2P64


Conserved Protein Domain Family
Beta-TrCP_D
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smart01028: Beta-TrCP_D 
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D domain of beta-TrCP
This domain is found in eukaryotes, and is approximately 40 amino acids in length. It is found associated with F-box domain, WD domain. The protein that contains this domain functions as a ubiquitin ligase. Ubiquitination is required to direct proteins towards the proteasome for degradation. This protein is part of the WD40 class of F box proteins. The D domain of these F box proteins is involved in mediating the dimerisation of the protein. Dimerisation is necessary to polyubiquitinate substrates so this D domain is vital in directing substrates towards the proteasome for degradation.
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Statistics
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PSSM-Id: 198096
Aligned: 7 rows
Threshold Bit Score: 65.592
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2P64_A        13 VKYFEQWSESDQVEFVEHLISQXCHYQHGHINSYLKPXLQ 52  human
XP_001511460 334 VKYFEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQ 373 platypus
NP_001027626 156 TKHFDTWSEQEQVDFVEHLILRMCHYQHGQINCFLKPMLQ 195 Ciona intestinalis
XP_001656745  33 LSYFAKWNEADQVDFVEQLLSRMCHYQHGHINAYLKPMLQ 72  yellow fever mosquito
NP_495285     41 IEEVLKWSEHEQLDFMDKIVHRLSHYQLGKVDNFIRPMLQ 80  nematode
BAD90368     172 VKYFEQWSESDQVEFVEHlISQMCHYQHgHINSYlkpmlq 211 house mouse
XP_001979334  46 FQYFTQWSESGQVDFVEHLLSRMCHYQHGQINAYLKPMLQ 85  Drosophila erecta
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