1SML,1YCF,2OHH,1E5D,3AJ0,1X8G,1WRA,2YCB,3AF5,2XF4,3DHA,1QH3,1M2X,1DD6,1VME,2BMI


Conserved Protein Domain Family
Lactamase_B
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smart00849: Lactamase_B 
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Metallo-beta-lactamase superfamily
Apart from the beta-lactamases a number of other proteins contain this domain. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor.
Links
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Statistics
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PSSM-Id: 214854
Aligned: 322 rows
Threshold Bit Score: 34.4514
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1SML_A       39 TALLVQT-PDGAVLLDG-----------------GmPQmAs-HLLDN------MKARGvtPrDLRLILLSHAHADHAGPV 93  Stenotrophomonas...
NP_608983    35 TCTLVRCrDGTNIIVDT-----------------LtaWd--gDhLRSl----lGQQGlgvDdIHVVVcSHgHSDHIGCN- 90  fruit fly
NP_142803    25 VSFLVEV-EGKKILFDTa------------------SY-Ae-PILFN------MKLLNlnPrDIDMIVLSHNHFDHTGGL 77  Pyrococcus horik...
1WRA_A       18 DAIILES-NGHFAMVDTgedydfpdgsdsrypwrEgIE-TsyKHVLTdrvfrrLKELS--VqKLDFILVTHTHSDHIGNV 93  Streptococcus pn...
NP_143261    30 FSALVEA-NGYRVLVDTg------------------TD-Gk-VLLNN------MSELGisPdDIDALFITHGHYDHTGGL 82  Pyrococcus horik...
BAB08807    124 NCMLVGN-YDRYILIDAgi--------------mFpDY-DepGIQKImpdtgfIRRWKh---KIEAVVITHGHEDHIGAL 184 thale cress
AAF97210     15 NATLLST-ESSHILVDq-------------------GF-Sg-VQLEKr-----LSLLDvsPnDLEAIVITHHHGDHGGGA 67  uncultured marin...
AAK18826     25 NSFYLET-PEKKILVDAg----------------LsGK-KitSL---------LAEIDrdPsDLDAILVTHEHKDHIHGV 77  Streptococcus th...
ZP_03593861  15 NAFYLET-EDHAFLVDAg----------------LsGK-AmdGL---------MAQIGrkLdDVDGIFVTHEHSDHIKGL 67  Bacillus subtili...
NP_347174    23 VSYYIED-ESTKLLLDv-------------------GY-Sd-IFIKN------ASALDvdLkNIDTIVISHGHDDHTRGL 74  Clostridium acet...

1SML_A       94 AELKRR---TGAKVA-ANAESA----VLLARGGSDDLHFg--------------dGITYPPANADRiVMDG--EVITVg- 148 Stenotrophomonas...
NP_608983    91 YLFQKa---RMHlVGaCASHHd----LYMd-------------------------HLGSGNPDEQLaLDSn--AEVVv-- 134 fruit fly
NP_142803    78 LGILREi-nRKVPIF-AHPEIFkvsfALEPEFMYAGTPRlkeeaeklggiwiltrDPITLMPGVFTlGEIKeeEKVEFe- 154 Pyrococcus horik...
1WRA_A       94 DELLSTy--PVDRVY-LKKYSD----SRITNSERLWDNLygydk------vlqtaTETGVSVIQNI-TQGD--AHFQF-- 155 Streptococcus pn...
NP_143261    83 RELLSAr-tEALDIY-AHPGIFkrrlALKPKKREIGIPFtreelee---lggkfiLSDKSKEILPGfISSGeiERITWd- 156 Pyrococcus horik...
BAB08807    185 PWVIPAl-dPNTPIF-ASSFTM----ELIKKRLKEHGIFvqs-----------rlKTFSTRRRFMA-------GPFEI-- 238 thale cress
AAF97210     68 LIAQKR---WGVPVY-ANHRTS---------------------------------QELGLLPEFTHhFESL--DVLQFs- 107 uncultured marin...
AAK18826     78 GVLARK---YGMDIY-ANEKTW----QIMDsk----------------------nMLGKVDNSQKHiFSRG--KLLTFg- 124 Streptococcus th...
ZP_03593861  68 GVVARK---YKLPIY-ANEKTW----KAME-------------------------NQIGKIDTDQKfVFPM--ETVKSfg 112 Bacillus subtili...
NP_347174    75 KYYFEQssvGEISIIaHKDAFK----EKIKDKLKICSPIlqe-----------elREKCNLILSKEpKKVS--ENLIFl- 136 Clostridium acet...

1SML_A      149 gIVFTA----HFM-AG-----HTPGSTA--WTWTD----TrngkpvR-----IAYA-DSlsapgy--------------- 191 Stenotrophomonas...
NP_608983   135 ----------RRSpGh-----TLScVSv--LVENSqlggRv-----------GITGdLferredi--------------- 171 fruit fly
NP_142803   155 kGSTGL----FKIeDGrviedKVEDEIGlaINTRK----G------L-----VVLAgCAhpgivsmvkkai--------- 206 Pyrococcus horik...
1WRA_A      156 -GDMDIq--lYNYeNEt----DSSGELKkiWDDNSnsliS------V-----VKVNgKKiylggdldnvh---------- 207 Streptococcus pn...
NP_143261   157 -RAV------GYFpDGsk--dPVRDDMA--LIVEEg--sK------S-----VVITgCGhsgiiniaihskk-------- 204 Pyrococcus horik...
BAB08807    239 -EPITV----THSiPD------CSG-----LFLRCa--dG------N-----ILHTgDWkideapldgkv---------- 279 thale cress
AAF97210    108 -QGTSL----LPVpVP-----HSGADNV--AFVAShggeR------T-----AIITdSWiwtde---------------- 148 uncultured marin...
AAK18826    125 dIDIES----FGV---------SHDAIDpqFYR-------------------FMKDgKSfvmlt---------------- 156 Streptococcus th...
ZP_03593861 113 gLDVES----FGVsHD------AAEPMFyvFHYSGrklaL------Mt---dTGYVsDRmkgiirsanvfvfesnhdvgm 173 Bacillus subtili...
NP_347174   137 gKIPKInnfeNRKsIGk---qVDGGKLVddYVMDDtalaY------KskngiYIITgCShsgicniveya---------- 197 Clostridium acet...

1SML_A      192 -----------qlqgnPRYPHLIEdyRRSFATVRALPCDv-----LLTPH 225 Stenotrophomonas maltophilia
NP_608983   172 ---------ddeniwmDAGSENEKvqREERSKMAQLCEFi-----IPGHg 207 fruit fly
NP_142803   207 -----klsgndkvyavLGGFHLINaeDSRIEKTVEAFKElev-kkVYAGH 250 Pyrococcus horikoshii OT3
1WRA_A      208 -----gaedkygpligKVDLMKFNhhHDTNKSNTKDFIKnlspslIVQTS 252 Streptococcus pneumoniae
NP_143261   205 ---ltnnriaaliggfHLKGIERSllDEAVKKLRELEIEk-----LYPGH 246 Pyrococcus horikoshii OT3
BAB08807    280 -----fdrealeelskEGVTLMMSdsTNVLSPGRTISEKv-----VADAL 319 thale cress
AAF97210    149 -----------lvhhvHGCQHIAVeaNYDSNRL------------LNGPY 175 uncultured marine group II euryarchaeote 37F11
AAK18826    157 -----------dtgyvSDRMAGLIenADGYLIESNHDIEi-----LRAGS 190 Streptococcus thermophilus
ZP_03593861 174 lqmgrypwsikrrilsDVGHVSNEdaALAMTDVIGDETSr-----IYLAH 218 Bacillus subtilis subsp. subtilis str. 168
NP_347174   198 -----kqvcrdnrvigIIGGFHLFevNEQVQKTIDYLVQnni-keLYPCH 241 Clostridium acetobutylicum ATCC 824
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