Conserved Protein Domain Family
LeuA_dimer

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smart00917: LeuA_dimer 
LeuA allosteric (dimerisation) domain
This is the C-terminal regulatory (R) domain of alpha-isopropylmalate synthase, which catalyses the first committed step in the leucine biosynthetic pathway. This domain, is an internally duplicated structure with a novel fold. It comprises two similar units that are arranged such that the two -helices pack together in the centre, crossing at an angle of 34 degrees, sandwiched between the two three-stranded, antiparallel beta-sheets. The overall domain is thus constructed as a beta-alpha-beta three-layer sandwich.
Statistics
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PSSM-Id: 214910
Aligned: 331 rows
Threshold Bit Score: 62.887
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_572334    439 EMTSKDITTAFRQTYHLggsiydgrlvlksfvtvdlfssqtpsvagtpdlspirsrsQT-RM-PP-LSLSS-SVAEPSPD 514 Cryptococcus ne...
YP_549142    422 ELTAQDIFALLEKEYGV----------------------------------------QT-VA-APqHLVIE-ETGNADGK 458 Polaromonas sp....
ZP_05823323  422 EISAKQIWTLFKDTYVE----------------------------------------VK-NH-HY-TVKNY-K-LSDING 456 Acinetobacter s...
YP_527770    420 EMTAAQIVDVFQQEYFG----------------------------------------AT-QG--F-EYVAC-HV-SDSKT 453 Saccharophagus ...
YP_001411293 420 EVRAADIWRIFEEEYLT----------------------------------------RA-EP-----IEYLsHSLYDESG 453 Parvibaculum la...
YP_935025    428 ELSAGDIWRAFEEEYLA----------------------------------------VA-AP-YA-YVEHH---LAEHGG 461 Azoarcus sp. BH72
YP_283738    420 EVSADGIWAMFARTYLD----------------------------------------AT-TPiRY-REHHL----FEQGR 453 Dechloromonas a...
YP_661056    420 EMSASGIVSLFESTYLI----------------------------------------QP-DW--I-EFKQC-QIKTVEQN 454 Pseudoalteromon...
YP_544857    421 EVSAEGIWQLFNEEYIA----------------------------------------AD-EP----VRYID-HVLDEQDD 454 Methylobacillus...
YP_968410    440 EMDGDALWSLFSQTYIA----------------------------------------APaQG-TP-GALTL-HGQRLDED 476 Acidovorax aven...
XP_572334    515 rsldrnlpsmSKR---LTAKVLVDGKLHEIVGEGNGPLSSFLNALESDLGIVLSVREYTEHAV---GAGSDVKAATYVEL 588 Cryptococcus ne...
YP_549142    459 ----------SFN---IKAHVRIAGRNHQVEGKGTGPIDAFVAGLNAATGHAVRVLDYHEHAI---GSGASAQAVAYLEL 522 Polaromonas sp....
ZP_05823323  457 ----------TQI---IELEIDVEGETQQLRGEGNGPISAFLNALQ----LPIDVLNYEERSI---SSGANAKALTLIEL 516 Acinetobacter s...
YP_527770    454 ----------IAEgmqVEVELVKQGEAFTVVGEGSGPIDAAVTAINKVVPAGVSVVDYHEHAV---REGADGEAVCYVEL 520 Saccharophagus ...
YP_001411293 454 ----------KQG---VKIRIRRFGKEEELSGSGNGPIDAAMDALK----LGVELRHYEEHSI---GSGTDAKAVAFMEV 513 Parvibaculum la...
YP_935025    462 ----------QQG---ISLTVEEAGVRRVLRGVGNGPIDAALHALDA----GAVLLGYEERAI---GQGGDARAVAYIEL 521 Azoarcus sp. BH72
YP_283738    454 ----------NQG---IRLNIDIDGTPHILTGEGNGPINAAVHALQSA-GINIQVRSYEERSMvpmGEDGNARACAFMEI 519 Dechloromonas a...
YP_661056    455 ----------QQQ---IDIQLIINNAEVNISGVGNGPIDAASRAMSQLIKTPLEIVDYHEHAI---GEGSGVTAVCYLEL 518 Pseudoalteromon...
YP_544857    455 ----------VQH---IKLIARIHGVETVLEGRGNGPIDALVHA----FGSKFRIHDYEERAL---GAGAAARAVAFAEL 514 Methylobacillus...
YP_968410    477 ----------GQG---ISLDVTIDGVRQTLQGRGNGPIDATVDAI----GLPLRVDHYEERAT---GAGAGAQALAIVEA 536 Acidovorax aven...
XP_572334    589 ---I-----P--AnvdakdktQ-G--GFWGVGVDADITASGLKAVVSAANGF 627 Cryptococcus neoformans var. neoformans JEC21
YP_549142    523 ---R-----I--N--------D-Q--TLFGIGMDGNIVSASLKAIVSGLQRs 553 Polaromonas sp. JS666
ZP_05823323  517 ---Q-----VkgT--------G-R--GSFGAGVHDNTVTSSIEAIIACTNRL 549 Acinetobacter sp. RUH2624
YP_527770    521 ---K-----Vg-N--------G-R--PVFGVGRHKNIVVAAVRAMVGGVNRA 552 Saccharophagus degradans 2-40
YP_001411293 514 adpE-----H--P--------G-D--LF-GVGIDANIITASFKAMLSaanra 546 Parvibaculum lavamentivorans DS-1
YP_935025    522 ---Ad---gE--G--------G-G--STFGVGIHANIVTASVLAIVSALDRL 554 Azoarcus sp. BH72
YP_283738    520 ---AgkggdK--S--------G-G--ECYGVGVDSNIVTASIKALLSGVNRL 555 Dechloromonas aromatica RCB
YP_661056    519 ---R-----T--G--------DtT--TRFGVAKDSNIMTAAVKAMLSGINRs 550 Pseudoalteromonas atlantica T6c
YP_544857    515 ---E-----K--D--------G-QpgTVYGAGIHDNLVTASILAVISGINRL 547 Methylobacillus flagellatus KT
YP_968410    537 ---A-----L--E--------G-VpgATFGVGLDHSIVSASVQAVVAVTNRL 569 Acidovorax avenae subsp. citrulli AAC00-1
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