3N72,1USV


Conserved Protein Domain Family
Aha1_N
?
smart01000: Aha1_N 
Click on image for an interactive view with Cn3D
Activator of Hsp90 ATPase, N-terminal
This domain is predominantly found in the protein 'Activator of Hsp90 ATPase', it adopts a secondary structure consisting of an N-terminal alpha-helix leading into a four-stranded meandering antiparallel beta-sheet, followed by a C-terminal alpha-helix. The two helices are packed together, with the beta-sheet curving around them. They bind to the molecular chaperone HSP82 and stimulate its ATPase activity.
Links
?
Statistics
?
PSSM-Id: 214964
Aligned: 42 rows
Threshold Bit Score: 71.1435
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
3N72_A        19 ERNYNKWAESYIKYNLSNLKI------EKED---------------------------LTIYFDNL-QVS--GNACVSIR 62  malaria parasit...
NP_506715     29 EKNATPWSLNRLRELLTGFs------sEDGP---------------------------IVVTIDEIkKID--GEATANNR 73  nematode
NP_566410     29 ETNCLEWSRNFFTKQFSGVDIl----sGEGN---------------------------LFIKVSKIeKVE--GEAYVNVR 75  thale cress
XP_646215     29 EKDCLPWSKNTIGGLFDKKVIq-----ETDE---------------------------YTFKISSTpVVS--GECTANNR 74  Dictyostelium d...
XP_628382     24 EKDYSKWGKEELRTIMESIKYs----fELEA---------------------------PKFELS-FsDLSirGEASISVR 71  Cryptosporidium...
XP_001388427 363 DKDVSETARSTLKRILLEGDGrhftgkVSEKgd-----------------------lnVSISIESVdNLS--GEASVAMI 417 Cryptosporidium...
XP_628382    240 EKPETNWVISTL--TKMIEDLstnksdSGN----------------------------SDLIPISFsEVKvtGEASSSVR 289 Cryptosporidium...
XP_001706051  25 EKDFTDWAITEIKKRLt---------fQHTL---------------------------SGTEVIDVsVTEakGEAFKNVR 68  Giardia lamblia...
XP_001350073 360 EKDMTKWAKNKIEECLKNIHFk----nDDDSdflnlnnqngnnfssvnypdilpiqylSKIQLNDVkNLS--VDAQIVVI 433 Plasmodium falc...
NP_200619     60 EKSLTKWATDRLKELLGSVGSl-----QFSS---------------------------GKAEIIDVnRCV--GDAFLVTV 105 thale cress

3N72_A        63 KGKQINSFEYI----IKFEWL------------------------------YSK---Kk----EGK----Dyf--gGSVE 95  malaria parasit...
NP_506715     74 KAKLIFLFEWV----IEGTFI------------------------------ARV---Sg----SED----Ey---kGTFD 105 nematode
NP_566410     76 KGKIIPGYELN----VSLSWE------------------------------GEA---Kd----SDGktllKa---dGLVD 111 thale cress
XP_646215     75 KGKTIFLYELD----VKMNWEvvfkpkkvlppppttkskgaaddideedddGKP---AepiitQKK----Ti---sGEFT 140 Dictyostelium d...
XP_628382     72 KKQPILAYEFS----ISGTWS------------------------------VNE---Ve----SQK----Kii--lGQIT 104 Cryptosporidium...
XP_001388427 418 RGTRRFLFDFS----VTLKCD------------------------------YTLdnnEn----EKY----S-----FSIN 450 Cryptosporidium...
XP_628382    290 KGKKICVLDCS----VFGRFN------------------------------AIIpegMl----SQN----KesnliGSFS 327 Cryptosporidium...
XP_001706051  69 KGKLRSSYDFK----IKMNVty----------------------------------kAa----DKD----Pl---eGTAV 99  Giardia lamblia...
XP_001350073 434 RGTKRHIFELScnldITIFInitel-----------------------------------------------hvhkVLVE 466 Plasmodium falc...
NP_200619    106 RNKKRVGYTYE----LSLKVE------------------------------GEws-fEe----NMK----Kv---kGSLE 139 thale cress

3N72_A        96 IPDFSTFSlEEND----YA----INIERTDESE--N--L---RF-IYDsILKKEGK------EKIKECLknfqeDLLKH 152 malaria parasite...
NP_506715    106 IPNLSDEN-DASE----VD----VNSSLSGNGP--M--A---HQ-IRQ-VLNKSFI------AKIQDVMgiyirELKEE 160 nematode
NP_566410    112 MPYISDEN-ADED----PE----IRFSVKDEGP--I--G---RT-LKE-AMVKKGK------EIILEKVrvyveAMarg 166 thale cress
XP_646215    141 VPYISDEN-GDEAptvrYT----INTTADNDET--KqsI---NM-VQS-LLKSHGV------PFVQSQCqefikLLKKE 201 Dictyostelium di...
XP_628382    105 IPEFSVDN-YEED----FP----IMITCKEVIS--K--DynsEL-ILS-EMKKKVV------VKLRKKLmefhnKLLNK 162 Cryptosporidium ...
XP_001388427 451 IPSLTSMC-NEDD----VFgikdCSINFTGKHKhnH--D---LTlIKD-FVFNSYCl-----IHLKDCI-----NLLTN 508 Cryptosporidium ...
XP_628382    328 LTEINMMD-THDY----GKki------nyESAElgL--K---TAdIPE-FIDFKGKiekqilGSLDSAIqkfcvEFLnk 389 Cryptosporidium ...
XP_001706051 100 LEPFCDTE-PEDW----EFt---FKVTDPAKYApdL--V---GEaKKA-ITSAPFL------ERMKEWCkvyeeive-- 156 Giardia lamblia ...
XP_001350073 467 IKELSSEL-EAGK----TWk--nFITIKKNDKL--K--I---PDnLFN-DIYDFVI------EKVQQQIknftqEYnkm 524 Plasmodium falci...
NP_200619    140 IPEFSFGE-LDDL----E-----VDVKLSEDKElsQ--Q---LKqRIK-LDMKQFL------EPIRLKLglfeqELKdr 196 thale cress
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap