3L4J,2XCO,2Y3P,3IFZ,2NOV,2INR,3QX3


Conserved Protein Domain Family
TOP4c

?
smart00434: TOP4c 
Click on image for an interactive view with Cn3D
DNA Topoisomerase IV
Bacterial DNA topoisomerase IV, GyrA, ParC
Statistics
?
PSSM-Id: 214660
Aligned: 64 rows
Threshold Bit Score: 409.262
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
3L4J_A     250 IPISDFINKELILFSLADNIRSIPNVLDGFKPGQRKVLYGCFKKNLKS-ELKVAQLAPYVSECTAYH-HgEQSLAQTIIG 327  baker's yeast
Q23670     728 VTFKDFVNRELVLFSNLDNERSIPCLVDGFKPGQRKVLFACFKRADKR-EVKVAQLAGAVAEISAYHhG-EQSLMGTIVN 805  Caenorhabditis e...
O41065     631 VPVPDFIDKELILFSRYDLERSIPSVVDGFKPSQRKVLYCAFKRNLTS-DVKVAQFSGYVAEHSAYHhG-EVSLQGTIVN 708  Paramecium bursa...
O16140     701 VTYSDFVNLELVLFSNGDNVRSIPSMIDGLKPGQRKVIFTCIKRNDKR-EVKVAQLAGSVAEHSAYHhG-EQSLAMTIVN 778  domestic silkworm
BAC28232   193 LTYNDFINKELILFSNsDNERSIPSMVDGLKPGQRKVLFTCFKRNDKR-EVKVAQLAGSVAEMSSYH-HgEMSLMMTIIN 270  house mouse
S44861    1952 ARMSDGV-EDLQRFE-SQRIQSIPSLIDGLKPSQRKILWTLLNNMDEStEIKVSQLAGAVAHRQSYHhG-EESLVRTIIR 2028 nematode
BAA07236   702 LTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKR-EVKVAQLAGSVAEMSAYHhG-EQALMMTIVN 779  house mouse
P27570     663 LTIGDFVHKEMVHFALVGNARAIPHCVDGLKPSQRKILWAMLKRHSSE-AAKVAQLSGYISEVSSFHhG-EASLQETIVK 740  Crithidia fascic...
BAA11510   787 ITYPDFINKELIHYSWAANLRSIPSLIDGLKPGQRKILFASFKRRLTN-EIKVSQLSGYVAEQTSYHhG-EQSLNSTIVK 864  Dictyostelium di...
NP_476760  673 ITYADFINLELVLFSNADNERSIPSLVDGLKPGQRKVMFTCFKRNDKR-EVKVAQLSGSVAEMSAYHhG-EVSLQMTIVN 750  fruit fly
3L4J_A     328 LAQNFVgsNNIYLLLPNGAFGTRatGGKDAAAARxYIYTELNKLTRKIFHPADDPLYKYIQEDEKTVEPEWYLPILPMIL 407  baker's yeast
Q23670     806 LAQDYVgsNNINLLLPIGQFGTRlqGGKDSASAR-YIFTQLSPVTRTLFPAHDDNVLRFLYEENQRIEPEWYCPIIPMVL 884  Caenorhabditis e...
O41065     709 LAQDYVgsNNINWLLPEGQFGSRlqGGKDHASAR-YIFTKLNPKTRQVFVDTDDNLLKYLYDDGDKIEPECYVPIIPSIL 787  Paramecium bursa...
O16140     779 LAQNYVgsNNINLLEPRGQFGTRlsGGKDSASPR-YIFTLMSPLTRLIFHPHDDPLLVHEFEDNQKIEPVYYLPIIPMVL 857  domestic silkworm
BAC28232   271 LAQNFVgsNNLNLLQPIGQFGTRlhGGKDSASPR-YIFTMLSPLARLLFPPKDDHTLRFLYDDNQRVEPEWYIPIIPMVL 349  house mouse
S44861    2029 MGQTFCgsSNLPLLQPIGQFGTRheGGNDAASAR-YIFTALAPTTRLLFPQADDDLLQKNVEEGMVVEPT-LCPIVPLIL 2106 nematode
BAA07236   780 LAQNFVgsNNINLLQPIGQFGTRlhGGKDAASPR-YIFTMLSSLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVL 858  house mouse
P27570     741 MAQNFTggNNINLLVPEGQFGSRqqLGNDHAAPR-YIFTKLSRFARLLFPEDDDPLLDYIDEEGTMVEPNHYVPILPLLL 819  Crithidia fascic...
BAA11510   865 MAHNFVgsNNLPLLTPSGQFGTRlqGGSD-SASA-RYILQLEPVGTLPFNELDDPLLNYLEEEGESIQPDYYIPIIPMLL 942  Dictyostelium di...
NP_476760  751 LAQNFVgaNNINLLEPRGQFGTRlsGGKDCASAR-YIFTIMSPLTRLIYHPLDDPLLDYQVDDGQKIEPLWYLPIIPMVL 829  fruit fly
3L4J_A     408 VNGAEGIGTGWSTYIPPFNPLEIIKNIRHLMNDEELEq----MHPWFRGWTGTIEEIEPlrYRMYGRIEQIGD------- 476  baker's yeast
Q23670     885 VNGAQGIGTGWSTNIPNYNPRELVKNIKRLIAGEPQKa----LAPWYKNFRGKIIQIDPsrFACYGEVAVLDD------- 953  Caenorhabditis e...
O41065     788 VNGSSGIGTGSSTNIPSYNPKDIVDNVKRLISGEDLVe----MKPWYKGFKGKIMETSPgvYVTKGLYMPNG-------- 855  Paramecium bursa...
O16140     858 VNGVEGIGTGWSTKIPNYNPRDIAENLRRLLDGEKPKv----MHPWYKNFKGNVEGFGDk-YVISGEAAILPG------- 925  domestic silkworm
BAC28232   350 INGAEGIGTGWSCKIPNFDVREVVNNIRRLLDGEEPl----pMLPSYKNFKGTIEELASnqYVINGEVAILDs------- 418  house mouse
S44861    2107 INGTEGIGTGWSTKIANRNPIDIIDMIRRKIDSISTEy---eIPPFYEEFRGKLEVVTPtkFISSGKIQLIRPerknast 2183 nematode
BAA07236   859 INGAEGIGTGWACKLPNYDAREIVNNVRRMLEGLDPHp----MLPNYKNFKGTIQELGQnqYAVSGEIFVVDR------- 927  house mouse
P27570     820 CNGAVGIGFGFATNIPSFHPLDVSAAVRAMINGESAKqvvrnLVPWAVGFQGTVRRGPEkeYIAVGKYTAHRN------- 892  Crithidia fascic...
BAA11510   943 VNGSEGIGVGMSTSIPLFSPIDIIDQLMLRLNNQVALk---kLIPWYRGFKGTISPDRHty-rTNGVIKLVG-------- 1010 Dictyostelium di...
NP_476760  830 VNGAEGIGTGWSTKISNYNPREIMKNLRKMINGQEPSv----MHPWYKNFLGRMEYVSDgrYIQTGNIQILSG------- 898  fruit fly
3L4J_A     477 NVLEITELPARTWTSTIKEYLLLGLSgND--KIKPWIKDMEEQhDDN-IKFIITLSPE---EMAKTRKIGFYERFKLISP 550  baker's yeast
Q23670     954 NTIEITELPIKQWTQDYKEKVLEGLM-ESsdKKSPVIVDYKEYhTDTtVKFVVKLSPGk--LRELERGQDLHQVFKLQAV 1030 Caenorhabditis e...
O41065     856 KTIVVSELPVGKWTHDYKEHLDGLLE-------KKIISYFREKhSDTdVLFEIDFVGN-----------PNIDILKLETT 917  Paramecium bursa...
O16140     926 DKIEITELPVGTWTHNYKENVLEPML--GtdKVKPLISEYREYnTDTtVRFVVSLLPG---KLSEIEAEGIHKVFKLQTT 1000 domestic silkworm
BAC28232   419 TTIEISELPIRTWTQTYKEQVLEPML-NGteKTPSLITDYREYhTDTtVKFVIKMTEE---KLAEAERVGLHKVFKLQSS 494  house mouse
S44861    2184 FSIEIVELPIGIWTSKYKEKLSKIVE-TLp------VLEFSERhTEKrVHFRITLDRKkssRFLQKSNSDLLNYFKLRTS 2256 nematode
BAA07236   928 NTVEITELPVRTWTQVYKEQVLEPML-NGtdKTPALISDYKEYhTDTtVKFVVKMTEE---KLAQAEAAGLHKVFKLQTT 1003 house mouse
P27570     893 GRLHVSELPWMTSIEAFRSHISSLAS-SD------VVQRIADYsGANhIDIDLIVREG-----SMTTWAECETDLALSQR 960  Crithidia fascic...
BAA11510  1011 RNLEITELPIGRWTSDYKEVLNDLID-KD------VIKSFQESnTENsVHFTILLNNNqleQMEDLTENELIKLFKLSAS 1083 Dictyostelium di...
NP_476760  899 NRLEISELPVGVWTQNYKENVLEPLS-NGteKVKGIISEYREYhTDTtVRFVISFAPGe-fERIHAEEGGFYRVFKLTTT 976  fruit fly
3L4J_A     551 ISLMNMVAFdpH-GKIKKYNSVnE--ILSEFYYVRLEYYQKRKDHMSERLq-wEvEKYSFQVKFIKMIIEKELTVTNKPR 626  baker's yeast
Q23670    1031 INTTCMVLFdaA-GCLRTYTSP-Ea-ITQEFYDSRQEKYVQRKEYLLGVLqaqS-KRLTNQARFILAKINNEIVLENKKK 1106 Caenorhabditis e...
O41065     918 IRSTNMHAFdpS-GKIKKYDTP-Ld-IIRDWFEVRKDLYVKRKAYLLEDLthrT-NIAQNKHRFITMVNNDEIIINKKHE 993  Paramecium bursa...
O16140    1001 ISMTCMNAFdyN-CCLEKYDKV-Ee-ILREFYDLRVKYYVRRKDYLEGQLqaeA-DKLSNQARFILKKCDKGLVIENKKR 1076 domestic silkworm
BAC28232   495 LTCNSMVLFd-HvGCLKKYDTVlD--ILRDFFELRLKYYGLRKEWLLGMLg-aEsSKLNNQARFILEKIDGKIVIENKPK 570  house mouse
S44861    2257 LTEN-RVLFdrN-GELKEFGNI-Se-IAAEFFEVRRDLYEKRLKIQKEECeakL-IYVENQLNFIEMVTNGTIEIRSMGR 2331 nematode
BAA07236  1004 LTCNSMVLFdhM-GCLKKYETV-Qd-ILKEFFDLRLSYYGLRKEWLVGMLgaeS-TKLNNQARFILEKIQGKITIENRSK 1079 house mouse
P27570     961 IYIN-GTVFspD-GTLSPIDAD-LspVLQWHYDRRLDLYKRRRTRQIGLLemdL-ARLQSTRKFVEHFRQGHIDFLAATD 1036 Crithidia fascic...
BAA11510  1084 LNFHLTCFDenS---KIQKLES-VeeIIDQFYKVRLQFYGKRREYLLKSLdnqI-KRLTTTIQFLEVIASGKLKIQGRSK 1158 Dictyostelium di...
NP_476760  977 LSTNQMHAFdqN-NCLRRFPTA-Id-ILKEYYKLRREYYARRRDFLVGQLtaqA-DRLSDQARFILEKCEKKLVVENKQR 1052 fruit fly
3L4J_A     627 NAIIqELENLGFPR------------------------------------------------------FnkegkpyygsE 652  baker's yeast
Q23670    1107 AAIVdVLIKMKFDAdpvkkwkeeqklkelresgeiel---------deddlaavaveedeaissaakaV----------E 1167 Caenorhabditis e...
O41065     994 SVISaELEKLNFYKv----------------------------------------------------------------- 1008 Paramecium bursa...
O16140    1077 KAMVeELIKRGYAPdpiadwkkraskiqgltaleddda------qeseeeepepdpkgkpvdpdkafqQ----------L 1140 domestic silkworm
BAC28232   571 KELIkVLIQRGYDSdpvkawkeaqqkv-----------------------------pdeeeneesdteT----------S 611  house mouse
S44861    2332 NQLEeKLQEMGFRVdpmatiaknskk------------------------------------------vnlinyedfqyL 2369 nematode
BAA07236  1080 KDLIqMLVQRGYESdpvkawkeaqekaae------------------------eedsqnqhddsssdsG----------T 1125 house mouse
P27570    1037 DTLTkTCVKLGLVRv----------------------------------------------------------------- 1051 Crithidia fascic...
BAA11510  1159 QDLIkELESGEIVGfenfgthppevyqhlfslsilditkeridnltnqltkrksehqsisssdpkslwT----------A 1228 Dictyostelium di...
NP_476760 1053 KAMCdELLKRGYRPdpvkewqrrikmedaeqadeedeee-----eeaapsvsskakkekevdpekafkK----------L 1117 fruit fly
3L4J_A     653 ELYGTYE------YLLGMRIWSLTKERYQKLLKQKQEKETELENLLKLSAKDIWNT 702  baker's yeast
Q23670    1168 TKLSDYD------YLVGMALIKLSEEEKNKLIKESEEKMAEVRVIEKKTWQDLWHE 1217 Caenorhabditis elegans
O41065    1009 --dGKYD------YLLNMRISSLTLERATELEREAVKLNKELDDLSKTTETDMWNN 1056 Paramecium bursaria Chlorella virus 1
O16140    1141 KEVKKFN------YLLGMSMWMLTKEKKDELLKQRDQKLTELTTLKNKTAPMLWRE 1190 domestic silkworm
BAC28232   612 TSDSAAEagptfnYLLDMPLWYLTKEKKDELCKQRNEKEQELNTLKQKSPSDLWKE 667  house mouse
S44861    2370 NFQANYG------YLLEMPVSRLTSDEMKRLEERKSRRRTELEAAESADWKSVWRS 2419 nematode
BAA07236  1126 PSGPDFN------YILNMSLWSLTKEKVEELIKQRDTKGREVNDLKRKSPSDLWKE 1175 house mouse
P27570    1052 --dDGYD------YILKKPITFYTKTSTEKLQADIKKTQDSIAVLKQTTPVKMWLT 1099 Crithidia fasciculata
BAA11510  1229 DLQQLKE------YLEKSDKEFQKKPLKTSSSSSFDVSSSSESAKLSSTRKSKTDK 1278 Dictyostelium discoideum
NP_476760 1118 TDVKKFD------YLLGMSMWMLTEEKKNELLKQRDTKLSELESLRKKTPEMLWLD 1167 fruit fly
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap