3LDV,3RU6,1DBT,3LV6,2YYT,2CZ5,2JGY,1KV8,3QW4,3EXR,1VQT,3F4W,3IEB


Conserved Protein Domain Family
OMPdecase
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smart00934: OMPdecase 
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Orotidine 5'-phosphate decarboxylase / HUMPS family
Orotidine 5'-phosphate decarboxylase (OMPdecase) catalyzes the last step in the de novo biosynthesis of pyrimidines, the decarboxylation of OMP into UMP. In higher eukaryotes OMPdecase is part, with orotate phosphoribosyltransferase, of a bifunctional enzyme, while the prokaryotic and fungal OMPdecases are monofunctional protein.
Links
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Statistics
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PSSM-Id: 214921
Aligned: 356 rows
Threshold Bit Score: 79.904
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3LDV_A        29 KVIVALDYDNLADALAFVDKIDPSTCRLKVGKEMFTL------FG-------P---D----F----VRE---LH---KR- 77  Vibrio cholerae...
XP_755170     34 NVTVSADVTTTRELLDLADRLGPYIAVIKTHIDILTD------FS-------V---Dti-nG----LNV---LA---QKh 86  Aspergillus fum...
NP_587705     34 NLSVAVDLTKKSEILELVDKIGPYVCVIKTHIDVVED------FD-------Q---D----M----VEK---LValgKKh 86  Schizosaccharom...
XP_447384     31 NLCASLDVTTTSELLKLVDTLGPYICLLKTHVDILSD------FSfe---ntV---K----P----LKE---MA---AKh 84  Candida glabrat...
NP_984802     31 NLCASLDVRTSRKLLELADTLGPHICLLKTHVDILTD------FD-------I---EttvkP----LQQ---LA---AKh 84  Ashbya gossypii...
XP_001386655  32 NLCASVDVKTTSEFLSLIDKLGPYICLVKTHIDIIDD------FS-------Y---E----GtivpLLE---LS---KKh 85  Pichia stipitis...
XP_773665     35 NLCVSVDVTKAAEVLEVVRRVGASVCMVKTHCDIIED------FT-------L---E----F----ADElvkLS---KQl 87  Cryptococcus ne...
XP_955875     42 NLCLSADVEHARDLLALADKVGPSIVVLKTHYDLITG------WDyhphtgtG---A----K----LAA---LA---RKh 98  Neurospora cras...
CAG10107     325 NLCVSADVTSSQELLQLADSLGPSICLLKTHVDILKVgpslppFVvsrhlraDallH----P----SPG---LR---RRr 390 spotted green p...
XP_385332     36 NLCLSADVATARELLYFADKIGPSIVVLKTHYDMVAG------WDfdprtgtG---A----K----LAS---LA---RKh 92  Gibberella zeae...

3LDV_A        78 --------------------------------------GFSVFLDLKFHDipntCS----KAVKAAAE--L-------GV 106 Vibrio cholerae...
XP_755170     87 --------------------------------------NFLIFEDRKFIDigntV--------QKQYH--G-------GA 111 Aspergillus fum...
NP_587705     87 --------------------------------------RFLIFEDRKFADigntVKl---QYASGVYKiaS-------WA 118 Schizosaccharom...
XP_447384     85 --------------------------------------NFLIFEDRKFADigntVKlqytSGVYKIAE----------WA 116 Candida glabrat...
NP_984802     85 --------------------------------------NFMIFEDRKFADigntVKlqysSGVYRIAE----------WA 116 Ashbya gossypii...
XP_001386655  86 --------------------------------------NFMIFEDRKFADigntV--------KSQYS--G-------GV 110 Pichia stipitis...
XP_773665     88 --------------------------------------DFVIFEDRKFADigntVS----LQYSSGTH--K-------IA 116 Cryptococcus ne...
XP_955875     99 --------------------------------------GFLIFEDRKFVD----IG----STVQKQYT--AgtariveWA 130 Neurospora cras...
CAG10107     391 qpptagsgrktqlphlrrpqvcrhrehgqasvrrrtvpDFILVPSRECPRgagtRG----GAGSERCG--Eap---rpWL 461 spotted green p...
XP_385332     93 --------------------------------------GFLIFEDRKFGD----IG----NTVELQYT--SgaariieWA 124 Gibberella zeae...

3LDV_A       107 -------WMVNVHASGGERMMAASREILE---PYGke---rP-------------------------------------- 135 Vibrio cholerae...
XP_755170    112 lrisewaHIINCSVLPGEGIVEALAQTAS---AQDfpygpeR-------------------------------------- 150 Aspergillus fum...
NP_587705    119 -------HITNCHTVPGEGIIQGLKEVGL---PLG------R-------------------------------------- 144 Schizosaccharom...
XP_447384    117 -------DITNAHGVTGQGIVTGLKQGAE---ETTne---pR-------------------------------------- 145 Candida glabrat...
NP_984802    117 -------DITNAHGVTGPGVIAGLKEAAKlasQEP------R-------------------------------------- 145 Ashbya gossypii...
XP_001386655 111 ykiaqwsDITNAHGVTGSGIVQGLKEAAR---ETTde---pR-------------------------------------- 146 Pichia stipitis...
XP_773665    117 sw----sDLTNAHSVPGPGIITGLASIGL---PLG------R-------------------------------------- 145 Cryptococcus ne...
XP_955875    131 -------HITNADIHAGEAMVSAMAQAAQ---KWR------Eripyevktsvsvgtpvadqfadeeaedqveelrkvvtr 194 Neurospora cras...
CAG10107     462 -------FADSADEFAGVPGLWGLHQRSGrlr------------------------------------------------ 486 spotted green p...
XP_385332    125 -------HIVNVNMVPGKASVTSLAHAAN---RWL------Eryhyevktsisigtptasqldedsersdgenqknapei 188 Gibberella zeae...

3LDV_A       136 --------------------------------------------------------LLIGVTVLTSMESADLQGigilSa 159 Vibrio cholerae...
XP_755170    151 --------------------------------------------------------GLLVLAEMTSKGSLATGE----Y- 169 Aspergillus fum...
NP_587705    145 --------------------------------------------------------GLLLLAEMSSKGSLATGs----Y- 163 Schizosaccharom...
XP_447384    146 --------------------------------------------------------GLLMLAELSSKGSLAHGE----Y- 164 Candida glabrat...
NP_984802    146 --------------------------------------------------------GLLMLAELSSQGSLARGDyt---- 165 Ashbya gossypii...
XP_001386655 147 --------------------------------------------------------GLLMLAELSSKGSIAHGk----Y- 165 Pichia stipitis...
XP_773665    146 --------------------------------------------------------ALLLLANMSSKGALATGEytkqT- 168 Cryptococcus ne...
XP_955875    195 etstttkdtdgrkssivsittvtqtyepadsprlvktiseddemvfpgieeapldrGLLILAQMSSKGCLMDGK----Y- 269 Neurospora cras...
CAG10107     487 ------------------------------------------------------pgGLFVGVFFPSRLGIPSLP----I- 507 spotted green p...
XP_385332    189 grdngr------kgsivstttvtqqyesadsprlvktipegdetvfpgideapierGLLILAQMSSEGNFMNKE----Y- 257 Gibberella zeae...

3LDV_A       160 PQDHVLRLAtlTK--NAGLDGVVCSA--QEAs--------------lLKQHLGR--EFKLVTPGI-----Rpags----- 209 Vibrio cholerae...
XP_755170    170 TKASVDYARk--Y--KNFVMGFVSTRalTEVqs------------dvSSASEDE--DFVVFTTGVnlsskG--------- 222 Aspergillus fum...
NP_587705    164 TEKTLEWFEkhT----DFCFGFIAGR--RFPnl-------------------qS--DYITMSPGI-----Gldvk----- 206 Schizosaccharom...
XP_447384    165 TKGTVDIAk--SD--KDFVIGFIAQK--DMGgr-----------------dEGF--DWLIMTPGV-----Glddk----- 209 Candida glabrat...
NP_984802    166 --agVVEMAk-lD--KDFVIGFIAQR--DMGgr-----------------adGF--DWLIMTPGV-----Glddk----- 209 Ashbya gossypii...
XP_001386655 166 TEETVEIAk--TD--KEFVIGFIAQR--DMGgq-----------------dEGF--DWIVMTPGV-----Glddk----- 210 Pichia stipitis...
XP_773665    169 M-----RMAreAG--REFVVGFIA------Qer------------vdAGEDG----DWLIMSPGV-----Glaas----- 209 Cryptococcus ne...
XP_955875    270 TWECVKAAR--KN--KGFVMGYVAQQ--NLNgitkealapsyedgesTTEEEAQadNFIHMTPGC-----Klpppgee-- 336 Neurospora cras...
CAG10107     508 LVFSPQLQM--AEgqADFVMGFICSS--KIS----------------------ArpEFIHMTPGV-----Qmqag----- 551 spotted green p...
XP_385332    258 TQACVEAAR--EH--KSFVMGFISQE--CLN-----------------TEPDd---DFIHMTPGC-----Qlppegaden 306 Gibberella zeae...

3LDV_A       210 -----eqgD---QRRIMTPAQAIASGSDYLVIGRPITQAA--HPEVVLEEI 250 Vibrio cholerae O1 biovar eltor str. N16961
XP_755170    223 --------DklgQQYQ-TPASAIGRGADFIIAGRGIYAAP--DPVEAAQRY 262 Aspergillus fumigatus Af293
NP_587705    207 ----gdglG---QQYRTPEEVIVNCGSDIIIVGRGVYGAGr-NPVVEAKRY 249 Schizosaccharomyces pombe 972h-
XP_447384    210 ----gdalG---QQYRTVDEV-FSTGTDIIIVGRG-LFAKgrDPKTEGERY 251 Candida glabrata CBS 138
NP_984802    210 ----gdglG---QQYRTVDEV-VSDGTDVIIVGRGlfdkgrdpnvegaryr 252 Ashbya gossypii ATCC 10895
XP_001386655 211 ----gdslG---QQYRTVDEV-VSTGTDIIIVGRGlfgkgrdpdvegqryr 253 Pichia stipitis CBS 6054
XP_773665    210 ----gdklG---QQYRTPKEVVRDAGADVIIVGRGIYGVQ--GGEEAVKAe 251 Cryptococcus neoformans var. neoformans B-3501A
XP_955875    337 -apqgdglG---QQYNTPDNLVNIKGTDIAIVGRGIITAA--DPPAEAERY 381 Neurospora crassa OR74A
CAG10107     552 ----gdvlG---QQYTTPEEVIFNKGTDIIIVGRGILEAP--DRLEAAELY 593 spotted green pufferfish
XP_385332    307 eaikgdgkG---QQYNTPQKIIGIAGADIAIVGRGIIKAG--DPEEEAERY 352 Gibberella zeae PH-1
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