This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli.
A lesion in the template strand blocks the RNA polymerase complex (RNAP). The RNAP-DNA-RNA complex is specifically recognised by the transcription-repair-coupling factor (TRCF) which releases RNAP and the truncated transcript.
Jiyao W et al.(2023). "The conserved domain database in 2023.",