Conserved Protein Domain Family
PSN

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smart00730: PSN 
Presenilin, signal peptide peptidase, family
Presenilin 1 and presenilin 2 are polytopic membrane proteins, whose genes are mutated in some individuals with Alzheimer's disease. Distant homologues, present in eukaryotes and archaea, also contain conserved aspartic acid residues which are predicted to contribute to catalysis. At least one member of this family has been shown to possess signal peptide peptidase activity.
Statistics
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PSSM-Id: 214793
Aligned: 29 rows
Threshold Bit Score: 111.574
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9HM09        32 TYGIGYVFVYIIAAFLFSFVIIYLGRKKK--------------------------------------------------- 60  Thermoplasma ac...
Q9VBL1       100 KFATLDTMHALCLPLGASISLLIMFFFFDs-------------------------------------------------- 129 fruit fly
Q9VPQ7        75 KADTMTKKDAMYFPLIASAALFGLYLFFKifq------------------------------------------------ 106 fruit fly
O81062        51 PTETMSKEHAMRFPLVGSAMLLSLFLLFKfls------------------------------------------------ 82  thale cress
Q9MA44       244 ETLDISAMGAVIFVISASTFLVLLFFFMSs-------------------------------------------------- 273 thale cress
Q9LQ94       290 GVVEVTVISAILFVVVASCFLIMLYKLMSf-------------------------------------------------- 319 thale cress
NP_116191    214 EYLTFSPLTVVIFVVICCVMMVLLYFFYK--------------------------------------------------- 242 human
AAH08938      66 MPETITSRDAARFPIIASCTLLGLYLFFKifs------------------------------------------------ 97  human
XP_002753140  27 siQTIDSTQALFLPIGASVSLLVMFFFFD--------------------------------------------------- 55  white-tufted-ea...
NP_502079     59 IEGSITMREARKFPISASLVLFGLYLFFKpaaerflwvarvfqilrvpeeyvqkinstiisytanttttgpsepfllrla 138 nematode
Q9HM09        61 ------------------------------L-RIFKVIYSIVVAYVIFYVFLILLSIFl--------------------- 88  Thermoplasma ac...
Q9VBL1       130 ------------------------------M-QLLFAVCTAIIATVALAFLLLPMCQYiirpctdgk------------- 165 fruit fly
Q9VPQ7       107 ---------------------------kvhI-NYLLTGYFFVLGVIALAHLLSPVINSlmpaavpkvpfhilf------- 151 fruit fly
O81062        83 ---------------------------kdlV-NAVLTAYFFVLGIVALSATLLPAIRRflpnpwndnliv---------- 124 thale cress
Q9MA44       274 -----------------------------wF-ILILTIFFVIGGMQGMHNINVTLITRrcskcgqkn------------- 310 thale cress
Q9LQ94       320 -----------------------------wF-IEVLVVLFCIGGVEQYLIEPSCTDVEsfvgairgcklvwslyshgmys 369 thale cress
NP_116191    243 ------------------------------WlVYVMIAIFCIASAMSLYNCLAALIHKipygqct--------------- 277 human
AAH08938      98 ----------------------------qeYiNLLLSMYFFVLGILALSHTISPFMNKffpasfpnrqyqllf------- 142 human
XP_002753140  56 ------------------------------SvQVVFTICTAVLATIAFAFLLLPMCQYltrpcspqn------------- 92  white-tufted-ea...
NP_502079    139 sripqervpeaiqnaatyaytnlptiqkaeC-MQLLTFLICFEGVNAFASLLKPFVTAflkkmplvpsflrfnapylfsl 217 nematode
Q9HM09        89 --------------------------YNVYAIFTVSIVVAIVFFYMILFr---nEWYVTDLAGFFLSVGISSIWGITfgV 139 Thermoplasma ac...
Q9VBL1       166 -----------------rfsfgfcgrFTAAELFSFTLSVSIVCIWVLTG-----HWLLMDAMGMGLCVAFIAFVRLPs-L 222 fruit fly
Q9VPQ7       152 ------------tkgegkhkedivnyKFSTHDIVCLVISSAIGVWYLLKk----HWIANNLFGLAFAINGVEMLHLNn-F 214 fruit fly
O81062       125 ---------------wrfpyfkslevEFTKSQVVAGIPGTFFCAWYAWKk----HWLANNILGLSFCIQGIEMLSLGs-F 184 thale cress
Q9MA44       311 ------------------lklpllgnTSILSLVVLLFCFVVAILWFMNRkt-shAWAGQDIFGICMMINVLQVARLPn-I 370 thale cress
Q9LQ94       370 ss-liniflwfrrfgesyvkvpflgaVSYLTLAICPFCIAFAVFWAVKRqy-syAWIGQDILGISLIITVLQIVRVPn-L 446 thale cress
NP_116191    278 -------------------iacrgknMEVRLIFLSGLCIAVAVVWAVFRnedrwAWILQDILGIAFCLNLIKTLKLPn-F 337 human
AAH08938     143 ------------tqgsgenkeeiinyEFDTKDLVCLGLSSIVGVWYLLRk----HWIANNLFGLAFSLNGVELLHLNn-V 205 human
XP_002753140  93 -----------------kisfgccgrFTAAELLSFSLSVMLVLIWVLTG-----HWLLMDALAMGLCVAMIAFVRLPs-L 149 white-tufted-ea...
NP_502079    218 kkgnkemeegdiedakkketeylfkiDFDRYDIIALLMCSPILISHLLKr----HWITNNIIGVSFSILGIERLHLAs-F 292 nematode
Q9HM09       140 WAAVAFLIAFEIYDYIAVYKT--------RHMISLARYAVDSdlp---------------mlfVLPENS--------GFT 188 Thermoplasma ac...
Q9VBL1       223 KVSTLLLTGLLIYDVFWVFLSsyi--fstNVMVKVATRPADNpvgivarklhlggivrdtpklNLPGKL--------VFP 292 fruit fly
Q9VPQ7       215 VTGVILLSGLFFYDIFWVFGT--------NVMVTVAKSFEAPik------------------lVFPQDL--------IEN 260 fruit fly
O81062       185 KTGAILLAGLFFYDIFWVFFT--------PVMVSVAKSFDAPik------------------lLFPT------------- 225 thale cress
Q9MA44       371 RVATILLCCAFFYDIFWVFISpli--fkqSVMIAVARGSKDTg-------------------eSIPMLL--------RIP 421 thale cress
Q9LQ94       447 KVGFVLLSCAFMYDIFWVFVSkww--freSVMIVVARGDRSGe-------------------dGIPMLL--------KIP 497 thale cress
NP_116191    338 KSCVILLGLLLLYDVFFVFITpfitkngeSIMVELAAGPFGNn-------------------eKLPVVI--------RVP 390 human
AAH08938     206 STGCILLGGLFIYDVFWVFGT--------NVMVTVAKFFEAPik------------------lVFPQDL--------LEK 251 human
XP_002753140 150 KVSCLLLSGLLIYDVFWVFFSayi--fnsNVMVKVATQPADNpl------------------dVLSRKLhlgpnvgrDVP 209 white-tufted-ea...
NP_502079    293 KAGSLLLVGLFFYDIFWVFGT--------DVMTSVAKGIDAPil------------------lQFPQDI--------YRN 338 nematode
Q9HM09       189 mrg----lsfDNRGDGNVLMIGFGDIALPSIMVVSSAIYg----------------------ISH--------------- 227 Thermoplasma ac...
Q9VBL1       293 ----------SLHNTGHFSMLGLGDVVMPGLLLCFVLRYdaykkaqgvtsdptlspprgvgsRLT--------------- 347 fruit fly
Q9VPQ7       261 -----------GLNASNFAMLGLGDIVIPGIFIALLLRFddsk----------------krkTRI--------------- 298 fruit fly
O81062       226 -----------GDALRPYSMLGLGDIVIPGIFVALALRFdvs-----------------rrrQPQ--------------- 262 thale cress
Q9MA44       422 r---------LSDPWGGYNMIGFGDILFPGLLICFIFRFdken---------------nkgvSNG--------------- 462 thale cress
Q9LQ94       498 r---------MFDPWGGYSIIGFGDIILPGLLVTFALRYdwla---------------nkrlKSG--------------- 538 thale cress
NP_116191    391 kliy---fsvMSVCLMPVSILGFGDIIVPGLLIAYCRRFdvq-----------------tgsSYI--------------- 435 human
AAH08938     252 -----------GLEANNFAMLGLGDVVIPGIFIALLLRFdisl----------------kknTHT--------------- 289 human
XP_002753140 210 rlslpgklvfPSSTGSHFSMLGIGDIVMPGLLLCFVLRYdny-----------------kkqASGdscgapgpanisgrm 272 white-tufted-ea...
NP_502079    339 g----------IMEASKHSMLGLGDIVIPGIFIALLRRFdyrvvqttae----skapqgslkGRY--------------- 389 nematode
Q9HM09       228 ----ILFFTVLPLAGGLIGMAVLYFWNRDrPAPGLPYINTGTIAGFLIAFLAF 276 Thermoplasma acidophilum
Q9VBL1       348 ----YFHCSLLGYFLGLLTATVSSEVFKA-AQPALLYLVPFTLLPLLLMAYLK 395 fruit fly
Q9VPQ7       299 ----YFYSTLIAYFLGLLATIFVMHVFKH-AQPALLYLVPACMGTPLLVALIR 346 fruit fly
O81062       263 ----YFTSAFIGYAVGVILTIVVMNWFQA-AQPALLYIVPAVIGFLASHCIWN 310 thale cress
Q9MA44       463 ----YFPWLMFGYGLGLFLTYLGLYVMNGhGQPALLYLVPCTLGITVILGLVR 511 thale cress
Q9LQ94       539 ----YFLGTMSAYGLGLLITYIALNLMDGhGQPALLYIVPFILGTLFVLGHKR 587 thale cress
NP_116191    436 ----YYVSSTVAYAIGMILTFVVLVLMKK-GQPALLYLVPCTLITASVVAWRR 483 human
AAH08938     290 ----YFYTSFAAYIFGLGLTIFIMHIFKH-AQPALLYLVPACIGFPVLVALAK 337 human
XP_002753140 273 qkvsYFHCTLIGYFVGLLTATVASRIHRA-AQPALLYLVPFTLLPLLTMAYLK 324 white-tufted-ear marmoset
NP_502079    390 ----YFVVTVVAYMAGLFITMAVMHHFKA-AQPALLYLVPCCLFVPLLLAVIR 437 nematode
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