Conserved Protein Domain Family
RasGAP

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smart00323: RasGAP 
GTPase-activator protein for Ras-like GTPases
All alpha-helical domain that accelerates the GTPase activity of Ras, thereby "switching" it into an "off" position. Improved domain limits from structure.
Statistics
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PSSM-Id: 214617
Aligned: 19 rows
Threshold Bit Score: 291.905
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O43374        244 HDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKlgmqgpGQLIPLIEETTSTecRQDVATNLLKLFLGQGLAKDF 323  human
O15815        206 LIQPEQMESFLGTVILTLFGDAFTPREEFLLLSLYRLSi-----QKEMANIATVGDFlkADTVVPKMIITYNKRKQGTDY 280  Dictyostelium...
CAA99093     1651 LEVFINIVTNYRTYTAKTDLGKLEAADKFLRYTIEHPQ--------LSSFGAAVCPAsdIDAYAAGLINAFETRNATHIV 1722 baker's yeast
Q13576        905 QMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTAl----eEEIKSKVDQVQDIvtGNPTVIKMVVSFNRGARGQNT 980  human
O00899        241 LIQADQMEDFLDTVFLTLFGDDFSPREEFLILSLFRLAi-----GQEMSRIKSAGDLlaVESVVPKMIITYTRRKQGHEF 315  Dictyostelium...
O01398       1227 LTQILQQGTEFDTLAETVLADRFEQ---LVQLVTMISDkg---eLPIAMALANVVTTsqMDELARVLVTLFDAKHLLSPL 1300 fruit fly
CAA52228      449 NKNFQIGTICIKISSNLNFILPSTNFVKLEKLLMNANLsm--vsNLIYKSSSSMENDnkLTQTSIIFLDIFQSLSRIEEW 526  baker's yeast
XP_517663     698 LKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQKe-------LHVVYALSHVC-GqdRTLLASILLRIFLHEKLESLL 769  chimpanzee
XP_002044930  583 tPMGEWGSLRLRMRYLDDLIMPCEEYSPLQQ---LLLEs----eLYAVKALAELCHn-dRVPLATALLRVFRQEKRETEL 654  Drosophila se...
AAD15839     1118 LQQGTEFDTLAETVLADRF-------ERLVELVTMMGDqg---eLPIAMALANVVPGsqWDELARVLVTLFDSRHLLYQL 1187 torafugu
O43374        324 LDLLFQLELSRTSET---------------NTLFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKK--YVELDP 386  human
O15815        281 LKAVIGPILS--------------------NVIKQELNLELKPNLVYAAIISEQEIRTGEKSTLDRNVSHEK--ALEVPE 338  Dictyostelium...
CAA99093     1723 VAQLIKNEIEKSSRP---------------TDILRRNSCATRSLSMLARSKGNEYLIRTLQPLLKKIIQNRD--FFEIEK 1785 baker's yeast
Q13576        981 LRQLLAPVVKE-------------------IIDDKSLIINTNPVEVYKAWVNQLETQTGEASKLPYDVTTEQ--ALTYPE 1039 human
O00899        316 LKQIIAPILEN---N---------------VVNAPDLNLELNAVQVYQNMISEQEIQTGAKSTLNRGLAEDQ--IIQLKE 375  Dictyostelium...
O01398       1301 LWNMFYREVEVSDCM---------------QTLFRGNSLGSKIMAFCFKIYGASYLQMLLEPLIRPLLDEEEetCFEVDP 1365 fruit fly
CAA52228      527 FHVLIDKELAKIDGTvsrinqknldskhvfNSLFRGNSILTKSIEQYFFRVGNEYLSKALSAILKEIIESNK--SCELDP 604  baker's yeast
XP_517663     770 LCTLNDREISMEDEA---------------TTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQ--SCELSP 832  chimpanzee
XP_002044930  655 IRMLCQAEVTRENET---------------TTLFRGASLATTLMDLYMRTECSGFLQSAVSETVQRILESKQ--SAELNP 717  Drosophila se...
AAD15839     1188 LWNMFSKEVELADSM---------------QTLFRGNSLASKIMTFCFKVYGAAYLQKLLEPLLRAVITTPDhiSFEVDP 1252 torafugu
O43374        387 SKVEvkdvgcsglhrpqteAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRE--------------- 451  human
O15815        339 VTK------------------TIKARVDQLISICEQFLDGIISSLNRLPYGIRWICKQIYQIAEK--------------- 385  Dictyostelium...
CAA99093     1786 LKPE---------------DSDAERQIELFVKYMNELLESISNSVSYFPPPLFYICQNIYKVACE--------------- 1835 baker's yeast
Q13576       1040 VKN------------------KLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVLKNSIHE--------------- 1086 human
O00899        376 v------------------QSILEPRVEKCIQICERFFTGIIQSLNRLPYGIRWICKQIQSIAQK--------------- 422  Dictyostelium...
O01398       1366 ARLDp--------------TEDIEQHRNNLIALTQKVFDAIINSSDRLPPQLRSMCHCLYQVLSK--------------- 1416 fruit fly
CAA52228      605 ARVKekde--------vkkRKIIADNYKRLYSWVTKIWKRLYATSNDLPIEIRNVLKIFRQKLEI--------------- 661  baker's yeast
XP_517663     833 SKLEk--------------NEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCLQKSVQH--------------- 883  chimpanzee
XP_002044930  718 TKMDv--------------NDDACTNAEFLLQILDLVTQSIFTSPDACPRNVRFICSCLQKAVMA--------------- 768  Drosophila se...
AAD15839     1253 TRLEq--------------GENLEENQRNLLQITERFFQAIIGSSSEFPPQLRSVCHCLYQATCHsllnkatvkekkenk 1318 torafugu
O43374        452 ------RFPGAqheNVPFIAVTSFLCLRFFSPAIMSPKLFHLRER----HADARTSRTLLLLAKAVQNVGNMDTpaSRAK 521  human
O15815        386 ------NFTKSt-qDETLKVIGYFIYYRFIQVAMVSPEEYDLVGR----EIHPTARKNLINVSKVLQALFNFAQ--FGSS 452  Dictyostelium...
CAA99093     1836 ------KFP-----DHAIIAAGSFVFLRFFCPALVSPDSENIIDI----SHLS-EKRTFISLAKVIQNIANGSE--NFSR 1897 baker's yeast
Q13576       1087 ------KFPDAt-eDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMtaggQINSDQRRNLGSVAKVLQHAASNKL--FEGE 1157 human
O00899        423 ------NFDSKp--DEIAKVIGYFVYYRFINLAIVTPDAFEILDK----ELSITSRKNLVNIAKVLQNLFTLKTfqNQGS 490  Dictyostelium...
O01398       1417 ------RFPNLl--QNNIGAVGTVIFLRFINPAIVSPQELGIVDK----QVHSSAKRGLMLMSKILQNIANHVE---FSK 1481 fruit fly
CAA52228      662 ------ICIDDt-lQIILNGISGLLFLRFFCPVILNPKLFKYVSQ----NLNETARRNLTLISKVLLNLSTLTQ--FANK 728  baker's yeast
XP_517663     884 ------KWPTNt--TMRTRVVSGFVFLRLICPAILNPRMFNIISD----SPSPIAARTLILVAKSVQNLANLVE--FGAK 949  chimpanzee
XP_002044930  769 ------KWPTEr--LVRTRVVSGFIFLRLLCPALLNPRQFGLVSE----TPPMAATRSLVMVAKCLQNLANLIE--FGGK 834  Drosophila se...
AAD15839     1319 kavvsqRFPQN-----SIGAVGSAMFLRFVNPAIVSPYEAGILEK----KPPPRIERGLKLMSKILQSIANHVL--F-TK 1386 torafugu
O43374        522 EAWMEPLQPTVRQGVAQLKDFITKLV-----------DIEEKDeldl-------qrtLSLQAPPVKEGPLFIHRTKG--- 580  human
O15815        453 EKHFIPLNGWITSHMGDIKNYLQEIIevgepedylqvDKYMELtqktkpviiislpeICNTHQLISKNLDSLVAKGEk-- 530  Dictyostelium...
CAA99093     1898 WPALCSQKDFLKECSDRIFRFLAELCrtdr----tidIQVRTDptpi-------afdYQFLHSFVYLYGLEVRRNVLn-- 1964 baker's yeast
Q13576       1158 NEHLSSMNNYLSETYQEFRKYFKEACnvpepeekfnmDKYTDLvtvskpviyisieeIISTHSLLLEHQDAIAPEKN--- 1234 human
O00899        491 ERWMQPLNKWILSKTSIVRQYLEDLIqvtdpseylrvDKYNELtlklnpvvvislgeISQTHRLLIANLAALKMKEK--- 567  Dictyostelium...
O01398       1482 EQHMLCFNDFLRDHFEAGRRFFIQIAsdc-----etvDQTSHSmsfi------sdanVLALHRLLWTHQEKIGDYLSssr 1550 fruit fly
CAA52228      729 EPWLMKMNNFIDKRHNDLLDYIDKMTqk-------klDFNSKIlnlsst---isrpkLAIEQTMLDDLPQIPYLLDKnl- 797  baker's yeast
XP_517663     950 EPYMEGVNPFIKSNKHRMIMFLDELGnvp-----elpDTTEHSrtdl-------srdLAALHEICVAHSDELRTLSNe-- 1015 chimpanzee
XP_002044930  835 EQYMEVVNPFILKNKERMIVFLDQLSsvndp-nqplgMFVEQStnlnsq---dtgreLATLHHICVSHSQELH-ELSn-- 907  Drosophila se...
AAD15839     1387 EEHMRPFNDFVKSNFDAARRFFLDIAsds-----ppsDSVNHSlsfi------sdgnVLALHRLLWNNQERIGQYLSsnr 1455 torafugu
O43374        581 ------K----GPLMSSSFKKLYFSLTTEALSFAK 605  human
O15815        531 ------D----DPMRIIMKELDEFGPPPDIAADDD 555  Dictyostelium discoideum
CAA99093     1965 ------E----AKHDDGDIDGDDFYKTTFLLIDDV 1989 baker's yeast
Q13576       1235 -----------DLLSELLGSLGEVPTVESFLGEGA 1258 human
O00899        568 ------E----DPLELILKALPAPLEVVDENDREI 592  Dictyostelium discoideum
O01398       1551 dhkavgR----RPFDKMATLLAYLGPPEHKPVDSH 1581 fruit fly
CAA52228      798 -----rE----TEFVNLIVNFSQEDMTKMEKYNHM 823  baker's yeast
XP_517663    1016 ------RgaqqHVLKKLLAITELLQQKQNQYTKTN 1044 chimpanzee
XP_002044930  908 ------I----LSIKKLVTVTDMLTKHKLKYREMI 932  Drosophila sechellia
AAD15839     1456 dhkavgR----RPFDKMATLLAYLGPPEHKPVADT 1486 torafugu
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