O00836 8 LLVYFPYSYiYPEQYSYMVALKRSLDNGG-PCILEMPSGTGKTVSLLSLISSYQVKNPS--------------------- 65 Dictyostelium dis... Q93575 17 LSVKFPFEP-YECQRIFMKNVVDVLDRKL-DAALESPTGTGKTLSLLCSTLAWVQRQKEtk------------------- 75 Caenorhabditis el... O14147 11 TNFHHPYTP-YDIQLEFMRSLYSSISDGK-IGIFESPTGTGKSLSLICASLTWLDEHGGvlledneksndnksn------ 82 Schizosaccharomyc... Q92770 11 IHFPFPFTP-YSIQEDFMAELYRVLEAGK-IGIFESPTGTGKSLSLICGALSWLRDFEQkkreeearlletgtgplhdek 88 human O58428 3 ELQYFPYEKfRPNQREFIEIVKEAVKRGE-NLIVEAPTGFGKTISVLAGVLPYAISLGY--------------------- 60 Pyrococcus horiko... Q21489 2 DEFSFPFQP-YDIQLNLMREIRQCIEQRK-IGIFESPTGTGKSLSVLCSTMTWLEAEELristdlstrlgevhtkitecd 79 Caenorhabditis el... CAA43022 8 LPILFPYPRiYPEQYQYMCDLKHSLDAGG-IALLEMPSGTGKTISLLSLIVSYQQHYPEh-------------------- 66 fission yeast Q60452 8 LLVYFPYDYiYPEQFSYMLELKRTLDAKG-HGVLEMPSGTGKTVSLLALIVAYQRAFPLe-------------------- 66 Chinese hamster NP_171818 8 VTVYFPYDNiYPEQYEYMVELKRALDAKG-HCLLEMPTGTGKTIALLSLITSYRLSRPDs-------------------- 66 thale cress EDV08993 8 LPVLFPYPKiYPEQYNYMCDIKKTLDVGG-NSILEMPSGTGKTVSLLSLTIAYQMHYPEh-------------------- 66 Saccharomyces cer... NP_127020 1 MFEYFPYKTlRPHQDEFIELVRDVVKRGE-KVIIEAPTGFGKTISVLAGVLPHAISFGY--------------------- 58 Pyrococcus abyssi... NP_015317 8 ETFYHPYKP-YDIQVQLMETVYRVLSEGKkIAILESPTGTGKTLSLICATMTWLRMNKAdiftrmetniktnedds---- 82 Saccharomyces cer... NP_569898 16 QEFGFPYSP-YEIQEQLMQELFQVLERGQ-VGIFESPTGTGKSLTLTCGALTWLARHEElvrtemlarirgveqelaklk 93 fruit fly
O00836 66 --------------------IKLIYCSRTVP-------------------EIEQATEEARRVLQ---------------- 90 Dictyostelium dis... Q93575 76 ------------------plDFATWQTSGAG-------------------GAEKTDEKLKSAYVpt-------------- 104 Caenorhabditis el... O14147 83 -----tsskipdwvleqdlkIQKDLVKETHA-------------------RLEQRLEEIRKRNQsrknqmsnnsttyhre 138 Schizosaccharomyc... Q92770 89 deslclssscegaagtprpaGEPAWVTQFVQkkeerdlvdrlkaeqarrkQREERLQQLQHRVQlkyaakrlrqeeeere 168 human O58428 61 ---------------------KVVYLARTHK-------------------QMDRVIEELRKIG----------------- 83 Pyrococcus horiko... Q21489 80 kittadnwetavrekmraqdVETEILEQIQSr-----------------eRLQSRIDQARRGMVevsrkrkapardtd-- 140 Caenorhabditis el... CAA43022 67 --------------------rKLIYCSRTMS-------------------EIDKALAELKRLMA---------------- 91 fission yeast Q60452 67 -------------------vTKLIYCSRTVP-------------------EIEKVIEELRKLLsf--------------- 93 Chinese hamster NP_171818 67 -------------------pIKLVYCTRTVH-------------------EMEKTLGELKLLHDyq-------------- 94 thale cress EDV08993 67 --------------------rKIIYCSRTMS-------------------EIEKALVELENLMD---------------- 91 Saccharomyces cer... NP_127020 59 ---------------------KVIYLARTHK-------------------QMDRVIEELKRI------------------ 80 Pyrococcus abyssi... NP_015317 83 ---enlsddepdwvidtyrkSVLQEKVDLLN-------------------DYEKHLNEINTTSCkqlktmcdldkehgry 140 Saccharomyces cer... NP_569898 94 eeseqssnwlesqgksraqrAELLRLQHLQAll----------------dKQEQQLDQIRKGAKkhkrqgrvhpg----- 152 fruit fly
O00836 91 ---------------------------------YRNS---------------------------------------EMGE 98 Dictyostelium dis... Q93575 105 --------------------------------iFYASrthsql----------------------------eqvvhELNR 124 Caenorhabditis el... O14147 139 tkrrni-----naeastsdncnnsntsvdpmdeYLVTaeytmpstseqsedl----------fnngysskvsellrKLSP 203 Schizosaccharomyc... Q92770 169 nllrlsremletgpeaerleqlesgeeelvlaeYESDeekkvasrvdededdleeehitkiyycsrthsqlaqfvhEVKK 248 human O58428 84 ----------------------------------------------------------------------------EK-- 85 Pyrococcus horiko... Q21489 141 -------------------qflepqdeaapseeYNNDeksekqrdsdffddvdeeeekplkclkifyasrthsqleQLAE 201 Caenorhabditis el... CAA43022 92 ---------------------------------YRTS---------------------------------------QLG- 98 fission yeast Q60452 94 --------------------------------------------------------------------------yeQQEG 99 Chinese hamster NP_171818 95 --------------------------------------------------------------------------vrHLG- 99 thale cress EDV08993 92 ---------------------------------YRTK---------------------------------------ELG- 98 Saccharomyces cer... NP_127020 81 -------------------------------------------------------------------------------R 81 Pyrococcus abyssi... NP_015317 141 ksvdplr----kkrkgarhldvsleeqdfiprpYESDsenndtskstrggrisd-----kdyklselnsqiitlldKIDG 211 Saccharomyces cer... NP_569898 153 -----------------------kleelekdldPESDsdsehetadgpqeaaedryrpvqiffcsrthsqlaqivaELRK 209 fruit fly
O00836 99 --ESPKTLCMSMS-SRRN-LCIQPRVS-EERDGKVV-----------------------------DALCRELTSSWNR-- 142 Dictyostelium dis... Q93575 125 --TEYKWVKTTILgSREH-FCINQKVK-KIKESNRQ-----------------------------AHVCRGLVSKRAChy 171 Caenorhabditis el... O14147 204 dnEKPPIVQKIYFtSRTH-SQLQQLVQeIKKLNNQTfstpirv----------------vslasrKNLCINNEVRKLRpt 266 Schizosaccharomyc... Q92770 249 spFGKDVRLVSLG-SRQN-LCVNEDVKsLGSVQLIN------------------------------DRCVDMQRSRHEkk 296 human O58428 86 ----SEVSGIEFR-SRKD-LCLHAYIQtFAQDAYTS-----------------------------MIVCKSLRKLGKCky 130 Pyrococcus horiko... Q21489 202 elAKTRFQPRIVTcASRGtLCVNEEVKkLKLNHLIN------------------------------EKCMELRKNGMSek 251 Caenorhabditis el... CAA43022 99 --YEEPFLGLGLT-SRKN-LCLHPSVR-REKNGNVV-----------------------------DARCRSLTAGFVReq 144 fission yeast Q60452 100 --EKLPFLGLALS-SRKN-LCIHPEVt-PLRFGKDV-----------------------------DGKCHSLTASYVRaq 145 Chinese hamster NP_171818 100 --TQAKILALGLS-SRKN-LCVNTKVL-AAENRDSV-----------------------------DAACRKRTASWVRal 145 thale cress EDV08993 99 --YQEDFRGLGLT-SRKN-LCLHPEVSk-ERKGTVV-----------------------------DEKCRRMTNGQAKrk 144 Saccharomyces cer... NP_127020 82 --EIAKVSGIEFR-SRKD-LCLHSYIRtFAQDAYTS-----------------------------MIVCKSLKRLGKCky 128 Pyrococcus abyssi... NP_015317 212 kvSRDPNNGDRFDvTNQNpVKIYYASRtYSQLGQFTsqlrlpsfpssfrdkvpdekvkylplaskKQLCINPKVMKWKtl 291 Saccharomyces cer... NP_569898 210 tpHGQSVRSISLG-SRQQ-LCGNPAVRkLKHVGLMN------------------------------ERCLDMATKKARpn 257 fruit fly
O00836 143 -------------Es--pTSEKCKFFENFESNGKei--------llEGVYSLEDLKEYGLKHQMCPYFLSRHMLNFANIV 199 Dictyostelium dis... Q93575 172 ------------yN----KFDACTTDKMTEFLDK------------GEAMDIEDFVKLGTQNSLCPYFMSRQRSETAELI 223 Caenorhabditis el... O14147 267 saln----ekcieLq--gSAHKCPFLQDNTQLWDfrd------ealAEIMDIEELVELGQRLKVCPYYGTREAVDSAQIV 334 Schizosaccharomyc... Q92770 297 kgaee--ekpkrrRq--eKQAACPFYNHEQMGLLrde-------alAEVKDMEQLLALGKEARACPYYGSRLAIPAAQLV 365 human O58428 131 ------------yEn--lKEKRDRVDEIVKFFLSfpp-------fpREVIEYSELLEL------CPYEITKKVGEKANVV 183 Pyrococcus horiko... Q21489 252 ekvqklekgttkkTk--tCATSCEFYNSTQIEDVvng------vlsNKLKSTLEVSKQGKLSNGCPYFATRKSVPQCQLV 323 Caenorhabditis el... CAA43022 145 -----------rlAg--mDVPTCEFHDNLEDLEPhsl-------isNGVWTLDDITEYGEKTTRCPYFTVRRMLPFCNVI 204 fission yeast Q60452 146 -----------yqQd--aSLPHCRFYEEFDAHGRqvp-------lpAGIYNLDDLKALGQRQGWCPYFLARYSILHANVV 205 Chinese hamster NP_171818 146 -----------stEn--pNVELCDFFENYEKAAEnal-------lpPGVYTLEDLRAFGKNRGWCPYFLARHMIQFANVI 205 thale cress EDV08993 145 -----------leEdpeaNVELCEYHENLYNIEVedy-------lpKGVFSFEKLLKYCEEKTLCPYFIVRRMISLCNII 206 Saccharomyces cer... NP_127020 129 ------------fEn--lKEKRDKVKEIVEFFLEnps-------ypWEVIEYSNLLEL------CPYEVTRKVGEKANVI 181 Pyrococcus abyssi... NP_015317 292 eain----dacadLr--hSKEGCIFYQNTNEWRHcpdtlalrdmifSEIQDIEDLVPLGKSLGICPYYASREALPIAEVV 365 Saccharomyces cer... NP_569898 258 psk------ksrlTa--eANSRCPFKAASLVESLrdl-------alTEPLDIEELANEGTACGGCSYYASRSAVEHAQLI 322 fruit fly
O00836 200 IFSYQYLLDPKIASLISSSF-Ps---NSIVVFDEAHNIDNVCINALSINIDNKLLDTSSKNIAKINKQIEDi-------- 267 Dictyostelium dis... Q93575 224 LLPYNYIIDPKMRRRYKLDL-K----NSIVIFDEAHNLESICESNASAELTSTSIALCIEELKKVLALLVDeee----ta 294 Caenorhabditis el... O14147 335 TLPYPLLLQESARNALNLTL-K----DNICIIDEAHNLIDAICSMHSSSISFRQVCIAETQLQQYFLRFEK--------- 400 Schizosaccharomyc... Q92770 366 VLPYQMLLHAATRQAAGIRL-Q----DQVVIIDEAHNLIDTITGMHSVEVSGSQLCQAHSQLLQYVERYGK--------- 431 human O58428 184 VASYLYMISPPIRQAFLENL-GvdysDLIVIFDEAHNLPDQAISALSDRLSVRSIER---AIKEAEEYGEK--------- 250 Pyrococcus horiko... Q21489 324 LLPYQVLLHDGTRKAWGIEL-K----DNVIVLDEAHNVLNTISSFFFRKLEKVSKNG-FKNCSLYSAEISTksltlalrl 397 Caenorhabditis el... CAA43022 205 IYSYHYLLDPKIAERVSRELsK----DCIVVFDEAHNIDNVCIESLSIDLTESSLRKASKSILSLEQKVNEv-------- 272 fission yeast Q60452 206 VYSYHYLLDPKIADLVSKEL-Ar---KAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRi-------- 273 Chinese hamster NP_171818 206 VYSYQYLLDPKVAGFISKELqK----ESVVVFDEAHNIDNVCIEALSVSVRRVTLEGANRNLNKIRQEIDRf-------- 273 thale cress EDV08993 207 IYSYHYLLDPKIAERVSNEVsK----DSIVIFDEAHNIDNVCIESLSLDLTTDALRRATRGANALDERISEv-------- 274 Saccharomyces cer... NP_127020 182 VASYLYMVNPWIRQAFLDGL-GleysDLIVIFDEAHNLPDQAISALSDRLSIRSVERA---IKEANEYGEKd-------- 249 Pyrococcus abyssi... NP_015317 366 TLPYQYLLSESTRSSLQINL-E----NSIVIIDEAHNLIETINSIYSSQISLEDLKNCHKGIVTYFNKF-Ks-------- 431 Saccharomyces cer... NP_569898 323 LLPYQLLLQKSARNQLGISL-K----GSIVIVDEAHNLLDSVAQLHGSEISRQQLERAKVQISGYKDHFQK--------- 388 fruit fly
O00836 268 -KKVDEKR 274 Dictyostelium discoideum Q93575 295 rSEADAET 302 Caenorhabditis elegans O14147 401 -RLNGNNR 407 Schizosaccharomyces pombe 972h- Q92770 432 --RLKAKN 437 human O58428 251 ----DIEN 254 Pyrococcus horikoshii Q21489 398 iREYNAHY 405 Caenorhabditis elegans CAA43022 273 -KQSDSKK 279 fission yeast Q60452 274 -KETDEQR 280 Chinese hamster NP_171818 274 -KATDAGR 280 thale cress EDV08993 275 -RKVDSQK 281 Saccharomyces cerevisiae RM11-1a NP_127020 250 -IENflsi 256 Pyrococcus abyssi GE5 NP_015317 432 -RLNPGNR 438 Saccharomyces cerevisiae S288c NP_569898 389 --RFTTKN 394 fruit fly
Jiyao W et al.(2023). "The conserved domain database in 2023.",