1LNS,1MPX,3IB3


Conserved Protein Domain Family
PepX_C
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smart00939: PepX_C 
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X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain
This domain is found at the C-terminus of cocaine esterase CocE, several glutaryl-7-ACA acylases, and the putative diester hydrolase NonD of Streptomyces griseus (all hydrolases). The domain, which is a beta sandwich, is also found in serine peptidases belonging to MEROPS peptidase family S15: Xaa-Pro dipeptidyl-peptidases. Members of this entry, that are not characterised as peptidases, show extensive low-level similarity to the Xaa-Pro dipeptidyl-peptidases.
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Statistics
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PSSM-Id: 214924
Aligned: 137 rows
Threshold Bit Score: 45.855
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1LNS_A       531 PPV-ILQENs-----kDQVWTMMNDFG-------ANTQIKL-PLGKTAV------SFAQFDN--NYDDET------FKKY 582 Lactococcus lactis
NP_822850    394 EPT--ADIEr-----hPDQWVTSTLWPpr----gTDAVTLR-PGTGTQA------GVGTLGL--RT-GSG------TETF 446 Streptomyces av...
NP_826521    308 PAFrVTRTGgvnstdgTAQLRGASGETyp----gLRSGRRT-IAL-SGR------EQNFANP--AGANPP------ALSA 367 Streptomyces av...
YP_951911    580 PQFeWVDQH--------GDWYSSEVYPva----sGESVTAT-LANGGKT------LPFVPFIggSGPNPA------ILTR 634 Mycobacterium v...
YP_110673    432 QPT--YVREt-----pTGDIPVGATLPpd----pNDTSDTLiGHCHSGHnprdciPTGELFI--KEDAWPktvdtfYHLR 498 Burkholderia ps...
YP_001136482 604 AQFeWVDQNg--------lWHSDDSYPaasgapiVVTREED-SRVMPI--------IPALFG--SGPNPL------IVTR 658 Mycobacterium g...
YP_951885    578 AQFeWVNQH--------GEWFSSETYPag----sLGAPIEA-SSDDPKT------IPFVPFIggSGPNPL------ILLK 632 Mycobacterium v...
YP_004076461 698 PRFeWFDQTgay--hsSDLLPTEPDFYge----pIVTDSDG-GFL---P------IIPILGG--SGPQTQ------SPTP 753 Mycobacterium s...
NP_626956    310 PTFrVTRTGgvdstdgQAQLRGASADHypg-lanGQRSVPL-RGREQS--------VDNPAG--ANPPAV------SALP 371 Streptomyces co...
YP_954860    648 VVFeWTDQYgdr--wtsEVSPTEAGFYdpp-gviPTTVWDT-GKVLPI--------IPLIGG--SGPNPE--------VP 705 Mycobacterium v...

1LNS_A       583 -----SKDFNVFKKD-LF------------ENKANEAVIDLE-LPSMLTINGPVELELRLKLNDTKGFLSAQILDFgqkk 643 Lactococcus lactis
NP_822850    447 -----TDDPRLSETD-WAahid-----estASKAG--FVTAP-LAGDVRLSGSSKVTVTATPTTSTAHLSAVLVDLg--- 509 Streptomyces av...
NP_826521    368 lpglgGSGGLSQLSS-LGiga------sldFPGQFARFDSAP-VTRDLRISGSPTATVHVKSTSEDTVLFGKVYDVg--- 436 Streptomyces av...
YP_951911    635 -----GVIRAVMGLP-SGapa------lnaVNLRV-----PD-ATEPTHLLGAPQLTLTYSGTGNAKHVYAQLVD----- 691 Mycobacterium v...
YP_110673    499 -----GDGRVGGLLT-PSpadgtqaasvdlSNATAVTYETKS-LANVTRYAGAIRVAMRGRFAPAVSNIKATLSVDg--- 568 Burkholderia ps...
YP_001136482 659 -----GLIATLLGLPs-------------aAAAYNAVNLQIPdATELTHVVGAPQVTMTYTGEGTAEHMYAQIVD----- 715 Mycobacterium g...
YP_951885    633 -----GLVRTLVGLPs-------------aAPALNAVNLTVPdATVETHIVGAPELTLTYSGTGTAKHVYAQIVD----- 689 Mycobacterium v...
YP_004076461 754 -----LIVSPALASE-ASlal------nleIAA-----------PAGTQIVGAPEITLTYSGLGTATHIYGQLVDDa--- 807 Mycobacterium s...
NP_626956    372 -----GIGGA-GGLSqLSslgvg---isldFPGQYAAFESAP-VGDDLRITGSPTATVHVRSTTEDAVLFAKVYDVg--- 438 Streptomyces co...
YP_954860    706 -----LPYS--LGDGsIAsnavt---ialeNPV------------AEANVVGSPSVVIHYSGFGTSRHIYAQVVDRs--- 760 Mycobacterium v...

1LNS_A       644 rledkvrvkdfkvldrgrnfmlddlvelpLV-------------------ESp--------------------yQLVTKG 684 Lactococcus lactis
NP_822850    510 ----------------------------pDTirdyadggegittltdrtcWGastagdsacfkntrattaavdyTVLSRG 561 Streptomyces av...
NP_826521    437 ----------------------------pG---------------------Gt--------------------qKVLPSQ 447 Streptomyces av...
YP_951911    692 --------------------------------------------------DEt--------------------gLVLGN- 700 Mycobacterium v...
YP_110673    569 ----------------------------hD----------------------------------------------VTYG 574 Burkholderia ps...
YP_001136482 716 --------------------------------------------------DEt--------------------gLVLGN- 724 Mycobacterium g...
YP_951885    690 --------------------------------------------------DEt--------------------gLVLGN- 698 Mycobacterium v...
YP_004076461 808 ----------------------------tG----------------------------------------------LVLG 813 Mycobacterium s...
NP_626956    439 ----------------------------pGg--------------------Ts--------------------pVLPSQ- 449 Streptomyces co...
YP_954860    761 ----------------------------tG--------------------------------------------LVVGN- 767 Mycobacterium v...

1LNS_A       685 FT-NLQN-QSLLTVSDLKADEWFTIKFELQPTIYHLEKADKLRVILYSTDFEHTV----------------RDNRKVTYE 746 Lactococcus lactis
NP_822850    562 WA-DLGNhASARKGVPLTPGKAYTITLDLAATDHVVPKGHRLALIVAGTDKDLIDppsst-------ptltLDLARTSAR 633 Streptomyces av...
NP_826521    448 LV-TPIRvEGAKEGK--------DVTLSLPAIDHEVRSGHRLRLVLASTDLGYASptapatytvslkgdllvptapgvtt 518 Streptomyces av...
YP_951911    701 QV-TPIPvVLD--------GESHTVTFSMEQIAHTLKPGESVTLQVLTSSFSFlnfysygaitvegmsvklptmaaaqvv 771 Mycobacterium v...
YP_110673    575 WA-NPRFyKGLDVAQLIVPNTDYDFTLEMMPRDFTVLPGSKVMLKLEGyqgtslvtldlshtvlampvvpkahvaavmvg 653 Burkholderia ps...
YP_001136482 725 HA-TPIPvTLDGTTR--------TATFSLEPVAHTLRPGQSVTVQIVTStakfinyyswgaitveeltvelptripagag 795 Mycobacterium g...
YP_951885    699 QA-TPIPvELDGQSH--------TATFSLEQVAHTLQPGQSVTVQIVTStisflnfyswgnvtvegmsvklptaiaaaas 769 Mycobacterium v...
YP_004076461 814 NLvTPIPvTLN--------GRTQTVTIDLEQIAYTAVPGGTLTLQLAGFATPYLDlfqvgfidvesvslslptvavgaga 885 Mycobacterium s...
NP_626956    450 LV-TPVRvEDAKAGK--------DVTVTLPAIDHEVQKGHRLRLVLASTDLGYASpaapatytvslegdleVPTAPGVTT 520 Streptomyces co...
YP_954860    768 IV-TPVPvTLNGRDQ--------VVTVDLNDIAYTVGPDSELELQIFTTATSYFNat------------qfGFINVESV- 825 Mycobacterium v...

1LNS_A       747 IDLSQSK 753 Lactococcus lactis
NP_822850    634 VPLvgga 640 Streptomyces avermitilis MA-4680
NP_826521    519 aaaplpa 525 Streptomyces avermitilis MA-4680
YP_951911    772 avaa--- 775 Mycobacterium vanbaalenii PYR-1
YP_110673    654 k------ 654 Burkholderia pseudomallei K96243
YP_001136482 796 agasrep 802 Mycobacterium gilvum PYR-GCK
YP_951885    770 saseetv 776 Mycobacterium vanbaalenii PYR-1
YP_004076461 886 saaqagv 892 Mycobacterium sp. Spyr1
NP_626956    521 AAAPLPA 527 Streptomyces coelicolor A3(2)
YP_954860    826 EVTMPTT 832 Mycobacterium vanbaalenii PYR-1
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