Conserved Protein Domain Family
MANEC

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smart00765: MANEC 
The MANEC domain, formerly called MANSC.
This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.
Statistics
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PSSM-Id: 129004
View PSSM: smart00765
Aligned: 15 rows
Threshold Bit Score: 83.6538
Threshold Setting Gi: 221330967
Created: 12-Jul-2011
Updated: 16-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148671603  74 GPREDCPGAggtavYRA-VPDT-IIRTQDSIAAGASFLRAPGSVRGWRQCVTACCSEPS------CSVAVVQLPRGPSVp 145
gi 158297357  57 MNIETCLVR-----FDV-HLNT-IIRTEESRSMGARFLDD-ADLNSREQCLRLCCETEN------CDVFVFE---EKSP- 118
gi 13385846   23 SAGQNCLTK-----S---LEDV-VIDIQSSLSKGIRG-NEPIHLATQEDCIGACCSTKDiagdkaCNLMIFDTRKTDRQ- 91
gi 19921118   42 MDLEVCIGH-----FDV-HKNT-IIRTGESQAIGGKYLQG-IELDTIEECERLCCETDA------CDVYIFE---RKAG- 103
gi 31542650   24 SASQNCLKK-----S---LEDV-VIDIQSSLSKGIRG-NEPVYTSTQEDCINSCCSTKNisgdkaCNLMIFDTRKTARQ- 92
gi 71897297   21 SRGQGCAA-------QR-MDNA-IIDINLSLPMGIRG-AEPVHVPTPEACIHACCLGEKlsggkkCNLVIFDAQRASTQ- 89
gi 160774012  28 EEEKLCKDK-----FSVgKEDF-VLNTDESVKEGATFLGSP-QVSKPEDCVMACCNDPN------CNLALMEHREDPKS- 93
gi 187466506  24 VFYRDCWIR-------R-FPGM-LLDLEESQRLGAQFLKY-YSENTGQKCGRSCCLRKDv----sCNVAVFFHDPVHDN- 88
gi 148230489  19 QQQPACDG------YEV-LDGVgLPAIGTPARQLMIELDSSRVANSEQDCWDLCCSTER------CELAEM------SE- 78
gi 76154620   29 dnngnCGKS-----FQF-KSNK-IILTQKSISAGAKFLKK-LKVASFKECYFKCCSTSE------CSTAVFE---SEAT- 90
                         90       100       110
                 ....*....|....*....|....*....|...
gi 148671603 146 apmpaPR-CYLFNCTARGRSVCKFAPLRGYRTY 177
gi 158297357 119 -----GT-CFLFQCGPPENFRCKFTRHSNYTSA 145
gi 13385846   92 -----PN-CYLFFC--PSEDACPLKPAKGLVTY 116
gi 19921118  104 -----GY-CYLFECGPPEDFRCKFTRHANYTSA 130
gi 31542650   93 -----PN-CYLFFC--PNEEACPLKPAKGLMSY 117
gi 71897297   90 -----PN-CYLFHC--PSTEACPMKPAMGLVSY 114
gi 160774012  94 -----INtCFIINCLYKQKKVCHFVRKKGFTNY 121
gi 187466506  89 -----VN-CLHVHC--PTLESCILEPGASAILY 113
gi 148230489  79 -----GN-CKLISCMYSGFNMCELKNKEGVRSF 105
gi 76154620   91 -----QS-CFLFDCRPPGQ--CFYSSHSNYDLI 115
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