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Conserved domains on  [gi|654690915|ref|WP_028149553|]
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MULTISPECIES: SMP-30/gluconolactonase/LRE family protein [Bradyrhizobium]

Protein Classification

SMP-30/gluconolactonase/LRE family protein( domain architecture ID 11465288)

SMP-30/gluconolactonase/LRE family protein similar to Staphylococcus lactonase drp35 and Zymomonas mobilis gluconolactonase, which hydrolyzes the gluconolactone formed by glucose-fructose oxidoreductase to form gluconate

CATH:  2.120.10.30
Gene Ontology:  GO:0016787
SCOP:  4003251

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 39-304 7.22e-56

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


:

Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 182.01  E-value: 7.22e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  39 PPGEYTFGiEGPAADLDGNLFVVNFGKpGTIGKLPAGGAASEQFtALPAGSVgNAIRFARDGTMFIADYKkHNIFAI--A 116
Cdd:COG3386    3 ADAGFRLG-EGPVWDPDGRLYWVDIPG-GRIHRYDPDGGAVEVF-AEPSGRP-NGLAFDPDGRLLVADHG-RGLVRFdpA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 117 KGTREPVVWFHSDEMNQPNDITVARDGTIYASDPNWKGREGHIWRIakSADGTVQgQVMSApraMGTTNGIDLSPDGKTL 196
Cdd:COG3386   78 DGEVTVLADEYGKPLNRPNDGVVDPDGRLYFTDMGEYLPTGALYRV--DPDGSLR-VLADG---LTFPNGIAFSPDGRTL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 197 YVGESSSGEIWSYTVRGN-ELTGAKLVKAFQPDTV--DGLRTDVAGRLYVARILKGTIALMKPNGAVEREIALKGKEPTN 273
Cdd:COG3386  152 YVADTGAGRIYRFDLDADgTLGNRRVFADLPDGPGgpDGLAVDADGNLWVALWGGGGVVRFDPDGELLGRIELPERRPTN 231

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 654690915 274 LAFGGSDGKTVFVT----QRQGGFVESFRTDQQGR 304
Cdd:COG3386  232 VAFGGPDLRTLYVTtarsLPLAGALFRVRVDVPGL 266
 
Name Accession Description Interval E-value
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 39-304 7.22e-56

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 182.01  E-value: 7.22e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  39 PPGEYTFGiEGPAADLDGNLFVVNFGKpGTIGKLPAGGAASEQFtALPAGSVgNAIRFARDGTMFIADYKkHNIFAI--A 116
Cdd:COG3386    3 ADAGFRLG-EGPVWDPDGRLYWVDIPG-GRIHRYDPDGGAVEVF-AEPSGRP-NGLAFDPDGRLLVADHG-RGLVRFdpA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 117 KGTREPVVWFHSDEMNQPNDITVARDGTIYASDPNWKGREGHIWRIakSADGTVQgQVMSApraMGTTNGIDLSPDGKTL 196
Cdd:COG3386   78 DGEVTVLADEYGKPLNRPNDGVVDPDGRLYFTDMGEYLPTGALYRV--DPDGSLR-VLADG---LTFPNGIAFSPDGRTL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 197 YVGESSSGEIWSYTVRGN-ELTGAKLVKAFQPDTV--DGLRTDVAGRLYVARILKGTIALMKPNGAVEREIALKGKEPTN 273
Cdd:COG3386  152 YVADTGAGRIYRFDLDADgTLGNRRVFADLPDGPGgpDGLAVDADGNLWVALWGGGGVVRFDPDGELLGRIELPERRPTN 231

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 654690915 274 LAFGGSDGKTVFVT----QRQGGFVESFRTDQQGR 304
Cdd:COG3386  232 VAFGGPDLRTLYVTtarsLPLAGALFRVRVDVPGL 266
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 73-287 3.43e-26

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 103.88  E-value: 3.43e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915   73 PAGGaasEQFTALPAGSVGNAIRFARDGTMFIADYKKHnIFAIAKGTREPVVWFHSDEM--NQPNDITVARDGTIYASDP 150
Cdd:pfam08450  29 PATG---KETVWDTPGPVGAIAPRDDGGLIVALKDGVA-LLDLATGELTPLADPEDDDWplNRFNDGKVDPDGRFWFGTM 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  151 NW----KGREGHIWRIakSADGTVQGQVmsapRAMGTTNGIDLSPDGKTLYVGESSSGEIWSYTV--RGNELTGAKLVKA 224
Cdd:pfam08450 105 GDdeapGGDPGALYRL--DPDGKLTRVL----DGLTISNGLAWSPDGRTLYFADSPARKIWAYDYdlDGGLISNRRVFAD 178

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 654690915  225 FQPDTV--DGLRTDVAGRLYVARILKGTIALMKPNGAVEREIALKGKEPTNLAFGGSDGKTVFVT 287
Cdd:pfam08450 179 FKPGLGrpDGMAVDAEGNVWVARWGGGKVVRFDPDGKLLREIELPAKRPTSCAFGGPDLRTLYVT 243
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 51-248 9.30e-12

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 64.26  E-value: 9.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  51 AADLDGNLFVVNFGK---------PGTIGKLPAGGAASEQFTAlPAGsvgnaIRFARDGTMFIADYKKHNIFAIAKGTRE 121
Cdd:cd05819   61 AVDSDGNLYVADTGNhriqkfdpdGNFLASFGGSGDGDGEFNG-PRG-----IAVDSSGNIYVADTGNHRIQKFDPDGEF 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 122 PVVW----FHSDEMNQPNDITVARDGTIYASDpnwkgREGHiwRIAK-SADGTVQ---GQVMSAPRAMGTTNGIDLSPDG 193
Cdd:cd05819  135 LTTFgsggSGPGQFNGPTGVAVDSDGNIYVAD-----TGNH--RIQVfDPDGNFLttfGSTGTGPGQFNYPTGIAVDSDG 207

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 654690915 194 kTLYVGESSSGEIWSYTVRGNEL--TGAKLVKAFQPDTVDGLRTDVAGRLYVA-----RILK 248
Cdd:cd05819  208 -NIYVADSGNNRVQVFDPDGAGFggNGNFLGSDGQFNRPSGLAVDSDGNLYVAdtgnnRIQV 268
 
Name Accession Description Interval E-value
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 39-304 7.22e-56

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 182.01  E-value: 7.22e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  39 PPGEYTFGiEGPAADLDGNLFVVNFGKpGTIGKLPAGGAASEQFtALPAGSVgNAIRFARDGTMFIADYKkHNIFAI--A 116
Cdd:COG3386    3 ADAGFRLG-EGPVWDPDGRLYWVDIPG-GRIHRYDPDGGAVEVF-AEPSGRP-NGLAFDPDGRLLVADHG-RGLVRFdpA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 117 KGTREPVVWFHSDEMNQPNDITVARDGTIYASDPNWKGREGHIWRIakSADGTVQgQVMSApraMGTTNGIDLSPDGKTL 196
Cdd:COG3386   78 DGEVTVLADEYGKPLNRPNDGVVDPDGRLYFTDMGEYLPTGALYRV--DPDGSLR-VLADG---LTFPNGIAFSPDGRTL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 197 YVGESSSGEIWSYTVRGN-ELTGAKLVKAFQPDTV--DGLRTDVAGRLYVARILKGTIALMKPNGAVEREIALKGKEPTN 273
Cdd:COG3386  152 YVADTGAGRIYRFDLDADgTLGNRRVFADLPDGPGgpDGLAVDADGNLWVALWGGGGVVRFDPDGELLGRIELPERRPTN 231

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 654690915 274 LAFGGSDGKTVFVT----QRQGGFVESFRTDQQGR 304
Cdd:COG3386  232 VAFGGPDLRTLYVTtarsLPLAGALFRVRVDVPGL 266
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 73-287 3.43e-26

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 103.88  E-value: 3.43e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915   73 PAGGaasEQFTALPAGSVGNAIRFARDGTMFIADYKKHnIFAIAKGTREPVVWFHSDEM--NQPNDITVARDGTIYASDP 150
Cdd:pfam08450  29 PATG---KETVWDTPGPVGAIAPRDDGGLIVALKDGVA-LLDLATGELTPLADPEDDDWplNRFNDGKVDPDGRFWFGTM 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  151 NW----KGREGHIWRIakSADGTVQGQVmsapRAMGTTNGIDLSPDGKTLYVGESSSGEIWSYTV--RGNELTGAKLVKA 224
Cdd:pfam08450 105 GDdeapGGDPGALYRL--DPDGKLTRVL----DGLTISNGLAWSPDGRTLYFADSPARKIWAYDYdlDGGLISNRRVFAD 178

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 654690915  225 FQPDTV--DGLRTDVAGRLYVARILKGTIALMKPNGAVEREIALKGKEPTNLAFGGSDGKTVFVT 287
Cdd:pfam08450 179 FKPGLGrpDGMAVDAEGNVWVARWGGGKVVRFDPDGKLLREIELPAKRPTSCAFGGPDLRTLYVT 243
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
49-306 1.05e-14

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 72.74  E-value: 1.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  49 GPAADLDGNLFVVNFGKpGTIGKL-PAGGAASEqfTALPAGSVGNAIRFARDGTMFIADYKKHNIFAIAKGTREPVVWFH 127
Cdd:COG4257   21 DVAVDPDGAVWFTDQGG-GRIGRLdPATGEFTE--YPLGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDPKTGEITTFAL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 128 SDEMNQPNDITVARDGTIYASDpNWKGReghIWRIAKsADGTVQgqVMSAPRAMGTTNGIDLSPDGKtLYVGESSSGEIW 207
Cdd:COG4257   98 PGGGSNPHGIAFDPDGNLWFTD-QGGNR---IGRLDP-ATGEVT--EFPLPTGGAGPYGIAVDPDGN-LWVTDFGANAIG 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 208 SYTVRGNELTGAKLVKAFQPDTvdGLRTDVAGRLYVARILKGTIALMKPNGAVEREIALKGKE--PTNLAFGGsDGKtVF 285
Cdd:COG4257  170 RIDPDTGTLTEYALPTPGAGPR--GLAVDPDGNLWVADTGSGRIGRFDPKTGTVTEYPLPGGGarPYGVAVDG-DGR-VW 245

                        250       260
                 ....*....|....*....|.
gi 654690915 286 VTQRQGGFVESFRTDQQGREH 306
Cdd:COG4257  246 FAESGANRIVRFDPDTELTEY 266
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 51-248 9.30e-12

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 64.26  E-value: 9.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  51 AADLDGNLFVVNFGK---------PGTIGKLPAGGAASEQFTAlPAGsvgnaIRFARDGTMFIADYKKHNIFAIAKGTRE 121
Cdd:cd05819   61 AVDSDGNLYVADTGNhriqkfdpdGNFLASFGGSGDGDGEFNG-PRG-----IAVDSSGNIYVADTGNHRIQKFDPDGEF 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 122 PVVW----FHSDEMNQPNDITVARDGTIYASDpnwkgREGHiwRIAK-SADGTVQ---GQVMSAPRAMGTTNGIDLSPDG 193
Cdd:cd05819  135 LTTFgsggSGPGQFNGPTGVAVDSDGNIYVAD-----TGNH--RIQVfDPDGNFLttfGSTGTGPGQFNYPTGIAVDSDG 207

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 654690915 194 kTLYVGESSSGEIWSYTVRGNEL--TGAKLVKAFQPDTVDGLRTDVAGRLYVA-----RILK 248
Cdd:cd05819  208 -NIYVADSGNNRVQVFDPDGAGFggNGNFLGSDGQFNRPSGLAVDSDGNLYVAdtgnnRIQV 268
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 49-287 1.28e-11

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 63.88  E-value: 1.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  49 GPAADLDGNLFVVNFGKpGTIGKLPAGGAASEQFTALPAGSVG----NAIRFARDGTMFIADYKKHNIFAIAKGTREPVV 124
Cdd:cd05819   12 GIAVDSSGNIYVADTGN-NRIQVFDPDGNFITSFGSFGSGDGQfnepAGVAVDSDGNLYVADTGNHRIQKFDPDGNFLAS 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 125 W----FHSDEMNQPNDITVARDGTIYASDpnwkgREGHiwRIAK-SADGTVQGQVMSAPRAMGTTN---GIDLSPDGkTL 196
Cdd:cd05819   91 FggsgDGDGEFNGPRGIAVDSSGNIYVAD-----TGNH--RIQKfDPDGEFLTTFGSGGSGPGQFNgptGVAVDSDG-NI 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 197 YVGESSSGEIWSYTVRGNELT--GAKLVKAFQPDTVDGLRTDVAGRLYVA-----RILKGTIALMKPNGAVEREIALKG- 268
Cdd:cd05819  163 YVADTGNHRIQVFDPDGNFLTtfGSTGTGPGQFNYPTGIAVDSDGNIYVAdsgnnRVQVFDPDGAGFGGNGNFLGSDGQf 242

                        250
                 ....*....|....*....
gi 654690915 269 KEPTNLAFgGSDGKtVFVT 287
Cdd:cd05819  243 NRPSGLAV-DSDGN-LYVA 259
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
80-300 1.22e-10

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 60.80  E-value: 1.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  80 EQFTALPAGSVGNAIRFARDGTMFIADYKKHNI--FAIAKGTrepVVWFHSDEMNQPNDITVARDGTIYASDPnwkgREG 157
Cdd:COG4257    8 TEYPVPAPGSGPRDVAVDPDGAVWFTDQGGGRIgrLDPATGE---FTEYPLGGGSGPHGIAVDPDGNLWFTDN----GNN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 158 HIWRIAKsADGTVqgQVMSAPRAMGTTNGIDLSPDGKtLYVGESSSGEIWSYTVRGNELTgakLVKAFQPDTVD-GLRTD 236
Cdd:COG4257   81 RIGRIDP-KTGEI--TTFALPGGGSNPHGIAFDPDGN-LWFTDQGGNRIGRLDPATGEVT---EFPLPTGGAGPyGIAVD 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 654690915 237 VAGRLYVARILKGTIALMKPNGAVEREIAL--KGKEPTNLAFgGSDGkTVFVTQRQGGFVESFRTD 300
Cdd:COG4257  154 PDGNLWVTDFGANAIGRIDPDTGTLTEYALptPGAGPRGLAV-DPDG-NLWVADTGSGRIGRFDPK 217
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 45-209 1.29e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 55.02  E-value: 1.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  45 FGIEGPAADLDGNLFVVNFGK-------P--GTIGKLPAGGAASEQFTAlPAGsvgnaIRFARDGTMFIADYKKHNIFAI 115
Cdd:cd05819  102 NGPRGIAVDSSGNIYVADTGNhriqkfdPdgEFLTTFGSGGSGPGQFNG-PTG-----VAVDSDGNIYVADTGNHRIQVF 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 116 AKGTREPVVW----FHSDEMNQPNDITVARDGTIYASDPNWKgreghiwRI----AKSADGTVQGQVMSAPRAMGTTNGI 187
Cdd:cd05819  176 DPDGNFLTTFgstgTGPGQFNYPTGIAVDSDGNIYVADSGNN-------RVqvfdPDGAGFGGNGNFLGSDGQFNRPSGL 248

                        170       180
                 ....*....|....*....|..
gi 654690915 188 DLSPDGKtLYVGESSSGEIWSY 209
Cdd:cd05819  249 AVDSDGN-LYVADTGNNRIQVF 269
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 76-303 2.69e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 50.78  E-value: 2.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  76 GAASEQFTAlPAGsvgnaIRFARDGTMFIADYKKHNIFAIAKGTREPVVW----FHSDEMNQPNDITVARDGTIYASDpN 151
Cdd:cd05819    1 GTGPGELNN-PQG-----IAVDSSGNIYVADTGNNRIQVFDPDGNFITSFgsfgSGDGQFNEPAGVAVDSDGNLYVAD-T 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 152 WKGReghIWRIakSADGTVQGQV---------MSAPRamgttnGIDLSPDGkTLYVGESSSGEIWSYTVRGNELT--GAK 220
Cdd:cd05819   74 GNHR---IQKF--DPDGNFLASFggsgdgdgeFNGPR------GIAVDSSG-NIYVADTGNHRIQKFDPDGEFLTtfGSG 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 221 LVKAFQPDTVDGLRTDVAGRLYVA-----RILKgtialMKPNGAVEREIALKG------KEPTNLAFGGSDgkTVFVTQR 289
Cdd:cd05819  142 GSGPGQFNGPTGVAVDSDGNIYVAdtgnhRIQV-----FDPDGNFLTTFGSTGtgpgqfNYPTGIAVDSDG--NIYVADS 214

                        250
                 ....*....|....
gi 654690915 290 QGGFVESFRTDQQG 303
Cdd:cd05819  215 GNNRVQVFDPDGAG 228
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 53-244 9.95e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 49.21  E-value: 9.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  53 DLDGNlFVVNFGKPGTI-GKL--PAGGAASEQ---------------FTA-------LPAGSVGNAIR-----FARDGTM 102
Cdd:cd14963   36 DYEGK-FKKSFGGPGTGpGEFkyPYGIAVDSDgniyvadlyngriqvFDPdgkflkyFPEKKDRVKLIspaglAIDDGKL 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 103 FIADYKKHNI----------FAIAKGTREPvvwfhsDEMNQPNDITVARDGTIYASDPNwKGR-------EGHIWRIAKS 165
Cdd:cd14963  115 YVSDVKKHKVivfdlegkllLEFGKPGSEP------GELSYPNGIAVDEDGNIYVADSG-NGRiqvfdknGKFIKELNGS 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 166 ADGTvqgQVMSAPRamgttnGIDLSPDGKtLYVGESSSG----------EIWSYTVRGNELTGAKLvkafqPdtvDGLRT 235
Cdd:cd14963  188 PDGK---SGFVNPR------GIAVDPDGN-LYVVDNLSHrvyvfdeqgkELFTFGGRGKDDGQFNL-----P---NGLFI 249


                 ....*....
gi 654690915 236 DVAGRLYVA 244
Cdd:cd14963  250 DDDGRLYVT 258
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
44-244 1.42e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.54  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  44 TFGIEGPAADLDGNLFVVNFGKPGTIGKLPAGGAASEQFTALPAGSVGNAIRFARDGTMFIADYKKHNIFAIAKGTREPV 123
Cdd:COG3391   24 AVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 124 VWFHSDEmnQPNDITVARDG-TIYASDpnwkGREGHIWRIAkSADGTVQGQVmsaprAMG-TTNGIDLSPDGKTLYVGES 201
Cdd:COG3391  104 ATIPVGG--GPRGLAVDPDGgRLYVAD----SGNGRVSVID-TATGKVVATI-----PVGaGPHGIAVDPDGKRLYVANS 171

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 654690915 202 SSGEIWSYTVRGNELTGAKLVKAFQPDTVDGLRTDVAGR-LYVA 244
Cdd:COG3391  172 GSNTVSVIVSVIDTATGKVVATIPVGGGPVGVAVSPDGRrLYVA 215
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
136-294 6.72e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 46.61  E-value: 6.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 136 DITVARDGTIYASDPNWKGREGHIWRIAKSADGTVQGQVMSAPRAMGTTNGIDLSPDGKTLYVGESSSGEIWSYTVRGNE 215
Cdd:COG3391   22 AVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGK 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 216 LTGAKLVkafqPDTVDGLRTDVAG-RLYVARILKGTIALM-KPNGAVEREIALkGKEPTNLAFGGsDGKTVFVTQRQGGF 293
Cdd:COG3391  102 VVATIPV----GGGPRGLAVDPDGgRLYVADSGNGRVSVIdTATGKVVATIPV-GAGPHGIAVDP-DGKRLYVANSGSNT 175


                 .
gi 654690915 294 V 294
Cdd:COG3391  176 V 176
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 129-276 1.99e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 45.36  E-value: 1.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 129 DEMNQPNDITVArDGTIYASDP-NWK----GREG-HIWRIAKSadGTVQGQvMSAPramgttNGIDLSPDGKtLYVGESS 202
Cdd:cd14963    7 DPLNKPMGVAVS-DGRIYVADTnNHRvqvfDYEGkFKKSFGGP--GTGPGE-FKYP------YGIAVDSDGN-IYVADLY 75

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 654690915 203 SGEIWSYTVRGNEL----TGAKLVKAFQPDtvdGLRTDvAGRLYVARILKGTIALMKPNGAVEREIALKGKEPTNLAF 276
Cdd:cd14963   76 NGRIQVFDPDGKFLkyfpEKKDRVKLISPA---GLAID-DGKLYVSDVKKHKVIVFDLEGKLLLEFGKPGSEPGELSY 149
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 48-151 1.05e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 42.97  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  48 EGPAADLDGNLFVVNFGKpGTIGKLPAGGAAseqFTALPAGSVGNAIRFARD--GTMFIADYKKHNIFAIAKGTREPVVW 125
Cdd:cd14952   97 TGVAVDAAGNVYVADTGN-NRVLKLAAGSNT---QTVLPFTGLSNPDGVAVDgaGNVYVTDTGNNRVLKLAAGSTTQTVL 172

                         90       100
                 ....*....|....*....|....*..
gi 654690915 126 -FHsdEMNQPNDITVARDGTIYASDPN 151
Cdd:cd14952  173 pFT--GLNSPSGVAVDTAGNVYVTDHG 197
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
35-204 1.19e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.76  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  35 VQVTPPGEYTFGIEGPAADLDGNLFVVNFGkPGTIGKLPAggAASEQFTALPAGSVGNAIRFARDG-TMFIADYKKHNIF 113
Cdd:COG3391   59 GLGLGAAAVADADGADAGADGRRLYVANSG-SGRVSVIDL--ATGKVVATIPVGGGPRGLAVDPDGgRLYVADSGNGRVS 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 114 AIAKGTREPVVWFHSDemNQPNDITVARDG-TIYASDpnwkGREGHIWRIAKSADgTVQGQVMSAPRAMGTTNGIDLSPD 192
Cdd:COG3391  136 VIDTATGKVVATIPVG--AGPHGIAVDPDGkRLYVAN----SGSNTVSVIVSVID-TATGKVVATIPVGGGPVGVAVSPD 208

                        170
                 ....*....|..
gi 654690915 193 GKTLYVGESSSG 204
Cdd:COG3391  209 GRRLYVANRGSN 220
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 38-271 1.52e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 42.65  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  38 TPPGEYTfGIEGPAADLDGNLFVVN--------FGKPGT-IGKLPAGGAASEQFTALpagsvgNAIRFARDGTMFIADYK 108
Cdd:cd14956    7 SGPGQFK-DPRGIAVDADDNVYVADarngriqvFDKDGTfLRRFGTTGDGPGQFGRP------RGLAVDKDGWLYVADYW 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 109 KHNIFAIAKGTREPVVWFHS----DEMNQPNDITVARDGTIYASD-PNwkgreghiWRIAK-SADGTVQGQVMSAPRAMG 182
Cdd:cd14956   80 GDRIQVFTLTGELQTIGGSSgsgpGQFNAPRGVAVDADGNLYVADfGN--------QRIQKfDPDGSFLRQWGGTGIEPG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 183 TTN---GIDLSPDGkTLYVGESSSGEIWSYTVRGNELT--GAKLVKAFQPDTVDGLRTDVAGRLYVARILKGTIALMKPN 257
Cdd:cd14956  152 SFNyprGVAVDPDG-TLYVADTYNDRIQVFDNDGAFLRkwGGRGTGPGQFNYPYGIAIDPDGNVFVADFGNNRIQKFTAD 230

                        250
                 ....*....|....
gi 654690915 258 GAVEREIALKGKEP 271
Cdd:cd14956  231 GTFLTSWGSPGTGP 244
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 49-149 2.45e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.81  E-value: 2.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  49 GPAADLDGNLFVVNFGkPGTIGKLPAGgaASEQfTALP--AGSVGNAIRFARDGTMFIADYKKHNIFAIAKGTREPVVwF 126
Cdd:cd14952  140 GVAVDGAGNVYVTDTG-NNRVLKLAAG--STTQ-TVLPftGLNSPSGVAVDTAGNVYVTDHGNNRVLKLAAGSTTPTV-L 214

                         90       100
                 ....*....|....*....|...
gi 654690915 127 HSDEMNQPNDITVARDGTIYASD 149
Cdd:cd14952  215 PFTGLNGPLGVAVDAAGNVYVAD 237
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 131-287 1.68e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 39.49  E-value: 1.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 131 MNQPNDITVARDGTIYASDP--------NWKGREGHIWRIAKsadgtvqGQVMSAPRamgttnGIDLSPDGkTLYVGESS 202
Cdd:cd14962   11 LTRPYGVAADGRGRIYVADTgrgavfvfDLPNGKVFVIGNAG-------PNRFVSPI------GVAIDANG-NLYVSDAE 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 203 SGEIWSYTVRGNELtgAKLVKAFQPDTVDGLRTDVAG-RLYVARILKGTIALMKPNGAVEREIALKGKE------PTNLA 275
Cdd:cd14962   77 LGKVFVFDRDGKFL--RAIGAGALFKRPTGIAVDPAGkRLYVVDTLAHKVKVFDLDGRLLFDIGKRGSGpgefnlPTDLA 154

                        170
                 ....*....|..
gi 654690915 276 FGGSDgkTVFVT 287
Cdd:cd14962  155 VDRDG--NLYVT 164
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 49-248 5.09e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 37.96  E-value: 5.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  49 GPAADLDGNLFVVNFGkPGTIGKLPAGgaaSEQFTALPAGSVGN--AIRFARDGTMFIADYKKHNIFAIAKGTREPVVWF 126
Cdd:cd14952   56 GVAVDAAGTVYVTDFG-NNRVLKLAAG---STTQTVLPFTGLNDptGVAVDAAGNVYVADTGNNRVLKLAAGSNTQTVLP 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 127 HSDeMNQPNDITVARDGTIYASDPnwkGREghiwRIAKSADGTvqgqvmSAPRAMGTT-----NGIDLSPDGkTLYVGES 201
Cdd:cd14952  132 FTG-LSNPDGVAVDGAGNVYVTDT---GNN----RVLKLAAGS------TTQTVLPFTglnspSGVAVDTAG-NVYVTDH 196

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 654690915 202 SSGEIWSYTVRGNELTGAKLVKAFQPdtvDGLRTDVAGRLYVA-----RILK 248
Cdd:cd14952  197 GNNRVLKLAAGSTTPTVLPFTGLNGP---LGVAVDAAGNVYVAdrgndRVVK 245
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
26-302 7.16e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 37.58  E-value: 7.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  26 HAETKLFESVQVTPpgeytfGIEGP---AADLDGN-LFVVNFGKPGTI---GKLPAGGAASEQFTALPAGSVGNAIRFAR 98
Cdd:COG2706   29 DTATGELTLLGLVA------ALGNPsflALSPDGRfLYAVNEVDDGGVsafRIDPADGTLTLLNTVSSGGASPCHLSVDP 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915  99 DG-TMFIADYKKHNI--FAIAK-GTREPVVWFHSDEMNQPND----------ITVARDG-TIYASDpnwKGR-EGHIWRI 162
Cdd:COG2706  103 DGrFLFVANYGGGSVsvFPIDAdGSLGEPVQVIQHEGSGPNPerqegphahsVVFDPDGrFLYVPD---LGTdRIYVYRL 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 163 AkSADGTVQGQVM------SAPRamgttnGIDLSPDGKTLYVGESSSGEIWSYTVrgNELTGAklVKAFQ-----PDTVD 231
Cdd:COG2706  180 D-PATGKLPEPPEvslppgSGPR------HLAFHPNGRFAYVINELDSTVSVYAY--DAATGT--LTLIQtvstlPEDFT 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 654690915 232 G------LRTDVAGR-LYVARILKGTIALMK---PNGAVER--EIALKGKEPTNLAFgGSDGKTVFVTQRQGGFVESFRT 299
Cdd:COG2706  249 GenwaadIHISPDGRfLYVSNRGHNSIAVFAidaDGGKLTLvgHVPTGGKWPRDFAI-DPDGRFLLVANQKSDNITVFRI 327


                 ...
gi 654690915 300 DQQ 302
Cdd:COG2706  328 DAD 330
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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