Conserved Protein Domain Family
Arfaptin
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smart01015: Arfaptin 
Arfaptin-like domain
Arfaptin interacts with ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules. The structure of arfaptin shows that upon binding to a small GTPase, arfaptin forms an elongated, crescent-shaped dimer of three-helix coiled-coils. The N-terminal region of ICA69 is similar to arfaptin.
Links
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Statistics
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PSSM-Id: 214974
Aligned: 29 rows
Threshold Bit Score: 217.139
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
CAG00443      94 NTYKCTKQMISERFGRGSR---------TVDLELEAQIEVLRDTKRKYENVLRLARALTNHFYNMVQTQHALGDTFADLS 164 spotted green p...
XP_003355393  99 ivlKKVKHRLVENMSSGTAdalglsraiLCNDGLVKRLEELERTAELYKGMTEHTKNLLRAFYELSQTHRAFGDVFSVIG 178 pig
XP_001381027 116 IVLKKVKHRLVENMSSGTAdalglsraiLCNDGLVKRLEELERTAELYKGMTEHTKSLLRAFFDLSQTHRAFGDVFSVIG 195 gray short-tail...
CAF90434      86 vakmiqavqgeatihynklqadpkqgksldiDGLVKKLEELEKTAELYKGLMEHTKRLLRAFFELSQSHRAFGDVFSVIG 165 spotted green p...
XP_002132162 113 IVLKKFKHRLVEQMDSGTAdalglsraiLCNDILIKRLQDLERTGMVYVGLMEHVKKLLKAYFNLCKTHREFGDIFSIIG 192 Ciona intestinalis
XP_317666    110 IVLKKMKHRLVERMSSSTAdtlglsraiLCNDSLVKRLQELERTETMYKGLVDHARRMLKAHFDVLQTYQAFGNIFASIS 189 Anopheles gambi...
XP_001969713 191 IILKKLKHRIVDNLSSNTAdtlglsraiLCNDSLVKRLEELEGTELMYKGLVEHARRMLKAYYDLLQTYKSFGDCFTQIS 270 Drosophila erecta
NP_871661     72 GTFKNSKQQLLEHMGKIDK---------TVDPEFEAQCEVLKDIHRRYGLVVAAAKNFSHVLTQMAEAEKKLSESFYQLS 142 nematode
NP_001070804 114 ldivlkkvkhrlvenmssgtadalglsrailcndglvkrleelektaelykglmehtkrllrafyelsqthrafgdvfsv 193 zebrafish
CAF92520       1 ------rQALAERLGRGSR---------TVDLDLESRLELLRHERQRYEQVGRLARTLAAQLAQFAATQRSLGDAFAELG 65  spotted green p...

CAG00443     165 QKSPEl---RdE-FGYNAETQKLLCKNGETLLGAVNFFVSSINTLVNKTMEDTLMTIKMYENARLEFDAYRSDLEElSMG 240 spotted green p...
XP_003355393 179 VREPQpaasE-A-FVKFADAHRSIEKFGIRLLKTIKPMLTDLNTYLNKAIPDTRLTIKKYLDVKFEYLSYCLKVKE--MD 254 pig
XP_001381027 196 VREPQpaasE-A-FVKFAEAHRNIEKFGIRLLKTIKPMLTDLNTYLNKAIPDTRLTIKKYLDVKFEYLSYCLKVKE--MD 271 gray short-tail...
CAF90434     166 VREPQaaasE-A-FVKFADAHRNIEKYGIRLLKTIKPMLHDLNTYLHKAIPDTKLTIRKYLDVKFEYLSYCLKVKE--MD 241 spotted green p...
XP_002132162 193 VREPHpnggE-A-FLKFSSSHREFEKSGFTLLKTLKPMLNDLNTYLNKAIPDTKLTIKKYADVKFEYLSFCLKVKE--LD 268 Ciona intestinalis
XP_317666    190 VREPQprasE-A-FRIFGELHRNMEKDGIKMIKTLKPILADMGTYLHKAIPDTKLTVKRYADAKFSYLSYCLKIKE--MD 265 Anopheles gambi...
XP_001969713 271 VHEPQqrasE-A-FRTFGEFHRTLEKDGLGIIKQIKPVLADLGTYLNKAIPDTKLTVRRYADAKFTYLSYCLKVKE--MD 346 Drosophila erecta
NP_871661    143 MKEEQi---K-AqCTMTSETMRGVGEQAASLDACLRYFISSMETVYNQTITDTLHTIYNTESARIEYDVDRNDISAaTNP 218 nematode
NP_001070804 194 igvrepqaaaseafvkfaeahrnmekfgiqllktikpmlhdlntylhKAIPDTKLTIRKYLDVKFGYLSYCLKVKE--MD 271 zebrafish
CAF92520      66 LRTPPl---H-VeFSVNADAQKFLSKSGKTLADAIGAFTADMDTLINKTMEDTLVNARQYQAARVEYDAFRVDLEElNLR 141 spotted green p...

CAG00443     241 PRDAAAM-------------ARIDAAQQQYQVQREKYERLRSDVTIKLKFLEENKvgvrlglpgpehsdltlrfgshrcv 307 spotted green p...
XP_003355393 255 DEEYSCIalgeplyrvstgnYEYRLILRCRQEARARFSQMRKDVLEKMELLDQKH------------------------- 309 pig
XP_001381027 272 DEEYSCIalgeplyrvstgnYEYRLILRCRQEARTRFAKMRKDVLEKIELLDQKH------------------------- 326 gray short-tail...
CAF90434     242 DEEYSSIamgeplyrvstgnYEYRLVLRCRQEARARFAKMRKDVMEKIELLDQKH------------------------- 296 spotted green p...
XP_002132162 269 DEEYSYAalqeplyrvetgnYEYRLVLRCRQQARAQFAKLRKDVMEKLELLDNKH------------------------- 323 Ciona intestinalis
XP_317666    266 DEEHGYAaiqeplyrvetgnYEYRLILRCRQEARLKFAKLRSDVLEKIELLECKH------------------------- 320 Anopheles gambi...
XP_001969713 347 DEEHGFAalqeplyrvetgnYEYRLILRCRQDARSKFAKLRTDVLEKMELLECKH------------------------- 401 Drosophila erecta
NP_871661    219 PQGQLTK-------------NLPVGATEKCEEKKAKYEKLKNDAKIKMRLLEENR------------------------- 260 nematode
NP_001070804 272 DEEYSCIalgdplyrvstgnYEYRLVLRCRQEARARFAKMRKDVLEKIELLDQKH------------------------- 326 zebrafish
CAF92520     142 PRDAGTL-------------ARLERAQRDFQDQRDRYQRVRRDLSVKVRLLEHNK------------------------- 183 spotted green p...

CAG00443     308 pqVKVMHKQLLLFHNAISAYFAGNQQQL 335 spotted green pufferfish
XP_003355393 310 --VQDIVFQLQRFVSTMSKYYNDCYAVL 335 pig
XP_001381027 327 --VQDIVFQLQRFVSTMSKYYDDCYAAL 352 gray short-tailed opossum
CAF90434     297 --VQDIVFQLQRFVSGMSHYYDECYAVL 322 spotted green pufferfish
XP_002132162 324 --VQDIVFQLQRFVSAVSQYHESCHESM 349 Ciona intestinalis
XP_317666    321 --ARDLASQLRKFIEGLATLASETVERL 346 Anopheles gambiae str. PEST
XP_001969713 402 --AMDLNKQLRSLLESLAELHRSLVDRL 427 Drosophila erecta
NP_871661    261 --ISVVAAQLEKLQSALAAYYSGNAKLL 286 nematode
NP_001070804 327 --VQDIVFQLQRFVSGMSHYYDDCYAVL 352 zebrafish
CAF92520     184 --VKVLHQQLWLLHGAMAAHSLSCHAHL 209 spotted green pufferfish
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