1W9J_A 81 NPIKFDGVEDMSELSYLN-----EPAVFHNLRVRYNQDL-IYTYSGLFLVAVNPFKRIp-IYTQEMVDIFKgrr------ 147 Dictyostelium... AAC47724 94 SLIDPMTYGDIGMLPHTN-----IPCVLDFLKVRFMKNQ-IYTTADPLVVAINPFRDLg-NTTLDWIVRYRdtfd----- 161 Toxoplasma go... AAC16332 334 QPHEKIYVDDLAFLDSPT-----EEVVLENLEQRYRKGE-IYTFAGDVLLTLNPGKVLp-LYGDQTAVKYCerg------ 400 Atlantic hors... AAA28718 327 EKPEKMYPEDLAALENPV-----DENIIESLRHRILMGE-SYSFIGDILLSLNSNEIKq-EFPQEFHAKYRfks------ 393 fruit fly PID:e1322451 258 LERFELLQSDSTRIGGVS-----EEMESSTPIHGFYKEKtSKPSWLASLVILKPFKQPtkASNVLVFVNDFndkdsed-- 330 Caenorhabditi... AAC47726 22 VIPCCFSSLFCVCLPLRRvrdtvPRAEFGTRKSRFLRSI-IYTTAEPLLVAINPFKDLg-NTTDAWISTYRnask----- 94 Toxoplasma go... XP_001010638 90 DSLQTLGYSDMVHMKYLN-----EAEIINNLRKRYQNNM-IFTYIGPTLVVMNPYKEIegVQDNQVIDKIKsdlgikfee 163 Tetrahymena t... P47808 70 KSVLDKSVDDLVQMDDIN-----EAMIVHNLRKRFKNDQ-IYTNIGTILISVNPFKRLp-LYTPTVMDQYMhkv------ 136 Acanthamoeba ... EAW48729 35 EEDSKKDVEDNCSLMYLN-----EATLLHNIKVRYSKDR-IYTYVANILIAVNPYFDIpkIYSSEAIKSYQgks------ 102 human CAA47462 53 CDGPQ-DHDDNCELMLLN-----EATFLDNLKTRYYKDK-IYTYVANILIAVNPYREIkeLYAPDTIKKYNgrs------ 119 fruit fly
1W9J_A 148 -----------rneVAPHIFAISDVAYRSMLD-DRQNQSLLITGESGAGKTENTKKVIQYLASV---------------- 199 Dictyostelium... AAC47724 162 -----------lskLAPHVFYTARRALDNLHA-VNKSQTIIVSGESGAGKTEATKQIMRYFAAA---------------- 213 Toxoplasma go... AAC16332 401 -----------rsdNPPHVFAVADRAYQQMLH-HKSPQAVILSGVSGSGKSFCTHQVIRHLAFL---------------- 452 Atlantic hors... AAA28718 394 -----------rseNQPHIFSVADIAYQDMLH-HKEPQHIVLSGESYSGKSTNARLLIKHLCYL---------------- 445 fruit fly PID:e1322451 331 -------qlswetsSTSGVNAVAKNALNKIFNmSSNAESIVFGGESGSGKSYNVFKAFKYLTSQ---------------- 387 Caenorhabditi... AAC47726 95 -----------pemLPPHVFKTARAALEDLEG-YKKNQSIIVSGESGAGKTEATKQIMRFFASA---------------- 146 Toxoplasma go... XP_001010638 164 dfkmnnlstnqniiNTPHTYTVSGLAYKQMFS-NKKNQAIVISGESGAGKTENAKLSMQFLTSLssgsdkqndllnqlkt 242 Tetrahymena t... P47808 137 -----------pkeMPPHTYNIADDAYRAMID-NRMNQSILISGESGAGKTECTKQCLTYFAEL---------------- 188 Acanthamoeba ... EAW48729 103 -----------lgtRPPHVFAIADKAFRDMKV-LKMSQSIIVSGESGAGKTENTKFVLRYLTES---------------- 154 human CAA47462 120 -----------lgeLPPHVFAIADKAIRDMRV-YKLSQSIIVSGESGAGKTESTKYLLKYLCYS---------------- 171 fruit fly
1W9J_A 200 --------AGrnq-anGSgvLEQQILQANPILEAFGNAKTTRNNNSSRFGKFIEIQFNSAG-FISGASIQSYLLEKSRVV 269 Dictyostelium... AAC47724 214 --------KTgs--mdLR--IQNAIMAANPVLEAFGNAKTIRNNNSSRFGRFMQLDVGREG-GIKFGSVVAFLLEKSRVL 280 Toxoplasma go... AAC16332 453 --------GAqn---kEG--MREKLEYLCPLLDTLGNAYTSTNPNSSHFVKILEVTFTKTG-KITGAILFTFLLEARRLT 518 Atlantic hors... AAA28718 446 --------GDgnrgatGR--VESSIK----AILMLVNAGTPVNNDSTRCVLQYCLTFGKTG-KMSGAVFNMYMLEKLRVA 510 fruit fly PID:e1322451 388 --------PKs----kVS--TKHSSSI-EFVFKSFGCAKTLKNDEATRFGCSIDLLYKRNV-LTGLNLKYTVPLEVPRVI 451 Caenorhabditi... AAC47726 147 --------SSev---rTT--IQDTIMAGNPILEAFGNAKTIRNNNSSRFGRFMMLDVSSHR-GIQHGSISNFLLEKVRVV 212 Toxoplasma go... XP_001010638 243 qtaknillEEfn---qFA--IEVKILACNPILEAFGNAKTVRNNNSSRFGKYVKIYIDKTSqKINGASIDSYLLEKSRIP 317 Tetrahymena t... P47808 189 --------AGs----tNG--VEQNILLANPILESFGNAKTLRN-NSSRFGKWVEIHFDQKG-SICGASTINHLLEKSRVV 252 Acanthamoeba ... EAW48729 155 --------YGt----gQD--IDDRIVEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKS-SVVGGFVSHYLLEKSRIC 219 human CAA47462 172 --------HDs----aGP--IETKILDANPVLEAFGNAKTTRNNNSSRFGKFIEVHYDAKC-QMVGGYISHYLLEKSRIC 236 fruit fly
1W9J_A 270 FQSETERNYHIFYQLLAGAT-AEEKKALHLAg---PESFNYLNQs-------------------------gCVDIK-GVS 319 Dictyostelium... AAC47724 281 TQDEQERSYHIFYQMCKGAD-AAMKERFHILp---LSEYKYINPl--------------------------CLDAP-GID 329 Toxoplasma go... AAC16332 519 DIPKGERNFHVFYYFYEGLRsEGRLKEFGLE----EKNYRYLPE---------------------------LKSSN-SPE 566 Atlantic hors... AAA28718 511 TTDGTQHNFHIFYYFYDFINqQNQLKEYNLKa---DRNYRYLRVppevpp-----------------sklkyrRDD-PEG 569 fruit fly PID:e1322451 452 SQKPGERNFNIFYEVYHGLS-DEMKAKFGIk---gLQKFFYINQgns--------------------------seN-IQH 500 Caenorhabditi... AAC47726 213 SQEANERSYHIFYQLLKGAT-SEMRAKYHLRs---LKEYAYLNGkn-----------------------ggCYDVP-GID 264 Toxoplasma go... XP_001010638 318 CPGKGERNYHIFYHMLKG---NQELSNLRLSqfknLSDFDYLKKs-------------------------dCFEVE-NIQ 368 Tetrahymena t... P47808 253 YQIKGERNFRIVATELVKAP-PRSRGGGGSSpa-rPESFKFLSQs-------------------------gCIDVE-GVD 304 Acanthamoeba ... EAW48729 220 VQGKEERNYHIFYRLCAGAS-EDIREKLHLSs---PDNFRYLNRgctryfanketdkqilqnrkspeylkaGSMKDpLLD 295 human CAA47462 237 TQSAEERNYHVFYMLLAGAP-QQLRDKLSLGk---PDDYRYLSgctqyfanakteql-ipgsqksknhqqkGPLKDpIID 311 fruit fly
1W9J_A 320 DSEEFKItr---qAMDIVG-FSQEEQMSIFKIIAGILHLGNIKFEKGAG---EGA--V------LKDKTALNAASTVFGV 384 Dictyostelium... AAC47724 330 DVAEFHEvc---eSFRSMN-LTEDEVASVWSIVSGVLLLGNVEVTATKDggiDDAaaIe-----GKNLEVFKKACGLLFL 400 Toxoplasma go... AAC16332 567 YVKGYQQfl---rALTSLA-FTEEEIFAIQKVLAAILLLGETEIQNSA-------------------------------- 610 Atlantic hors... AAA28718 570 NVERYREfe---nILRDID-FNHKQLETVRKVLAAILNIGNIRFRQNGKy--AEVenT----------DIVSRIAELLRV 633 fruit fly PID:e1322451 501 DVNRFKHle---sALHVLG-FSDDHCMSIYKIISTILHIGNIYFRTKRN---PNVe---------qDVVEIGNLAELKWI 564 Caenorhabditi... AAC47726 265 DKADFEEvl---qSLDAMQ-ITGSKRHSVFSILSGLLLIGNVSIEGKDAqgvPDAayIs-----PQSEEILEEACQLLSV 335 Toxoplasma go... XP_001010638 369 DAKLYLEvk---kSFRQMN-FSNQEQEAIFSLISAILLLGNANLDSSKAs--DTQapTflnmslPTHHKEFKNASELLQV 442 Tetrahymena t... P47808 305 DVKEFEErvlchgQARVRVqFSEDDINNCMELISAILHLGNFEFVSGQG---KNVetSt-----VANREEVKIVATLLKV 376 Acanthamoeba ... EAW48729 296 DHGDFIRmc---tAMKKIG-LDDEEKLDLFRVVAGVLHLGNIDFEEAG----STSggCnl---kNKSAQSLEYCAELLGL 364 human CAA47462 312 DYQHFHNld---kALGRLG-LSDTEKLGIYSLVAAVLHLGNIAFEEIPD---DVRggCqv---sEASEQSLTITSGLLGV 381 fruit fly
1W9J_A 385 NP--SVLEKALMEPRILAGRD-----LVAQHLNVEKSSSSRDALVKALYGRLFLWLVKKINNVLC-Qe---RKAYFIGVL 453 Dictyostelium... AAC47724 401 DA--ERIREELTVKVSYAGNQ-----EIRGRWKQEDGDMLKSSLAKAMYDKLFMWIIAVLNRSIKpPg---GFKIFMGML 470 Toxoplasma go... AAC16332 611 -A--FKLLGAESSELE---------------NTLTQDVNARDVYARAMYLRLFSWIVAVVNRQLSfSrlvfGDVYSVTVI 672 Atlantic hors... AAA28718 634 DE--KKFMWSLTNFIMVKGGI-----AERRQYTTEEARDARDAVASTLYSRLVDFIINRINMNMSfPravfGDTNAIIIH 706 fruit fly PID:e1322451 565 AFllEVDFDQLVKFLLPTSED-------GSTIELNAALDNRDSFAMMIYEELFKWVLNRIGLQLKcS----LHTGVISIL 633 Caenorhabditi... AAC47726 336 DD--AALKKEILVKSTKVGPQ-----VIEGVRTKDEAKTSVLSLSKNVYDKLFDWLVRQLNSLIDaPd---GMPNFIGIL 405 Toxoplasma go... XP_001010638 443 NP--KDLEESLVFKVRKVGTT-----VIKSPQTAEECLSMRDSLSKNLYDSLFNFLVWKLNQNLLpPqdllNKSLSIGLL 515 Tetrahymena t... P47808 377 DP--ATLEQNVTSKLMEIKGCd----PTRIPLTPVQATDATNALAKAIYSKLFDWLVKKINESMEpQk--gAKTTTIGVL 448 Acanthamoeba ... EAW48729 365 DQ--DDLRVSLTTRVMLTTAGgtkgtVIKVPLKVEQANNARDALAKTVYSHLFDHVVNRVNQCFPfE----TSSYFIGVL 438 human CAA47462 382 DQ--TELRTALVSRVMQSKGGgfkgtVIMVPLKIYEASNARDALAKAIYSRLFDRIVGLINQSIPfQ----ASNFYIGVL 455 fruit fly
1W9J_A 454 DIYGFEIFKVNSFEQLCINYTNEKLQQFFNHHMFKLEQEEYLKEKINWTFIDFg-lDSQATIDLIDGrQp-PGILALLDE 531 Dictyostelium... AAC47724 471 DIFGFEVFKNNSLEQFFINITNEMLQKNFVDIVFDRESKLYRDEGVSSKELIFt--SNAEVIKILTA-Kn-NSVLAALED 546 Toxoplasma go... AAC16332 673 DSPGFENGLHNSLHQLCANVISDNLQNYIQQIIFFKELEEYGEEGVNVPFNLEggvDHRTLVNKLMD-Sg-QGLLTAISK 750 Atlantic hors... AAA28718 707 DMFGFECFNRNGLEQLMINTLNEQMQYHYNQRIFISEMLEMEAEDIDTINLNFy--DNKTALDNLLT-Kp-DGLFYIIDD 782 fruit fly PID:e1322451 634 DHYGFEKYNNNGVEEFLINSVNERIENLFVKHCFHDQLIDYAKDGISVDYKVPnsiENGKTVELLFK-Kp-YGLLSLLTD 711 Caenorhabditi... AAC47726 406 DIFGFEVLEVNSLEQVLINITNEYLQKHFIDVVFDMETKLYQAEGVPTEALEYt--DNLALVGALCG-Kn-DSFFALLED 481 Toxoplasma go... XP_001010638 516 DIFGFESFDINSFEQLCINFTNEKFQQLYVQYVFKSEEEDYKQEGILDVFSDLqyqENQLIIDTIEK-Kp-NGIMVLLDE 593 Tetrahymena t... P47808 449 DIFGFEIFDKNSFEQLCINFTNEKLQQHFNQYTFKLEEKLYQSEEVKYEHITFi--DNQPVLDLIEK-KqpQGLMLVLDE 525 Acanthamoeba ... EAW48729 439 DIAGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHYv--DNQDCIDLIEA-Kl-VGILDILDE 514 human CAA47462 456 DIAGFEYFTVNSFEQFCINYCNEKLQKFFNDNILKNEQELYKREGLNVPEITFt--DNQDIIELIEA-Ks-NGIFTLLDE 531 fruit fly
1W9J_A 532 QSVFpNATDNTLITKLhs-hfSKKNAKYEE---------PRFSKTEFGVTHYAGQVMYEIQDWLEKNKDPLQQDLELCFK 601 Dictyostelium... AAC47724 547 QCLApGGSDEKFLSTCkn-alKGTTKFKPA---------KVSPNINFLISHTVGDIQYNAEGFLFKNKDVLRAEIMEIVQ 616 Toxoplasma go... AAC16332 751 ATQYqRKGESGWMESLqeadsEELVEFSN-----------VNGKPIVSVKHIFRKVSYDATDLVKKNVEDKTRALTSTMQ 819 Atlantic hors... AAA28718 783 ASRS--CQDQNLIMDRv---sEKHSQFVKKh-----------tATEISVAHYTGRIIYDTRAFTDINRDFVPPEMIETFR 846 fruit fly PID:e1322451 712 ECKFpKGTHETYLEHCnl-nhTDRSAYGKA---------RNKERLEFGVRHCIGTTWYNVTDFFARNKRIISLSAVQLMR 781 Caenorhabditi... AAC47726 482 ACLGiRSTDEGFCGTIlr-rlEPSGFFLES---------RRDKRLKFIIRHTIADIEYTCEGMLEKNKDFLRKEVMDVMK 551 Toxoplasma go... XP_001010638 594 NCSLgSGTDDSFLNQItk-nhSKNQLVSFP----------KKDKYSFSLSHTAKQVVYDVRGFRDKNKDEVSTEVEKCLQ 662 Tetrahymena t... P47808 526 QISIpKSSDATFFIKAnqtqaARSTQLRGG----------EDSRTDFIIKHYAGDVIYDSTGMLEKNKDTLQKDLLVLSE 595 Acanthamoeba ... EAW48729 515 ENRLpQPSDQHFTSAVhq-khKDHFRLTIPrksklavhrNIRDDEGFIIRHFAGAVCYETTQFVEKNNDALHMSLESLIC 593 human CAA47462 532 ESKLpKPSYSHFTAEVhk-swANHYRLGLPrssrlkahrTLRDEEGFLVRHFAGAVCYNTEQFIEKNNDALHASLEGLVQ 610 fruit fly
1W9J_A 602 DSSDNVVTKLFndPNiasr-------------------------------akkGANFITVAAQYK---EQLASLMATLET 647 Dictyostelium... AAC47724 617 QSKNPVVAQLF--AGivme-------------------------------kgkMAKGQLIGSQFL---SQLQSLMELINS 660 Toxoplasma go... AAC16332 820 RSCDPRIRAIF--SSenpspflssp-------------------rrssiqenmLLPERTVTDSLHs--ALSSVLNLASTE 876 Atlantic hors... AAA28718 847 SSLDESIMLMF--TNqltkagnltmpfeavqhkdeserksyalntlsagcisqVNNLRTLAANFRftcLTLLKMLSQNAN 924 fruit fly PID:e1322451 782 NSKNPIIGLLF--ESyggn--------------------------------tsdIIVSQAQFVLR----GAQDIADKINV 823 Caenorhabditi... AAC47726 552 ASTDPVTKALF--EGieie-------------------------------agkIGKGTLIASRFL---KNLEEMIGIVAQ 595 Toxoplasma go... XP_001010638 663 SSKCPVIANLL--SYqgsqtqqnketqnlqnfg---nnlnfkkaeisnqmnssKKN----------------ELMIELNN 721 Tetrahymena t... P47808 596 SSKQKLMKLLF--PPseg---------------------------------dqKTSKVTLGGQFR---KQLDSLMTALNA 637 Acanthamoeba ... EAW48729 594 ESRDKFIRELF--ESstnnnkd-------------------------tkqkagKLSFISVGNKFK---TQLNLLLDKLRS 643 human CAA47462 611 ECDNPLLQTLF--PSgsst------------------------------svrgKLNFISVGSKFK---TQLGELMEKLEQ 655 fruit fly
1W9J_A 648 TNPHFVRCIIPNNKQLPAKLEDKVVLDQLRCNGVLEGIRITRKGFPNRIIYADFVKRYY-LLAPNVPRdaedsqkAT--- 723 Dictyostelium... AAC47724 661 TEPHFIRCIKPNDTKKPLDWVPSKMLIQLHALSVLEALQLRQLGYSYRRPFKEFLFQFKfIDLSASENpnldpkeAA--- 737 Toxoplasma go... AAC16332 877 DPPHLILCMRPQKKELINDYDSKSVQIQLHALNVLETILIRQFGFARRISFVDFLNRYQyLAFDFNENvel-tkeNC--- 952 Atlantic hors... AAA28718 925 LGVHFVRCIRADLEYKPRSFHSDVVQQQMKALGVLDTVIARQKGFSSRLPFDEFLRRYQfLAFDFDEPvem-tkdNC--- 1000 fruit fly PID:e1322451 824 SHVHFVRCIKSNNERQSTKFDIPLVNRQIKNLLLAELLSFRVKGYPVKISKTTFARQYRcLLPGDIAQcqn-ekeII--- 899 Caenorhabditi... AAC47726 596 TEAHFIRCLKPNEEKKPLGWNGSKVLNQLFSLSILEALQLRQVGYAYRRNFSEFCSHFRwLDLGLVNSdrd-rkeVA--- 671 Toxoplasma go... XP_001010638 722 SDVHFIRCIKPNEEKKKNFFKYDYVYQQVQYLGILDSIKIRKVGYSYRMTYENFFLEYQeLGQKTKGLtlqkvqqQKldl 801 Tetrahymena t... P47808 638 TEPHYIRCIKPNSEKQADLFHGFMSLQQLRYAGVFEAVRIRQTGYPFRYSHENFLKRYGfLVKDIHKRygpnlkqNC--- 714 Acanthamoeba ... EAW48729 644 TGASFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGYPSRASFHELYNMYKkYMPDKLARldp--rlFC--- 718 human CAA47462 656 NGTNFIRCIKPNSKMIDRQFEGSLALAQLKCSGTISVLELMEHGYPSRVLFADLYSMYKsVLPPELVSlpa--rtFC--- 730 fruit fly
1W9J_A 724 ------DAV-----LKHLn-IDPEQYRFGITKIFFR-AGQLARIEEARE 759 Dictyostelium discoideum AAC47724 738 ------LRL-----LKSSk-LPSEEYQLGKTMVFLK-QTGAKELTQIQR 773 Toxoplasma gondii AAC16332 953 ------RLL-----LLRL---KMDGWTLGKNKVFLK-YYSEEYLSRIYE 986 Atlantic horseshoe crab AAA28718 1001 ------RLL-----FLRL---KMEGWALGKTKVFLR-YYNDEFLARLYE 1034 fruit fly PID:e1322451 900 ------QDI-----LQGQgvKYEDDFKIGTEYVFLR-ERLAERYDGLQN 936 Caenorhabditis elegans AAC47726 672 ------HVL-----LEQSg-IPESSWVIGKTMVFVK-PDAAKELSILQR 707 Toxoplasma gondii XP_001010638 802 kqlittEIFektnlLQNKq-LPQKCVAFGKTKIFLK-NEeilpqefnen 848 Tetrahymena thermophila P47808 715 ------DLL-----LKSMkgDCXSKVQVGKTRVLYRaPEQR-GLELQRN 751 Acanthamoeba castellanii EAW48729 719 ------KAL-----FKALg-LNENDYKFGLTKVFFR-PGKFAEFDQIMK 754 human CAA47462 731 ------EAM-----FQSLn-LSAKDFKFGITKVFFR-PGKFVEFDRIMR 766 fruit fly
Jiyao W et al.(2023). "The conserved domain database in 2023.",