Conserved Protein Domain Family
ParB
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smart00470: ParB 
ParB-like nuclease domain
Plasmid RK2 ParB preferentially cleaves single-stranded DNA. ParB also nicks supercoiled plasmid DNA preferably at sites with potential single-stranded character, like AT-rich regions and sequences that can form cruciform structures. ParB also exhibits 5-->3 exonuclease activity.
Links
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Statistics
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PSSM-Id: 214678
Aligned: 64 rows
Threshold Bit Score: 43.0619
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
AAD06646   34 VELGIDEVMp---NPYQPRKi--fSEDSLEELAQSIKE-HGLL-QPVLVVSEn-------GRYHLIAGERRLRASKLAKM 99  Helicobacter pylor...
AAC67083    1 MLIDIDQIK----IKKRIRKn----IGDIETLKNSIIK-HGLI-YPIIIDKN----------KNLIAGLRRYQALKEIGY 60  Borrelia burgdorfe...
AAB68645    1 MKIRVSDIK----VKNRIRKd----LGDLQPLKESIQK-LGLL-HPILIDLE----------NTLISGERRLESVKILGW 60  Leptospira interro...
AAC06628   16 TLLPIEDIVip-pIQRDLS------ETLIKKLMLSIEK-VGFV-DPILVVEGe------eGKYEVINGQHRLKAAELLGI 80  Aquifex aeolicus VF5
AAC06747   20 KEVETDKVVip-pIERPLS------ETLIERLVSSIQK-LGFI-DPIMVVPEeq-----eGYYEVIDGQHRLEAAKIVGL 85  Aquifex aeolicus VF5
AAC82684   14 LQVEVANLRp---NPWNTNSv---gAQNFEKLKGSIEK-LGFF-KPILARELd------gGIFEILGGEHRWRAAMEQGI 79  Yersinia pestis KI...
AAC82685   20 YRNPAELIPy---EMNAKKHd----EQQIRDLAAAIKK-RGFD-QPITVDKH----------DVIITGHGRREAALLAGL 80  Yersinia pestis KI...
AAF04014   13 ESVDPEELQv---DGANPNEq---NEETFGLLCKNMQT-KGWIgNAIVANTGdlpgydgdAEGLIADGEHRWRAAKEIEL 85  Natrialba phage Ph...
NP_444154   6 ASVRPDRMEhcllSAAQLIPteevNPDRVDALKAQILQaGSWT-APITAEKDa---------LFVIDDYHRLTVAHRLRL 75  Rhizobium sp. NGR234
NP_415883   8 VYRPLQELS----PYAHNARt--hSTEQVAQLVESIKQ-FGWT-NPVLIDEK----------GEIIAGHGRVMAAEMLKM 69  Escherichia coli s...

AAD06646  100 PTIKAIVVDIE-QEKMREVALIENI 123 Helicobacter pylori J99
AAC67083   61 KEIEVKVISIEnKKTLLEIELDENN 85  Borrelia burgdorferi B31
AAB68645   61 EYVDVRIVDIRnKKERVQMEAEENN 85  Leptospira interrogans serovar Lai
AAC06628   81 REIPAIILPQEtKDYIISLNVEKAP 105 Aquifex aeolicus VF5
AAC06747   86 EKVPAFVLPKElRNYILSFNIEKAP 110 Aquifex aeolicus VF5
AAC82684   80 STVPVISVGKInDLVAKQMSLVDNE 104 Yersinia pestis KIM 10
AAC82685   81 ERVPVIVRDDL-SEEEVKAKRLEDN 104 Yersinia pestis KIM 10
AAF04014   86 EEVPVKFYDFEdDAERRLWRQELNK 110 Natrialba phage PhiCh1
NP_444154  76 TRMPVVLLDND-SVRVESWRPGGNI 99  Rhizobium sp. NGR234
NP_415883  70 DSVPVIVLSGL--TDEQKQR----- 87  Escherichia coli str. K12 substr. MG1655
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