2BGW,2ZIX


Conserved Protein Domain Family
ERCC4
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smart00891: ERCC4 
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ERCC4 domain
This entry represents a structural motif found in several DNA repair nucleases, such as Rad1/Mus81/XPF endonucleases, and in ATP-dependent helicases. The XPF/Rad1/Mus81-dependent nuclease family specifically cleaves branched structures generated during DNA repair, replication, and recombination, and is essential for maintaining genome stability. The nuclease domain architecture exhibits remarkable similarity to those of restriction endonucleases.
Links
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Statistics
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PSSM-Id: 214888
Aligned: 129 rows
Threshold Bit Score: 45.8027
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2BGW_A        12 YVD--------VREERSP------------------VPSILESLGVQVIPKQ---------------------LPMGDYL 44  Aeropyrum pernix
XP_448742    289 IVDfsps-llsfLDKQTEilksilapatiqksihdeLPRIRFFRKCHSFYDLqhdfffpsnykiveenttilyFDSKEFF 367 Candida glabrat...
EDZ73780      71 IIEfsps-llqlFKKGDSdlqqqlapavvqssyndsMPLLRFLRKCDSIYDFsndfyypcdpkiveenvlilyYDAQEFF 149 Saccharomyces c...
NP_983778    422 VLSineq-vhqyLLEQKVpiaevlgpt-tvihnfesVPIIRFKRKCTSMYDLnndiyypcettmcnepicllfYNAVDFF 499 Ashbya gossypii...
XP_454463    403 IHS----------KHISFeeelkplt---iiqnyeeFPIIRFKRKCRSIYDQthgvfypcdevianesicvlvYEALPFF 469 Kluyveromyces l...
XP_461019    258 VIQipsl-lydrDFEDEYmkqifiep--kvektnsnLPIISWKRKVKARYDAerdvfipcepteinekniviyYKAKDFV 334 Debaryomyces ha...
XP_001384703 181 IIMmapc--vksMFKQDYletqfekp--hisdfisdLPMICWNRKVKALYNPetdlfvpceetelqeknivlyYEAQEFF 256 Pichia stipitis...
XP_963667    400 IVDlpss-lppaTKIQMEeflkkidvkeintwtspvDNVVRWRRAVKSRYNEerhhydpipetietekiilviLPAAEFA 478 Neurospora cras...
XP_381867    374 MVDipss-lnstVTTALQamlepfdvq-yttwdspvENVIKWRRKVRSRYNDdiglwepiplriqdekhalvvMHCDELV 451 Gibberella zeae...
XP_753332    330 ILDlassfretSVGNQSIelmkrlgve-htfftssiPNLVKWRRKVTARYNEaaghwepcphhireedhvlclVTAQEFV 408 Aspergillus fum...

2BGW_A        45 -VSDS--------------------------------------------------------------------------- 48  Aeropyrum pernix
XP_448742    368 vKYKEdkrslfeklkeierdnyeiilvlydlakfkrelekieetkyrsrvqsqi------------ydsqqsiqqnkvtt 435 Candida glabrat...
EDZ73780     150 eQYTSqkkelyrkirffskngkhvililsdinklkraifqlenekykarveqrl-----------sgteealrprskkss 218 Saccharomyces c...
NP_983778    500 tKYKNqkqrlysevqdlkragnkviiilneysrlekslaelenrcmrsrveqql------------tgdksprrktvkev 567 Ashbya gossypii...
XP_454463    470 hRYRTdkrglwdeirqfskngmkvivvmyglnalrkklcnmenrqhedrvleqlsgs------assqsqsktrrrstqet 543 Kluyveromyces l...
XP_461019    335 nSLIEgtisslldeckteakrhnlssgshiiiivegyvqfltkirnmedkrykkavl------dklnpndgdtgnkrskk 408 Debaryomyces ha...
XP_001384703 257 eKVHErtlkyqvnralslrkqdndtimykiiimvegydvfinklkrmeqnkykskvldr-lnepdslsssqsqpkrrknt 335 Pichia stipitis...
XP_963667    479 kLAMGaeghnleahvlkvqrhfpnhqtiylieglkkllssnrnkrnndfasvvrsrl------aedesastsssrrtnkk 552 Neurospora cras...
XP_381867    452 kLALDdaisshvekvrkhfsehhviylieglttwirknrnlrsrqfassvr-----------------aqeaatsgnrrn 514 Gibberella zeae...
XP_753332    409 nMAIApadpvtgttelelhlshikkayprhkliyliegltswmrknqnsrnrafqaqvrqqlvpddpssstrrrkapakt 488 Aspergillus fum...

2BGW_A        49 ----------------------------------IIVERKT-SSDFAKSLFD-----------------------GRLFE 70  Aeropyrum pernix
XP_448742    436 pqsdyglkkfdveqrlryinrewglkihivnshnDFVHSLPnLCSIIGKQRMdpairymr-------yahlnvksASDRK 508 Candida glabrat...
EDZ73780     219 qvgklgikkfdleqrlrfidrewhvkihtvnshmEFINSLPnLVSLIGKQRMdpairymk-------yahlnvksAQDST 291 Saccharomyces c...
NP_983778    568 qltalemnskdlgrkvnemiikcdidifpinsaaSFANWISnLVWVVAKMRYdpmmknvn-------wshinvkiGKTPT 640 Ashbya gossypii...
XP_454463    544 kmrelniksknldriinevtiyanvdvfpienlnEFSHWMKnLVWVVGKMRYdvsvkyke-------wshlnvksGKSPT 616 Kluyveromyces l...
XP_461019    409 qedgvslspkeidqlvnesqvrlsvnifpvknnkDAINWLQsFTYTIAYALYdkfernisl------anlgtvksGTDTK 482 Debaryomyces ha...
XP_001384703 336 ieptlditakeaellmnsvqielkvniftvrnssEAVDWLLsYTYAISYSLYdkfernssl------anigvvrsGSDSK 409 Pichia stipitis...
XP_963667    553 ndppmtisesqidaallrlqllysmqiqettclqDTAHHLQlFTQNVAVAPYkrhqedylmksagfcmdsgqvrtAIGTE 632 Neurospora cras...
XP_381867    515 kpaqeyvpeekiedallqlqvmhevlihhtmvpmETAEQILtFTQHISTIPYrkqrdqatlga-gfcmesgqvktGEDTK 593 Gibberella zeae...
XP_753332    489 aestppvdddtiedallelqvthaclihhtsaasESAEWIKnFTEHISTIPYkrermdgndsa--fcmdtgqvkpGEDKA 566 Aspergillus fum...

2BGW_A        71 QA--SRLAE--------------HYETVFIIVEG 88  Aeropyrum pernix
XP_448742    509 DTlkKTINEigkvpdikasaisdIYSSFQSLLHD 542 Candida glabrata CBS 138
EDZ73780     292 ETlkKTFHQigrmpemkannvvsLYPSFQSLLED 325 Saccharomyces cerevisiae AWRI1631
NP_983778    641 EVlsKTLQQingvteiragrvtsTYPSFQQIFTD 674 Ashbya gossypii ATCC 10895
XP_454463    617 DVlySFLQQvahvnepkakrvvtHYKSFQSMMND 650 Kluyveromyces lactis NRRL Y-1140
XP_461019    483 STyfQTVKQfrlmtepkieklygFYTSIFALYSR 516 Debaryomyces hansenii CBS767
XP_001384703 410 STfiGGVRQfkllteakaerlysHYPSLQSIYQV 443 Pichia stipitis CBS 6054
XP_963667    633 EAyvRMLQEvaritapiamgianVYPRVGQLVRA 666 Neurospora crassa OR74A
XP_381867    594 DTyvRMLQEiarvtapiahgvakEFDTVSDLVRG 627 Gibberella zeae PH-1
XP_753332    567 DTfvKMLQEvnrvtasmaygiaaKYPSVVDLVRG 600 Aspergillus fumigatus Af293
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