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Conserved domains on  [gi|447017364|ref|WP_001094620|]
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MULTISPECIES: tryptophan--tRNA ligase [Salmonella]

Protein Classification

tryptophan--tRNA ligase( domain architecture ID 11485732)

tryptophan--tRNA ligase is a class I tRNA synthetase and aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12282 PRK12282
tryptophanyl-tRNA synthetase II; Reviewed
 3-332 0e+00

tryptophanyl-tRNA synthetase II; Reviewed


:

Pssm-ID: 183400 [Multi-domain]  Cd Length: 333  Bit Score: 653.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   3 TLPIILTGDRPTGSLHLGHYVGSLRQRVALQQDHQQYVLIADLQGLTDNGSNPQKIRDNIPQVLADYLAVGIDPTLTTIC 82
Cdd:PRK12282   1 TKPIILTGDRPTGKLHLGHYVGSLKNRVALQNEHEQFVLIADQQALTDNAKNPEKIRRNILEVALDYLAVGIDPAKSTIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  83 LQSALPALAELTVLYMNIVTVARVERNPTVKNEIAQKGFTRSLPVGFMAYPISQAADITAFKAEMVPVGDDQLPMIEQTN 162
Cdd:PRK12282  81 IQSQIPELAELTMYYMNLVTVARLERNPTVKTEIAQKGFGRSIPAGFLTYPVSQAADITAFKATLVPVGDDQLPMIEQTR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 163 EIVHKMNSLFSSPVLRPCQALLSDMGRLPGIDGSAKMSKSLGNTLLLSASEETIHRAVSAMYTDPNHLKISDPGKIEGNV 242
Cdd:PRK12282 161 EIVRRFNSLYGTDVLVEPEALLPEAGRLPGLDGKAKMSKSLGNAIYLSDDADTIKKKVMSMYTDPNHIRVEDPGKVEGNV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 243 VFTWLDAFHPDKAKVAAMKAHYQQGGLGDRVCKNELETCLQELIAPIRERRATFIADKGMLMELLKKGSERAHEVTQKTL 322
Cdd:PRK12282 241 VFTYLDAFDPDKAEVAELKAHYQRGGLGDVKCKRYLEEVLQELLAPIRERRAEFAKDPGYVLEILKAGSEKAREVAAQTL 320

                        330
                 ....*....|
gi 447017364 323 QEVKRGLGLP 332
Cdd:PRK12282 321 SEVKDAMGLN 330
 
Name Accession Description Interval E-value
PRK12282 PRK12282
tryptophanyl-tRNA synthetase II; Reviewed
 3-332 0e+00

tryptophanyl-tRNA synthetase II; Reviewed


Pssm-ID: 183400 [Multi-domain]  Cd Length: 333  Bit Score: 653.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   3 TLPIILTGDRPTGSLHLGHYVGSLRQRVALQQDHQQYVLIADLQGLTDNGSNPQKIRDNIPQVLADYLAVGIDPTLTTIC 82
Cdd:PRK12282   1 TKPIILTGDRPTGKLHLGHYVGSLKNRVALQNEHEQFVLIADQQALTDNAKNPEKIRRNILEVALDYLAVGIDPAKSTIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  83 LQSALPALAELTVLYMNIVTVARVERNPTVKNEIAQKGFTRSLPVGFMAYPISQAADITAFKAEMVPVGDDQLPMIEQTN 162
Cdd:PRK12282  81 IQSQIPELAELTMYYMNLVTVARLERNPTVKTEIAQKGFGRSIPAGFLTYPVSQAADITAFKATLVPVGDDQLPMIEQTR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 163 EIVHKMNSLFSSPVLRPCQALLSDMGRLPGIDGSAKMSKSLGNTLLLSASEETIHRAVSAMYTDPNHLKISDPGKIEGNV 242
Cdd:PRK12282 161 EIVRRFNSLYGTDVLVEPEALLPEAGRLPGLDGKAKMSKSLGNAIYLSDDADTIKKKVMSMYTDPNHIRVEDPGKVEGNV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 243 VFTWLDAFHPDKAKVAAMKAHYQQGGLGDRVCKNELETCLQELIAPIRERRATFIADKGMLMELLKKGSERAHEVTQKTL 322
Cdd:PRK12282 241 VFTYLDAFDPDKAEVAELKAHYQRGGLGDVKCKRYLEEVLQELLAPIRERRAEFAKDPGYVLEILKAGSEKAREVAAQTL 320

                        330
                 ....*....|
gi 447017364 323 QEVKRGLGLP 332
Cdd:PRK12282 321 SEVKDAMGLN 330
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 5-331 4.88e-158

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 445.26  E-value: 4.88e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   5 PIILTGDRPTGSLHLGHYVGSLRQRVALQQDHQQYVLIADLQGLTDNgSNPQKIRDNIPQVLADYLAVGIDPTLTTICLQ 84
Cdd:COG0180    4 KRVLSGIQPTGRLHLGNYLGALKNWVELQDEYECFFFIADLHALTTP-QDPEELRENTREVAADYLAAGLDPEKSTIFVQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  85 SALPALAELTVLYMNIVTVARVERNPTVKNEIAQKGfTRSLPVGFMAYPISQAADITAFKAEMVPVGDDQLPMIEQTNEI 164
Cdd:COG0180   83 SDVPEHAELAWLLSCLTPLGELERMPQFKDKSAKNG-KENVNAGLLTYPVLMAADILLYKADLVPVGEDQKQHLELTRDI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 165 VHKMNSLFSsPVLRPCQALLSDMG-RLPGIDGSAKMSKSLGNTLLLSASEETIHRAVSAMYTDPNHLKISDPGKIEGNVV 243
Cdd:COG0180  162 ARRFNHRYG-EVFPEPEALIPEEGaRIPGLDGRKKMSKSYGNTINLLDDPKEIRKKIKSAVTDSERLRYDDPGKPEVCNL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 244 FTWLDAFHpDKAKVAAMKAHYQQGGLGDRVCKNELETCLQELIAPIRERRATFIADKGMLMELLKKGSERAHEVTQKTLQ 323
Cdd:COG0180  241 FTIYSAFS-GKEEVEELEAEYRAGGIGYGDLKKALAEAVVEFLAPIRERRAELLADPAELDEILAEGAEKARAIAAKTLA 319


                 ....*...
gi 447017364 324 EVKRGLGL 331
Cdd:COG0180  320 EVREAMGL 327
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 6-285 2.31e-108

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 317.22  E-value: 2.31e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   6 IILTGDRPTGSLHLGHYVGSLRQRVALQQ-DHQQYVLIADLQGLTDNGSNPQKIRDNIPQVLADYLAVGIDPTLTTICLQ 84
Cdd:cd00806    1 RVLSGIQPSGSLHLGHYLGAFRFWVWLQEaGYELFFFIADLHALTVKQLDPEELRQNTRENAKDYLACGLDPEKSTIFFQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  85 SALPALAELTVLYMNIVTVARVERNPTVKNEIAQkgfTRSLPVGFMAYPISQAADITAFKAEMVPVGDDQLPMIEQTNEI 164
Cdd:cd00806   81 SDVPEHYELAWLLSCVVTFGELERMTGFKDKSAQ---GESVNIGLLTYPVLQAADILLYKACLVPVGIDQDPHLELTRDI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 165 VHKMNSLFsSPVLRPCQALLSDMGRLPGI-DGSAKMSKSLG-NTLLLSASEETIHRAVSAMYTDPNH--LKISDPGKIEG 240
Cdd:cd00806  158 ARRFNKLY-GEIFPKPAALLSKGAFLPGLqGPSKKMSKSDPnNAIFLTDSPKEIKKKIMKAATDGGRteHRRDGGGPGVS 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 447017364 241 NVVFTWLDAFHPDKAKVAAMKaHYQQGGLGDRVCKNELETCLQEL 285
Cdd:cd00806  237 NLVEIYSAFFNDDDEELEEID-EYRSGGLGYGECKKLLAEAIQEF 280
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 5-331 1.25e-75

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 235.69  E-value: 1.25e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364    5 PIILTGDRPTGSLHLGHYVGSLRQRVALQQDHQQYVLIADLQGLTDNGSNPQKIRDNIPQVLADYLAVGIDPTLTTICLQ 84
Cdd:TIGR00233   3 FRVLTGIQPSGKMHLGHYLGAIQTKWLQQFGVELFICIADLHAITVKQTDPDALRKAREELAADYLAVGLDPEKTFIFLQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   85 SALPALAELTVLYMNIVTVARVERNPTVKNeiaqKGFTRSLPVGFMAYPISQAADITAFKAEMVPVGDDQLPMIEQTNEI 164
Cdd:TIGR00233  83 SDYPEHYELAWLLSCQVTFGELKRMTQFKD----KSQAENVPIGLLSYPVLQAADILLYQADLVPVGIDQDQHLELTRDL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  165 VHKMNSLFSSPVLRPcQALLS-DMGRLPGIDGSaKMSKSLGNT-LLLSASEETIHRAVSAMYTDPNHLKISDPGKIEGN- 241
Cdd:TIGR00233 159 AERFNKKFKNFFPKP-ESLISkFFPRLMGLSGK-KMSKSDPNSaIFLTDTPKQIKKKIRKAATDGGRVTLFEHREKPGVp 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  242 ---VVFTWLDAFHPDKAKVAAMKAHYQQGGLGDRVCKNELETCLQELIAPIRERRATFIADkgMLMELLKKGSERAHEVT 318
Cdd:TIGR00233 237 nllVIYQYLSFFLIDDDKLKEIYEAYKSGKLGYGECKKALIEVLQEFLKEIQERRAEIAEE--ILDKILEPGAKKARETA 314

                         330
                  ....*....|...
gi 447017364  319 QKTLQEVKRGLGL 331
Cdd:TIGR00233 315 NKTLADVYKAMGL 327
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
5-279 5.49e-44

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 152.82  E-value: 5.49e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364    5 PIILTGDRPTGSLHLGHyVGSLRQRVALQQD-HQQYVLIADLQGLTDN--GSNPQKIRDNIPQVLAD---YLAVGIDPTL 78
Cdd:pfam00579   6 LRVYSGIDPTGPLHLGY-LVPLMKLRQFQQAgHEVFFLIGDLHAIIGDpsKSPERKLLSRETVLENAikaQLACGLDPEK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   79 TTICLQSALPALAELTVLYMNIVTVARVERNPTVKNEIAQKGFTRSLPVGFMAYPISQAADITAFKAEMVPVGDDQLPMI 158
Cdd:pfam00579  85 AEIVNNSDWLEHLELAWLLRDLGKHFSLNRMLQFKDVKKRLEQGPGISLGEFTYPLLQAYDILLLKADLQPGGSDQWGNI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  159 EQTNEIVHKMNSLFsspvLRPCQALLSDMgrLPGIDGSAKMSKSLGNT-LLLSASEETIHRAVSAMYTDPNHLKISD-PG 236
Cdd:pfam00579 165 ELGRDLARRFNKKI----FKKPVGLTNPL--LTGLDGGKKMSKSAGNSaIFLDDDPESVYKKIQKAYTDPDREVRKDlKL 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 447017364  237 KIEG-NVVFTWLDAFHPDKAKVAA--MKAHYQQGGLGDRVCKNELE 279
Cdd:pfam00579 239 FTFLsNEEIEILEAELGKSPYREAeeLLAREVTGLVHGGDLKKAAA 284
 
Name Accession Description Interval E-value
PRK12282 PRK12282
tryptophanyl-tRNA synthetase II; Reviewed
 3-332 0e+00

tryptophanyl-tRNA synthetase II; Reviewed


Pssm-ID: 183400 [Multi-domain]  Cd Length: 333  Bit Score: 653.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   3 TLPIILTGDRPTGSLHLGHYVGSLRQRVALQQDHQQYVLIADLQGLTDNGSNPQKIRDNIPQVLADYLAVGIDPTLTTIC 82
Cdd:PRK12282   1 TKPIILTGDRPTGKLHLGHYVGSLKNRVALQNEHEQFVLIADQQALTDNAKNPEKIRRNILEVALDYLAVGIDPAKSTIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  83 LQSALPALAELTVLYMNIVTVARVERNPTVKNEIAQKGFTRSLPVGFMAYPISQAADITAFKAEMVPVGDDQLPMIEQTN 162
Cdd:PRK12282  81 IQSQIPELAELTMYYMNLVTVARLERNPTVKTEIAQKGFGRSIPAGFLTYPVSQAADITAFKATLVPVGDDQLPMIEQTR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 163 EIVHKMNSLFSSPVLRPCQALLSDMGRLPGIDGSAKMSKSLGNTLLLSASEETIHRAVSAMYTDPNHLKISDPGKIEGNV 242
Cdd:PRK12282 161 EIVRRFNSLYGTDVLVEPEALLPEAGRLPGLDGKAKMSKSLGNAIYLSDDADTIKKKVMSMYTDPNHIRVEDPGKVEGNV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 243 VFTWLDAFHPDKAKVAAMKAHYQQGGLGDRVCKNELETCLQELIAPIRERRATFIADKGMLMELLKKGSERAHEVTQKTL 322
Cdd:PRK12282 241 VFTYLDAFDPDKAEVAELKAHYQRGGLGDVKCKRYLEEVLQELLAPIRERRAEFAKDPGYVLEILKAGSEKAREVAAQTL 320

                        330
                 ....*....|
gi 447017364 323 QEVKRGLGLP 332
Cdd:PRK12282 321 SEVKDAMGLN 330
TrpS COG0180
Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; ...
 5-331 4.88e-158

Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Tryptophanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439950 [Multi-domain]  Cd Length: 330  Bit Score: 445.26  E-value: 4.88e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   5 PIILTGDRPTGSLHLGHYVGSLRQRVALQQDHQQYVLIADLQGLTDNgSNPQKIRDNIPQVLADYLAVGIDPTLTTICLQ 84
Cdd:COG0180    4 KRVLSGIQPTGRLHLGNYLGALKNWVELQDEYECFFFIADLHALTTP-QDPEELRENTREVAADYLAAGLDPEKSTIFVQ 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  85 SALPALAELTVLYMNIVTVARVERNPTVKNEIAQKGfTRSLPVGFMAYPISQAADITAFKAEMVPVGDDQLPMIEQTNEI 164
Cdd:COG0180   83 SDVPEHAELAWLLSCLTPLGELERMPQFKDKSAKNG-KENVNAGLLTYPVLMAADILLYKADLVPVGEDQKQHLELTRDI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 165 VHKMNSLFSsPVLRPCQALLSDMG-RLPGIDGSAKMSKSLGNTLLLSASEETIHRAVSAMYTDPNHLKISDPGKIEGNVV 243
Cdd:COG0180  162 ARRFNHRYG-EVFPEPEALIPEEGaRIPGLDGRKKMSKSYGNTINLLDDPKEIRKKIKSAVTDSERLRYDDPGKPEVCNL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 244 FTWLDAFHpDKAKVAAMKAHYQQGGLGDRVCKNELETCLQELIAPIRERRATFIADKGMLMELLKKGSERAHEVTQKTLQ 323
Cdd:COG0180  241 FTIYSAFS-GKEEVEELEAEYRAGGIGYGDLKKALAEAVVEFLAPIRERRAELLADPAELDEILAEGAEKARAIAAKTLA 319


                 ....*...
gi 447017364 324 EVKRGLGL 331
Cdd:COG0180  320 EVREAMGL 327
TrpRS_core cd00806
catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) ...
 6-285 2.31e-108

catalytic core domain of tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. TrpRS is a homodimer which attaches Tyr to the appropriate tRNA. TrpRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding


Pssm-ID: 173903 [Multi-domain]  Cd Length: 280  Bit Score: 317.22  E-value: 2.31e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   6 IILTGDRPTGSLHLGHYVGSLRQRVALQQ-DHQQYVLIADLQGLTDNGSNPQKIRDNIPQVLADYLAVGIDPTLTTICLQ 84
Cdd:cd00806    1 RVLSGIQPSGSLHLGHYLGAFRFWVWLQEaGYELFFFIADLHALTVKQLDPEELRQNTRENAKDYLACGLDPEKSTIFFQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  85 SALPALAELTVLYMNIVTVARVERNPTVKNEIAQkgfTRSLPVGFMAYPISQAADITAFKAEMVPVGDDQLPMIEQTNEI 164
Cdd:cd00806   81 SDVPEHYELAWLLSCVVTFGELERMTGFKDKSAQ---GESVNIGLLTYPVLQAADILLYKACLVPVGIDQDPHLELTRDI 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 165 VHKMNSLFsSPVLRPCQALLSDMGRLPGI-DGSAKMSKSLG-NTLLLSASEETIHRAVSAMYTDPNH--LKISDPGKIEG 240
Cdd:cd00806  158 ARRFNKLY-GEIFPKPAALLSKGAFLPGLqGPSKKMSKSDPnNAIFLTDSPKEIKKKIMKAATDGGRteHRRDGGGPGVS 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 447017364 241 NVVFTWLDAFHPDKAKVAAMKaHYQQGGLGDRVCKNELETCLQEL 285
Cdd:cd00806  237 NLVEIYSAFFNDDDEELEEID-EYRSGGLGYGECKKLLAEAIQEF 280
PRK00927 PRK00927
tryptophanyl-tRNA synthetase; Reviewed
 5-331 8.06e-104

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 234866 [Multi-domain]  Cd Length: 333  Bit Score: 307.79  E-value: 8.06e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   5 PIILTGDRPTGSLHLGHYVGSLRQRVALQQDHQQYVLIADLQGLTdNGSNPQKIRDNIPQVLADYLAVGIDPTLTTICLQ 84
Cdd:PRK00927   2 KRVLSGIQPTGKLHLGNYLGAIKNWVELQDEYECFFCIADLHALT-VPQDPEELRENTRELAADYLACGIDPEKSTIFVQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  85 SALPALAELTVLYMNIVTVARVERNPTVKNEIAQKGFtrSLPVGFMAYPISQAADITAFKAEMVPVGDDQLPMIEQTNEI 164
Cdd:PRK00927  81 SHVPEHAELAWILNCITPLGELERMTQFKDKSAKQKE--NVSAGLFTYPVLMAADILLYKADLVPVGEDQKQHLELTRDI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 165 VHKMNSLFSsPVLRPCQALLSDMG-RLPGIDG-SAKMSKSLG---NTLLLSASEETIHRAVSAMYTDPNHLKISDPG--- 236
Cdd:PRK00927 159 ARRFNNLYG-EVFPVPEPLIPKVGaRVMGLDGpTKKMSKSDPndnNTINLLDDPKTIAKKIKKAVTDSERLREIRYDlpn 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 237 KIEGNVVFTWLDAFHPDKakVAAMKAHYQQGGLGDRVCKNELETCLQELIAPIRERRATFIADKGMLMELLKKGSERAHE 316
Cdd:PRK00927 238 KPEVSNLLTIYSALSGES--IEELEAEYEAGGKGYGDFKKDLAEAVVEFLAPIRERYEELLADPAYLDEILAEGAEKARA 315

                        330
                 ....*....|....*
gi 447017364 317 VTQKTLQEVKRGLGL 331
Cdd:PRK00927 316 VASKTLKEVREAMGL 330
trpS TIGR00233
tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members ...
 5-331 1.25e-75

tryptophanyl-tRNA synthetase; This model represents tryptophanyl-tRNA synthetase. Some members of the family have a pfam00458 domain amino-terminal to the region described by this model. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272975 [Multi-domain]  Cd Length: 327  Bit Score: 235.69  E-value: 1.25e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364    5 PIILTGDRPTGSLHLGHYVGSLRQRVALQQDHQQYVLIADLQGLTDNGSNPQKIRDNIPQVLADYLAVGIDPTLTTICLQ 84
Cdd:TIGR00233   3 FRVLTGIQPSGKMHLGHYLGAIQTKWLQQFGVELFICIADLHAITVKQTDPDALRKAREELAADYLAVGLDPEKTFIFLQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   85 SALPALAELTVLYMNIVTVARVERNPTVKNeiaqKGFTRSLPVGFMAYPISQAADITAFKAEMVPVGDDQLPMIEQTNEI 164
Cdd:TIGR00233  83 SDYPEHYELAWLLSCQVTFGELKRMTQFKD----KSQAENVPIGLLSYPVLQAADILLYQADLVPVGIDQDQHLELTRDL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  165 VHKMNSLFSSPVLRPcQALLS-DMGRLPGIDGSaKMSKSLGNT-LLLSASEETIHRAVSAMYTDPNHLKISDPGKIEGN- 241
Cdd:TIGR00233 159 AERFNKKFKNFFPKP-ESLISkFFPRLMGLSGK-KMSKSDPNSaIFLTDTPKQIKKKIRKAATDGGRVTLFEHREKPGVp 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  242 ---VVFTWLDAFHPDKAKVAAMKAHYQQGGLGDRVCKNELETCLQELIAPIRERRATFIADkgMLMELLKKGSERAHEVT 318
Cdd:TIGR00233 237 nllVIYQYLSFFLIDDDKLKEIYEAYKSGKLGYGECKKALIEVLQEFLKEIQERRAEIAEE--ILDKILEPGAKKARETA 314

                         330
                  ....*....|...
gi 447017364  319 QKTLQEVKRGLGL 331
Cdd:TIGR00233 315 NKTLADVYKAMGL 327
PRK12283 PRK12283
tryptophanyl-tRNA synthetase; Reviewed
 7-331 1.82e-67

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 183401 [Multi-domain]  Cd Length: 398  Bit Score: 216.74  E-value: 1.82e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   7 ILTGDRPTGSLHLGHYVGSLRQRVALQQDHQQYVLIADLQGLTDNGSNPQKIRDNIPQVLADYLAVGIDPTLTTICLQSA 86
Cdd:PRK12283   5 VLSGMRPTGRLHLGHYHGVLKNWVKLQHEYECFFFVADWHALTTHYETPEVIEKNVWDMVIDWLAAGVDPAQATLFIQSK 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  87 LPALAELTVLYMNIVTVARVERNPTVKNEIaQKGFTRSLPV-GFMAYPISQAADITAFKAEMVPVGDDQLPMIEQTNEIV 165
Cdd:PRK12283  85 VPEHAELHLLLSMITPLGWLERVPTYKDQQ-EKLKEKDLSTyGFLGYPLLQSADILIYRAGLVPVGEDQVPHVEMTREIA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 166 HKMNSLFSSP---------------------------------------------------------------------V 176
Cdd:PRK12283 164 RRFNHLYGREpgfeekaeaaikklgkkraklyhelrnayqeegddealeqarallqeqqnlsmgdrerlfgylegagkiI 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 177 LRPCQALLSDMGRLPGIDGsAKMSKSLGNTLLLSASEETIHRAVSAMYTDPNHLKISDPGKIEGNVVftWldAFHpdkaK 256
Cdd:PRK12283 244 LPEPQALLTEASKMPGLDG-QKMSKSYGNTIGLREDPESVTKKIRTMPTDPARVRRTDPGDPEKCPV--W--QLH----Q 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 257 V---AAMKAHYQQG----GLGDRVCKNEL-ETCLQELiAPIRERRATFIADKGMLMELLKKGSERAHEVTQKTLQEVKRG 328
Cdd:PRK12283 315 VysdEETKEWVQKGcrsaGIGCLECKQPViDAILREQ-QPMRERAQKYEDDPSLVRAIVADGCEKARKVARETMRDVREA 393


                 ...
gi 447017364 329 LGL 331
Cdd:PRK12283 394 MGL 396
PRK12556 PRK12556
tryptophanyl-tRNA synthetase; Provisional
 5-331 1.16e-57

tryptophanyl-tRNA synthetase; Provisional


Pssm-ID: 183592 [Multi-domain]  Cd Length: 332  Bit Score: 189.55  E-value: 1.16e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   5 PIILTGDRPTGSLHLGHYVGSLRQ--RVALQQDHQQYVLIADLQGLTdNGSNPQKIRDNIPQVLADYLAVGIDPTLTTIC 82
Cdd:PRK12556   4 KIMLTGIKPTGYPHLGNYIGAIKPalQMAKNYEGKALYFIADYHALN-AVHDPEQFRSYTREVAATWLSLGLDPEDVIFY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  83 LQSALPALAELT-VL-------YMNIVTVARVERNptvKNEIAQKGFTRSLPVGFMAYPISQAADITAFKAEMVPVGDDQ 154
Cdd:PRK12556  83 RQSDVPEIFELAwILscltpkgLMNRAHAYKAKVD---QNKEAGLDLDAGVNMGLYTYPILMAADILLFQATHVPVGKDQ 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 155 LPMIEQTNEIVHKMNSLFSSPVLRPCQALLSDMGRLPGIDGSaKMSKSLGNTLLLSASEETIHRAVSAMYTDPnhLKISD 234
Cdd:PRK12556 160 IQHIEIARDIATYFNHTFGDTFTLPEYVIQEEGAILPGLDGR-KMSKSYGNVIPLFAEQEKLRKLIFKIKTDS--SLPNE 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 235 PGKIEGNVVFTWLDAFHPDKAkVAAMKAHYQQG-GLGDrvCKNELETCLQELIAPIRERRATFIADKGMLMELLKKGSER 313
Cdd:PRK12556 237 PKDPETSALFTIYKEFATEEE-VQSMREKYETGiGWGD--VKKELFRVVDRELAGPREKYAMYMNEPSLLDEALEKGAER 313

                        330
                 ....*....|....*...
gi 447017364 314 AHEVTQKTLQEVKRGLGL 331
Cdd:PRK12556 314 AREIAKPNLAEIKKAIGF 331
tRNA-synt_1b pfam00579
tRNA synthetases class I (W and Y);
5-279 5.49e-44

tRNA synthetases class I (W and Y);


Pssm-ID: 395461 [Multi-domain]  Cd Length: 292  Bit Score: 152.82  E-value: 5.49e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364    5 PIILTGDRPTGSLHLGHyVGSLRQRVALQQD-HQQYVLIADLQGLTDN--GSNPQKIRDNIPQVLAD---YLAVGIDPTL 78
Cdd:pfam00579   6 LRVYSGIDPTGPLHLGY-LVPLMKLRQFQQAgHEVFFLIGDLHAIIGDpsKSPERKLLSRETVLENAikaQLACGLDPEK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   79 TTICLQSALPALAELTVLYMNIVTVARVERNPTVKNEIAQKGFTRSLPVGFMAYPISQAADITAFKAEMVPVGDDQLPMI 158
Cdd:pfam00579  85 AEIVNNSDWLEHLELAWLLRDLGKHFSLNRMLQFKDVKKRLEQGPGISLGEFTYPLLQAYDILLLKADLQPGGSDQWGNI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  159 EQTNEIVHKMNSLFsspvLRPCQALLSDMgrLPGIDGSAKMSKSLGNT-LLLSASEETIHRAVSAMYTDPNHLKISD-PG 236
Cdd:pfam00579 165 ELGRDLARRFNKKI----FKKPVGLTNPL--LTGLDGGKKMSKSAGNSaIFLDDDPESVYKKIQKAYTDPDREVRKDlKL 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 447017364  237 KIEG-NVVFTWLDAFHPDKAKVAA--MKAHYQQGGLGDRVCKNELE 279
Cdd:pfam00579 239 FTFLsNEEIEILEAELGKSPYREAeeLLAREVTGLVHGGDLKKAAA 284
PRK12284 PRK12284
tryptophanyl-tRNA synthetase; Reviewed
 7-334 9.75e-44

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237036 [Multi-domain]  Cd Length: 431  Bit Score: 155.55  E-value: 9.75e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   7 ILTGDRPTGSLHLGHYVGSLRQRVA--LQQDHQQYVLIADLQGL--TDNgsnPQKIRDNIPQVLADYLAVGIDPTLTTIC 82
Cdd:PRK12284   5 VLTGITTTGTPHLGNYAGAIRPAIAasRQPGVESFYFLADYHALikCDD---PARIQRSTLEIAATWLAAGLDPERVTFY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  83 LQSALPALAELTVLyMNIVTV-----------ARVERNpTVKNEIAQKGFTRSLpvgFMaYPISQAADITAFKAEMVPVG 151
Cdd:PRK12284  82 RQSDIPEIPELTWL-LTCVAGkgllnrahaykAAVDKN-VAAGEDPDAGVTAGL---FM-YPVLMAADILMFNAHKVPVG 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 152 DDQLPMIEQTNEIVHKMNSLFSSPVLRPCQALLSD-MGRLPGIDGSaKMSKSLGNTLLLSASEETIHRAVSAMYTD---P 227
Cdd:PRK12284 156 RDQIQHIEMARDIAQRFNHLYGGEFFVLPEAVIEEsVATLPGLDGR-KMSKSYDNTIPLFAPREELKKAIFSIVTDsraP 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 228 NHLKisDPgkiEGNVVFTWLDAFhPDKAKVAAMKAHYQQG-GLGDrvCKNELETCLQELIAPIRERRATFIADKGMLMEL 306
Cdd:PRK12284 235 GEPK--DT---EGSALFQLYQAF-ATPEETAAFRQALADGiGWGD--AKQRLFERIDRELAPMRERYEALIARPADIEDI 306

                        330       340
                 ....*....|....*....|....*...
gi 447017364 307 LKKGSERAHEVTQKTLQEVKRGLGLPTL 334
Cdd:PRK12284 307 LLAGAAKARRIATPFLAELREAVGLRSL 334
PLN02886 PLN02886
aminoacyl-tRNA ligase
 7-330 5.52e-42

aminoacyl-tRNA ligase


Pssm-ID: 215478 [Multi-domain]  Cd Length: 389  Bit Score: 149.97  E-value: 5.52e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   7 ILTGDRPTGSLHLGHYVGSLRQRVALQQDHQQYVLIADLQGLTDNgSNPQKIRDNIPQVLADYLAVGIDPTLTTICLQSA 86
Cdd:PLN02886  49 VVSGVQPTGSIHLGNYLGAIKNWVALQETYDTFFCVVDLHAITLP-HDPRELGKATRSTAAIYLACGIDPSKASVFVQSH 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  87 LPALAELTVLYMNIVTVARVERNPTVKnEIAQKGFTRSLPVGFMAYPISQAADITAFKAEMVPVGDDQLPMIEQTNEIVH 166
Cdd:PLN02886 128 VPAHAELMWLLSCSTPIGWLNKMIQFK-EKSRKAGDENVGVGLLTYPVLMASDILLYQADLVPVGEDQKQHLELTRDIAE 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 167 KMNSLF-----------SSPVLRPCQALLSDMG-RLPGI-DGSAKMSKSL---GNTLLLSASEETIHRAVSAMYTDpnhl 230
Cdd:PLN02886 207 RVNNLYggrkwkklggrGGSVFKVPEALIPPAGaRVMSLtDGTSKMSKSApsdQSRINLLDPPDVIANKIKRCKTD---- 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 231 kiSDPGkiegnvvftwLDAFHPDKAKVAAMKAHYQ--QGGLGDRV---CKN--------ELETCLQELIAPIRERRATFI 297
Cdd:PLN02886 283 --SFPG----------LEFDNPERPECNNLLSIYQlvTGKTKEEVlaeCGDmrwgdfkpLLTDALIEHLSPIQVRYEEIM 350

                        330       340       350
                 ....*....|....*....|....*....|...
gi 447017364 298 ADKGMLMELLKKGSERAHEVTQKTLQEVKRGLG 330
Cdd:PLN02886 351 SDPSYLDSVLKEGADAAAEIADRTLANVYQAMG 383
PRK12285 PRK12285
tryptophanyl-tRNA synthetase; Reviewed
 7-294 1.87e-22

tryptophanyl-tRNA synthetase; Reviewed


Pssm-ID: 237037 [Multi-domain]  Cd Length: 368  Bit Score: 96.47  E-value: 1.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   7 ILTGDRPTGSLHLGHYVgSLRQRVALQQ-DHQQYVLIADLQGLTDNGSNPQKIRDNIPQVLADYLAVGIDPTLTTICLQS 85
Cdd:PRK12285  69 VYTGFMPSGPMHIGHKM-VFDELKWHQEfGANVYIPIADDEAYAARGLSWEETREWAYEYILDLIALGFDPDKTEIYFQS 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  86 ALPALAELTVLYMNIVTVARVErnptvkneiAQKGFTRSLPVGFMAYPISQAADI------TAFKAEMVPVGDDQLPMIE 159
Cdd:PRK12285 148 ENIKVYDLAFELAKKVNFSELK---------AIYGFTGETNIGHIFYPATQAADIlhpqleEGPKPTLVPVGIDQDPHIR 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 160 QTNEIVHKMNSLFSspvLRPCQALLSDMgrLPGIDGSaKMSKSLGNTLL-LSASEETIHRAVSAMYTD-----PNHLKIS 233
Cdd:PRK12285 219 LTRDIAERLHGGYG---FIKPSSTYHKF--MPGLTGG-KMSSSKPESAIyLTDDPETVKKKIMKALTGgratlEEQRKLG 292

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447017364 234 dpGKIEGNVVFTWLdAFH--PDKAKVAAMKAHYQQGGL--GDrvCKNELETCLQELIAPIRERRA 294
Cdd:PRK12285 293 --GEPDECVVYELL-LYHleEDDKELKEIYEECRSGELlcGE--CKKEAAEKIAEFLKEHQEKRE 352
Tyr_Trp_RS_core cd00395
catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Tyrosinyl-tRNA ...
 7-211 9.93e-17

catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS)/Tryptophanyl-tRNA synthetase (TrpRS) catalytic core domain. These enzymes attach Tyr or Trp, respectively, to the appropriate tRNA. These class I enzymes are homodimers, which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173893 [Multi-domain]  Cd Length: 273  Bit Score: 78.88  E-value: 9.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   7 ILTGDRPTG-SLHLGHYVGsLRQRVALQQ-DHQQYVLIADLQGLTDNGS---------NPQKIRDNIPQVLADYLAVGID 75
Cdd:cd00395    2 LYCGIDPTAdSLHIGHLIG-LLTFRRFQHaGHRPIFLIGGQTGIIGDPSgkksertlnDPEEVRQNIRRIAAQYLAVGIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  76 --PTLTTICLQSALP---ALAELTVLYMNIVTVARVERNPTVKNEIAQkgftrSLPVGFMAYPISQAADI----TAFKAE 146
Cdd:cd00395   81 edPTQATLFNNSDWPgplAHIQFLRDLGKHVYVNYMERKTSFQSRSEE-----GISATEFTYPPLQAADFlllnTTEGCD 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 447017364 147 MVPVGDDQLPMIEQTNEIVHKMNsLFSSPVLRPCQALLSDMGRlpgidgsaKMSKSLGNTLLLSA 211
Cdd:cd00395  156 IQPGGSDQWGNITLGRELARRFN-GFTIAEGLTIPLVTKLDGP--------KFGKSESGPKWLDT 211
PRK08560 PRK08560
tyrosyl-tRNA synthetase; Validated
 5-292 3.70e-13

tyrosyl-tRNA synthetase; Validated


Pssm-ID: 236286 [Multi-domain]  Cd Length: 329  Bit Score: 69.12  E-value: 3.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   5 PIILTGDRPTGSLHLGHYVgSLRQRVALQQ-DHQQYVLIADLQGLTDNGSNPQKIRDnipqvLADYL-----AVGIDPTL 78
Cdd:PRK08560  31 PKAYIGFEPSGKIHLGHLL-TMNKLADLQKaGFKVTVLLADWHAYLNDKGDLEEIRK-----VAEYNkkvfeALGLDPDK 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  79 TTICLQSALPALAELTVLYMNI---VTVARVERNPTvknEIAQKGftRSLPVGFMAYPISQAADITAFKAEMVPVGDDQ- 154
Cdd:PRK08560 105 TEFVLGSEFQLDKEYWLLVLKLaknTTLARARRSMT---IMGRRM--EEPDVSKLVYPLMQVADIFYLDVDIAVGGMDQr 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 155 -LPMIeqTNEIVHKMNslFSSPVlrpcqALLSDMgrLPGIDGSA-KMSKS-LGNTLLLSASEETIHRAVSAMYTdPnhlk 231
Cdd:PRK08560 180 kIHML--AREVLPKLG--YKKPV-----CIHTPL--LTGLDGGGiKMSKSkPGSAIFVHDSPEEIRRKIKKAYC-P---- 243

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 447017364 232 isdPGKIEGN--------VVFTWLDAFH---PDKA-------KVAAMKAHYQQGGLGDRVCKNELETCLQELIAPIRER 292
Cdd:PRK08560 244 ---PGEVEGNpvleiakyHIFPRYDPFVierPEKYggdleyeSYEELERDYAEGKLHPMDLKNAVAEYLIEILEPVREY 319
TyrRS_core cd00805
catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) ...
 13-206 6.46e-09

catalytic core domain of tyrosinyl-tRNA synthetase; Tyrosinyl-tRNA synthetase (TyrRS) catalytic core domain. TyrRS is a homodimer which attaches Tyr to the appropriate tRNA. TyrRS is a class I tRNA synthetases, so it aminoacylates the 2'-OH of the nucleotide at the 3' end of the tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formationof the enzyme bound aminoacyl-adenylate. It contains the class I characteristic HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173902 [Multi-domain]  Cd Length: 269  Bit Score: 56.08  E-value: 6.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  13 PTG-SLHLGHYVGSLRQRVALQQDHQQYVLIADLQGLTDNGSNPQKIR------------DNIPQVLADYLaVGIDPTLT 79
Cdd:cd00805    9 PTApSLHLGHLVPLMKLRDFQQAGHEVIVLIGDATAMIGDPSGKSEERklldlelirenaKYYKKQLKAIL-DFIPPEKA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  80 TICLQSA-LPALAELTVLYM-NIVTVARVERNPTVKNEiaqkgFTRSLPVGF--MAYPISQAADITAFKAEMVPVGDDQL 155
Cdd:cd00805   88 KFVNNSDwLLSLYTLDFLRLgKHFTVNRMLRRDAVKVR-----LEEEEGISFseFIYPLLQAYDFVYLDVDLQLGGSDQR 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 447017364 156 PMIEQTNEIVHKMNslfsspvLRPCQALLSDMgrLPGIDGsAKMSKSLGNT 206
Cdd:cd00805  163 GNITLGRDLIRKLG-------YKKVVGLTTPL--LTGLDG-GKMSKSEGNA 203
PLN02486 PLN02486
aminoacyl-tRNA ligase
 9-295 3.68e-08

aminoacyl-tRNA ligase


Pssm-ID: 178104  Cd Length: 383  Bit Score: 54.36  E-value: 3.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   9 TGDRPTG-SLHLGHYVGSLRQRVaLQQDHQQYVLIAdlqgLTDNGSNPQK-IRDNIPQVLA-----DYLAVGIDPTLTTI 81
Cdd:PLN02486  78 TGRGPSSeALHLGHLIPFMFTKY-LQDAFKVPLVIQ----LTDDEKFLWKnLSVEESQRLArenakDIIACGFDVERTFI 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  82 ClqSALPALAelTVLYMNIVTVARVernPTVKNEIAQKGFTRSLPVGFMAYPISQAA--------DITAFKAEM---VPV 150
Cdd:PLN02486 153 F--SDFDYVG--GAFYKNMVKIAKC---VTLNQVRGIFGFSGEDNIGKISFPAVQAApsfpssfpHLFGGKDKLrclIPC 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 151 GDDQLPMIEQTNEIVHKMN----SLFSSPVLRPCQAllsdmgrlpgidGSAKMSKSLGNT-LLLSASEETIHRAVSAMYT 225
Cdd:PLN02486 226 AIDQDPYFRMTRDVAPRLGyykpALIESRFFPALQG------------ESGKMSASDPNSaIYVTDTPKEIKNKINKYAF 293

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447017364 226 DPNHLKISDPGKIEGN----VVFTWLDAFHPDKAKVAAMKAHYQQGGLGDRVCKNELETCLQELIAPIRERRAT 295
Cdd:PLN02486 294 SGGQDTVEEHRELGANlevdIPWKYLNFFLEDDAELERIKKEYGSGRMLTGEVKKRLIEVLTEIVERHQRARAA 367
PTZ00126 PTZ00126
tyrosyl-tRNA synthetase; Provisional
 125-308 1.05e-07

tyrosyl-tRNA synthetase; Provisional


Pssm-ID: 240282 [Multi-domain]  Cd Length: 383  Bit Score: 53.16  E-value: 1.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 125 LPVGFMAYPISQAADITAFKAEMVPVGDDQlpmieqtneivHKMNSLF----------SSPVLrpcqaLLSDMgrLPGI- 193
Cdd:PTZ00126 191 QPCAQILYPCMQCADIFYLKADICQLGMDQ-----------RKVNMLAreycdkkkikKKPII-----LSHHM--LPGLl 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364 194 DGSAKMSKSLGNT-LLLSASEETIHRAVSAMYtdpnhlkiSDPGKIEGN--------VVFTWLDAFH-PDKAK------- 256
Cdd:PTZ00126 253 EGQEKMSKSDPNSaIFMEDSEEDVNRKIKKAY--------CPPGVIEGNpilayfksIVFPAFNSFTvLRKEKnggdvty 324

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 447017364 257 --VAAMKAHYQQGGLGDRVCKNELETCLQELIAPIRERRATFIADKGMLMELLK 308
Cdd:PTZ00126 325 ttYEELEKDYLSGALHPGDLKPALAKYLNLMLQPVRDHFQNNPEAKSLLSEVKS 378
tyrS TIGR00234
tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up ...
 1-280 1.10e-07

tyrosyl-tRNA synthetase; This tyrosyl-tRNA synthetase model starts picking up tryptophanyl-tRNA synthetases at scores of 0 and below. The proteins found by this model have a deep split between two groups. One group contains bacterial and organellar eukaryotic examples. The other contains archaeal and cytosolic eukaryotic examples. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 272976 [Multi-domain]  Cd Length: 378  Bit Score: 52.78  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364    1 MNTLPIILTGDRPTG-SLHLGHYVGSLRQRVALQQDHQQYVLIADLQGLTDNGSNPQKIRD--NIPQVLADY------LA 71
Cdd:TIGR00234  28 LERPLKLYLGFDPTApSLHLGHLVPLLKLRDFQQAGHEVIVLLGDFTALIGDPTGKSEVRKilTREEVQENAenikkqIA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364   72 VGIDPTLTTICLQSA-LPALAELTVLYM--NIVTVARVERNPTVKneiaqKGFTRSLPVGFMAYPISQAADITAFKAEMV 148
Cdd:TIGR00234 108 RFLDFEKAKFVYNSEwLLKLNYTDFIRLlgKIFTVNRMLRRDAFS-----SRFEENISLHEFIYPLLQAYDFVYLNVDLQ 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 447017364  149 PVGDDQLPMIEQTNEIVHKMNslfsspvlrPCQALLSDMGRLPGIDGSaKMSKSLGNTLLLSA-----------SEETIH 217
Cdd:TIGR00234 183 LGGSDQWFNIRKGRDLARENL---------PSLQFGLTVPLLTPADGE-KMGKSLGGAVSLDEgkydfyqkvinTPDELV 252

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 447017364  218 RAVSAMYTDPN--------HLKISDPGKIEGNVVFTWLDAFH-PDKAKVA--AMKAHYQQGGLGDRVCKNELET 280
Cdd:TIGR00234 253 KKYLKLFTFLGleeieqlvELKGPNPREVKENLALEITKYVHgPEAALAAeeISEAIFSGGLNPDEVPIFRPEK 326
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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