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Conserved domains on  [gi|487943518|ref|WP_002016984|]
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MULTISPECIES: M60 family metallopeptidase [Bacillus cereus group]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_M60 super family cl24257
Peptidase M60, enhancin and enhancin-like; This family of peptidases contains a zinc ...
 169-427 6.02e-56

Peptidase M60, enhancin and enhancin-like; This family of peptidases contains a zinc metallopeptidase motif (HEXXHX(8,28)E) and possesses mucinase activity. It includes the viral enhancins as well as enhancin-like peptidases from bacterial species. Enhancins are a class of metalloproteases found in some baculoviruses that enhance viral infection by degrading the peritrophic membrane (PM) of the insect midgut. Bacterial enhancins are found to be cytotoxic when compared to viral enhancin, however, suggesting that the bacterial enhancins do not enhance infection in the same way as viral enhancin. Bacterial enhancins may have evolved a distinct biochemical function. These bacterial domains are peptidases targetting host glycoproteins and thus probably play an important role in successful colonization of both vertebrate mucosal surfaces and the invertebrate digestive tract by both mutualistic and pathogenic microbes. This family has been augmented by a merge with the sequences in the Enhancin Pfam family.


The actual alignment was detected with superfamily member pfam13402:

Pssm-ID: 433178 [Multi-domain]  Cd Length: 268  Bit Score: 192.21  E-value: 6.02e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518  169 PFFELGKHTKQDLINMLDQYPnAHAVELKGERVLITASPARVKKYllgSNTDPVQLLKKMDEATRIQDKVAGLSEEQVD- 247
Cdd:pfam13402   6 PYFVYGKTTDEEWEEMLRNYP-APWAELDGGRVILTVPSEFLRQL---DRLNPQALWRLWDRVMYSVNEVAGLPRRSDGr 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518  248 -KHYIHYVEENHSPDYYMYATSYRTAYVGDAIQYVLDINKFIKDG-WGPWHEAGHLRQQSP-WKFY-NMTEVQNNIYSLS 323
Cdd:pfam13402  82 vTRPVRFVFDRQISAGFMHAGYPIMAFPPGSASELVNYDSARKSGcWGPLHELGHNFQQRWgWTWPgHTGEVTNNILSLY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518  324 VEKAFTSNQSFR-------------LQQEGAYTKAFQYLEQPNKnydevsdvfvKLVMLWQLQLAYGEDFYPKLHQLYRD 390
Cdd:pfam13402 162 VQELLTGIDSTRqinfngrarwgpaLGGWARDKHAKEYLNKGKD----------LLVFYGQLLYYFGWDFYRKLFRAYRT 231

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 487943518  391 MSSSELPQTDENKKQLFMISASKVAKQNLIPFFEKWG 427
Cdd:pfam13402 232 QPYLPRNNSDGDKMSEFMLTFSKVAKRDLRPFFKAWG 268
Mucin_bdg super family cl24152
Putative mucin or carbohydrate-binding module; This family is the putative binding domain for ...
 478-592 2.47e-21

Putative mucin or carbohydrate-binding module; This family is the putative binding domain for the substrates of enhancin, and other similar metallopeptidases. This is not the enzymically active, peptidase, part of the proteins - see pfam13402.


The actual alignment was detected with superfamily member pfam03272:

Pssm-ID: 460871  Cd Length: 116  Bit Score: 89.70  E-value: 2.47e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518  478 SLKGISDFEFAKINFNKSTEEMQIDLKAGIPHHYF-NEMYASIKVQNASGKVVYNKDIYGNKQQNAESQKVPVKVGDYIE 556
Cdd:pfam03272   1 QFLGLSDDQFATVTLDLVKKKLTVTVTNTTPHYYFpNETYASIRVYDADGNEKLNKDIEGTEKTFAGVDEIPFKGGYVLK 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 487943518  557 LTHLEGVHRATFTNVDNSKQESFGKKAMYEVTKEGL 592
Cdd:pfam03272  81 IFHAEPSNRLRINPDQGDVLDPKSKTNSFIITSKGL 116
Mucin_bdg super family cl24152
Putative mucin or carbohydrate-binding module; This family is the putative binding domain for ...
 612-731 1.82e-18

Putative mucin or carbohydrate-binding module; This family is the putative binding domain for the substrates of enhancin, and other similar metallopeptidases. This is not the enzymically active, peptidase, part of the proteins - see pfam13402.


The actual alignment was detected with superfamily member pfam03272:

Pssm-ID: 460871  Cd Length: 116  Bit Score: 81.61  E-value: 1.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518  612 SLKGYSDREIAKVNYNRVTEKMQVNLEAGVPHSYFNN-TYASIKVQNSSGSVVYNKEIVGNRQQTAERQTVPVKVGDYIE 690
Cdd:pfam03272   1 QFLGLSDDQFATVTLDLVKKKLTVTVTNTTPHYYFPNeTYASIRVYDADGNEKLNKDIEGTEKTFAGVDEIPFKGGYVLK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 487943518  691 FTHLEgeavkEKTRATLINLENSKQEYIGKKRTYQVTSTGL 731
Cdd:pfam03272  81 IFHAE-----PSNRLRINPDQGDVLDPKSKTNSFIITSKGL 116
M60-like_N super family cl38578
N-terminal domain of M60-like peptidases; This accessory domain has a jelly roll topology.
 82-149 2.05e-12

N-terminal domain of M60-like peptidases; This accessory domain has a jelly roll topology.


The actual alignment was detected with superfamily member pfam17291:

Pssm-ID: 435844 [Multi-domain]  Cd Length: 106  Bit Score: 63.89  E-value: 2.05e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487943518   82 SPYEPTGLYAKPNEQITINVEGN--QNIQAYIGTYSyDASWREDS------KIKSFTLKPGINTIQSPNGGMVYFY 149
Cdd:pfam17291  17 SDWQSTGLYAPPGELITIEVPDNavGKLVVQIGCHT-DNLGHADElfrppvVTCRFPLDEGVNKISWPYGGLIYII 91
 
Name Accession Description Interval E-value
Peptidase_M60 pfam13402
Peptidase M60, enhancin and enhancin-like; This family of peptidases contains a zinc ...
 169-427 6.02e-56

Peptidase M60, enhancin and enhancin-like; This family of peptidases contains a zinc metallopeptidase motif (HEXXHX(8,28)E) and possesses mucinase activity. It includes the viral enhancins as well as enhancin-like peptidases from bacterial species. Enhancins are a class of metalloproteases found in some baculoviruses that enhance viral infection by degrading the peritrophic membrane (PM) of the insect midgut. Bacterial enhancins are found to be cytotoxic when compared to viral enhancin, however, suggesting that the bacterial enhancins do not enhance infection in the same way as viral enhancin. Bacterial enhancins may have evolved a distinct biochemical function. These bacterial domains are peptidases targetting host glycoproteins and thus probably play an important role in successful colonization of both vertebrate mucosal surfaces and the invertebrate digestive tract by both mutualistic and pathogenic microbes. This family has been augmented by a merge with the sequences in the Enhancin Pfam family.


Pssm-ID: 433178 [Multi-domain]  Cd Length: 268  Bit Score: 192.21  E-value: 6.02e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518  169 PFFELGKHTKQDLINMLDQYPnAHAVELKGERVLITASPARVKKYllgSNTDPVQLLKKMDEATRIQDKVAGLSEEQVD- 247
Cdd:pfam13402   6 PYFVYGKTTDEEWEEMLRNYP-APWAELDGGRVILTVPSEFLRQL---DRLNPQALWRLWDRVMYSVNEVAGLPRRSDGr 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518  248 -KHYIHYVEENHSPDYYMYATSYRTAYVGDAIQYVLDINKFIKDG-WGPWHEAGHLRQQSP-WKFY-NMTEVQNNIYSLS 323
Cdd:pfam13402  82 vTRPVRFVFDRQISAGFMHAGYPIMAFPPGSASELVNYDSARKSGcWGPLHELGHNFQQRWgWTWPgHTGEVTNNILSLY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518  324 VEKAFTSNQSFR-------------LQQEGAYTKAFQYLEQPNKnydevsdvfvKLVMLWQLQLAYGEDFYPKLHQLYRD 390
Cdd:pfam13402 162 VQELLTGIDSTRqinfngrarwgpaLGGWARDKHAKEYLNKGKD----------LLVFYGQLLYYFGWDFYRKLFRAYRT 231

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 487943518  391 MSSSELPQTDENKKQLFMISASKVAKQNLIPFFEKWG 427
Cdd:pfam13402 232 QPYLPRNNSDGDKMSEFMLTFSKVAKRDLRPFFKAWG 268
Mucin_bdg pfam03272
Putative mucin or carbohydrate-binding module; This family is the putative binding domain for ...
 478-592 2.47e-21

Putative mucin or carbohydrate-binding module; This family is the putative binding domain for the substrates of enhancin, and other similar metallopeptidases. This is not the enzymically active, peptidase, part of the proteins - see pfam13402.


Pssm-ID: 460871  Cd Length: 116  Bit Score: 89.70  E-value: 2.47e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518  478 SLKGISDFEFAKINFNKSTEEMQIDLKAGIPHHYF-NEMYASIKVQNASGKVVYNKDIYGNKQQNAESQKVPVKVGDYIE 556
Cdd:pfam03272   1 QFLGLSDDQFATVTLDLVKKKLTVTVTNTTPHYYFpNETYASIRVYDADGNEKLNKDIEGTEKTFAGVDEIPFKGGYVLK 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 487943518  557 LTHLEGVHRATFTNVDNSKQESFGKKAMYEVTKEGL 592
Cdd:pfam03272  81 IFHAEPSNRLRINPDQGDVLDPKSKTNSFIITSKGL 116
Mucin_bdg pfam03272
Putative mucin or carbohydrate-binding module; This family is the putative binding domain for ...
 612-731 1.82e-18

Putative mucin or carbohydrate-binding module; This family is the putative binding domain for the substrates of enhancin, and other similar metallopeptidases. This is not the enzymically active, peptidase, part of the proteins - see pfam13402.


Pssm-ID: 460871  Cd Length: 116  Bit Score: 81.61  E-value: 1.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518  612 SLKGYSDREIAKVNYNRVTEKMQVNLEAGVPHSYFNN-TYASIKVQNSSGSVVYNKEIVGNRQQTAERQTVPVKVGDYIE 690
Cdd:pfam03272   1 QFLGLSDDQFATVTLDLVKKKLTVTVTNTTPHYYFPNeTYASIRVYDADGNEKLNKDIEGTEKTFAGVDEIPFKGGYVLK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 487943518  691 FTHLEgeavkEKTRATLINLENSKQEYIGKKRTYQVTSTGL 731
Cdd:pfam03272  81 IFHAE-----PSNRLRINPDQGDVLDPKSKTNSFIITSKGL 116
M60-like_N pfam17291
N-terminal domain of M60-like peptidases; This accessory domain has a jelly roll topology.
 82-149 2.05e-12

N-terminal domain of M60-like peptidases; This accessory domain has a jelly roll topology.


Pssm-ID: 435844 [Multi-domain]  Cd Length: 106  Bit Score: 63.89  E-value: 2.05e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487943518   82 SPYEPTGLYAKPNEQITINVEGN--QNIQAYIGTYSyDASWREDS------KIKSFTLKPGINTIQSPNGGMVYFY 149
Cdd:pfam17291  17 SDWQSTGLYAPPGELITIEVPDNavGKLVVQIGCHT-DNLGHADElfrppvVTCRFPLDEGVNKISWPYGGLIYII 91
ImpA_fam_HExGH NF038322
ImpA family metalloprotease; Members of this family are metalloproteases related to the ImpA ...
 291-458 1.53e-11

ImpA family metalloprotease; Members of this family are metalloproteases related to the ImpA from Pseudomonas aeruginosa (PA0572 in strain PAO1), a virulence factor that cleaves CD44 on the surface of human macrophages, inhibiting phagocytosis. Members of this family are distinguished by a strong motif, CGxGCSGNPxD, just a few residues upstream of the familiar metalloprotease motif HExxH (typically HELGH here) and completely lacking in more distant homologs of ImpA.


Pssm-ID: 468474 [Multi-domain]  Cd Length: 879  Bit Score: 68.03  E-value: 1.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518 291 GWGPWHEAGHLRQQSPWKFYN--MTEVQNNIYSLSV-------------------EKAFTSNQSFRLQQEG-AYTKAFQY 348
Cdd:NF038322 644 GWGDSHELGHNLQQGRLRIYGgrSGECSNNIFPYYSkwryyaetgndpscqrldhKDLFALLQASRAQADPeAYRADMYQ 723

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518 349 LEQPNKNYDEVSDVFVKLVMLWQLQ-----LAYGEDFYPKLHQLYRDMSSSELPQT--DENKKQL--------------- 406
Cdd:NF038322 724 RLWSDGNNGPRMAFYIQLAMLAQKLglgdtLDNGWHLFTLLYLHERLFGKAAASEAdwDANKAKLgfgsyalaeansisn 803

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 487943518 407 --FM-ISASKVAKQNLIPFFEKWGLRPNNDTIQKVAALGYPILTAEIWKGTDSNP 458
Cdd:NF038322 804 ndFLlVALSKITGRDMRPYFDMWGLPYSDKAAAQVAALGLPAAPLVFYALPPGKG 858
 
Name Accession Description Interval E-value
Peptidase_M60 pfam13402
Peptidase M60, enhancin and enhancin-like; This family of peptidases contains a zinc ...
 169-427 6.02e-56

Peptidase M60, enhancin and enhancin-like; This family of peptidases contains a zinc metallopeptidase motif (HEXXHX(8,28)E) and possesses mucinase activity. It includes the viral enhancins as well as enhancin-like peptidases from bacterial species. Enhancins are a class of metalloproteases found in some baculoviruses that enhance viral infection by degrading the peritrophic membrane (PM) of the insect midgut. Bacterial enhancins are found to be cytotoxic when compared to viral enhancin, however, suggesting that the bacterial enhancins do not enhance infection in the same way as viral enhancin. Bacterial enhancins may have evolved a distinct biochemical function. These bacterial domains are peptidases targetting host glycoproteins and thus probably play an important role in successful colonization of both vertebrate mucosal surfaces and the invertebrate digestive tract by both mutualistic and pathogenic microbes. This family has been augmented by a merge with the sequences in the Enhancin Pfam family.


Pssm-ID: 433178 [Multi-domain]  Cd Length: 268  Bit Score: 192.21  E-value: 6.02e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518  169 PFFELGKHTKQDLINMLDQYPnAHAVELKGERVLITASPARVKKYllgSNTDPVQLLKKMDEATRIQDKVAGLSEEQVD- 247
Cdd:pfam13402   6 PYFVYGKTTDEEWEEMLRNYP-APWAELDGGRVILTVPSEFLRQL---DRLNPQALWRLWDRVMYSVNEVAGLPRRSDGr 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518  248 -KHYIHYVEENHSPDYYMYATSYRTAYVGDAIQYVLDINKFIKDG-WGPWHEAGHLRQQSP-WKFY-NMTEVQNNIYSLS 323
Cdd:pfam13402  82 vTRPVRFVFDRQISAGFMHAGYPIMAFPPGSASELVNYDSARKSGcWGPLHELGHNFQQRWgWTWPgHTGEVTNNILSLY 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518  324 VEKAFTSNQSFR-------------LQQEGAYTKAFQYLEQPNKnydevsdvfvKLVMLWQLQLAYGEDFYPKLHQLYRD 390
Cdd:pfam13402 162 VQELLTGIDSTRqinfngrarwgpaLGGWARDKHAKEYLNKGKD----------LLVFYGQLLYYFGWDFYRKLFRAYRT 231

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 487943518  391 MSSSELPQTDENKKQLFMISASKVAKQNLIPFFEKWG 427
Cdd:pfam13402 232 QPYLPRNNSDGDKMSEFMLTFSKVAKRDLRPFFKAWG 268
Mucin_bdg pfam03272
Putative mucin or carbohydrate-binding module; This family is the putative binding domain for ...
 478-592 2.47e-21

Putative mucin or carbohydrate-binding module; This family is the putative binding domain for the substrates of enhancin, and other similar metallopeptidases. This is not the enzymically active, peptidase, part of the proteins - see pfam13402.


Pssm-ID: 460871  Cd Length: 116  Bit Score: 89.70  E-value: 2.47e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518  478 SLKGISDFEFAKINFNKSTEEMQIDLKAGIPHHYF-NEMYASIKVQNASGKVVYNKDIYGNKQQNAESQKVPVKVGDYIE 556
Cdd:pfam03272   1 QFLGLSDDQFATVTLDLVKKKLTVTVTNTTPHYYFpNETYASIRVYDADGNEKLNKDIEGTEKTFAGVDEIPFKGGYVLK 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 487943518  557 LTHLEGVHRATFTNVDNSKQESFGKKAMYEVTKEGL 592
Cdd:pfam03272  81 IFHAEPSNRLRINPDQGDVLDPKSKTNSFIITSKGL 116
Mucin_bdg pfam03272
Putative mucin or carbohydrate-binding module; This family is the putative binding domain for ...
 612-731 1.82e-18

Putative mucin or carbohydrate-binding module; This family is the putative binding domain for the substrates of enhancin, and other similar metallopeptidases. This is not the enzymically active, peptidase, part of the proteins - see pfam13402.


Pssm-ID: 460871  Cd Length: 116  Bit Score: 81.61  E-value: 1.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518  612 SLKGYSDREIAKVNYNRVTEKMQVNLEAGVPHSYFNN-TYASIKVQNSSGSVVYNKEIVGNRQQTAERQTVPVKVGDYIE 690
Cdd:pfam03272   1 QFLGLSDDQFATVTLDLVKKKLTVTVTNTTPHYYFPNeTYASIRVYDADGNEKLNKDIEGTEKTFAGVDEIPFKGGYVLK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 487943518  691 FTHLEgeavkEKTRATLINLENSKQEYIGKKRTYQVTSTGL 731
Cdd:pfam03272  81 IFHAE-----PSNRLRINPDQGDVLDPKSKTNSFIITSKGL 116
M60-like_N pfam17291
N-terminal domain of M60-like peptidases; This accessory domain has a jelly roll topology.
 82-149 2.05e-12

N-terminal domain of M60-like peptidases; This accessory domain has a jelly roll topology.


Pssm-ID: 435844 [Multi-domain]  Cd Length: 106  Bit Score: 63.89  E-value: 2.05e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 487943518   82 SPYEPTGLYAKPNEQITINVEGN--QNIQAYIGTYSyDASWREDS------KIKSFTLKPGINTIQSPNGGMVYFY 149
Cdd:pfam17291  17 SDWQSTGLYAPPGELITIEVPDNavGKLVVQIGCHT-DNLGHADElfrppvVTCRFPLDEGVNKISWPYGGLIYII 91
ImpA_fam_HExGH NF038322
ImpA family metalloprotease; Members of this family are metalloproteases related to the ImpA ...
 291-458 1.53e-11

ImpA family metalloprotease; Members of this family are metalloproteases related to the ImpA from Pseudomonas aeruginosa (PA0572 in strain PAO1), a virulence factor that cleaves CD44 on the surface of human macrophages, inhibiting phagocytosis. Members of this family are distinguished by a strong motif, CGxGCSGNPxD, just a few residues upstream of the familiar metalloprotease motif HExxH (typically HELGH here) and completely lacking in more distant homologs of ImpA.


Pssm-ID: 468474 [Multi-domain]  Cd Length: 879  Bit Score: 68.03  E-value: 1.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518 291 GWGPWHEAGHLRQQSPWKFYN--MTEVQNNIYSLSV-------------------EKAFTSNQSFRLQQEG-AYTKAFQY 348
Cdd:NF038322 644 GWGDSHELGHNLQQGRLRIYGgrSGECSNNIFPYYSkwryyaetgndpscqrldhKDLFALLQASRAQADPeAYRADMYQ 723

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 487943518 349 LEQPNKNYDEVSDVFVKLVMLWQLQ-----LAYGEDFYPKLHQLYRDMSSSELPQT--DENKKQL--------------- 406
Cdd:NF038322 724 RLWSDGNNGPRMAFYIQLAMLAQKLglgdtLDNGWHLFTLLYLHERLFGKAAASEAdwDANKAKLgfgsyalaeansisn 803

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 487943518 407 --FM-ISASKVAKQNLIPFFEKWGLRPNNDTIQKVAALGYPILTAEIWKGTDSNP 458
Cdd:NF038322 804 ndFLlVALSKITGRDMRPYFDMWGLPYSDKAAAQVAALGLPAAPLVFYALPPGKG 858
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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