Conserved Protein Domain Family
CHASE2
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smart01080: CHASE2 
CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria.
Specifically, CHASE2 domains are found in histidine kinases, adenylate cyclases, serine/threonine kinases and predicted diguanylate cyclases/phosphodiesterases. Environmental factors that are recognised by CHASE2 domains are not known at this time.
Links
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Statistics
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PSSM-Id: 215016
Aligned: 135 rows
Threshold Bit Score: 83.9578
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
NP_969440  46 EVLDLRFNDIKYK-----LRPPS----QSQ--APVALIAID-----DA------S-----------------------VR 80  Bdellovibrio bacte...
NP_713466 116 ekeseegtieYTR-----YNPPP----GAR--QDIQIIGIT-----TT------S-----------------------LE 150 Leptospira interro...
YP_616817  31 gevadRVLDAVVG-----RLAMR----PVS--GEVVIVALD-----ER------T-----------------------IT 65  Sphingopyxis alask...
NP_924095  37 ASLDRQSRDWLSR-----WQLQA----SLP--EAVTIVGID-----GEledrrtS-----------------------DR 77  Gloeobacter violac...
NP_419417 126 GEPDREMLSTAFK-----LTKDA----VVGdgPPAVLLDID-----DA------T-----------------------LR 162 Caulobacter cresce...
NP_868023 104 EFSRMVSDAVMLR-----EGGPRlgarELS--GDVVLVSFG-----TS------S-----------------------AE 142 Rhodopirellula bal...
YP_477676  51 VRMESDAQEWLYA-----WRGPQ----QPS--PEVVIVGIDgriglDR------DsgaehvpangnsgqgesngrtsgAE 113 Synechococcus sp. ...
YP_459628  95 QDVYAQTYMEQARkagrdEDGDP----VGR--QDISVVLLG-----ET------G-----------------------LD 134 Erythrobacter lito...
YP_497597  26 APIDHIFWNTRSKfg----------shAAS--GATVIVSFD-----DG------V-----------------------HA 59  Novosphingobium ar...
YP_844692  35 EPWNSQLVDKLFVlrssvSWLRP----VYD--PTVVHVDIT-----NS------T-----------------------LH 74  Syntrophobacter fu...

NP_969440  81 ------EI-------GR----FP---------WSREMVAEMTDNLL-K----L---GAKSVS--FDVIFAEPETSnpqad 124 Bdellovibrio bacte...
NP_713466 151 ------KLq------GK----WP---------LPWKYYANIID-IF-K----N---TSNQLM--FDIFFVDYKPG----- 189 Leptospira interro...
YP_616817  66 ------QS-------PS----RN---------FSMTQYANVVEAVD-K----A---GARRLF--IDFYFDRREAD----- 104 Sphingopyxis alask...
NP_924095  78 ------RL-------PD----FY---------LEPDTYAVLLERLLgD----A---KAKAVL--LALPRSFSKVS----- 117 Gloeobacter violac...
NP_419417 163 ------QQtyvpvrpGR----EPta------sAPRGMLADLLKFIL-AtpssS---MPGAVI--VDVDIGAPAPD----- 215 Caulobacter cresce...
NP_868023 143 ------RL-------GK----KP----------DLETDRKLYENLM-N----A---DAKVVAdlRNLVCTDPDDFe---- 183 Rhodopirellula bal...
YP_477676 114 ------HL-------GQhqvdFL---------LERANYAGLTLRLL-Ee---A---EARVVV--LNLPSSFVVPQ----- 157 Synechococcus sp. ...
YP_459628 135 mlapgrTL-------DP----MDmfdlvdqiaYAHLAMDEPEDGVD-S----EkprPPRAIF--VDMSLGQFAPPqltgq 196 Erythrobacter lito...
YP_497597  60 s------E-------KS----VP----------STSQVADVLDRLA-S----Q---MPRRIY--LDSQLKFGVDR----- 97  Novosphingobium ar...
YP_844692  75 r------L-------DD----FY---------LKRVQFARVVRNLA-A----M---RTAAQA--YDFIFGTKPDDrddpa 118 Syntrophobacter fu...

NP_969440 125 tafakviadnp-------drivlgtfsenlidfQ---PHQDLCVAEAFLATGg----------------dQLVKINPSFA 178 Bdellovibrio bacte...
NP_713466 190 ---------------------------------Q---T---EEMAQALAKNPqvmfdypmetsleskssiLNLEKRIEIL 230 Leptospira interro...
YP_616817 105 ---------------------------------H-----DFPRFVSAVKNMGd----------------rIVLAVSTRQV 130 Sphingopyxis alask...
NP_924095 118 ---------------------------------Gi--GEQDRRLRAVIDRYNg----------------rVVLEAVPFN- 145 Gloeobacter violac...
NP_419417 216 ---------------------------------D---PQGSEALRQALENWAa----------------tPHAPRLIIAR 243 Caulobacter cresce...
NP_868023 184 --------------------------------aS---VRPTLDLIQQVAPKRn----------------lVRDVYLTLDV 212 Rhodopirellula bal...
YP_477676 158 ---------------------------------NlgnENLDAPLRQVVQRYPd----------------rLVLATRSSES 188 Synechococcus sp. ...
YP_459628 197 ellalgeaeraacelgnraeiespfrcmlyffaQ---MTAYEKWRDDIRCQDn----------------pVAKAMCIRSA 257 Erythrobacter lito...
YP_497597  98 --------------------------------------AGDEALARALKRLQp----------------dATLVLRSREI 123 Novosphingobium ar...
YP_844692 119 l-------------------------------iaaarEAGNAYFGLALALSPq----------------rAARETKVDEE 151 Syntrophobacter fu...

NP_969440 179 IDEETH--AID---DL------N----WAPlfttlfqtiqereqndllkslgkkspeelstfqknnlkarqslalfeyck 243 Bdellovibrio bacte...
NP_713466 231 RKFKLE--NVE---DPgdagrtW----LKF-------------------------------------------------- 251 Leptospira interro...
YP_616817 131 PGREDK--VTT---FP------------SK-------------------------------------------------- 143 Sphingopyxis alask...
NP_924095 146 -GEVDI--FNN---LL------P----YGD-------------------------------------------------- 159 Gloeobacter violac...
NP_419417 244 EAFAPAvlGLE---GE------S----PTL-------------------------------------------------- 260 Caulobacter cresce...
NP_868023 213 DYKVVE--SYH---DC------IvhhgMSF-------------------------------------------------- 231 Rhodopirellula bal...
YP_477676 189 FGRSEI--NIYnhfLP------F----SSL-------------------------------------------------- 206 Synechococcus sp. ...
YP_459628 258 GGLPLV--FAD---IS------K----ETElgana--------------------------------------------- 277 Erythrobacter lito...
YP_497597 124 GGLKHK--FGpa-------------------------------------------------------------------- 133 Novosphingobium ar...
YP_844692 152 ALRTLA--STK---WV------L----NVEgdvtgf-------------------------------------------- 172 Syntrophobacter fu...

NP_969440 244 twltkhdiflspeniaqVETLYHDVVAEAPDLKNLK-----Fedlrsrirkaykthpipqygewtpntlelqtpanytss 318 Bdellovibrio bacte...
NP_713466 252 -----------------PQPPIEPVAEKASGLGFANi----K-------------------------------------- 272 Leptospira interro...
YP_616817 144 -----------------KFGPDVPIASIAVESEFWQ-------------------------------------------- 162 Sphingopyxis alask...
NP_924095 160 -----------------DLRLTVPLEQMVGVRQFLE-------------------------------------------- 178 Gloeobacter violac...
NP_419417 261 -----------------PQTDYDPIVAKAQNIHWST-----V-------------------------------------- 280 Caulobacter cresce...
NP_868023 232 -----------------KSPTMVNRHSRIFPIAMHDyfalrE-------------------------------------- 256 Rhodopirellula bal...
YP_477676 207 -----------------RLEYLVPPEHVQGVVQH-------R-------------------------------------- 224 Synechococcus sp. ...
YP_459628 278 ------------aagfaALGQIAILASVSYDSEIDY-----Plv------------------------------------ 304 Erythrobacter lito...
YP_497597 134 ---------------dfDIPPKGTIDEVPIVLSAWD-----Gn------------------------------------- 156 Novosphingobium ar...
YP_844692 173 ------------hrgsaPLATFPALAAVSKGLGHISi------------------------------------------- 197 Syntrophobacter fu...

NP_969440 319 fiaqL---DADGYVRRYPL---F---F----RS-------GHkl------------------gtSFIPSMALQSFLLSGP 360 Bdellovibrio bacte...
NP_713466 273 ----K---DESGLNRRMPL---V---A----KLmnagplrET----------------------EYYPSIDLIIACNYLG 313 Leptospira interro...
YP_616817 163 -------------VWRVPI---A---Y----RA-------EG----------------------KLLPTFASIMAGKSSD 190 Sphingopyxis alask...
NP_924095 179 --------DPDGIVRRTRTevnL---D----RA-------DG----------------------GGIQTFFSADFLAVRK 214 Gloeobacter violac...
NP_419417 281 ----RvlaDLHGTVREFLP---F---QcvvqNG-------RV----------------------APLYSAALLASEALSG 321 Caulobacter cresce...
NP_868023 257 ----T---TPFWVVQRLTD---Q---P----NG-------GQtgfyerl---------dqagliHHWLEFFPQMINLLQS 303 Rhodopirellula bal...
YP_477676 225 ----V---DSAGILRQAQL---RglyL----RR-------DS----------------------QEEQMFASVEALAFAK 261 Synechococcus sp. ...
YP_459628 305 ---sP---QSEQARRNVRY---Q---L----HP-------APllyaiyceeeaaiaansanderIAQPCADTPIEPPDPD 361 Erythrobacter lito...
YP_497597 157 ----F---MEFGVSSPYKI---T---I----Gg-------------------------------KVYPTFAAVLAERFDG 188 Novosphingobium ar...
YP_844692 198 ---kI---DADGIVRRVPL---L---V----RY-------EDg----------------------FYPSLPFRVICDYLG 232 Syntrophobacter fu...

NP_969440 361 Y-------------------RAel----------------kMAT-AK-------------------------DGEKSLEQ 379 Bdellovibrio bacte...
NP_713466 314 VdvkrdvevvmgkyvkikniPQ-------------------KTL-TH-------------------------FDRKTLKM 348 Leptospira interro...
YP_616817 191 T-------------------PK-------------------S-------------------------------------- 194 Sphingopyxis alask...
NP_924095 215 F-------------------LG-------------------RSP-RG-------------------------FGP----- 225 Gloeobacter violac...
NP_419417 322 K-------------------PP-------------------AGS-PAalafeeapkacanshahahaanhhmDEDGEVIH 362 Caulobacter cresce...
NP_868023 304 P-------------------SG-------------------EET-IA-------------------------PNPKLADY 319 Rhodopirellula bal...
YP_477676 262 Y-------------------DP-------------------ERAsRW-------------------------FRERGLQP 278 Synechococcus sp. ...
YP_459628 362 G-------------------ANwrssywgwsqafsspleiiWGI-GA-------------------------PSDFTIER 396 Erythrobacter lito...
YP_497597 189 L-------------------QP---------------------------------------------------------- 191 Novosphingobium ar...
YP_844692 233 V-------------------PP---------------------Q-HI-------------------------RVVPAEAV 246 Syntrophobacter fu...

NP_969440 380 FNIYDTSKEPEIKI-------ASYPVDGSG------Qlliny----ygrqmSLP----YVSAKEL-----FND----E-- 427 Bdellovibrio bacte...
NP_713466 349 ETKDIMNRPNEKRE-------VVIPIDADG------Qmq-----------iNFPgglySFRAHEI-----FEA----A-- 393 Leptospira interro...
YP_616817 195 -----------------------FRLDLSY------Dt------------rTIT----EYSAADL-----LSG----K-- 218 Sphingopyxis alask...
NP_924095 226 -------------D-------ERIHYYGPAg--------------------TFV----RYPVEQIcppspLEGcmplK-- 259 Gloeobacter violac...
NP_419417 363 FQLSLAPRHEEPAW-------ALLPASWPG------Fktcga----dsdasVFR----RVSASDI-----LAA----G-- 410 Caulobacter cresce...
NP_868023 320 QVGHNEVNWIGFGSefptvspAGIWVDYGF------Np------------sDLT----RLEYGDL-----AEG----D-- 366 Rhodopirellula bal...
YP_477676 279 IQFNPLGSQHGIPI-------IPIERVCPPavlqagSg------------sVAP----MINPSQA-----CRG----Qeg 326 Synechococcus sp. ...
YP_459628 397 AAISQTLDAADECE-------PAQDTDGVL------LtlvrrmfagidlgaRTP----CFYSRSL-----TYE----Q-- 448 Erythrobacter lito...
YP_497597 192 ---------SFAPE-------YLLDLD------------------------SVP----QLSATKF-----LRG----D-- 216 Novosphingobium ar...
YP_844692 247 VLQQARRPGAPPRD-------IRIPIDRAG------Smivsf----igpweTMK----HYNFADV-----YIA----S-- 294 Syntrophobacter fu...

NP_969440 428 ----TTvkvttsvmnqeskqlvietkeydkKE---FFKDRSLIVG----ATAVGLYD--LRN--TPL-EANYPGPELHLT 491 Bdellovibrio bacte...
NP_713466 394 ----TEw----------------------nEEtasQFQNTIFLVAmyyaTGAGAAKD--THL--SPF-GD-MSGIEHHAA 441 Leptospira interro...
YP_616817 219 ----Ig------------------------AR---ELAGKDVIFA----PTAPSFQD--YFY--LPG-HDRVPGGFIHVI 258 Sphingopyxis alask...
NP_924095 260 ----DPa----------------------iLK---HFTGKLVIVG-----HVDGHPEasIVQ--TPF-GP-MDALNVHAN 301 Gloeobacter violac...
NP_419417 411 ----PDa----------------------gRE---FLCRRLAIIG----GTNSVAND--FQQ--TPL-HM-MSGPMILTN 451 Caulobacter cresce...
NP_868023 367 ----FD------------------------PE---LVRGKAVLIDl--eMSFVPSSD--RYD--IPIrDRQADALDVTGV 409 Rhodopirellula bal...
YP_477676 327 ipplDPe----------------------vAD---QLRDKIVLVG----FVG-GYPE--TFPvrTAD-GSQIAAVELQAQ 373 Synechococcus sp. ...
YP_459628 449 ----VAdasp-----------------dlvGM---AFSDTLVMIG----LSTQAAND--TIE--TEA-FGaIPGVFWHAM 495 Erythrobacter lito...
YP_497597 217 ----FPn---------------------------gLLTGRTVIVNs--sGTAPAIGL--YGR--GRV-HP----LALDLA 254 Novosphingobium ar...
YP_844692 295 ----DSrdel-----------------evwRD---ELEGKIVVVS----DVSTGSTD--LRP--VPT-DTeYPLSGMHAN 341 Syntrophobacter fu...

NP_969440 492 MLANLF-DK--------HFLKQWNqeAQWLPVVLFVGGTALAV 525 Bdellovibrio bacteriovorus HD100
NP_713466 442 AINTIL-NQ--------DFLFELPlwGEFLIIILVGMLAGVVq 475 Leptospira interrogans serovar Lai str. 56601
YP_616817 259 AAETLK-RG--------DPI--DIgwLPPLLVAIALTGITLLr 290 Sphingopyxis alaskensis RB2256
NP_924095 302 LVADLL-QG--------HTDRVLPplWDLVLILSFGVLSGWCL 335 Gloeobacter violaceus PCC 7421
NP_419417 452 AVRGISgTD--------GGLRQAGfpAQIAALLCISLMITFGF 486 Caulobacter crescentus CB15
NP_868023 410 AIETLL-NG--------ITMQMAAwyVTPALLIGFSVLACVIA 443 Rhodopirellula baltica SH 1
YP_477676 374 VLSSLL-TG--------Evyqsvpggvavavvlllgvgtglll 407 Synechococcus sp. JA-2-3B'a(2-13)
YP_459628 496 ALDNLI-VKgadyahseRSLFGGYmtDQDLFEFGALFLTLVGV 537 Erythrobacter litoralis HTCC2594
YP_497597 255 GADALR-KP----------LALALgsYPLLMLFWLMVRTTSRL 286 Novosphingobium aromaticivorans DSM 12444
YP_844692 342 AIHTIL-TE--------DFFRESTaaEAFLVELSLMACLIVLA 375 Syntrophobacter fumaroxidans MPOB
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