NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|242018684|ref|XP_002429804|]
View 

Annexin A2, putative [Pediculus humanus corporis]

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 225-288 1.30e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 80.60  E-value: 1.30e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 242018684  225 AERLFKSMDGPGTDNKTLIRIIVARSEIDLGDIKQQYEKMYGHTLESKIEGDITGDYRKLMLQL 288
Cdd:pfam00191   3 AELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 148-213 4.73e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 79.05  E-value: 4.73e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242018684  148 DAKALHEAgEGKWGTDESVINSILVTKSFAQLRKIFEEYEKLAGHDIEYAIKREFHGSLEKGYLSV 213
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 64-129 7.17e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 78.67  E-value: 7.17e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242018684   64 FYADEVKDAVSGVGTDEAALAEILSTLSNYGIRTIAATYEKKYGKTLEKAIKKDTSGQFKKLLVSL 129
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 1-57 3.43e-18

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 76.74  E-value: 3.43e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 242018684    1 MKGFGTDEKAIINIIAHRSIVQRLEIADHYKTMFGKKLVSELKSEIGGNFKNAVVAL 57
Cdd:pfam00191  10 MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 225-288 1.30e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 80.60  E-value: 1.30e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 242018684  225 AERLFKSMDGPGTDNKTLIRIIVARSEIDLGDIKQQYEKMYGHTLESKIEGDITGDYRKLMLQL 288
Cdd:pfam00191   3 AELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 148-213 4.73e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 79.05  E-value: 4.73e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242018684  148 DAKALHEAgEGKWGTDESVINSILVTKSFAQLRKIFEEYEKLAGHDIEYAIKREFHGSLEKGYLSV 213
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 64-129 7.17e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 78.67  E-value: 7.17e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242018684   64 FYADEVKDAVSGVGTDEAALAEILSTLSNYGIRTIAATYEKKYGKTLEKAIKKDTSGQFKKLLVSL 129
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 1-57 3.43e-18

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 76.74  E-value: 3.43e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 242018684    1 MKGFGTDEKAIINIIAHRSIVQRLEIADHYKTMFGKKLVSELKSEIGGNFKNAVVAL 57
Cdd:pfam00191  10 MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
5-57 3.56e-17

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 73.60  E-value: 3.56e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 242018684     5 GTDEKAIINIIAHRSIVQRLEIADHYKTMFGKKLVSELKSEIGGNFKNAVVAL 57
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
77-129 5.61e-17

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 73.21  E-value: 5.61e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 242018684    77 GTDEAALAEILSTLSNYGIRTIAATYEKKYGKTLEKAIKKDTSGQFKKLLVSL 129
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
236-288 1.14e-16

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 72.44  E-value: 1.14e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 242018684   236 GTDNKTLIRIIVARSEIDLGDIKQQYEKMYGHTLESKIEGDITGDYRKLMLQL 288
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
161-213 4.39e-14

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 65.12  E-value: 4.39e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 242018684   161 GTDESVINSILVTKSFAQLRKIFEEYEKLAGHDIEYAIKREFHGSLEKGYLSV 213
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 225-288 1.30e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 80.60  E-value: 1.30e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 242018684  225 AERLFKSMDGPGTDNKTLIRIIVARSEIDLGDIKQQYEKMYGHTLESKIEGDITGDYRKLMLQL 288
Cdd:pfam00191   3 AELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 148-213 4.73e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 79.05  E-value: 4.73e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242018684  148 DAKALHEAgEGKWGTDESVINSILVTKSFAQLRKIFEEYEKLAGHDIEYAIKREFHGSLEKGYLSV 213
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 64-129 7.17e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 78.67  E-value: 7.17e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 242018684   64 FYADEVKDAVSGVGTDEAALAEILSTLSNYGIRTIAATYEKKYGKTLEKAIKKDTSGQFKKLLVSL 129
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 1-57 3.43e-18

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 76.74  E-value: 3.43e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 242018684    1 MKGFGTDEKAIINIIAHRSIVQRLEIADHYKTMFGKKLVSELKSEIGGNFKNAVVAL 57
Cdd:pfam00191  10 MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
5-57 3.56e-17

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 73.60  E-value: 3.56e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 242018684     5 GTDEKAIINIIAHRSIVQRLEIADHYKTMFGKKLVSELKSEIGGNFKNAVVAL 57
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
77-129 5.61e-17

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 73.21  E-value: 5.61e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 242018684    77 GTDEAALAEILSTLSNYGIRTIAATYEKKYGKTLEKAIKKDTSGQFKKLLVSL 129
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
236-288 1.14e-16

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 72.44  E-value: 1.14e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 242018684   236 GTDNKTLIRIIVARSEIDLGDIKQQYEKMYGHTLESKIEGDITGDYRKLMLQL 288
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
161-213 4.39e-14

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 65.12  E-value: 4.39e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 242018684   161 GTDESVINSILVTKSFAQLRKIFEEYEKLAGHDIEYAIKREFHGSLEKGYLSV 213
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH