2HEK,3IBJ,1ZKL,3BJC,3GW7


Conserved Protein Domain Family
HDc

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smart00471: HDc 
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Metal dependent phosphohydrolases with conserved 'HD' motif.
Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).
Statistics
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PSSM-Id: 214679
Aligned: 135 rows
Threshold Bit Score: 30.7274
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2HEK_A        47 AQHTRFEHSLGVYHI------TE------RICESLKv------kE------K---ELVKLAGLLHDLGHPPFSHTTEVLl 99   Aquifex aeolicus
NP_001022705 419 vPYHNWSHAFAVTHF------CWltlrtdAIRRALSd------mE------R---LSLLIACLCHDIDHRGTTNSFQMQs 477  nematode
NP_015005    262 nkfHNFRHAIDVMQA------TW------RLCTYLLk------dN------PvqtLLLCMAAIGHDVGHPGTNNQLLCNc 317  Saccharomyces ...
NP_491544    482 VAYHNWAHGWSVAHA------MF------ATLMNSPdaf--tklE------A---LALYVSCLCHDLDHRGKNNAYMKTm 538  nematode
XP_001253230 376 VAYHNWRHAFNTAQC------MF------AALKAGKiqkrltdlE------I---LALLIAALSHDLDHRGVNNSYIQRs 434  cattle
XP_851951    647 PPYHNWMHAFSVSHF------CY------LLYKNLEltnylediE------I---FALFISCMCHDLDHRGTNNSFQVAs 705  dog
XP_638612    484 NRYHNFTHAFDVTQT------VY------TFLTSFNaaqylthlD------I---FALLISCMCHDLNHPGFNNTFQVNa 542  Dictyostelium ...
3IBJ_A       440 pPYHNWMHAFSVSHF------CY------LLYKNLEl------tNyledieI---FALFISCMCHDLDHRGTNNSFQVAs 498  human
1ZKL_A        80 NPYHNAVHAADVTQA------MH------CYLKEPKlansvtpwD------I---LLSLIAAATHDLDHPGVNQPFLIKt 138  human
3BJC_A       613 vAYHNWRHAFNTAQCmfaalkAG------KIQNKLTd------lE------I---LALLIAALSHDLDHRGVNNSYIQRs 671  human
2HEK_A       100 p--------------rERShEDFTERVIKeTE--------------IYE-----------IL-----------KQdys-- 127  Aquifex aeolicus
NP_001022705 478 lqktplsvlystegsvLERhHFAQTIKLLqQE--------------ECS-----------IL-----------ENlpaad 521  nematode
NP_015005    318 esevaq---nfknvsiLENfHRELFQQLLsEH--------------WPQllsiskkkfdfIS-----------EAila-- 367  Saccharomyces ...
NP_491544    539 stplas----iystsvMERhHFNQTVTILqqD--------------GHN-----------IL-----------KSlssed 578  nematode
XP_001253230 435 ehplaq----lychsiMEHhHFDQCLMILnsP--------------GNQ-----------IL-----------SGlsiee 474  cattle
XP_851951    706 ksvlaal--yssegsvMERhHFAQAIAILntH--------------GCN-----------IF-----------DHfsrkd 747  dog
XP_638612    543 qtelsl---eyndisvLENhHAMLTFKILrnS--------------ECN-----------IL-----------EGlnedq 583  Dictyostelium ...
3IBJ_A       499 ksvlaal--yssegsvMERhHFAQAIAILnTH--------------GCN-----------IF-----------DHfsrkd 540  human
1ZKL_A       139 nhylat---lykntsvLENhHWRSAVGLLrESglfshlplesrqqmETQ-----------IG-----------ALilatd 193  human
3BJC_A       672 ehplaq----lychsiMEHhHFDQCLMILnSP--------------GNQ-----------ILsglsieeykttLKiik-- 720  human
2HEK_A       128 ---------------heDI--------ER---------LVritlgk-------pedeeE------------KLLSEIITG 156  Aquifex aeolicus
NP_001022705 522 frtivntirevilatdiSA--------HLrkqeriktmISegyn----------pmsfD------------HRYLLMCLV 571  nematode
NP_015005    368 --------------tdmAL--------HS---------QYedrlm---------henpM------------KQITLISLI 395  Saccharomyces ...
NP_491544    579 ykktlslikhcilatdlAL--------FF---------SNkaklnvildnntfdinrqE------------HRLLTQAVM 629  nematode
XP_001253230 475 ykttlkiikqailatdlAL--------YI---------KRrgeffelimknqfnledpH------------QKELFLAML 525  cattle
XP_851951    748 yqrmldlmrdiilatdlAH--------HL---------RIfkdlqkmae-------------vgydrtnkqHHSLLLCLL 797  dog
XP_638612    584 ykelrrsvvqlilatdmQN--------HF---------EHtnkfqhhlnnlpfdrnkkE------------DRQMILNFL 634  Dictyostelium ...
3IBJ_A       541 yqrmldlmrdiilatdlAH--------HL---------RIfkd-------------lqKmaevgydrnnkqHHRLLLCLL 590  human
1ZKL_A       194 isr------qneylslfRS--------HL---------DRgdl-------------clEdt---------rHRHLVLQMA 228  human
3BJC_A       721 --------------qaiLAtdlalyikRR---------GEffelirkn---qfnledpH------------QKELFLAML 762  human
2HEK_A       157 EFGSDRMDYLRRDAYFCGV 175  Aquifex aeolicus
NP_001022705 572 MTASDLSDQAKNFHNAKRI 590  nematode
NP_015005    396 IKAADISNVTRTLSISARW 414  Saccharomyces cerevisiae S288c
NP_491544    630 MTGCDLVASAKPWNIQTET 648  nematode
XP_001253230 526 MTACDLSAITKPWPIQQRI 544  cattle
XP_851951    798 MTSCDLSDQTKGWKTTRKI 816  dog
XP_638612    635 IKCGDISNIARPWHLNFEW 653  Dictyostelium discoideum AX4
3IBJ_A       591 MTSCDLSDQTKGWkttrki 609  human
1ZKL_A       229 LKCADICNPCRTWELSKQW 247  human
3BJC_A       763 MTACDLSAITKPWPIQQRI 781  human
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