1Z60


Conserved Protein Domain Family
C1_4
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smart01047: C1_4 
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TFIIH C1-like domain
The carboxyl-terminal region of TFIIH is essential for transcription activity. This regions binds three zinc atoms through two independent domain. The first contains a C4 zinc finger motif, whereas the second is characterised by a CX(2)CX(2-4)FCADCD motif. The solution structure of the second C-terminal domain revealed homology with the regulatory domain of protein kinase C.
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Statistics
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PSSM-Id: 214993
Aligned: 27 rows
Threshold Bit Score: 51.5935
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1Z60_A        18 CYGCQGEL------------------KDQHV----YVCAVCQNVFCVDCDVFVHDSLHSCPGCI 59  human
XP_572800    402 CFGCDSEFsdatain-----agvaqvEDGVSptgrYRCAKCKHDFCADCDLYIHDTLHTCPGCs 460 Cryptococcus neoformans var. ne...
XP_314533    353 CYACQKTLas---------------gTDKMV----YECDACKQVFCIDCDIFIHETLHSCVGCT 397 Anopheles gambiae str. PEST
XP_002085951 356 CYGCAKALgq---------------gVDKVAdkvvFRCGFCKQFFCVDCDIFIHDTLHACVGCN 404 Drosophila simulans
XP_645146    369 CIGCLSs-------------------SEKSIlslfFSCPRCQEIFCLDCDLFIHESLHNCPGCE 413 Dictyostelium discoideum AX4
NP_683275    362 CFGCQQSLig---------------aGNKPVpc--vTCRKCKHYFCLDCDIYIHESLHNCPGCE 408 thale cress
XP_761428    453 CFSCNVPFpslqerkeksaaankaleEAGLSpssrYRCGRCAIDFCLECDAFVHEQLHEpsdsf 516 Ustilago maydis 521
XP_626865    365 CELCESQFsnnv----------ylnsGSRSNiinkYLCTNCSTQFCNECCKFIFNTLHQCPICC 418 Cryptosporidium parvum Iowa II
NP_001071980 341 CYSCCKP-----------------------IttatYVCEQCAISFCMDCNAFIHETLHSCPGCI 381 Ciona intestinalis
NP_499239    336 CYACETRLsg-----------------------egFRCGSCQLVFCLDCDTLLHESLHVCPGCN 376 nematode
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