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Conserved domains on  [gi|116174734|ref|NP_068755|]
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pappalysin-2 isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ZnMc super family cl00064
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
634-811 1.51e-39

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


The actual alignment was detected with superfamily member cd04275:

Pssm-ID: 444678 [Multi-domain]  Cd Length: 225  Bit Score: 145.95  E-value: 1.51e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174734 634 NMLNDF------DDGDCCDPQVADVRKTCFDPDSPKRAYMSVKELKEALQLNSTHFLNIYFASSVREDLAGAATWPWDKD 707
Cdd:cd04275   32 DVLNDDysglnaGVDLGIEFVLAGTTRTVNSAWPVFAGSGTEDAMKSALRKGGYKYLNIYVANFLGGGLLGYATFPDSLV 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174734 708 AVT-HLGGIVLSPAYYGMPG-----HTDTMIHEVGHVLGLYHVFKGVSerescndpcketvPSMETGDLCADTAPTPKSE 781
Cdd:cd04275  112 SLAfITDGVVINPSSLPGGSaapynLGDTATHEVGHWLGLYHTFQGGS-------------PCCTTGDYVADTPAEASPS 178
                        170       180       190
                 ....*....|....*....|....*....|
gi 116174734 782 lCREPEPTsDTCGFTRFPgAPFTNYMSYTG 811
Cdd:cd04275  179 -YGCPAGR-DTCPGQPGL-DPIHNYMDYSD 205
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
282-437 3.86e-21

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


:

Pssm-ID: 433165 [Multi-domain]  Cd Length: 151  Bit Score: 90.52  E-value: 3.86e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174734  282 IPREAFTVEAWVKPEGGQNNPAIIAGVFdncshtvSDKGWALGIRSGKdkgkrdaRFFFSLCTDRVKKATIlISHSRYQP 361
Cdd:pfam13385  14 LPTSDFTVSAWVKPDSLPGWARAIISAS-------GGGGYSLGLDGDG-------RLRFAVNGGGGGWDTV-TSGASLPL 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 116174734  362 GTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNspfmASCRSLLLGGDSSEDgHYFRGHLGTLVFWSTALPQSH 437
Cdd:pfam13385  79 GQWTHVAVTYDGGTLRLYVNGVLVGSSTLTGGPPT----GTGGPLYIGRSPGGD-DYFNGLIDEVRIYDRALTAAE 149
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
585-612 1.23e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


:

Pssm-ID: 197463  Cd Length: 38  Bit Score: 42.70  E-value: 1.23e-05
                           10        20
                   ....*....|....*....|....*...
gi 116174734   585 NCEpSKIGNDHCDPECEHPLTGYDGGDC 612
Cdd:smart00004  12 QCW-DKFGDGVCDEECNNAECLWDGGDC 38
 
Name Accession Description Interval E-value
ZnMc_pappalysin_like cd04275
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ...
634-811 1.51e-39

Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.


Pssm-ID: 239802 [Multi-domain]  Cd Length: 225  Bit Score: 145.95  E-value: 1.51e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174734 634 NMLNDF------DDGDCCDPQVADVRKTCFDPDSPKRAYMSVKELKEALQLNSTHFLNIYFASSVREDLAGAATWPWDKD 707
Cdd:cd04275   32 DVLNDDysglnaGVDLGIEFVLAGTTRTVNSAWPVFAGSGTEDAMKSALRKGGYKYLNIYVANFLGGGLLGYATFPDSLV 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174734 708 AVT-HLGGIVLSPAYYGMPG-----HTDTMIHEVGHVLGLYHVFKGVSerescndpcketvPSMETGDLCADTAPTPKSE 781
Cdd:cd04275  112 SLAfITDGVVINPSSLPGGSaapynLGDTATHEVGHWLGLYHTFQGGS-------------PCCTTGDYVADTPAEASPS 178
                        170       180       190
                 ....*....|....*....|....*....|
gi 116174734 782 lCREPEPTsDTCGFTRFPgAPFTNYMSYTG 811
Cdd:cd04275  179 -YGCPAGR-DTCPGQPGL-DPIHNYMDYSD 205
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
282-437 3.86e-21

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 433165 [Multi-domain]  Cd Length: 151  Bit Score: 90.52  E-value: 3.86e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174734  282 IPREAFTVEAWVKPEGGQNNPAIIAGVFdncshtvSDKGWALGIRSGKdkgkrdaRFFFSLCTDRVKKATIlISHSRYQP 361
Cdd:pfam13385  14 LPTSDFTVSAWVKPDSLPGWARAIISAS-------GGGGYSLGLDGDG-------RLRFAVNGGGGGWDTV-TSGASLPL 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 116174734  362 GTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNspfmASCRSLLLGGDSSEDgHYFRGHLGTLVFWSTALPQSH 437
Cdd:pfam13385  79 GQWTHVAVTYDGGTLRLYVNGVLVGSSTLTGGPPT----GTGGPLYIGRSPGGD-DYFNGLIDEVRIYDRALTAAE 149
LamGL smart00560
LamG-like jellyroll fold domain;
286-433 1.22e-19

LamG-like jellyroll fold domain;


Pssm-ID: 214722  Cd Length: 133  Bit Score: 85.55  E-value: 1.22e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174734   286 AFTVEAWVKPEGGQNNPAIIagvfdncshtvsdKGWALGIRSGKDKgkrDARFFFSLCTDRvkKATILISHSRYQP-GTW 364
Cdd:smart00560   2 SFTLEAWVKLESAGGSQPII-------------TGAAVAQPTISEK---ALTFFLRAKSVQ--GWQTARTGATADWiGVW 63
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116174734   365 THVAATYDG--RHMALYVDGTQVASSLDQSGPLNSPFMASCRsLLLGGDSsedGHYFRGHLGTLVFWSTAL 433
Cdd:smart00560  64 VHLAGVYDGgaGKLSLYVNGVEVATSETQPSPSSGNLPQGGR-ILLGGAG---GENFSGRLDEVRVYNRAL 130
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
585-612 1.23e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 42.70  E-value: 1.23e-05
                           10        20
                   ....*....|....*....|....*...
gi 116174734   585 NCEpSKIGNDHCDPECEHPLTGYDGGDC 612
Cdd:smart00004  12 QCW-DKFGDGVCDEECNNAECLWDGGDC 38
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
720-743 9.77e-03

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 37.33  E-value: 9.77e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 116174734   720 AYYGMPG------------HTDTMIHEVGHVLGLYH 743
Cdd:smart00235  65 SHAGRPGgdqhlslgngciNTGVAAHELGHALGLYH 100
 
Name Accession Description Interval E-value
ZnMc_pappalysin_like cd04275
Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma ...
634-811 1.51e-39

Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor. This model includes pappalysins and related metalloprotease domains from all three kingdoms of life. The three-dimensional structure of an archaeal representative, ulilysin, has been solved.


Pssm-ID: 239802 [Multi-domain]  Cd Length: 225  Bit Score: 145.95  E-value: 1.51e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174734 634 NMLNDF------DDGDCCDPQVADVRKTCFDPDSPKRAYMSVKELKEALQLNSTHFLNIYFASSVREDLAGAATWPWDKD 707
Cdd:cd04275   32 DVLNDDysglnaGVDLGIEFVLAGTTRTVNSAWPVFAGSGTEDAMKSALRKGGYKYLNIYVANFLGGGLLGYATFPDSLV 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174734 708 AVT-HLGGIVLSPAYYGMPG-----HTDTMIHEVGHVLGLYHVFKGVSerescndpcketvPSMETGDLCADTAPTPKSE 781
Cdd:cd04275  112 SLAfITDGVVINPSSLPGGSaapynLGDTATHEVGHWLGLYHTFQGGS-------------PCCTTGDYVADTPAEASPS 178
                        170       180       190
                 ....*....|....*....|....*....|
gi 116174734 782 lCREPEPTsDTCGFTRFPgAPFTNYMSYTG 811
Cdd:cd04275  179 -YGCPAGR-DTCPGQPGL-DPIHNYMDYSD 205
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
282-437 3.86e-21

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 433165 [Multi-domain]  Cd Length: 151  Bit Score: 90.52  E-value: 3.86e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174734  282 IPREAFTVEAWVKPEGGQNNPAIIAGVFdncshtvSDKGWALGIRSGKdkgkrdaRFFFSLCTDRVKKATIlISHSRYQP 361
Cdd:pfam13385  14 LPTSDFTVSAWVKPDSLPGWARAIISAS-------GGGGYSLGLDGDG-------RLRFAVNGGGGGWDTV-TSGASLPL 78
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 116174734  362 GTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNspfmASCRSLLLGGDSSEDgHYFRGHLGTLVFWSTALPQSH 437
Cdd:pfam13385  79 GQWTHVAVTYDGGTLRLYVNGVLVGSSTLTGGPPT----GTGGPLYIGRSPGGD-DYFNGLIDEVRIYDRALTAAE 149
LamGL smart00560
LamG-like jellyroll fold domain;
286-433 1.22e-19

LamG-like jellyroll fold domain;


Pssm-ID: 214722  Cd Length: 133  Bit Score: 85.55  E-value: 1.22e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174734   286 AFTVEAWVKPEGGQNNPAIIagvfdncshtvsdKGWALGIRSGKDKgkrDARFFFSLCTDRvkKATILISHSRYQP-GTW 364
Cdd:smart00560   2 SFTLEAWVKLESAGGSQPII-------------TGAAVAQPTISEK---ALTFFLRAKSVQ--GWQTARTGATADWiGVW 63
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116174734   365 THVAATYDG--RHMALYVDGTQVASSLDQSGPLNSPFMASCRsLLLGGDSsedGHYFRGHLGTLVFWSTAL 433
Cdd:smart00560  64 VHLAGVYDGgaGKLSLYVNGVEVATSETQPSPSSGNLPQGGR-ILLGGAG---GENFSGRLDEVRVYNRAL 130
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
585-612 1.23e-05

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 42.70  E-value: 1.23e-05
                           10        20
                   ....*....|....*....|....*...
gi 116174734   585 NCEpSKIGNDHCDPECEHPLTGYDGGDC 612
Cdd:smart00004  12 QCW-DKFGDGVCDEECNNAECLWDGGDC 38
ZnMc_serralysin_like cd04277
Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases ...
684-743 2.55e-04

Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not require n-terminal signal sequences which are cleaved after the transmembrane translocation. A calcium-binding domain c-terminal to the metalloprotease domain, which contains multiple tandem repeats of a nine-residue motif including the pattern GGxGxD, and which forms a parallel beta roll may be involved in the translocation mechanism and/or substrate binding. Serralysin family members may have a broad spectrum of substrates each, including host immunoglobulins, complement proteins, cell matrix and cytoskeletal proteins, as well as antimicrobial peptides.


Pssm-ID: 239804 [Multi-domain]  Cd Length: 186  Bit Score: 42.79  E-value: 2.55e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 116174734 684 LNIYFASSVREDLAGAATWPWDKDAVTHLGGIVLSPAYYG---MPG--HTDTMIHEVGHVLGLYH 743
Cdd:cd04277   65 IRFGNSSDPDGNTAGYAYYPGSGSGTAYGGDIWFNSSYDTnsdSPGsyGYQTIIHEIGHALGLEH 129
ZnMc_MMP_like cd04268
Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix ...
703-749 5.44e-04

Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases.


Pssm-ID: 239796 [Multi-domain]  Cd Length: 165  Bit Score: 41.33  E-value: 5.44e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 116174734 703 PWDKDAVT---HLGGIVLSPAYYGMPGH--TDTMIHEVGHVLGLYHVFKGVS 749
Cdd:cd04268   65 PSQVDPLTgeiLLARVYLYSSFVEYSGArlRNTAEHELGHALGLRHNFAASD 116
LamG smart00282
Laminin G domain;
348-430 1.48e-03

Laminin G domain;


Pssm-ID: 214598  Cd Length: 132  Bit Score: 39.63  E-value: 1.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174734   348 KKATILISHSRYQPGTWTHVAATYDGRHMALYVDGTqvaSSLDQSGPLNSPFMASCRSLLLGG-------DSSEDGHYFR 420
Cdd:smart00282  45 GPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG---NRVSGESPGGLTILNLDGPLYLGGlpedlklPPLPVTPGFR 121
                           90
                   ....*....|
gi 116174734   421 GHLGTLVFWS 430
Cdd:smart00282 122 GCIRNLKVNG 131
ZnMc smart00235
Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a ...
720-743 9.77e-03

Zinc-dependent metalloprotease; Neutral zinc metallopeptidases. This alignment represents a subset of known subfamilies. Highest similarity occurs in the HExxH zinc-binding site/ active site.


Pssm-ID: 214576 [Multi-domain]  Cd Length: 139  Bit Score: 37.33  E-value: 9.77e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 116174734   720 AYYGMPG------------HTDTMIHEVGHVLGLYH 743
Cdd:smart00235  65 SHAGRPGgdqhlslgngciNTGVAAHELGHALGLYH 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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