Conserved Protein Domain Family
DENN
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smart00799: DENN 
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Links
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Statistics
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PSSM-Id: 214823
Aligned: 69 rows
Threshold Bit Score: 106.126
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_002821883  337 TLTSL--CVL-SHYPFFS-TFR-------ECLYTLKRL--VD--C-CSERLLgkklgiprgvqrdtmwriftgsllveek 400  Sumatran oran...
XP_636830     111 ILECL--CII-SHHAWSS-TFG-------SMLEILETR--YR--V-SIDEIH---------------------------- 146  Dictyostelium...
XP_843401     123 ngEAV--VTI-SPYPWCN-FFY-------R-LAYLF----VT--N-GQEGGQ---------------------------- 155  Leishmania ma...
EFZ26172      124 fvngeaavsL-SPYPWCR-FFA-------Q-LATLFRTngYD--H-GKAI------------------------------ 160  Trypanosoma c...
XP_646194     110 ePICY--CII-SRKPFFK-LFD-------RVFIAIQEK--YE--IkSKNSIH---------------------------- 146  Dictyostelium...
XP_655061      66 ltqthstlIF-SHRVWVT-CFR-------YLINIIKHL--YI--D-NKPLFY---------------------------- 103  Entamoeba his...
XP_647978      67 TDECT--FILtSQYLHWS-LF----------INILLHL--IQ--L-PSPQRV---------------------------- 100  Entamoeba his...
XP_629905     866 IPTSFssSSL-SSLSNSN-----------NSHQQQQSE--HPslV-EEEIQ----------------------------- 901  Dictyostelium...
NP_179622     688 CESVFssA----RSVLSD-DVDelsnsenDFGDDLILE--WAkdH-NNDSLQ---------------------------- 731  thale cress
XP_635823     556 APRVY--CFL-TRFPFFQlHFQml----hSILEGERML--MLfsL-SQSTDP---------------------------- 597  Dictyostelium...

XP_002821883  401 ssallhdlreieA--------WIYRLLRSPVP--VSGQKRVD------------IEV-----------L--PQE--LQpa 443  Sumatran oran...
XP_636830     147 ------------N--------FLAASLLSVIP--APGDSFTV------------YIYdnpfisdkkptN--LPV--SY-- 186  Dictyostelium...
XP_843401     156 ------------K--------LVKALCKCSTP--PSGGMFNT-----------------------------PLD--LGl- 181  Leishmania ma...
EFZ26172      161 ----------------------VEALCRSPTP--PSGSNFVL------------STS-----------I--PI------- 184  Trypanosoma c...
XP_646194     147 ------------N--------LLSALIAYPIP--KSSTTIEL------------TTT-----------A--TNS--AT-- 175  Dictyostelium...
XP_655061     104 ------------Q--------TINYLIHYNIQ--PSTSSLYY-------------------------------P--EA-- 126  Entamoeba his...
XP_647978     101 ------------L--------FLSSL-HHLIP--LPTLNQLN------------YPL-----------F--S-------- 124  Entamoeba his...
XP_629905     902 ---------------------TIEYYYSKSVPleNEKLSLQF-----------------------------PGDsnPT-- 929  Dictyostelium...
NP_179622     732 ------------L---------VCGYHSLAIP--SRGSEVVFhplehlqsisytRPP-----------VsaLGLs-eE-- 774  thale cress
XP_635823     598 ------------QnngsstadLLNLYYNISM---EGVKEKVQ------------FKA-----------P--CHNy-kT-- 634  Dictyostelium...

XP_002821883  444 lT-FALPD----PSRFTLV-D-------Fp-lHLPLELLG-VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY 508  Sumatran oran...
XP_636830     187 -T-LKRPV----STDKSSLhD-------Gt-lQPLIETLS-SQKLLHLFISLLFERRVIIYSENINRVSKFINAIVSLLD 251  Dictyostelium...
XP_843401     182 -T-FNRPY----DRLCSFI-D-------TaplDMLFIFPN-MDDLFSVLADLMLEKHIIIVGPNFSIVSNVVMSLQALVA 246  Leishmania ma...
EFZ26172      185 -V-FQRPY----DRLCSFI-D-------Ts-pIDLINIFPeTETLFSVLADLLLEKRVIVVGPNFGLVSHVVMSLQSLIS 249  Trypanosoma c...
XP_646194     176 -EnWVFPF----LKPRTNF-D-------Hi-dYELIHKMN-PAHIIRLFEFAITESRVILLSKDISVVSNGILALSSLLS 240  Dictyostelium...
XP_655061     127 -Q-INFQF----NNINQSI-Q-------Td-aFSFLSKIS-ENTLRCLFASILNERRVVVIGQNPSEFSVVVLLLLEILI 190  Entamoeba his...
XP_647978     125 ---FHSHL----PQQINQP-S-------Sg-cLSSLLCLP-ITQLMMLFSSILNERRIIIQSNSAQKISEFIVSLLEIFS 187  Entamoeba his...
XP_629905     930 -I-YGCGD-----DSFQLE-K-------Wc-lSGLVKALS-LKTLIQAMSCILLEKYLLVTSKNIGTISNSVFAFIPLLK 992  Dictyostelium...
NP_179622     775 -Y-ICSSDskeiNARLAAA-EeamglsmWt-tATVCRILS-LETIMSLLAGVLLEKQIVIICPNLGVLSAIVLSLVPMIR 849  thale cress
XP_635823     635 -D-YHCPL----GSEDRLI-Ad------Ws-lHPTFESLS-VEDILNIYCWILLERSVLVVSKNLGNVSALVFSFIPLLK 699  Dictyostelium...

XP_002821883  509 PLEYMFPVIPLLPTCMASaeqLLLAPTPYIIGVPASFFLYKLDFKMpDD---VWLVDLDSN 566  Sumatran orangutan
XP_636830     252 PFAWQHIFIPILPRSLLD---YCTAPMPFIIGIHSSLLAPIRRKPL-NE---IVFVDLDKD 305  Dictyostelium discoideum AX4
XP_843401     247 PFDWMHILIPILPTSLLD---VLAAPPPYLVGILTSQLPHVARVPL-DS---VVAVHLGPG 300  Leishmania major strain Friedlin
EFZ26172      250 PFDWMHILAPILPSSLMD---VLAAPTPYLVGILNSQIPLLERVPI-EN---CVLIHLGST 303  Trypanosoma cruzi
XP_646194     241 PLVWQHIFISILPNALMP---YVAAPIPFLVGILESSLKSFYQQPT-EQ---VILYNLDTl 294  Dictyostelium discoideum AX4
XP_655061     191 PFEWQHIIITHLPVSMVS---LLQSPLPFIIGMKTNEFIQVS-----NE---VVVFNIDTl 240  Entamoeba histolytica HM-1:IMSS
XP_647978     188 PLKWQHLLVPFLPIKYTE---LTETPTPFIIGVDPSIMEIIDLF---DI---IVFVDIDKG 239  Entamoeba histolytica HM-1:IMSS
XP_629905     993 PFIYQGAFIPVLPNSALD---ALYCPIPFIIGITKNLATLSSEMPD-ALs-nCYVLDIDRD 1048 Dictyostelium discoideum AX4
NP_179622     850 PFQWQSLLLPVLPGRMFD---FLEAPVPFLVGIHSKPIDWKVKTSN------LILVNILNN 901  thale cress
XP_635823     700 PFVWQCCFIPILPESLIE---SIDAPFPYIIGYQC---EEVGPELM-DDkrdYLIVDIDQK 753  Dictyostelium discoideum AX4
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