1JEQ,1JEQ


Conserved Protein Domain Family
Ku78

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smart00559: Ku78 
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Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen
This is a single stranded DNA- and ATP-depedent helicase that has a role in chromosome translocation. This is a domain of unknown function C-terminal to its von Willebrand factor A domain, that also occurs in bacterial hypothetical proteins.
Statistics
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PSSM-Id: 128831
View PSSM: smart00559
Aligned: 22 rows
Threshold Bit Score: 117.008
Threshold Setting Gi: 289769105
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1JEQ_A    308 GGLLLPSDTKRSQIYGSRQIILEK--EETEELKRFDD--------PGLMLMGFKPLV-LLKKHHYLR-PSLFVYPEESL- 374 human
NP_588445 290 kKELKKDEIRRSYSYGGSSVVFGS--DELNKVRSFEP--------PTLRIIGFRDFS-TLKPWHCLK-PAVFLRPKDDE- 356 Schizosaccharomyce...
AAD49720  302 ETEVSKEDTIQGYRYGSDIIPFSK--VDEEQMKYKSEg-------KCFSVLGFCKSS-QVHRRFFMG-HQVLKVFAAKD- 369 house mouse
NP_564520 278 TEVIAPEERIKGFRYGPQVIPISP--DQIETLKFKTD--------KGMKLLGFTEAS-NILRHYYMK-DVNIVVPDP-S- 343 thale cress
NP_596791 307 sFEVKREDLESGYSYGRTIVPISR--SDEDVLALDTI--------PGYEILGFIPKS-SLPIYYTIS-DTNIIVPKD--- 371 Schizosaccharomyce...
ACI96822  213 EITPLPENLITGYMLGGTPVPYD---EAVLEPKEPHP--------PGLHFFGFIKRN-AVPDEYFCG-ESLYLLVHQKH- 278 fruit fly
AAF99835  292 TGAIMQDPIQRIQPYKNQNIMFTV--EELSQVKRIST--------GHLRLLGFKPLS-CLKDYHNLK-PSTFLYPSDKE- 358 thale cress
AAT92882  323 TGEDVTGKTVKVYPYGDLDINLSDsqDQIVMEAYTQKd-------AFLKIIGFRSSSkSIHYFNNID-KSSFIVPDEAK- 393 baker's yeast
NP_497899 307 lNFLKSIINASGYNFGKSVIMMDP---EYLKEKYNDHnfnegqtgGVLKLIQFTKRA-NILDSYLLDaSAKTVLPALNSp 382 nematode
NP_536773 319 EYQIKVTGGWYTCNVGERDLRISM--DQLNRVRNLHK--------PQMMLLGFKHRS-SLPEVSYIK-PANFMYPDDQS- 385 fruit fly
1JEQ_A    375 VIGSSTLFSALLIKCLEKEVAALCRYTPRRNI-P-PYFVALVP-------QEEEL-DD--Qkiqv----tppGFQLVFLP 438 human
NP_588445 357 IIGSGAVFSAIHKKLLASNKIGIAWFVSRPNA-N-PCFVAMLAtpgsihiRDDFE-LP--L-----------GIFLVQLP 420 Schizosaccharomyce...
AAD49720  370 DEAAAVALSSLVHALDELNMVAIVRYAYDKRS-N-PQVGVAFP-------YIKDT-Y---E-----------CLVYVQLP 425 house mouse
NP_564520 344 KEKSVLAVSAIAREMKETNKVAIVRCVWRNGQgN-VVVGVLTP-------NVSER-DDtpD-----------SFYFNVLP 403 thale cress
NP_596791 372 DFESKLNFSAFVQSLEREHRYALARFVSKDKG-V-PVLLVLMP-------YVEFK-R---H-----------YLVDIQLP 427 Schizosaccharomyce...
ACI96822  279 NQSAAVKLDALVRALVSSDRAILCWKIYSTKF-NrPQMVVLLP-------RLADDtHP--A-----------TLYMLEVS 337 fruit fly
AAF99835  359 VIGSTRAFIALHRSMIQLERFAVAFYGGTT---P-PRLVALVA-------QLVEFwQL--H-----------SKPGVAAP 414 thale cress
AAT92882  394 YEGSIRTLASLLKILRKKDKIAILWGKLKSNS-H-PSLYTLSP-------SSVKD-YN--E-----------GFYLYRVP 450 baker's yeast
NP_497899 383 KSGATKATVSLIEAMLSLRVAAICRYTFHAKS-H-VQLIALLP-------HQDEE-TGv-F-----------YLRSVKLP 440 nematode
NP_536773 386 IIGSKRLFRALWERCLVRDKIAICLFMCKRKS-I-PRYVALVP-------VEAPD-NG--EdknyrsllcgdGFKIVYLP 453 fruit fly
1JEQ_A    439 FA--DDKRKMPFTEKIMA 454 human
NP_588445 421 TA--DDIRSLPPINPNPi 436 Schizosaccharomyces pombe 972h-
AAD49720  426 FM--EDLRQYMFSSLKNN 441 house mouse
NP_564520 404 FA--EDVREFPFPSFNKl 419 thale cress
NP_596791 428 FA--EDVRPYSFSEFEKl 443 Schizosaccharomyces pombe 972h-
ACI96822  338 YT--SQHHFWDFPALRTT 353 fruit fly
AAF99835  415 RAsdDQLKKASALMRRle 432 thale cress
AAT92882  451 FL--DEIRKFPSLLSYDD 466 baker's yeast
NP_497899 441 FS--DDMRTLKFPKFSFD 456 nematode
NP_536773 454 EA--KHIRHLDLQDWNNT 469 fruit fly
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