NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|116057|sp|P19336|]
View 

RecName: Full=CCN family member 1; AltName: Full=Cellular communication network factor 1; AltName: Full=Protein CEF-10; AltName: Full=Protein CYR61; Flags: Precursor

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 224-267 3.44e-17

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


:

Pssm-ID: 465952  Cd Length: 44  Bit Score: 74.29  E-value: 3.44e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 116057     224 CIVQTTSWSQCSKTCGTGISTRVTNDNPDCKLIKETRICEVRPC 267
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 288-371 6.00e-15

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


:

Pssm-ID: 394966  Cd Length: 105  Bit Score: 70.13  E-value: 6.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116057     288 PSPVRFTYAGCSSVKKYRPKYC-GSCV-------DGR-------CCTPQQTRTVKIRFRCDDGETFTKSVMMIQSCRCNy 352
Cdd:pfam00007   8 NYTISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTYPVALSCHCG- 86

                          90
                  ....*....|....*....
gi 116057     353 NCPHANEAYPFYRLVNDIH 371
Cdd:pfam00007  87 NCPTDNSDCTRLSLQPDSC 105
IGFBP pfam00219
Insulin-like growth factor binding protein;
26-78 3.31e-10

Insulin-like growth factor binding protein;


:

Pssm-ID: 459717  Cd Length: 53  Bit Score: 55.02  E-value: 3.31e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 116057      26 CPAVC---QCPAAAPQCAPGVglVPDGCGCCKVCAKQLNEDCS-RTQPCDhtKGLEC 78
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGvYTPPCG--KGLRC 53
VWC smart00214
von Willebrand factor (vWF) type C domain;
100-159 5.76e-08

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 49.05  E-value: 5.76e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116057      100 CEYNSKIYQNGESFQPNCKHQCTCIDGA-VGCIPL-CPqelslPNLGCPSPRLVKVPGQCCE 159
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 224-267 3.44e-17

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 74.29  E-value: 3.44e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 116057     224 CIVQTTSWSQCSKTCGTGISTRVTNDNPDCKLIKETRICEVRPC 267
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 288-371 6.00e-15

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 70.13  E-value: 6.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116057     288 PSPVRFTYAGCSSVKKYRPKYC-GSCV-------DGR-------CCTPQQTRTVKIRFRCDDGETFTKSVMMIQSCRCNy 352
Cdd:pfam00007   8 NYTISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTYPVALSCHCG- 86

                          90
                  ....*....|....*....
gi 116057     353 NCPHANEAYPFYRLVNDIH 371
Cdd:pfam00007  87 NCPTDNSDCTRLSLQPDSC 105
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 287-355 6.51e-13

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 63.58  E-value: 6.51e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116057      287 SPSPVRFTYAGCSSVKkYRPKYC-GSCVD------------GRCCTPQQTRTVKIRFRCDDGETFTKSVMMIQSCRCNYN 353
Cdd:smart00041   2 SPVRQTITYNGCTSVT-VKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPN 80


                   ..
gi 116057      354 CP 355
Cdd:smart00041  81 CP 82
IGFBP pfam00219
Insulin-like growth factor binding protein;
26-78 3.31e-10

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 55.02  E-value: 3.31e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 116057      26 CPAVC---QCPAAAPQCAPGVglVPDGCGCCKVCAKQLNEDCS-RTQPCDhtKGLEC 78
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGvYTPPCG--KGLRC 53
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 25-89 2.34e-08

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 50.54  E-value: 2.34e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116057       25 PCPAVC--QCPAAAPQCApgVGLVPDGCGCCKVCAKQLNEDCS-RTQPCdhTKGLECNFGASPAATNG 89
Cdd:smart00121   2 RCPPCDpaRCPPCPPGCA--ELVRLDGCGCCPVCARQEGEPCGvYTPRC--APGLRCQPPPGEERPLR 65
VWC smart00214
von Willebrand factor (vWF) type C domain;
100-159 5.76e-08

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 49.05  E-value: 5.76e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116057      100 CEYNSKIYQNGESFQPNCKHQCTCIDGA-VGCIPL-CPqelslPNLGCPSPRLVKVPGQCCE 159
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 100-160 1.77e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 47.42  E-value: 1.77e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116057     100 CEYNSKIYQNGESFQPNCKHQCTCIDGAVGCIPlcpqeLSLPNLGCPSPRLVKVPGQCCEE 160
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDK-----IICPPLDCPNPRLEIPPGECCPV 56
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 227-267 3.91e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.26  E-value: 3.91e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 116057      227 QTTSWSQCSKTCGTGISTRV--------TNDNPDCK-LIKETRICEVRPC 267
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCTgEDVETRACNEQPC 52
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 224-267 3.44e-17

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 74.29  E-value: 3.44e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 116057     224 CIVQTTSWSQCSKTCGTGISTRVTNDNPDCKLIKETRICEVRPC 267
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
Cys_knot pfam00007
Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of ...
 288-371 6.00e-15

Cystine-knot domain; The family comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerization.


Pssm-ID: 394966  Cd Length: 105  Bit Score: 70.13  E-value: 6.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116057     288 PSPVRFTYAGCSSVKKYRPKYC-GSCV-------DGR-------CCTPQQTRTVKIRFRCDDGETFTKSVMMIQSCRCNy 352
Cdd:pfam00007   8 NYTISVEKEGCTSCKTINTTICaGYCYtrdpvykDGRravsqrvCTYRDVTYETVVLPGCPPGVDPTVTYPVALSCHCG- 86

                          90
                  ....*....|....*....
gi 116057     353 NCPHANEAYPFYRLVNDIH 371
Cdd:pfam00007  87 NCPTDNSDCTRLSLQPDSC 105
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 287-355 6.51e-13

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 63.58  E-value: 6.51e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116057      287 SPSPVRFTYAGCSSVKkYRPKYC-GSCVD------------GRCCTPQQTRTVKIRFRCDDGETFTKSVMMIQSCRCNYN 353
Cdd:smart00041   2 SPVRQTITYNGCTSVT-VKNAFCeGKCGSassysiqdvqhsCSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPN 80


                   ..
gi 116057      354 CP 355
Cdd:smart00041  81 CP 82
IGFBP pfam00219
Insulin-like growth factor binding protein;
26-78 3.31e-10

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 55.02  E-value: 3.31e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 116057      26 CPAVC---QCPAAAPQCAPGVglVPDGCGCCKVCAKQLNEDCS-RTQPCDhtKGLEC 78
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGvYTPPCG--KGLRC 53
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 25-89 2.34e-08

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 50.54  E-value: 2.34e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116057       25 PCPAVC--QCPAAAPQCApgVGLVPDGCGCCKVCAKQLNEDCS-RTQPCdhTKGLECNFGASPAATNG 89
Cdd:smart00121   2 RCPPCDpaRCPPCPPGCA--ELVRLDGCGCCPVCARQEGEPCGvYTPRC--APGLRCQPPPGEERPLR 65
VWC smart00214
von Willebrand factor (vWF) type C domain;
100-159 5.76e-08

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 49.05  E-value: 5.76e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116057      100 CEYNSKIYQNGESFQPNCKHQCTCIDGA-VGCIPL-CPqelslPNLGCPSPRLVKVPGQCCE 159
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVeCP-----PPPDCPNPERVKPPGECCP 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 100-160 1.77e-07

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 47.42  E-value: 1.77e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116057     100 CEYNSKIYQNGESFQPNCKHQCTCIDGAVGCIPlcpqeLSLPNLGCPSPRLVKVPGQCCEE 160
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDK-----IICPPLDCPNPRLEIPPGECCPV 56
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 229-267 8.94e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 36.87  E-value: 8.94e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 116057     229 TSWSQCSKTCGTGISTRV-------TNDNPDCKLIKETRICEVRPC 267
Cdd:pfam19028   7 SEWSECSVTCGGGVQTRTrtvivepQNGGRPCPELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 227-267 3.91e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 35.26  E-value: 3.91e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 116057      227 QTTSWSQCSKTCGTGISTRV--------TNDNPDCK-LIKETRICEVRPC 267
Cdd:smart00209   3 EWSEWSPCSVTCGGGVQTRTrsccspppQNGGGPCTgEDVETRACNEQPC 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH