2D8S


Conserved Protein Domain Family
RINGv

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smart00744: RINGv 
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The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins.
Some of these proteins have been shown both in vivo and in vitro to have ubiquitin E3 ligase activity. The RING-variant domain is reminiscent of both the RING and the PHD domains and may represent an evolutionary intermediate. To describe this domain the term PHD/LAP domain has been used in the past. Extended description: The RING-variant (RINGv) domain contains a C4HC3 zinc-finger-like motif similar to the PHD domain, while some of the spacing between the Cys/His residues follow a pattern somewhat closer to that found in the RING domain. The RINGv domain, similar to the RING, PHD and LIM domains, is thought to bind two zinc ions co-ordinated by the highly conserved Cys and His residues. RING variant domain: C-x (2) -C-x(10-45)-C-x (1) -C-x (7) -H-x(2)-C-x(11-25)-C-x(2)-C As opposed to a PHD: C-x(1-2) -C-x (7-13)-C-x(2-4)-C-x(4-5)-H-x(2)-C-x(10-21)-C-x(2)-C Classical RING domain: C-x (2) -C-x (9-39)-C-x(1-3)-H-x(2-3)-C-x(2)-C-x(4-48) -C-x(2)-C
Statistics
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PSSM-Id: 128983
View PSSM: smart00744
Aligned: 44 rows
Threshold Bit Score: 60.0002
Threshold Setting Gi: 74938917
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2D8S_A        17 ICRICHC-----EGDD-ESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCK 65  human
Q9XF50        19 RCRICHE------EEE-ESFFEVPCACSGTVKFAHRNCIQRWCNEKGNTTCEICL 66  thale cress
Q9LS14        53 QCRICHD------EDE-DTNMDTPCSCSGTLKFAHHNCVQRWCNEKGDTVCEICR 100 thale cress
Q9SQT6       217 VCRICLD-----VCEE-GNTLKMECSCKGDLRLVHEACAMKWFSTKGTRTCDVCR 265 thale cress
Q940P1       265 VCRICLVe----LGED-SEAFKMECLCRGELALAHKECTIKWFTIKGNRTCDVCK 314 thale cress
Q9FIL2        80 DCRICHLp---lETNN-GLPLQLGCSCKGDLGVAHSKCAETWFKIKGNMTCEICG 130 thale cress
Q8S283       127 NCRICHLglesaAAES-GSGMFLGCSCKDDLSCAHKQCAETWFKIRGNRICEICG 180 Oryza sativa Japonica Group
O64633        73 QCRVCLQ------DKE-EVLIELGCQCRGGLAKAHRSCIDAWFRTKGSNQCEICQ 120 thale cress
Q9FFJ5        78 DCRICHMsldaaNLES-GVPIELGCSCKADLAAAHKHCAETWFKIKGNKICEVCG 131 thale cress
NP_001042834  14 QCRICHE-----EEEEgCTAMESPCGCSGSLKYAHRGCVQRWCDEKGSTLCEICl 63  Japanese rice
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