Conserved Protein Domain Family
dDENN

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smart00801: dDENN 
Domain always found downstream of DENN domain, found in a variety of signalling proteins
The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Statistics
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PSSM-Id: 129037
View PSSM: smart00801
Aligned: 61 rows
Threshold Bit Score: 39.9658
Threshold Setting Gi: 183233271
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_588362     833 SQQILVTFLKFF--IKILGS-YRNYL-R---------KphmsrenfgiSKGSGGL-IGSFDFNKFTRQASKVH--GSWIS 896  Schizosacchar...
XP_653340     570 NCAVRIILFKFI--NVMLNE-YRDYI-G---------Y----------TWIADKE-SVVFSSEEFIYNQPSDR--RDFLK 623  Entamoeba his...
XP_654679     531 NISIQLCFFKAV--IQLLLN-YKQYI-Gy--------T----------WISNENV-IIHFNDDQFILSHPSEQ--MDFLK 585  Entamoeba his...
XP_001072997  437 NCKIQHITLQLL--VGIFRE-VKNHL-N---------Y----------------E-HRVFNSEEFLKTRAAGD--QQFYK 484  Norway rat
XP_652794     563 NLKVRLAYFKFL--TKLLEG-YDEFI-N---------Y----------VWVADNE-VFDFDVYSFFLTKSFDC--EPLIK 616  Entamoeba his...
XP_656473     625 NEYIQLCFVKGI--SLLMKG-YEEHLgI---------M----------KITENDN-VYLF-EDEFIRERNIEE--HNFLK 678  Entamoeba his...
XP_636981     626 ELKLq-PFVSAI--NNHISGlFDNFK-Rhc------vR----------NVTHQKTiS-VFVKESFMFTEYPEEehHQWID 684  Dictyostelium...
CAG11947      388 NREIQkISLELM--VNIFRD-ISGHL-N----------------------YE----HWVFNSEDFLKSREPTE--QLFYR 435  spotted green...
CAF99362      314 NRQIQnIMLELL--VNTFRG-VQDFL-N-------------------------HE-HRVFNSEEFLRTREPAD--QLFYK 361  spotted green...
XP_647447     706 NESVHrIYSTIQqyTLWL---FKKIE-IqfitvnvfdS----------LEIED------FKKK-FLSTVSDHN--KEFIK 762  Dictyostelium...
NP_588362     897 SL-CSSQAFAEFIGDR 911  Schizosaccharomyces pombe 972h-
XP_653340     624 AL-FESQHFSFFLQNf 638  Entamoeba histolytica HM-1:IMSS
XP_654679     586 YL-TETQSFKFFCESy 600  Entamoeba histolytica HM-1:IMSS
XP_001072997  485 QV-LDTYMFHSFLKAR 499  Norway rat
XP_652794     617 HF-CESGTFLEYIKEQ 631  Entamoeba histolytica HM-1:IMSS
XP_656473     679 EM-MKTQNVVYYIENT 693  Entamoeba histolytica HM-1:IMSS
XP_636981     685 EF-TKTLMFSMYLDQK 699  Dictyostelium discoideum AX4
CAG11947      436 KVivlvqstintnlti 451  spotted green pufferfish
CAF99362      362 KVrSHSPRQTRALAEC 377  spotted green pufferfish
XP_647447     763 ML-LDTQHFSHFLHHN 777  Dictyostelium discoideum AX4
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