLVVGTLAWpspwVIVVGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKANGEPTWALLLTALIA 560
Cdd:pfam13520  259 VAAllfQAVGGKWGAI----IVVILLALSLLGAVNTAIVGASRLLYALARDGVLPFSRFFAKVNKFGSPIRAIILTAILS 334
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672084811   561 ELGILIASLDMVAPI----LSMFFLMCYLFVNLACAVqtLLRTPNWRPRFKYYHWALSFLGMsLCLALMFVSSWYYALVA 636
Cdd:pfam13520  335 LILLLLFLLSPAAYNallsLSAYGYLLSYLLPIIGLL--ILRKKRPDLGRIPGRWPVAIFGI-LFSLFLIVALFFPPVGP 411
                          250
                   ....*....|.
gi 672084811   637 MVIAGMIYKYI 647
Cdd:pfam13520  412 ATGSSLNYAII 422
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH