Conserved Protein Domain Family
s48_45
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smart00970: s48_45 
Sexual stage antigen s48/45 domain
This family contains sexual stage s48/45 antigens from Plasmodium (approximately 450 residues long). These are surface proteins expressed by Plasmodium male and female gametes that have been shown to play a conserved and important role in fertilisation.
Links
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Statistics
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PSSM-Id: 214945
Aligned: 29 rows
Threshold Bit Score: 41.696
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001351365 1316 KIKGCSFQIDED-------------PLlyk------------------------------------dySEKESFLSNKII 1346 Plasmodium fa...
XP_001349600  733 KINGCAFLDEDEeeekygnqieedeHN-----------------------------------------EKIKMKTFFTQN 771  Plasmodium fa...
ABO41480       24 tqYVCDFYFNPL-------------TN-----------------------------------------VKPTVVGSSEIY 49   malaria paras...
ZP_03796621   460 KILIWDFKNELR-------------KE-----------------------------------------GFFTQQIKNDSS 485  Borrelia burg...
AAL74349       45 IGYKCNFSNEGV-------------HN----------------------------------------------LKPDMRE 65   malaria paras...
XP_966115     169 ILYGCDFDHDEK-------------LMknktaftnfydkqkilplignnnndddnndddnnndnnnndNNNNNNNNNNNN 235  Plasmodium fa...
AAL74380      294 VIHGCNFSSNVS-------------SKht--------------------------------------fTDSLDISLVDDS 322  malaria paras...
XP_001349600 2666 IIHGCDFLYLEN-------------QTndai---------------------------------snnnNNSYSIFTHNKN 2699 Plasmodium fa...
ABO41483      275 HIDGCDFTKPKG-------------KGi---------------------------------------yKNGFIINDIPNE 302  malaria paras...
XP_001349599 1807 KILGCDFIDTPS-------------TLssastless-----------------------ygshassplSSSHHVLHNDNQ 1850 Plasmodium fa...

XP_001351365 1347 LN----NsnrntECVLHAS-N------------------------EIVGFQCGppyksydniqyrhltnksndiqknifg 1397 Plasmodium fa...
XP_001349600  772 IY----KknniyPCYMKLY-Sg-----------------------DIGGILFP--------------------------- 796  Plasmodium fa...
ABO41480       50 EE----Vg-----CTINNP-Tl----------------------gDHIVLICPkknn----------------------g 75   malaria paras...
ZP_03796621   486 QYinarKn----NISFSIKrEg-----------------------SKITFECP--------------------------- 511  Borrelia burg...
AAL74349       66 RR----Si----FCTIHSY-Fi----------------------yDKIRLIIPkks------------------------ 90   malaria paras...
XP_966115     236 NN----NnnnniTCNVTIK-Ks----------------------qVYLGIICP--------------------------- 261  Plasmodium fa...
AAL74380      323 AH----Is-----CNVHLS-Epk--------------------ynHLVGLNCP--------------------------- 345  malaria paras...
XP_001349600 2700 TE----Nn---lICDISLI-Pk-----------------------TVIGIKCP--------------------------- 2721 Plasmodium fa...
ABO41483      303 EE----Ri---cTVHLWNK-Kn----------------------qTIAGIKCP--------------------------- 325  malaria paras...
XP_001349599 1851 GH----DvhminHIDISNK-KnsfefeieliegkntycnieaienDIVGFSCP--------------------------- 1898 Plasmodium fa...

XP_001351365 1398 iySNNNSSYSHLFKNIFNNEhklyNVGGYFQTepincfefvndninvEDI--LPGAVPFPRFDLIHHDLDVNQTry-iL- 1473 Plasmodium fa...
XP_001349600  797 --KN--IKSTTCFEEMIPYNkeikWNKENKSL---------------GNL--VNNSVVYNKEMNAKYFNVQYVH----I- 850  Plasmodium fa...
ABO41480       76 dfSNIEIVPTNCFESHLYS------AYKNDSS---------------AYH--LEKLDIDKKYAINSSFSDFYLK----Il 128  malaria paras...
ZP_03796621   512 --NNHLIIIQDLFRETIL------------------------------NL--EKITKEVETVSLRAKKLDYSIN------ 551  Borrelia burg...
AAL74349       91 ssPEFKILPEKCFQKVYTDY----ENRVETDI---------------SELglIEYEIEENDTNPNYNERT--IT----I- 144  malaria paras...
XP_966115     262 --DGYTLYPNDCFKNVIYDN------NIIIPLk---------------KI--IPHDILYHQDKNKRITFASFTLn----- 311  Plasmodium fa...
AAL74380      346 ----GDIIP-DCFFQVYQPE-----SEELEPSn-------------iVYL--DSQINIGDIEYYEDAEGDDKIKlf-gI- 398  malaria paras...
XP_001349600 2722 ---NKKLNPQTCFDEVYYVKqedvPSKTITADkyntf-----skdkiGNI--LKNAISINNPDEKDNTYTYLILpekfE- 2790 Plasmodium fa...
ABO41483      326 ----YKLIPPYCFKHVLYEKe--iDSQKTYKT---------------FLL--SDVLDTPNIEYYGNNKEGMYMLa---L- 378  malaria paras...
XP_001349599 1899 --YNFLTTPSDCFESIQIEGv--dKELETHKL---------------EKL--LKGVKILNNDIYKYNFTPSYII----L- 1952 Plasmodium fa...

XP_001351365 1474 --LNETNQDKTISCTCNYF 1490 Plasmodium falciparum 3D7
XP_001349600  851 --PTSYKDTLNLFCSIILK 867  Plasmodium falciparum 3D7
ABO41480      129 viPNEYKSHKTIYCRCDNS 147  malaria parasite P. falciparum
ZP_03796621   552 --YDKILSNINLNKRIKKE 568  Borrelia burgdorferi 29805
AAL74349      145 --SPFSPKDIEFFCFCDNT 161  malaria parasite P. falciparum
XP_966115     312 ----INENPPGFTCYCIKD 326  Plasmodium falciparum 3D7
AAL74380      399 --VGSIPKTTSFTCICKKD 415  malaria parasite P. falciparum
XP_001349600 2791 --EELIDTKKVLACTCDNK 2807 Plasmodium falciparum 3D7
ABO41483      379 --PTKPEKTNKIRCICEQG 395  malaria parasite P. falciparum
XP_001349599 1953 --PKKIKKSLKIFCRCNSV 1969 Plasmodium falciparum 3D7
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