pappalysin-2 isoform 2 precursor [Homo sapiens]
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
ZnMc super family | cl00064 | Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ... |
634-811 | 1.51e-39 | ||||
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease. The actual alignment was detected with superfamily member cd04275: Pssm-ID: 444678 [Multi-domain] Cd Length: 225 Bit Score: 145.95 E-value: 1.51e-39
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Laminin_G_3 | pfam13385 | Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ... |
282-437 | 3.86e-21 | ||||
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily. : Pssm-ID: 433165 [Multi-domain] Cd Length: 151 Bit Score: 90.52 E-value: 3.86e-21
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NL | smart00004 | Domain found in Notch and Lin-12; The Notch protein is essential for the proper ... |
585-612 | 1.23e-05 | ||||
Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains. : Pssm-ID: 197463 Cd Length: 38 Bit Score: 42.70 E-value: 1.23e-05
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Name | Accession | Description | Interval | E-value | ||||
ZnMc_pappalysin_like | cd04275 | Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ... |
634-811 | 1.51e-39 | ||||
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved. Pssm-ID: 239802 [Multi-domain] Cd Length: 225 Bit Score: 145.95 E-value: 1.51e-39
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Laminin_G_3 | pfam13385 | Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ... |
282-437 | 3.86e-21 | ||||
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily. Pssm-ID: 433165 [Multi-domain] Cd Length: 151 Bit Score: 90.52 E-value: 3.86e-21
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LamGL | smart00560 | LamG-like jellyroll fold domain; |
286-433 | 1.22e-19 | ||||
LamG-like jellyroll fold domain; Pssm-ID: 214722 Cd Length: 133 Bit Score: 85.55 E-value: 1.22e-19
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NL | smart00004 | Domain found in Notch and Lin-12; The Notch protein is essential for the proper ... |
585-612 | 1.23e-05 | ||||
Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains. Pssm-ID: 197463 Cd Length: 38 Bit Score: 42.70 E-value: 1.23e-05
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ZnMc | smart00235 | Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ... |
720-743 | 9.77e-03 | ||||
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site. Pssm-ID: 214576 [Multi-domain] Cd Length: 139 Bit Score: 37.33 E-value: 9.77e-03
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Name | Accession | Description | Interval | E-value | ||||
ZnMc_pappalysin_like | cd04275 | Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ... |
634-811 | 1.51e-39 | ||||
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved. Pssm-ID: 239802 [Multi-domain] Cd Length: 225 Bit Score: 145.95 E-value: 1.51e-39
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Laminin_G_3 | pfam13385 | Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ... |
282-437 | 3.86e-21 | ||||
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily. Pssm-ID: 433165 [Multi-domain] Cd Length: 151 Bit Score: 90.52 E-value: 3.86e-21
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LamGL | smart00560 | LamG-like jellyroll fold domain; |
286-433 | 1.22e-19 | ||||
LamG-like jellyroll fold domain; Pssm-ID: 214722 Cd Length: 133 Bit Score: 85.55 E-value: 1.22e-19
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NL | smart00004 | Domain found in Notch and Lin-12; The Notch protein is essential for the proper ... |
585-612 | 1.23e-05 | ||||
Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains. Pssm-ID: 197463 Cd Length: 38 Bit Score: 42.70 E-value: 1.23e-05
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ZnMc_serralysin_like | cd04277 | Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases ... |
684-743 | 2.55e-04 | ||||
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not require n-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain c-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides. Pssm-ID: 239804 [Multi-domain] Cd Length: 186 Bit Score: 42.79 E-value: 2.55e-04
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ZnMc_MMP_like | cd04268 | Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ... |
703-749 | 5.44e-04 | ||||
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases. Pssm-ID: 239796 [Multi-domain] Cd Length: 165 Bit Score: 41.33 E-value: 5.44e-04
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LamG | smart00282 | Laminin G domain; |
348-430 | 1.48e-03 | ||||
Laminin G domain; Pssm-ID: 214598 Cd Length: 132 Bit Score: 39.63 E-value: 1.48e-03
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ZnMc | smart00235 | Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ... |
720-743 | 9.77e-03 | ||||
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site. Pssm-ID: 214576 [Multi-domain] Cd Length: 139 Bit Score: 37.33 E-value: 9.77e-03
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Blast search parameters | ||||
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