1W5F,2R6R,1FSZ,1Z2B,2VAW,1Z5V,1TUB


Conserved Protein Domain Family
Tubulin

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smart00864: Tubulin 
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Tubulin/FtsZ family, GTPase domain
This domain is found in all tubulin chains, as well as the bacterial FtsZ family of proteins. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea.
Statistics
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PSSM-Id: 214867
Aligned: 245 rows
Threshold Bit Score: 76.3721
Created: 15-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1W5F_A        23 KIKVIGVG---GAGNNAINRMIEIGihGVEFVAVN---TDLQVLE-ASNADVKI--QIGENITRGLGAggrpeIGEQAAL 93  Thermotoga mari...
XP_002917205  55 dGGSISKGkicSLKARAVLIDMEEG--VVNEILQG---PLRDVFDsKQLITDIS--GSGNNWAVGHKV-----FGSLYQE 122 giant panda
XP_002941372  32 RYPYFSRDg----MINAICVDSEPK--VIRKLWKr---VKKGSLRdSNLIVGRK--GRGNNWAFGYSG-----DGTDTEK 95  western clawed ...
NP_001002093  40 DERFFYQNsagELVARSVLVDMEPK--VISQALAkaskSGRWRYGdKAHFSQKQ--GSGNNWANGFCV-----HGPRHKE 110 zebrafish
XP_001348899  59 LKENNNCSkkeNLKARAILIDTETG--VANEIMKS---TISPYIDeNNIFTQQS--GAGNNWSQGYMY-----YGKMYEN 126 Plasmodium falc...
XP_003392470  41 AVFLEDMNhpgRLKARCVAVDMEQG--VLHAMLRG---PLKDIFDaNFFVSDVS--GAGNNWAVGHME-----YGDRYID 108 Leishmania infa...
XP_002128990  56 FDVPRGVNkiqNLKARAILVDMEEG--VVNELVQG---YIGDIFDhKQLITDVS--GSGNNWAVGNKV-----YGSRYRE 123 Ciona intestinalis
NP_957279     54 YGAEATGGkitGLKARAVLVDMEEG--VLGGILQG---PLRSLFSsAQLISDVS--GSGNNWAVGHHT-----YGLAYRE 121 zebrafish
XP_001464052 141 FNTFFSETgagKHVPRCIFLDLEPT--VVDEVrt---gTYRQLFNpEQLVSGKE--DAANNYARGHYT-----IGKEIVD 208 Leishmania infa...
XP_500603     51 KEVFFYQAddtRYVPRTLLLDLEPR--VINSTal--esPYARIYNpENVYMSADgsGAGNIFACGYS------AAAKMAD 120 Yarrowia lipoly...
1W5F_A        94 ----ESEEKIREVLQDT---HMVFITAgfgggtgtgaS----------PVIAKIAK-EMGiLt--VAIVTTP---FYFEG 150 Thermotoga mari...
XP_002917205 123 ----QILEKLRKSAEHCdclQCFFIIH----------SmgggtgsglgTFLLKVLEdEFP-EvyrFVTSIYPs--GEDDV 185 giant panda
XP_002941372  96 sllaRTMESFRHELERRdcySGTVLLH----------SlcggtgsglgARLCEEIRdTYP-AghiLSVAVAPh--ETGDT 162 western clawed ...
NP_001002093 111 ----DVEDLVRMEVERCdrlAGIFTMM----------SvaggtgsgvgTYITQRLRdLYP-QsfiLNQVTWPy--GAGEV 173 zebrafish
XP_001348899 127 ----IIDNIIRRNVEKCdslQSFYITS----------SlgggtgsglgSYILEMLSdTFR-Ei-kFSNCVFPs--VCDDV 188 Plasmodium falc...
XP_003392470 109 ----AIAESVRNQVEQCnciQSFFLMH----------SlsggtgsglgTRVLGMLEdEFP-HvfrICPVVMPs--EVDDV 171 Leishmania infa...
XP_002128990 124 ----DITEQVRKAVEACdclQCFFILH----------SmgggtgsglgTAILSILEdSFP-EvhrFVTAVYPs--KDDDV 186 Ciona intestinalis
NP_957279    122 ----QIVDQVRKAAEHCdclQCFFLIH----------SmgggtgsglgTFVLKLLEeEFP-EvyrIVTSVYPt--AEDDV 184 zebrafish
XP_001464052 209 ----LALDRIR-KLAdn--cTGLQGFM----------VfrespfllplSLPLPLPLfPPLpRegnTKEKIAK-------- 263 Leishmania infa...
XP_500603    121 ----TLLDMLDREADGSdslEGFMLLH----------SiaggtgsgmgSFLLEQIHdRYPkKl-iQTYSVFPsssQVSDV 185 Yarrowia lipoly...
1W5F_A       151 PERLKKAIEGLKKLRKHVDTLIKISNNKLMEELPRD---------------------------VKIKDAFLKADETLHqG 203 Thermotoga mari...
XP_002917205 186 ITSPYNSILAMKELNEHADCVLPIDNQSLFDIISKIdlmvnsgklgttvkpkslvtssagavkKRHQKPFDAMNNIVA-N 264 giant panda
XP_002941372 163 PLQHYNSLLCLSWLQRYSDGILLFQNDDIMHRVAALgekkv-----------------plvsgVEAPVSIAAMNSHIAsC 225 western clawed ...
NP_001002093 174 IVQNYNSVLTLSHLYQLSDAILVHENDTVHKICSQLm--------------------------NIKHISISDINKVIShQ 227 zebrafish
XP_001348899 189 ITSPYNSFFALNKIHEFSNCVLPVSNDALLNILNSKklreidktvkn-----nninsvndkntSIVKNDYSKMNNIVA-N 262 Plasmodium falc...
XP_003392470 172 VTAPYNSCFSLKELIEHADCVLPLDNDALARMADRAlssrpkgrgvmacsvpqpqafsaakptDTKGLPYDSMNGLVA-Q 250 Leishmania infa...
XP_002128990 187 ITSPYNSVLAMKELTDKADCVMPINNESLMNICNKIqhtlprkekiqsvskitsgvgslggtknnEK-PFDHMNNIVA-N 264 Ciona intestinalis
NP_957279    185 ITSPYNSVLAMKELTEHADCVLPVDNQSLVDIVGKIkhmsntgkpgcaikkdstiisgqggvvKVEK-PFDAMNNIVA-N 262 zebrafish
XP_001464052 264 --------DSDVYMMRHKDEINPPMPPP-----LPSl------------------------------pPCVCVRVFFLlL 300 Leishmania infa...
XP_500603    186 VVQPYNSMLTLRRLAEYADSVVVLDNGALGNITAEAl--------------------------rVQSPTFDQTNQLVAsV 239 Yarrowia lipoly...
1W5F_A       204 VKGISELIT-KRG 215 Thermotoga maritima
XP_002917205 265 LLLNLTSSArFEG 277 giant panda
XP_002941372 226 LAGLLYPTNtLRT 238 western clawed frog
NP_001002093 228 LASVLQPVYtAHS 240 zebrafish
XP_001348899 263 VILNLTSSMrFEG 275 Plasmodium falciparum 3D7
XP_003392470 251 LLSNLTCAMrFPG 263 Leishmania infantum JPCM5
XP_002128990 265 MLLNMTSHCrFDG 277 Ciona intestinalis
NP_957279    263 LLLNITSSArFEG 275 zebrafish
XP_001464052 301 S-VAVVPLL-FPF 311 Leishmania infantum JPCM5
XP_500603    240 MSASTSTLR-YPG 251 Yarrowia lipolytica CLIB122
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