2GAI,1GL9,1CY1,2O19


Conserved Protein Domain Family
TOP1Ac

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smart00437: TOP1Ac 
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Bacterial DNA topoisomerase I DNA-binding domain
Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Statistics
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PSSM-Id: 214663
Aligned: 48 rows
Threshold Bit Score: 207.869
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2GAI_A       230 EEKKvsvKKFAPPEPFKTSTLQQEAYSKLGFSVSKTMMIAQQLYE-GvetkdghiA-FITYMRTDSTRVSDYAkee---a 304 Thermotoga mari...
NP_248662    268 KKTK---RKLKPLPPFDLGTLQREAYSYFKISPKETQEIAQKLYE-N--------A-LISYPRTSSQKLPKDRkyl--ed 332 Methanocaldococ...
NP_438605    289 KDVR---EKETAPLPYSLSALQIDAAKRFGMSAQAVLDTCQRLYE-T--------HrLITYPRSDCRYLPEEHfaerhnv 356 Haemophilus inf...
NP_276736    273 RVRD---TIRKPPVPFDLGTLQSEAYRVFGFSPKKTQTIAQNLYT-E--------G-YTSYPRTSSQKLPESIgye--ki 337 Methanothermoba...
YP_002412778 299 NDKR---ESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYEtH--------K-LITYPRSDCRYLPEEHfagrhav 366 Escherichia col...
NP_388307    262 KKTA---KKSFAPALYDLTELQRDAHKRFGFSAKETLSVLQKLYE-Qh-------K-LVTYPRTDSRFLSSDIvptlkdr 329 Bacillus subtil...
NP_047305    277 KKNL---KKSQSPRLFSLSDLQTEVNKRYHASASDTLKAVQKLYE-Q--------K-ILTYPRTDCNFITDNEfny---l 340 Lactococcus lactis
P34184       276 KEEM---RTYQPPLLYXLSTLQMDAGNAFGFKPAETLKYAQSLYD-K--------G-YLSYPRTQDERITESDare---l 339 Bacillus pseudo...
ZP_07858190  172 advqtkekktnspslfslsslqskvNQLYKATASQTLKAMQGLYE-A--------K-LLSYPRTDTPFITENEfay---l 238 Enterococcus fa...
NP_863632    276 EKEI---GYTMPPKFYDLSALQEDMNDKYKISAKRTLEIAQTLYE-K--------K-LITYPRTDSRYITEDEkem---l 339 Staphylococcus ...
2GAI_A       305 rNLITEVFG----EEYVG-----SKREr-rKSNakIQDAHEAIRPT-NVFMTPEEAGkyLNSDQKKLYELIWKRFLASQM 373 Thermotoga mari...
NP_248662    333 iLNIIKNHP----VYGKWaerilKENLk-pVEGkkEDPAHPAIHIVdIPKEELSEKE--KE-----IYDLIARRTLAAFW 400 Methanocaldococ...
NP_438605    357 lNAISTHCE----AYQVLpnvilTEQRn-rCWNdkKVEAHHAIIPTaKNRP----VN--LTQEERNIYSLIARQYLMQFC 425 Haemophilus inf...
NP_276736    338 lKNLAKN-P----RFGVHierlrG-PLk-pHEGkkEDDAHPAIHPTgLLPS-----E--LSKDEKKVYDLIVHRFISVFG 403 Methanothermoba...
YP_002412778 367 mNAISVHAP----D-LLPqpvvdPDIRn-rCWDdkKVDAHHAIIPT----ARSSAIN--LTENEAKVYNLIARQYLMQFC 434 Escherichia col...
NP_388307    330 lEGMEVKPY----AQYVSqikkrGIKShkgYVNdaKVSDHHAIIPTeEPLVLSS-----LSDKERKLYDLIAKRFLAVLM 400 Bacillus subtil...
NP_047305    341 kENLSKYIS----FLNKDinlnnTNPNk-rYVDssKVQEHHAIILTkTVPSKDNFNK--LSDLEKKIYQLVLKTTLAMFA 413 Lactococcus lactis
P34184       340 eNNIQFLSGhdtfGALFPlpvstLMNNk-rYIG--EVTDHHALLITdKIPKD---KD--LSEDEKSIYHLVVKRILAAHY 411 Bacillus pseudo...
ZP_07858190  239 kANFGKYSG----FLGLDlemvqTEPRk-rYVDgsKVQEHHAIIPTkQVPTESALAK--MDDLQRKIYALVVKTTVAMFL 311 Enterococcus fa...
NP_863632    340 lENIDYLKE----ITKINlnnelTNNSl---INpsKIEDHYAILITgNDF---NKVD--LKEEEINVYKSILQNVAMNFM 407 Staphylococcus ...
2GAI_A       374 KPSQYEETRFVLRTKD-GKYRFKGTVLkkIFDGYEKVWKTErnt---------geFPFEEGESVKPVVVKIEEQETKPKP 443 Thermotoga mari...
NP_248662    401 DNAEREYLNVKIDIKG-EKFKLSGSRT--VKEGWHEIY-YFpkfd------eielPPLKKNDIIKVEKITITRKETQPPK 470 Methanocaldococ...
NP_438605    426 PDAEYRKSKITLNIAG-GTFIAQARNL--QTAGWKELLGKEddten----qepllPIVKKGQILHCERGEVMSKKTQPPK 498 Haemophilus inf...
NP_276736    404 EDAILQTMKVELEIGE-EEFSFSRKRV--SKAGWMESYPYTkmed-------eefPEISGGDSLAVRSVSADERETKPPA 473 Methanothermoba...
YP_002412778 435 PDAVFRKCVIELDIAK-GKFVAKARFL--AEAGWRTLLGSKerdeen---dgtplPVVAKGDELLCEKGEVVERQTQPPR 508 Escherichia col...
NP_388307    401 PAFEYEETKVIAEIGG-ETFTAKGKTV--QSQGWKAVYDMAeeddeqeddrdqtlPALQKGDTLAVRTLTETSGQTKPPA 477 Bacillus subtil...
NP_047305    414 DPFEYEETVILTKVNL-AIFKTIGKTP--KNIGWKELFSEEskeskd---denllPAVTIGDIVKV-DLSVDQKETKPPI 486 Lactococcus lactis
P34184       412 PDVAMSHKEIITKVMDrFTFRSKGKEL--LSKGWHHIIPPTnend-------imlPTLLKGSEGVVTDTLTTKSKTKPPN 482 Bacillus pseudo...
ZP_07858190  312 PDYLYEETKIQTKVAD-LLFQSIGKTP--KQEGWKILFKQQtkeeee---dvqtlPLVIIGEHAEV-DVKSAEKETQPPK 384 Enterococcus fa...
NP_863632    408 DKEQYETTTIEIAVKK-LMFEVKGKII--QDNGFKALLNKQktse-------etiPNFEKNEEVDI-ELDLLEKETTPPK 476 Staphylococcus ...
2GAI_A       444 RYTEGSLVKEM-----------------ER-----------------L-------------------G------------ 458 Thermotoga mari...
NP_248662    471 RYTVASIIKEL-----------------EK-----------------R-------------------G------------ 485 Methanocaldococ...
NP_438605    499 PFTDATLLSAMtgiarfvqdkelkkilrET-----------------D-------------------G------------ 530 Haemophilus inf...
NP_276736    474 RYNEASLIREL-----------------ER-----------------R-------------------G------------ 488 Methanothermoba...
YP_002412778 509 HFTDATLLSAM-----------------TG-----------------Iarfvqdkdl--kkilratdG------------ 540 Escherichia col...
NP_388307    478 RFNEGTLLSAM-----------------EN-----------------PsafmqgeekglvktlgetgG------------ 511 Bacillus subtil...
NP_047305    487 PYTEGTLIKAM-----------------KTagkdlddeedqeilkdiE-------------------G------------ 518 Lactococcus lactis
P34184       483 RYTSSSLIGFM-----------------KN-----------------A-------------------Aqaiededrksis 509 Bacillus pseudo...
ZP_07858190  385 AFTEGTLLTAM-----------------KTanktvddeeaikilqevE-------------------G------------ 416 Enterococcus fa...
NP_863632    477 RYTEKTLLKAManpietledeglkstlkEV-----------------K-------------------G------------ 508 Staphylococcus ...
2GAI_A       459 ---IGRPSTYASTIKLLLNRGYIKKIRGYLYPTIVGSVV 494 Thermotoga maritima MSB8
NP_248662    486 ---LGTKATRAEIIDKLIKRGYVIDD-GSLKVTDLGISV 520 Methanocaldococcus jannaschii DSM 2661
NP_438605    531 ---LGTEATRAGIIELLFKRGFLTKKGRNIHSTETGRIL 566 Haemophilus influenzae Rd KW20
NP_276736    489 ---LGTKSTRADIIAKLYDRKYI--EGKKIRVSPLGENI 522 Methanothermobacter thermautotrophicus str. Delta H
YP_002412778 541 ---LGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKAL 576 Escherichia coli UMN026
NP_388307    512 ---LGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQL 547 Bacillus subtilis subsp. subtilis str. 168
NP_047305    519 ---IGTEATRANILETLKNKQYLLTEKNKLTVSQQGITL 554 Lactococcus lactis
P34184       510 nlpLGTEATRAGLITLLESRKYIEWKKNKVYPTLLGITV 548 Bacillus pseudofirmus OF4
ZP_07858190  417 ---IGTEATRASIIEALKQKEYIQVIKNKLVVTEKGKLL 452 Enterococcus faecium TX0133B
NP_863632    509 ---LGTPATRADIIENLKKNKYIQVQKNKIYITKNGILA 544 Staphylococcus aureus
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