Conserved Protein Domain Family
TOP2c

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smart00433: TOP2c 
TopoisomeraseII
Eukaryotic DNA topoisomerase II, GyrB, ParE
Statistics
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PSSM-Id: 214659
Aligned: 48 rows
Threshold Bit Score: 596.461
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O69998         52 GLMHCLWEIIDNSVDEALGG-Y------CDHIEVILHD-D-A-SVEVRDNGRGIPVDVEPKTGLSGVEVVMTKLHAGGKF 121  Streptomyces ...
O41065         49 ALLKIFDEIITNSADCYNRD-Kk-----LTVLKVCIDE-K-S--VSVHNDGCNIPIEKHDVEKCYIPELIFGHLLAGENF 118  Paramecium bu...
O59864        167 GLYKIFDEIVVNAADNKQND-Dn-----MDEIRVTYSR-E-TnEISVWNNGKGIPVEMHEEHGMYIPQLIFGNLLTSSNY 238  Emericella ni...
NP_595805     125 GLYKIFDEIIVNAADNKVRD-Pn-----MNTLKVTLDP-EaN-VISIYNNGKGIPIEIHDKEKIYIPELIFGNLLTSSNY 196  Schizosacchar...
BAA33955       58 GLFKIFDEILVNAADNKVRD-Ps-----MKRIDVTINP-EeN-FIEVRNDGKGIPIEIHEKEKIYIPELIFGHLLTSSNY 129  Candida glabrata
P87078        109 GLYKIFDEILVNAADNKIRD-Ps-----MKNIRVKIDA-E-NnIIEVMNDGKGIPIEMHTKENMYIPELIFGNLLTSSNY 180  Candida albicans
BAA11510      172 GLLKIYDEILVNAADNKKRDsK------MSFIKVEINPnE-N-SISIMNDGKGIPVVMHQTENCYVVEMVMGNLMSGSNF 243  Dictyostelium...
S44861       1347 GLLKIFDEILVNAADNKARD-Ss-----MNRLEVWLDR-EtA-RISVWNNGSGLPVEIHPTEGIYVPTLVFGNLFTSSNY 1418 nematode
P27570         54 GLLKIVDEILLNAADNINNS-Vrg--arMTYISIKISD---SgEIMVENDGAGLPIVKSKEHKMYIPEMVFGHLLTSSNY 127  Crithidia fas...
XP_001348490   58 GLYKIFDEIIVNAADVKARE-KeksenpMTCIKIEINK-E-NkRISVYNDGEGIPVDIHKEMNIYVPHMIFGELLTSDNY 134  Plasmodium fa...
O69998        122 GGGAYAASGGLHGVGASVVNALSARLDIEVDL--G--GHTHAISFRR-GVPGTFAKA--GPD-AKf--EA-GSGLRKVKK 190  Streptomyces ...
O41065        119 DDTEQRTGAGRNGIGSKATNIFSKKFDVEICD--G--KKKYKQSWENnMSVMSKPKV--TTC-SK---DS-YITTTFFPD 187  Paramecium bu...
O59864        239 DDAKEKITGGRNGFGAKLCNVFSTEFTVETQD--SkqKKRYLQTWTDnMQTVGKPKI--TAA-KG---SD-FTRVTFKAD 309  Emericella ni...
NP_595805     197 DDNQKKVTGGRNGYGAKLCNIFSTEFVVETAD--KerMKKYKQTWYDnMSRKSEPVI--TSL-KK---PDeYTKITFKPD 268  Schizosacchar...
BAA33955      130 DDDEKKVTGGRNGYGAKLCNIFSTEFTLETADpkN--GRKYVQTWENnMNVCHPPKI--TSY-KKv--PS-YTKVAFKPD 201  Candida glabrata
P87078        181 DDDQKKVTGGRNGFGAKLCNIFSTQFEVETAD--LnmGKLYKQSWTNnMSNVSKPKI--TTLrTK---KE-YTKITFRPD 252  Candida albicans
BAA11510      244 NDSELKVVGGRNGFGAKLTNIFSKEFTVETVD--KssGKKYFQRWSNnMGDRSEPIItpIGE-GE---SD-YTKITFKPD 316  Dictyostelium...
S44861       1419 DDSEIKTVGGRNGYGAKLCNIFSKEFIVETVD--TriKRRFRQKWYDnMKKCNEAEV--VEI-LDetvKD-YTKVEFVPD 1492 nematode
P27570        128 NNDASSTTAGRHGYGAKLTNILSTKFSVVCRT--A--GREFHMSWTDhMRMATTPRV--SNV-DPk-eKN-VTRVTFMPD 198  Crithidia fas...
XP_001348490  135 DDAEDRITGGRNGFGAKLTNIFSKEFIVQCGD--SsrKKEFKMTWSDnMSKFSEPHI--KNY-NG---KD-YVKVTFKPD 205  Plasmodium fa...
O69998        191 VPKSRRGT----RVR--YWADRQIFLKDAKLS-LDNLHQRARQTAFlvpgltivvrdefglgdggskgeesfRFDGGISE 263  Streptomyces ...
O41065        188 FERFGIDSf--dDDT--MSIMVRRVYDMAAVL-NKVKVMLNGKR----------------------------LEIKNTED 234  Paramecium bu...
O59864        310 FPRFGMDGi--dDDF--EALIKRRVYDLAGTT--GVTVKLNGTR----------------------------LPVRNFKK 355  Emericella ni...
NP_595805     269 LAKFGMDKi--dDDM--VSIIKRRIYDMAGTV-RETKVYLNNER----------------------------ISISGFKK 315  Schizosacchar...
BAA33955      202 LSRFGMESl--dSDI--LGVMRRRVYDINGSV-RDVNVYLNGKP----------------------------LKIRNFKN 248  Candida glabrata
P87078        253 LSKFDMDC----LDNdlLSVLRRRVYDLCGTV-KNCNIYLNDKR----------------------------LNISSFKG 299  Candida albicans
BAA11510      317 LEKFKIKSlw-dDNI--LQLMERRLYDIAGCN-TELMVTLNGKRLN--------------------------YNFQSYVK 366  Dictyostelium...
S44861       1493 LERFQIDKl--sDDV--IDLIGRRVFEVAATLpRDVDVYLNGQK----------------------------CDVDGFED 1540 nematode
P27570        199 YAHFGFPTaaisLDM--KRVLHKRIMDLAAMF-SKIEVRLNNVP----------------------------FGFQTFND 247  Crithidia fas...
XP_001348490  206 LNKFGMTEm--dDDI--ESLLFKRVYDLAGTC--SVRVYLNGQR----------------------------LAVKDFKS 251  Plasmodium fa...
O69998        264 FCEFLAGDRPVCDVlrfsg---------------------------------qgsfKE----------TVPVLDEDGqmt 300  Streptomyces ...
O41065        235 YFSLYVGNKTE---------------------------------------------------------TKRAFEHTP--- 254  Paramecium bu...
O59864        356 YMEMYTKAIRRERg------------------------------------------DD----------DSKSDPIITcs- 382  Emericella ni...
NP_595805     316 YVEMYLASDTKPDE------------------------------------------EP----------PRVIYEHVN--- 340  Schizosacchar...
BAA33955      249 YVELYLKSLEKMRKmdnges-------------------------------dttpsNI----------PTILYERVS--- 284  Candida glabrata
P87078        300 YVEMYVKAIKERSP------------------------------------------EPepqdgtiknfTTIVHEVFN--- 334  Candida albicans
BAA11510      367 LYEHHLNNSTNVKIm----------------------------------------rHI----------VKNPFEFGE--- 393  Dictyostelium...
S44861       1541 YVKMFNDSSSLLFL------------------------------------------HP----------TPRWHVGVA--- 1565 nematode
P27570        248 YARLYSLPGADGAm------------------------------------------PP----------EPFVHTGPN--- 272  Crithidia fas...
XP_001348490  252 YVDLYLKDNSNDNKnnkgqndnnnnnnnnndenanqnndnldvslsnepadgtptkNN----------NNNNNNNDEdei 321  Plasmodium fa...
O69998        301 psevtrdL--GVDVALRWGTGYDTTVRSFVNIIATPKGGTHVAGFEQAVAKTMNEVLRTKKMLRVaeD-DIVKDDALEGL 377  Streptomyces ...
O41065        255 -------E--NWDVAVSCSDE--FTPVSFVNSVVT-RGGTHVNAVTDAVAKAVVEAAAKKKIV-------VKPMTVKGRM 315  Paramecium bu...
O59864        383 -----phP--YWEIGFAVSDGS-FKQVSFVNSIATTSGGTHVNYIADQIAGKLSESLKKNKKGTG--S-ILKPAQIRNYC 451  Emericella ni...
NP_595805     341 -------D--RWDVAFAVSDG-QFKQVSFVNNISTIRGGTHVNYVANKIVDAIDEVVKKEN--KK--A-PVKAFQIKNYV 405  Schizosacchar...
BAA33955      285 -------D--RWEIAFAVSDI-SFKQVSFVNSIATTTGGTHVNYIADQIVRKVSDIL----KKKK--K-NIKPYQIKNNM 347  Candida glabrata
P87078        335 -------D--RWEVAFAVSDG-SFNQVSFVNSIATTSGGTHVKYVSDQIINKLVETLSKKEKGKK--KlMIKPQEVRDNM 402  Candida albicans
BAA11510      394 -------IspRWKIGIGLSETGQFTQVSFVNSINTVKGGTHVNFLADQIVRYVGEKLKKKHSDLE-----IRPMNIKHHL 461  Dictyostelium...
S44861       1566 -------K--RNNF-FGESHVVLPKIVSFVNNINTEKGGSHVDYVMDKIVNIIKPIVDSKLGDPT--K-SVKPAVIKNNL 1632 nematode
P27570        273 -------G--SIAFVPQLTQSP-KRIVGVVNGVVTYNGGTHCTSAMEILETGLDSLSRSLKKDG---K-VIDTNRVARHF 338  Crithidia fas...
XP_001348490  322 vkihekqH--RWEIVVSKSDGSqFQQVSFVNSICTTKGGSHVNYIVEQLLSSLSKKANAKNKGG---M-EIKSGHIRNHL 395  Plasmodium fa...
O69998        378 TAVVTVRLAEPQFEGQTKEVLGTSAARRIVNNVISRELKAFLTSTKRDAAQQARVVMEKAVAAARtriaaRQHKDAQRRK 457  Streptomyces ...
O41065        316 FVFVNATVVNPTFDSQTKEILTSRNARVT------LSDTFVKKAVGVLLDAVIQETNVRTSLVDQ------KELKKTDGa 383  Paramecium bu...
O59864        452 FLFVNAKIVNPAFSSQTKEQLTTKQTQFG-----SKPILDESFLKKVANSGVLDSLKRFADHKAD------LMLKKSDGG 520  Emericella ni...
NP_595805     406 QVFVNCQIENPSFDSQTKETLTTKVSAFG-----SQCTLSDKFLKAIKKSSVVEEVLKFATAKAD------QQLSKGDGG 474  Schizosacchar...
BAA33955      348 FIFINCLIENPAFTSQTKEQLTTRVKDFG-----SRCDISSDYINKIMKTDLATKIFEIADENAN------NALKKSDGs 416  Candida glabrata
P87078        403 FLFINCLIENPAFTSQTKEQLTTKVSQFGGKD---KFVANDNLINRILKTSIVDKIRAIANANED------KALQKADGs 473  Candida albicans
BAA11510      462 ALFVNCLVDNPSFDSQSKETLTTKPMLFGSTPEIPESLLAQFVKN----SKIIERVAGWALMKQK-----ADLIHSTSGR 532  Dictyostelium...
S44861       1633 SIFINCLIENPSFESQTKETLTTKAKNFGS---IFECDAKKTAEWA-EQSGLIEDIVEEVLNMKK---------KKLPGK 1699 nematode
P27570        339 TVLVFLIQSQPKFDSQSKARLVSTVTMPRV----PRTALDQYLAAMPFLEAHMNSMDDQLAAELN------KEIGTGKRL 408  Crithidia fas...
XP_001348490  396 WVFVNCLIVNPTFDSQTKETLTTKPVKFG-----SKCILSDKTINNVLKSPILSNILLWAQAKAQ------VELKKKMKA 464  Plasmodium fa...
O69998        458 t---ALESSSLPAKLADCRSDD----V---D---RSELFIVEGDSALGTAKLARN---SEFQALLPIRGKILNVQKSSVT 521  Streptomyces ...
O41065        384 ----KKSRVSGIPKLNDAAWAG----T---NhskMCTLILTEGDSAATLAIAGLSvvgRERYGVFPLRGKLLNVRDASVA 452  Paramecium bu...
O59864        521 ----RRSRMN-NPKLTDANRAG----T---KdgyKCTLILTEGESAKGLAMAGRAvvgADLFGVYPLRGKMLNVRDASFD 588  Emericella ni...
NP_595805     475 l----RSRITGLTKLEDANKAG----T---KeshKCVLILTEGDSAKSLAVSGLSvvgRDYYGVFPLRGKLLNVREASHS 543  Schizosacchar...
BAA33955      417 ----RKSRITDYPKLEDANKAG----T---KdgyKCTLILTEGDSALSLAVAGLAvvgRDYYGCYPLRGKMLNVREATAD 485  Candida glabrata
P87078        474 ----RKSRIKGQVNLVDANKAG----T---KdghNCTLILTEGLSAMNLAVAGLSvvgRDYYGCFPLRGKLLNVREASAD 542  Candida albicans
BAA11510      533 q--sKTTLIKSISKLDDANWAG----GlksK---ECTLIITEGDSAKSLALAGLSvvgRNSYGVFPLRGKLLNVRDVASK 603  Dictyostelium...
S44861       1700 r--vSVSSVRDIVKLEDAEWAGitgtA---E---KCTLILTEGDSAKALALAGLEvlgRETYGVFPLKGKLLNVSNLDDA 1771 nematode
P27570        409 s---SRSLISSITKLVDATSSR----S---DgknIRTLIVTEGDSAKALALNSLSseqKKFCGVFPLRGKLLNVRNKNLK 478  Crithidia fas...
XP_001348490  465 gsskARERIIGIPKLEDANDAG----S---KysqECTLILTEGDSAKTSCLAGLSivgRDKYGVFPLKGKLLNVRDASFK 537  Plasmodium fa...
O69998        522 DMLKNAECGAIIQVIGAGSGRT--F---D----I--DAARYGKIIMMTDADVDGSHIRTLLLTLFHRYMRPMVEA-G--R 587  Streptomyces ...
O41065        453 SITKNEEITALKQILGLQTGKVy-K---D----T--SSLRYGHVMIMTDADVDGTHISGLVMNFFHSCFPSLLEI-Pg-F 520  Paramecium bu...
O59864        589 QISKNEEIQSIKNFMGLQHKKEy-T---D----T--KGLRYGHLMIMTDQDHDGSHIKGLLINFLEAQFPSLLKI-Pe-F 656  Emericella ni...
NP_595805     544 QILNNKEIQAIKKIMGFTHKKT--Yt--D----V--KGLRYGHLMIMTDQDHDGSHIKGLIINYLESSYPSLLQIpG--F 611  Schizosacchar...
BAA33955      486 QILKNAEIQAIKKIMGLQHRKK--Ye--D----T--KSLRYGHLMIMTDQDHDGSHIKGLIINFIETSFPGLLDIpG--F 553  Candida glabrata
P87078        543 QISKNAEINSLKQIIGLQHKKV--YtaeN----I--KSLRYGHIMIMTDQDQDGSHIKGLIINFLETSFPGLLDIpG--F 612  Candida albicans
BAA11510      604 QLLSNEEINNLTTILGLSHKNS--Y---DtdesM--EDLRYGRVMIMADQDHDGSHIKGLVMNFIHYFWPNLLKR-G--F 673  Dictyostelium...
S44861       1772 RASKNEEISNLLRILGLKFEDS--N---S----ItrESLRYGRLLILADQDEDGSHIKGLIVNFIHKFWPSLVHTdG--F 1840 nematode
P27570        479 RLKTCKELQDLFLALGLELGKTy-K---S----P--AELRYQRLLVMTDQDADGSHIKGLVINAFESLWPSLLQH-NpgY 547  Crithidia fas...
XP_001348490  538 QLMDNKEIQNIFRIMGLDITDKnkD---D----I--KGLRYGSLMIMTDQDYDGSHIKGLLINMIHKFWPSLLKH-Kg-F 606  Plasmodium fa...
O69998        588 VFAAVPPLHRIELV----QPkkgqDKYVYTYSDRELRDKLMEFQSknIRYK-DSIQRYKGLGEMDADQLAETTMDPRRRT 662  Streptomyces ...
O41065        521 LKKFITPIVVAKKG----KD------VREFYSLPDYEDWVKTTK---DYSK-YQIKYYKGLGTSSSTDAKHYFSNLKTLM 586  Paramecium bu...
O59864        657 LIEFITPIVKVWKG----DIkd-pTKQHSFFTIQEYNAWKEKHG---HERG-WEHKYYKGLGTSSTEEAQEYFRDLDRHL 727  Emericella ni...
NP_595805     612 LIQFITPIIKCTRG----NQ------VQAFYTLPEYEYWKEAN-N--NGRG-WKIKYYKGLGTSDHDDMKSYFSDLDRHM 677  Schizosacchar...
BAA33955      554 LIEFITPIVKVTIT----KPi---KKVISFFNLPDYEKWRE-EES--HKYS-WKQKYYKGLGTSTSPEIIEYFSNLDTHL 622  Candida glabrata
P87078        613 LLEFITPIVKVTVKargaGG----KRVIPFYTMPEFEHWRD-TEG--KQCR-WTQKYYKGLGTSTPMEAREYFTALDRHL 684  Candida albicans
BAA11510      674 LVEFVTPIIKATKS----ST----QKK-SFFTIKDYEKWRETISS--DQLKqYTIKYYKGLGTSTSAEAKEYFSNLDKHV 742  Dictyostelium...
S44861       1841 IQSFRTPLLKAKKG----DK------VRSFFSMNEYRKWADVEEG--G--K-WKIKYYKGLGTSTSNEAREYFSDLDHHT 1905 nematode
P27570        548 ISLFSTPIVKIKVN----GKa---kEVVAFHSFRDFHRWQRANP----NAR-YSAKYYKGLGTSTTAEGKEYFADMERNV 615  Crithidia fas...
XP_001348490  607 LSEFVTPIVKVQKG----SQ------EYSFFTIAEYEQWKENT----NLLG-WKIKYYKGLGTSTDREFKQYFSDIKNHK 671  Plasmodium fa...
O69998        663 LRRINLTDLDSAeQVFDLLMGNDVAPRKEFISSSAA 698  Streptomyces coelicolor
O41065        587 KTFTWTSDSGE--LIDRSFNKTRAEDRKEWMTAYEP 620  Paramecium bursaria Chlorella virus 1
O59864        728 KEFHVMQDKEHE-LIELAFSKKKVEERKEWLRQYNP 762  Emericella nidulans
NP_595805     678 KYFHAMQEKD-AeLIEMAFAKKKADVRKEWLRTYRP 712  Schizosaccharomyces pombe 972h-
BAA33955      623 KKFHALQGDDKd-LIDLAFSKKKADDRKEWLRQYEP 657  Candida glabrata
P87078        685 KRFHALQGEDKd-YIDLAFSKKKADERKEWLQGFLP 719  Candida albicans
BAA11510      743 IKFIWGDEADd--LIKMAFAKDLSSLRQRWIKEtdm 776  Dictyostelium discoideum
S44861       1906 VNFKYTGTTDDd-AIRMAFDRDKSDERKEWIRRSEN 1940 nematode
P27570        616 MRLVVEPKDHR--LLDSVFDSAEVEWRKEWMSKANA 649  Crithidia fasciculata
XP_001348490  672 IMFLWTGDRDGD-SIDMAFSKKRIEDRKLWLQNFIL 706  Plasmodium falciparum 3D7
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