1ZIV


Conserved Protein Domain Family
CysPc

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smart00230: CysPc 
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Calpain-like thiol protease family.
Calpain-like thiol protease family (peptidase family C2). Calcium activated neutral protease (large subunit).
Statistics
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PSSM-Id: 128526
View PSSM: smart00230
Aligned: 14 rows
Threshold Bit Score: 366.651
Threshold Setting Gi: 68052402
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1ZIV_A         21 FEQMRQECLQRGTLFEDADFPASN---SSLFYSERPQ-----I------PFVWKRPGEIVKN-------PEFILGGAT-R 78   human
O35646         13 YQELKQECMKDGRLFCDPTFLPEN---DSLFFNRLLP-----G------KVVWKRPQDISDD-------PHLIVGNIS-N 70   house mouse
Q22386        123 YSNIISYCKSSNSPFIDDSFLHNKksiGSLQFTKNGV-----KrheepdFLNWLRPSQMFTKdg---rsSPWSVLNNPrP 194  Caenorhabditi...
Q00204        122 WKAEPSLTEFETGTNGDVLFTDKP----DLHLSNLQR-----Di-----FAGWKRPHELLSGqvddagmPLNPVMTVSgN 187  Emericella ni...
EAW92545       61 FEQLHKKCLEKKVLYVDPEFPPDE---TSLFYSQKFP-----I------QFVWKRPPEICEN-------PRFIIDGAN-R 118  human
NP_990634      35 YEALKQECIESGTLFRDPQFPAGP---TALGFKELGP-----Yssk-trGVEWKRPSELVDD-------PQFIVGGAT-R 97   chicken
Q22036         15 YEKLRKICIKKKQPFVDTLFPPTN---QSLFLEQRQS-----S------DIVWKRPGELHPD-------PHLFVEGAS-P 72   Caenorhabditi...
AAC51869       13 YSALRQDCRRRKVLFEDPLFPATD---DSLYYKGTPG-----P------AVRWKRPKGICED-------PRLFVDGIS-S 70   human
XP_002577797  841 YETLVKRLKTERTLWEDPDFPAND---KAIGNLPDFR-----E------RIEWKRPHEINPN-------AKFFAGGAS-R 898  Schistosoma m...
NP_001162813 1000 WQNIIQYCRDNSELFVDDSFPPAP---KSLYYNPASGagegnP------VVQWRRPHEINCDgg---ayPPWAVFRTPlP 1067 fruit fly
1ZIV_A         79 TDICQG-ELGDCWLLAAIASLTLNQK------ALARVIP--QDQSFG----P----GYAGIFHFQFWQHSEWLDVVIDDR 141  human
O35646         71 HQLIQG-RLGNKAMISAFSCLAVQES------HWTKAIPnhKDQEWDprkpE----KYAGIFHFRFWHFGEWTEVVIDDL 139  house mouse
Q22386        195 SDIEQGtLVGDCWLMSAMALIAERPD------VLDDIIP---KKQYS----------HYGVYQIKLCVEGKWEVIIVDDF 255  Caenorhabditi...
Q00204        188 TDLVQD-VLTDCSVVASLCATTSRSErglddtLLPIVYPciHNSMKSd---I----SPSGKYIFRFYFNGCFRKVVIDDR 259  Emericella ni...
EAW92545      119 TDICQG-ELGDCWFLAAIACLTLNQH------LLFRVIP--HDQSFI----E----NYAGIFHFQFWRYGEWVDVVIDDC 181  human
NP_990634      98 TDICQG-ALGDCWLLAAIGSLTLNEE------LLHRVVP--HGQSFQ----E----DYAGIFHFQIWQFGEWVDVVVDDL 160  chicken
Q22036         73 NDVTQG-ILGNCWFVSACSALTHNFK------LLAQVIPdaDDQEWSt--kH----AYAGIFRFRFWRFGKWVEVVIDDL 139  Caenorhabditi...
AAC51869       71 HDLHQG-QVGNCWFVAACSSLASRES------LWQKVIPdwKEQEWD----PrkaqAYAGIFHFHFWRLG-MVDVVIDER 138  human
XP_002577797  899 FDIEQG-ALGDCWLLAVVASISGYPQ------LFDQVVP--KDQELKg---P----EYVGVVRFRFWRFGHWVEVLIDDR 962  Schistosoma m...
NP_001162813 1068 SDICQG-VLGNCWLLSALAVLAERED------LVKEVLV---TKEIC----------GQGAYQVRLCKDGKWTTVLVDDL 1127 fruit fly
1ZIV_A        142 LPTFRDR--LVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAETFQTKE-----A--------PE 206  human
O35646        140 LPTINGD--LVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIMDFTGTLAEIIDMQK-----GrytdlveeKY 212  house mouse
Q22386        256 FPCYSKTn-SIAMAVGRRNQLWVPLIEKAMAKVLGSYSKLHGASLAQGLSMLTGASCVNYNCPP-----Ipss--vddVD 327  Caenorhabditi...
Q00204        260 LPSSKTSrsLYMIDRNHRNFMWPALVEKAYLKLRGGYEFPGSNSGTDLWV-LTGWIPEQVFLHS-----Dev-----tAD 328  Emericella ni...
EAW92545      182 LPTYNNQ--LVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRD-----A--------PS 246  human
NP_990634     161 LPTKDGE--LLFVHSAECTEFWSALLEKAYAKLNGCYESLSGGSTTEGFEDFTGGVAEMYDLKR-----A--------PR 225  chicken
Q22036        140 LPTRDGK--LLFARSKTPNEFWSALLEKAFAKLYGCYENLVGGHLSDALQDVSGGVAETLHVRK-----FlkddpndtEL 212  Caenorhabditi...
AAC51869      139 LPTVNNQ--LIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDFTGGVSEPIDLTE-----GdfandetkRN 211  human
XP_002577797  963 LPVRQGRntLVFMHSNDPTEFWSALLEKAYAKLNGCYAHLSGGSQSEAMEDLTGGICLSLELNQ-----Ke------rPS 1031 Schistosoma m...
NP_001162813 1128 LPCDKRG--HLVYSQAKRKQLWVPLIEKAVAKIHGCYEALVSGRAIEGLATLTGAPCESIPLQAsslpmPs-------ED 1198 fruit fly
1ZIV_A        207 NFYEILEKALKRG-----SLLGCFIDTRS------------------------------------------------AAE 233  human
O35646        213 KLFGELYKTFTKG-----GLICCSIESPS------------------------------------------------QEE 239  house mouse
Q22386        328 TFWAQLVSSKESG-----FLMCCHCGAFEn-----------------------------------------------VVA 355  Caenorhabditi...
Q00204        329 QIWSDLFKSFHSG------DVLLTIGTGK-------------------------------------------------LT 353  Emericella ni...
EAW92545      247 DMYKIMKKAIERG-----SLMGCSIDDGTnmtygtspsglnmgeliarmvrnmdnsllqdsdldprgsderptrtiiPVQ 321  human
NP_990634     226 NMGHIIRKALERG-----SLLGCSIDITS------------------------------------------------AFD 252  chicken
Q22036        213 KLFNDLKTAFDKG-----ALVVAAIAART------------------------------------------------KEE 239  Caenorhabditi...
AAC51869      212 QLFERMLKVHSRG-----GLISASIKAVT------------------------------------------------AAD 238  human
XP_002577797 1032 DLIDQLKIYAQRC-----CLMGCSIDSS---------------------------------------------------V 1055 Schistosoma m...
NP_001162813 1199 ELDKDLIWAQLLSsrcvrFLMGASCGGGNm-----------------------------------------------KVD 1231 fruit fly
1ZIV_A        234 SEARTPFGLIKGHAYSVTGIDQVSFRgqR----------------I--ELIRIRNPWG-QVEWNGSWSDSSPEWRSVGPA 294  human
O35646        240 QEVETDWGLLKGYTYTMTDIRKLRLG--Erlvev------fstekL--YMVRLRNPLG-RQEWSGPWSEISEEWQQLTVT 308  house mouse
Q22386        356 EAEFKAMGLLTNHAYSILDVIYEQGY--R--------------------LLRIRNPWG-QFVWNGKWSDGWPGWP--IGM 410  Caenorhabditi...
Q00204        354 EREQKELGLVSEHDYAILDMKELKGR--R--------------------QFLIKNPWA---GTDAVYPALFADPG----- 403  Emericella ni...
EAW92545      322 YETRMACGLVRGHAYSVTGLDEVPFK--G----------------EkvKLVRLRNPWG-QVEWNGSWSDRWKDWSFVDKD 382  human
NP_990634     253 MEAVTFKKLVKGHAYSVTAFKDVNYR--G----------------QqeQLIRIRNPWG-QVEWTGAWSDGSSEWDNIDPS 313  chicken
Q22036        240 IEESLDCGLVKGHAYAVSAVCTIDVT--NpnersftsfimgskrkQ--NLIRLQNPWG-EKEWNGAWSDDSPEWQNVSAS 314  Caenorhabditi...
AAC51869      239 MEARLACGLVKGHAYAVTDVRKVRLG--Hgllaf------fksekL--DMIRLRNPWG-EREWNGPWSDTSEEWQKVSKS 307  human
XP_002577797 1056 MEQKMDNGLIGSHAYSLTGVYPVNYR--Gr--------------tQ--WLMRLRNPWGdSHEWKGAWCDGSPQWREISEQ 1117 Schistosoma m...
NP_001162813 1232 EEEYQQKGLRPRHAYSVLDVKDIQGH--R--------------------LLKLRNPWG-HYSWRGDWSDDSSLWT---DD 1285 fruit fly
1ZIV_A        295 EQKRLCHTAL----DDGEFWMAFKDFKAHFDKVEICNLTPDALEEDA 337  human
O35646        309 DRKNLGLVMS----DDGEFWMSLEDFCHNFHKLNVCRNVNNPVFGRK 351  house mouse
Q22386        411 KQKFLNQRKD----ETGAFWMDLEDFVARFASVTVCKLRMDWSELRV 453  Caenorhabditis elegans
Q00204        404 PFPNSPFLS------PGTFWMDCEMVLQNFENLYL-NWNPGIFAYQE 443  Emericella nidulans
EAW92545      383 EKARLQHQVT----EDGEFWMSYEDFIYHFTKLEICNLTADALQSDK 425  human
NP_990634     314 DREELQLKM-----EDGEFWMSFRDFMREFSRLEICNLTPDALTKDE 355  chicken
Q22036        315 QLSTMGVQPAnsdsDDGDFWMPWESFVHYFTDISLCQLFNTSVFSFS 361  Caenorhabditis elegans
AAC51869      308 EREKMGVTVQ----DDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIH 350  human
XP_002577797 1118 EKKNINLSFT----ADGEFWMSYEDFVTCFSRVEVCHLGLESLEYNQ 1160 Schistosoma mansoni
NP_001162813 1286 LRDALMPHGA----SEGVFWISFEDVLNYFDCIDICKVRSGWNEVRl 1328 fruit fly
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