3JVA,2QDE,3CYJ,3RIT,3Q45,3HPF,3MZN,3DDM,2O56,2P88,1JPM,2HNE,2PP0,2OVL,2GGG,3FCP,3CT2,3I4K,2OPJ,1WUE,2ZC8,3DFY,3IJI,3PX5,3N6H,2PGE,3FXG,3SJN,3I6E,2OZT,3RR1,3I6T,3EEZ,3GC2


Conserved Protein Domain Family
MR_MLE
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smart00922: MR_MLE 
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Mandelate racemase / muconate lactonizing enzyme, C-terminal domain
Mandelate racemase (MR) and muconate lactonizing enzyme (MLE) are two bacterial enzymes involved in aromatic acid catabolism. They catalyze mechanistically distinct reactions yet they are related at the level of their primary, quaternary (homooctamer) and tertiary structures.. This entry represents the C-terminal region of these proteins.
Links
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Statistics
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PSSM-Id: 214914
Aligned: 507 rows
Threshold Bit Score: 38.0314
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3JVA_A       140 PNVMAQkAVe--KVK-LGFDTLKIKVGTGI-----------EA--------------------DIARVKAIREAVG---- 181 Enterococcus fa...
ADP85774     146 PSEMAEaARr--VEAeG-FFGVDINMG-------------------------------------CSVAAIVRRGCG---- 181 Desulfovibrio v...
YP_826292    162 IKEHAQaVMaagYRAfR-MGAADTPANGTF-----------Nther--------------lnkmAEDCAQAREGVG---- 211 Solibacter usit...
YP_814779    144 PQD-YAnNTk-iALEkG-FKTVKINFLTFD-----------EqgkqipwqrqtaflspnylnlaEERIKAVRNVLE---- 205 Lactobacillus g...
YP_873667    181 GVETYHaLKavlKGR--GLATGLGDEGGFA-----------Pnla-----------------hnREALDLILEAIGkagf 230 Acidothermus ce...
NP_148623    185 AVETYGeLKsllKDRyGASAVNVGDEGGFA-----------Ppmr-----------------saEEALKTLVDAVEkagy 236 Aeropyrum perni...
NP_882725    163 VDSFRAaAAr--AVQa-GYRFVEVHAAHGY-----------Llh------------------sfLSPISNQREDLYggs- 209 Bordetella para...
YP_001712622 158 QQDFAAaAKr--AVEa-GFELIEVHAAHGY-----------Llh------------------qfLSPIANQRTDEYggs- 204 Acinetobacter b...
YP_355502    143 VEAFAAaALr--AKKa-GFDAVQIHAAHGY-----------Lls------------------efLSPYFNQRTDEYggp- 189 Pelobacter carb...
YP_001336187 150 PEEYAAfAE---KLVaRGYKAIKLHTWMPpisfapnpkmdikA--------------------Ca----AVREAVG---- 198 Klebsiella pneu...

3JVA_A       182 ---FDIKLRLDANQ--------------AWT-PKDAVKAIQALAdy---qIELVEQPVKR------RDLEGLKYVTSQVN 234 Enterococcus fa...
ADP85774     182 -----ADLLRDEEr--------------AVRmVESVRRAVDCPVlvk-frTGWSPDPQGAvalarrFEDAGADALVFHPR 241 Desulfovibrio v...
YP_826292    212 ---KNGDWCIDFHQr------------fDLSeAIRGCDLIKDFAp------YFVEDPVRTea-----flEDIPLLRRSAK 265 Solibacter usit...
YP_814779    206 ---ENGELILENH---------------ALTdKLSAVQYGKMFSky---nILYFEEPVKPd-------pDLLSYVHQETG 257 Lactobacillus g...
YP_873667    231 rpgRDIAVAIDAAAtefyrdgryilegqPRTaAELIRYYEELVAsy---pLVSLEDPLAEe------dWDGWRELTAALG 301 Acidothermus ce...
NP_148623    237 qpgSEIALGIDAAAsqlysngrysvegkSLSrEELLSLYQRLVEqy---pIVYLEDPFSEd------dYEGFKAAVDALS 307 Aeropyrum perni...
NP_882725    210 -leNRMRFPLEVVAav----------raALPdEVPLSVRISAVDgve--hgWQLADSIVFare-lkALGVDLVDCSSGGI 275 Bordetella para...
YP_001712622 205 -leNRMRMTLEVLQai----------klAVPeGYPVGVRLSATDwmdgneQWDIESTVGLska-leQLGAAYIHVSSGGL 272 Acinetobacter b...
YP_355502    190 -veNRAKLVLEVLQav----------rkAVGpDYPVLIKLNSEDfve--ggVTVEDMLKVaer-lqQAGIDAVEMSGGTI 255 Pelobacter carb...
YP_001336187 199 ---PDIDLMIDGYhw------------ysRAeALWIGKELEKLN------FAWFEEPMEEd------SMSSYAWLAENLS 251 Klebsiella pneu...

3JVA_A       235 T 235 Enterococcus faecalis V583
ADP85774     242 V 242 Desulfovibrio vulgaris RCH1
YP_826292    266 V 266 Solibacter usitatus Ellin6076
YP_814779    258 L 258 Lactobacillus gasseri ATCC 33323
YP_873667    302 G 302 Acidothermus cellulolyticus 11B
NP_148623    308 T 308 Aeropyrum pernix K1
NP_882725    276 Q 276 Bordetella parapertussis 12822
YP_001712622 273 H 273 Acinetobacter baumannii AYE
YP_355502    256 Y 256 Pelobacter carbinolicus DSM 2380
YP_001336187 252 I 252 Klebsiella pneumoniae subsp. pneumoniae MGH 78578
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