Conserved Protein Domain Family
MANEC

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smart00765: MANEC 
The MANEC domain, formerly called MANSC.
This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.
Statistics
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Aligned: 15 rows
Threshold Bit Score: 83.6538
Threshold Setting Gi: 221330967
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDL03550      74 GPREDCPGAggtavYRA-VPDT-IIRTQDSIAAGASFLRAPGSVRGWRQCVTACCSEPS------CSVAVVQLPRGPSVp 145 house mouse
XP_317605     57 MNIETCLVR-----FDV-HLNT-IIRTEESRSMGARFLDD-ADLNSREQCLRLCCETEN------CDVFVFE---EKSP- 118 Anopheles gambi...
NP_080621     23 SAGQNCLTK-----S---LEDV-VIDIQSSLSKGIRG-NEPIHLATQEDCIGACCSTKDiagdkaCNLMIFDTRKTDRQ- 91  house mouse
NP_609451     42 MDLEVCIGH-----FDV-HKNT-IIRTGESQAIGGKYLQG-IELDTIEECERLCCETDA------CDVYIFE---RKAG- 103 fruit fly
NP_060520     24 SASQNCLKK-----S---LEDV-VIDIQSSLSKGIRG-NEPVYTSTQEDCINSCCSTKNisgdkaCNLMIFDTRKTARQ- 92  human
NP_001026552  21 SRGQGCAA-------QR-MDNA-IIDINLSLPMGIRG-AEPVHVPTPEACIHACCLGEKlsggkkCNLVIFDAQRASTQ- 89  chicken
AAI55205      28 EEEKLCKDK-----FSVgKEDF-VLNTDESVKEGATFLGSP-QVSKPEDCVMACCNDPN------CNLALMEHREDPKS- 93  zebrafish
CAQ51867      24 VFYRDCWIR-------R-FPGM-LLDLEESQRLGAQFLKY-YSENTGQKCGRSCCLRKDv----sCNVAVFFHDPVHDN- 88  house mouse
NP_001089642  19 QQQPACDG------YEV-LDGVgLPAIGTPARQLMIELDSSRVANSEQDCWDLCCSTER------CELAEM------SE- 78  African clawed ...
AAX26069      29 dnngnCGKS-----FQF-KSNK-IILTQKSISAGAKFLKK-LKVASFKECYFKCCSTSE------CSTAVFE---SEAT- 90  Schistosoma jap...
EDL03550     146 apmpaPR-CYLFNCTARGRSVCKFAPLRGYRTY 177 house mouse
XP_317605    119 -----GT-CFLFQCGPPENFRCKFTRHSNYTSA 145 Anopheles gambiae str. PEST
NP_080621     92 -----PN-CYLFFC--PSEDACPLKPAKGLVTY 116 house mouse
NP_609451    104 -----GY-CYLFECGPPEDFRCKFTRHANYTSA 130 fruit fly
NP_060520     93 -----PN-CYLFFC--PNEEACPLKPAKGLMSY 117 human
NP_001026552  90 -----PN-CYLFHC--PSTEACPMKPAMGLVSY 114 chicken
AAI55205      94 -----INtCFIINCLYKQKKVCHFVRKKGFTNY 121 zebrafish
CAQ51867      89 -----VN-CLHVHC--PTLESCILEPGASAILY 113 house mouse
NP_001089642  79 -----GN-CKLISCMYSGFNMCELKNKEGVRSF 105 African clawed frog
AAX26069      91 -----QS-CFLFDCRPPGQ--CFYSSHSNYDLI 115 Schistosoma japonicum
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